Incidental Mutation 'R2991:Lypd8l'
ID 257910
Institutional Source Beutler Lab
Gene Symbol Lypd8l
Ensembl Gene ENSMUSG00000037145
Gene Name LY6/PLAUR domain containing 8 like
Synonyms 2210407C18Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R2991 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 58499030-58504318 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 58501516 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 156 (V156I)
Ref Sequence ENSEMBL: ENSMUSP00000104449 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048801] [ENSMUST00000108821]
AlphaFold Q6YI28
Predicted Effect possibly damaging
Transcript: ENSMUST00000048801
AA Change: V156I

PolyPhen 2 Score 0.805 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000039283
Gene: ENSMUSG00000037145
AA Change: V156I

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
low complexity region 209 220 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000108821
AA Change: V156I

PolyPhen 2 Score 0.805 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000104449
Gene: ENSMUSG00000037145
AA Change: V156I

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
low complexity region 209 220 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126695
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts15 T A 9: 30,832,690 (GRCm39) T282S probably benign Het
Asic2 C A 11: 81,858,863 (GRCm39) V50L probably benign Het
Cdadc1 T C 14: 59,823,521 (GRCm39) M324V possibly damaging Het
Cdcp3 A T 7: 130,848,429 (GRCm39) D861V probably damaging Het
Col12a1 A T 9: 79,607,547 (GRCm39) V427D probably damaging Het
Col3a1 C A 1: 45,374,939 (GRCm39) probably benign Het
Esp24 A T 17: 39,350,894 (GRCm39) E31D possibly damaging Het
Igkv14-100 T A 6: 68,496,335 (GRCm39) L76* probably null Het
Itsn2 T C 12: 4,708,474 (GRCm39) V843A probably benign Het
Llgl2 T C 11: 115,741,946 (GRCm39) S663P probably benign Het
Lsg1 T C 16: 30,380,547 (GRCm39) N630S probably damaging Het
Msh4 A G 3: 153,611,497 (GRCm39) V42A probably benign Het
Nkx6-1 T C 5: 101,807,401 (GRCm39) Y327C probably damaging Het
Or9i1b G A 19: 13,896,675 (GRCm39) C97Y probably damaging Het
Pde4a T C 9: 21,114,539 (GRCm39) S369P probably damaging Het
Pkdrej T C 15: 85,704,137 (GRCm39) I600V probably benign Het
Plekhg6 T C 6: 125,347,432 (GRCm39) E479G probably damaging Het
Rab36 G A 10: 74,880,328 (GRCm39) V63I probably damaging Het
Rap1gap2 C A 11: 74,298,148 (GRCm39) A491S possibly damaging Het
Rgmb A T 17: 16,041,352 (GRCm39) D78E probably damaging Het
Samd12 C T 15: 53,723,592 (GRCm39) E34K probably damaging Het
Slc22a21 T G 11: 53,850,195 (GRCm39) E220A probably damaging Het
Smc6 A G 12: 11,339,982 (GRCm39) E430G probably damaging Het
Snx15 C A 19: 6,171,515 (GRCm39) L186F probably damaging Het
Tiam2 A G 17: 3,568,525 (GRCm39) E1557G probably benign Het
Vwa8 A T 14: 79,232,589 (GRCm39) T644S probably benign Het
Zcchc4 T A 5: 52,961,780 (GRCm39) F247Y probably damaging Het
Zmynd11 A G 13: 9,745,858 (GRCm39) V165A probably damaging Het
Other mutations in Lypd8l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00763:Lypd8l APN 11 58,503,707 (GRCm39) utr 5 prime probably benign
IGL02341:Lypd8l APN 11 58,503,656 (GRCm39) missense possibly damaging 0.70
IGL02609:Lypd8l APN 11 58,503,442 (GRCm39) missense probably damaging 1.00
R0466:Lypd8l UTSW 11 58,503,331 (GRCm39) splice site probably benign
R0598:Lypd8l UTSW 11 58,499,230 (GRCm39) missense probably benign 0.27
R0612:Lypd8l UTSW 11 58,502,799 (GRCm39) splice site probably null
R2352:Lypd8l UTSW 11 58,503,676 (GRCm39) missense probably damaging 1.00
R2352:Lypd8l UTSW 11 58,502,934 (GRCm39) nonsense probably null
R2439:Lypd8l UTSW 11 58,501,603 (GRCm39) missense probably damaging 1.00
R2910:Lypd8l UTSW 11 58,499,252 (GRCm39) nonsense probably null
R2911:Lypd8l UTSW 11 58,499,252 (GRCm39) nonsense probably null
R3609:Lypd8l UTSW 11 58,503,384 (GRCm39) missense possibly damaging 0.95
R4863:Lypd8l UTSW 11 58,503,338 (GRCm39) critical splice donor site probably null
R4925:Lypd8l UTSW 11 58,501,513 (GRCm39) missense probably damaging 0.96
R6954:Lypd8l UTSW 11 58,499,314 (GRCm39) missense probably benign 0.01
R7725:Lypd8l UTSW 11 58,499,325 (GRCm39) missense probably benign 0.21
R9148:Lypd8l UTSW 11 58,499,338 (GRCm39) missense probably benign 0.08
Z1186:Lypd8l UTSW 11 58,503,397 (GRCm39) missense probably benign 0.00
Z1186:Lypd8l UTSW 11 58,503,387 (GRCm39) missense probably benign 0.14
Z1186:Lypd8l UTSW 11 58,499,335 (GRCm39) missense probably benign 0.00
Z1187:Lypd8l UTSW 11 58,503,397 (GRCm39) missense probably benign 0.00
Z1187:Lypd8l UTSW 11 58,503,387 (GRCm39) missense probably benign 0.14
Z1187:Lypd8l UTSW 11 58,499,335 (GRCm39) missense probably benign 0.00
Z1188:Lypd8l UTSW 11 58,503,397 (GRCm39) missense probably benign 0.00
Z1188:Lypd8l UTSW 11 58,503,387 (GRCm39) missense probably benign 0.14
Z1188:Lypd8l UTSW 11 58,499,335 (GRCm39) missense probably benign 0.00
Z1189:Lypd8l UTSW 11 58,503,397 (GRCm39) missense probably benign 0.00
Z1189:Lypd8l UTSW 11 58,503,387 (GRCm39) missense probably benign 0.14
Z1189:Lypd8l UTSW 11 58,499,335 (GRCm39) missense probably benign 0.00
Z1190:Lypd8l UTSW 11 58,503,397 (GRCm39) missense probably benign 0.00
Z1190:Lypd8l UTSW 11 58,503,387 (GRCm39) missense probably benign 0.14
Z1190:Lypd8l UTSW 11 58,499,335 (GRCm39) missense probably benign 0.00
Z1191:Lypd8l UTSW 11 58,503,397 (GRCm39) missense probably benign 0.00
Z1191:Lypd8l UTSW 11 58,503,387 (GRCm39) missense probably benign 0.14
Z1191:Lypd8l UTSW 11 58,499,335 (GRCm39) missense probably benign 0.00
Z1192:Lypd8l UTSW 11 58,503,397 (GRCm39) missense probably benign 0.00
Z1192:Lypd8l UTSW 11 58,503,387 (GRCm39) missense probably benign 0.14
Z1192:Lypd8l UTSW 11 58,499,335 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ACCCTGAGCATCTGAAGGAC -3'
(R):5'- AGCTCATCCTCACTGCAACG -3'

Sequencing Primer
(F):5'- GCCAGTGACATGCTCAGATTCTAG -3'
(R):5'- CACTGCAACGCTTTTTGGTAGAATC -3'
Posted On 2015-01-11