Incidental Mutation 'R3017:Slco1a4'
ID 257666
Institutional Source Beutler Lab
Gene Symbol Slco1a4
Ensembl Gene ENSMUSG00000030237
Gene Name solute carrier organic anion transporter family, member 1a4
Synonyms Oatp2, Oatp1a4, Slc21a5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # R3017 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 141751166-141801925 bp(-) (GRCm39)
Type of Mutation splice site (4 bp from exon)
DNA Base Change (assembly) T to C at 141758396 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000130746 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032364] [ENSMUST00000032364] [ENSMUST00000165990] [ENSMUST00000165990]
AlphaFold Q9EP96
Predicted Effect probably null
Transcript: ENSMUST00000032364
SMART Domains Protein: ENSMUSP00000032364
Gene: ENSMUSG00000030237

DomainStartEndE-ValueType
Pfam:OATP 19 598 3.2e-196 PFAM
Pfam:MFS_1 22 421 9.2e-27 PFAM
Pfam:Kazal_2 445 486 5e-10 PFAM
transmembrane domain 600 622 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000032364
SMART Domains Protein: ENSMUSP00000032364
Gene: ENSMUSG00000030237

DomainStartEndE-ValueType
Pfam:OATP 19 598 3.2e-196 PFAM
Pfam:MFS_1 22 421 9.2e-27 PFAM
Pfam:Kazal_2 445 486 5e-10 PFAM
transmembrane domain 600 622 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000165990
SMART Domains Protein: ENSMUSP00000130746
Gene: ENSMUSG00000030237

DomainStartEndE-ValueType
Pfam:OATP 21 597 3.2e-164 PFAM
Pfam:MFS_1 22 421 7.2e-27 PFAM
Pfam:Kazal_2 445 486 6.8e-11 PFAM
transmembrane domain 600 622 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000165990
SMART Domains Protein: ENSMUSP00000130746
Gene: ENSMUSG00000030237

DomainStartEndE-ValueType
Pfam:OATP 21 597 3.2e-164 PFAM
Pfam:MFS_1 22 421 7.2e-27 PFAM
Pfam:Kazal_2 445 486 6.8e-11 PFAM
transmembrane domain 600 622 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 93.4%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired organic anion transporter activity and urinary metabolomic profiles. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 16 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aox4 T C 1: 58,274,363 (GRCm39) V383A probably benign Het
Aplp1 A T 7: 30,135,396 (GRCm39) probably null Het
Bahd1 C T 2: 118,746,887 (GRCm39) P169S probably damaging Het
Gmnc G A 16: 26,779,165 (GRCm39) H281Y probably benign Het
Gusb T C 5: 130,029,325 (GRCm39) D152G probably damaging Het
Kcnk4 A T 19: 6,905,162 (GRCm39) V163E probably damaging Het
Lcmt1 T G 7: 123,029,359 (GRCm39) L327W probably damaging Het
Med18 G A 4: 132,187,128 (GRCm39) R124C probably damaging Het
Odf1 A G 15: 38,226,675 (GRCm39) T192A unknown Het
Pitpna C T 11: 75,483,016 (GRCm39) R8W probably damaging Het
Pkn1 A G 8: 84,396,799 (GRCm39) Y951H probably benign Het
Rad18 T C 6: 112,658,327 (GRCm39) T193A possibly damaging Het
Ruvbl2 G T 7: 45,071,588 (GRCm39) L432I probably damaging Het
Tlr11 T A 14: 50,600,178 (GRCm39) C721* probably null Het
Tubgcp6 A T 15: 88,987,285 (GRCm39) C1229* probably null Het
Vmn2r114 ATTT ATT 17: 23,509,906 (GRCm39) probably null Het
Other mutations in Slco1a4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00976:Slco1a4 APN 6 141,752,908 (GRCm39) critical splice acceptor site probably null
IGL01573:Slco1a4 APN 6 141,758,577 (GRCm39) splice site probably benign
IGL01735:Slco1a4 APN 6 141,763,477 (GRCm39) missense probably benign 0.00
IGL03115:Slco1a4 APN 6 141,763,585 (GRCm39) missense probably damaging 1.00
IGL03115:Slco1a4 APN 6 141,765,329 (GRCm39) missense probably benign 0.05
R0062:Slco1a4 UTSW 6 141,765,205 (GRCm39) nonsense probably null
R0062:Slco1a4 UTSW 6 141,765,205 (GRCm39) nonsense probably null
R0305:Slco1a4 UTSW 6 141,763,479 (GRCm39) missense possibly damaging 0.47
R0511:Slco1a4 UTSW 6 141,776,586 (GRCm39) splice site probably benign
R0660:Slco1a4 UTSW 6 141,758,467 (GRCm39) missense probably benign 0.05
R0664:Slco1a4 UTSW 6 141,758,467 (GRCm39) missense probably benign 0.05
R1589:Slco1a4 UTSW 6 141,791,173 (GRCm39) missense probably benign
R1606:Slco1a4 UTSW 6 141,785,337 (GRCm39) missense probably damaging 1.00
R1665:Slco1a4 UTSW 6 141,785,303 (GRCm39) missense possibly damaging 0.79
R1742:Slco1a4 UTSW 6 141,770,771 (GRCm39) missense probably benign 0.07
R1763:Slco1a4 UTSW 6 141,758,457 (GRCm39) missense probably benign 0.26
R1893:Slco1a4 UTSW 6 141,780,342 (GRCm39) splice site probably null
R1908:Slco1a4 UTSW 6 141,761,173 (GRCm39) critical splice donor site probably null
R1944:Slco1a4 UTSW 6 141,785,276 (GRCm39) missense probably benign 0.00
R2144:Slco1a4 UTSW 6 141,755,104 (GRCm39) missense probably damaging 1.00
R2276:Slco1a4 UTSW 6 141,761,308 (GRCm39) missense possibly damaging 0.49
R2340:Slco1a4 UTSW 6 141,787,103 (GRCm39) missense probably benign 0.00
R3769:Slco1a4 UTSW 6 141,785,357 (GRCm39) missense probably damaging 1.00
R4577:Slco1a4 UTSW 6 141,765,266 (GRCm39) missense probably damaging 0.97
R4650:Slco1a4 UTSW 6 141,758,424 (GRCm39) missense possibly damaging 0.94
R4801:Slco1a4 UTSW 6 141,791,223 (GRCm39) start gained probably benign
R4802:Slco1a4 UTSW 6 141,791,223 (GRCm39) start gained probably benign
R4896:Slco1a4 UTSW 6 141,761,231 (GRCm39) missense possibly damaging 0.91
R5126:Slco1a4 UTSW 6 141,761,308 (GRCm39) missense possibly damaging 0.94
R5183:Slco1a4 UTSW 6 141,785,357 (GRCm39) missense probably damaging 1.00
R5399:Slco1a4 UTSW 6 141,776,433 (GRCm39) missense probably damaging 0.98
R5645:Slco1a4 UTSW 6 141,780,385 (GRCm39) missense possibly damaging 0.95
R5650:Slco1a4 UTSW 6 141,755,120 (GRCm39) missense possibly damaging 0.69
R5832:Slco1a4 UTSW 6 141,765,270 (GRCm39) missense probably benign 0.00
R6180:Slco1a4 UTSW 6 141,763,546 (GRCm39) missense possibly damaging 0.95
R6415:Slco1a4 UTSW 6 141,780,415 (GRCm39) nonsense probably null
R6992:Slco1a4 UTSW 6 141,765,330 (GRCm39) missense probably benign 0.05
R7024:Slco1a4 UTSW 6 141,780,434 (GRCm39) missense probably benign 0.00
R7696:Slco1a4 UTSW 6 141,756,237 (GRCm39) nonsense probably null
R7751:Slco1a4 UTSW 6 141,780,413 (GRCm39) missense possibly damaging 0.47
R8743:Slco1a4 UTSW 6 141,765,255 (GRCm39) missense possibly damaging 0.93
R9173:Slco1a4 UTSW 6 141,761,299 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- AGAATTGCCTGGAACCTTGG -3'
(R):5'- GGTGTTTCAAAATTGTAGCTGC -3'

Sequencing Primer
(F):5'- ACTGCCTCAAATAGAGCGTG -3'
(R):5'- AGCTGCATTCAGTCATCAGG -3'
Posted On 2015-01-11