Incidental Mutation 'R3015:Nop9'
ID 257655
Institutional Source Beutler Lab
Gene Symbol Nop9
Ensembl Gene ENSMUSG00000019297
Gene Name NOP9 nucleolar protein
Synonyms 2610027L16Rik
MMRRC Submission 040536-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.946) question?
Stock # R3015 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 55983150-55992957 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 55988631 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 358 (S358P)
Ref Sequence ENSEMBL: ENSMUSP00000019441 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000001497] [ENSMUST00000019441]
AlphaFold Q8BMC4
Predicted Effect probably benign
Transcript: ENSMUST00000001497
SMART Domains Protein: ENSMUSP00000001497
Gene: ENSMUSG00000022219

DomainStartEndE-ValueType
CAD 36 108 2.16e-41 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000019441
AA Change: S358P

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000019441
Gene: ENSMUSG00000019297
AA Change: S358P

DomainStartEndE-ValueType
low complexity region 11 55 N/A INTRINSIC
Blast:Pumilio 92 127 3e-15 BLAST
Pumilio 189 220 2.74e2 SMART
Blast:Pumilio 263 298 3e-14 BLAST
Pumilio 314 349 4.38e1 SMART
Pumilio 351 387 1.03e1 SMART
Pumilio 509 546 1.72e1 SMART
Pumilio 547 582 9.17e0 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136270
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227300
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency 100% (38/38)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts9 T C 6: 92,849,913 (GRCm39) H380R probably benign Het
Aff3 A T 1: 38,249,649 (GRCm39) I486N probably benign Het
Bltp1 T A 3: 36,929,611 (GRCm39) F76Y probably damaging Het
Cfap44 A C 16: 44,230,832 (GRCm39) D271A probably benign Het
Dbndd2 T A 2: 164,330,270 (GRCm39) V34D probably damaging Het
Erc2 T A 14: 27,733,732 (GRCm39) probably null Het
Fcgbp T C 7: 27,774,838 (GRCm39) probably benign Het
Frem3 T C 8: 81,417,402 (GRCm39) S2036P probably damaging Het
Golph3l A G 3: 95,499,024 (GRCm39) probably benign Het
Grm7 G T 6: 110,623,309 (GRCm39) V161F probably damaging Het
Ifrd2 G A 9: 107,467,221 (GRCm39) G60S probably null Het
Ints9 T A 14: 65,187,727 (GRCm39) W3R probably benign Het
Jmjd1c A G 10: 66,993,711 (GRCm39) E64G probably damaging Het
Katnip T A 7: 125,465,512 (GRCm39) H1321Q probably damaging Het
Matn3 A C 12: 9,002,217 (GRCm39) Q143P probably damaging Het
Myo18a A T 11: 77,749,846 (GRCm39) probably benign Het
Pard3b T C 1: 62,384,037 (GRCm39) S801P probably damaging Het
Pax2 T C 19: 44,804,463 (GRCm39) F268L probably damaging Het
Pik3r1 A G 13: 101,823,771 (GRCm39) I538T probably damaging Het
Plekha8 T C 6: 54,599,107 (GRCm39) S214P probably benign Het
Ppme1 T C 7: 99,981,084 (GRCm39) H352R probably damaging Het
Ppp1r26 A C 2: 28,342,314 (GRCm39) D648A probably damaging Het
Prom1 C A 5: 44,191,733 (GRCm39) V337F probably damaging Het
Rapgef4 T C 2: 72,028,717 (GRCm39) I378T probably damaging Het
Rnf115 T C 3: 96,661,675 (GRCm39) S43P probably damaging Het
Rnf216 A G 5: 143,061,480 (GRCm39) probably null Het
Scn7a G T 2: 66,530,240 (GRCm39) Q702K probably benign Het
Shisal2b T A 13: 104,994,899 (GRCm39) I83F possibly damaging Het
Slc2a1 T A 4: 118,989,340 (GRCm39) N13K probably damaging Het
Tnr A G 1: 159,715,829 (GRCm39) I864V probably benign Het
Tspyl3 A T 2: 153,066,650 (GRCm39) M196K probably damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Umod T C 7: 119,071,763 (GRCm39) D326G probably damaging Het
Upf2 A G 2: 5,980,890 (GRCm39) D492G unknown Het
Vash1 A G 12: 86,732,194 (GRCm39) T126A probably benign Het
Vsig10l T A 7: 43,116,881 (GRCm39) I574K possibly damaging Het
Other mutations in Nop9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02156:Nop9 APN 14 55,990,740 (GRCm39) nonsense probably null
IGL02803:Nop9 APN 14 55,987,533 (GRCm39) missense probably benign
R0443:Nop9 UTSW 14 55,991,205 (GRCm39) missense probably benign 0.00
R1766:Nop9 UTSW 14 55,989,591 (GRCm39) missense possibly damaging 0.94
R1785:Nop9 UTSW 14 55,988,599 (GRCm39) missense probably damaging 1.00
R1786:Nop9 UTSW 14 55,988,599 (GRCm39) missense probably damaging 1.00
R4784:Nop9 UTSW 14 55,983,859 (GRCm39) small deletion probably benign
R5046:Nop9 UTSW 14 55,983,397 (GRCm39) missense possibly damaging 0.90
R5787:Nop9 UTSW 14 55,983,791 (GRCm39) missense possibly damaging 0.93
R6271:Nop9 UTSW 14 55,991,198 (GRCm39) missense probably damaging 1.00
R6379:Nop9 UTSW 14 55,983,249 (GRCm39) missense possibly damaging 0.83
R6943:Nop9 UTSW 14 55,990,270 (GRCm39) missense probably benign 0.25
R7562:Nop9 UTSW 14 55,986,809 (GRCm39) missense probably benign 0.01
R8916:Nop9 UTSW 14 55,991,101 (GRCm39) missense probably benign 0.17
R8992:Nop9 UTSW 14 55,983,438 (GRCm39) missense possibly damaging 0.86
R9070:Nop9 UTSW 14 55,990,757 (GRCm39) missense probably damaging 1.00
R9206:Nop9 UTSW 14 55,987,592 (GRCm39) critical splice donor site probably null
R9385:Nop9 UTSW 14 55,988,584 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TAACCACAGAGCTGCCTCTC -3'
(R):5'- GGAAAACACCGTTTCTCTGTCTG -3'

Sequencing Primer
(F):5'- ACAGAGCTGCCTCTCTAGCC -3'
(R):5'- ACCTTTGATCTCAGCAGTCAGGATG -3'
Posted On 2015-01-11