|Institutional Source||Beutler Lab|
|Gene Name||suppressor of cytokine signaling 5|
|Synonyms||Cish5, 1810018L08Rik, SOCS-5|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R3160 (G1)|
|Chromosomal Location||87107679-87137583 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to T at 87134718 bp|
|Amino Acid Change||Glutamine to Leucine at position 362 (Q362L)|
|Ref Sequence||ENSEMBL: ENSMUSP00000038591 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000041369]|
|Predicted Effect||probably damaging
AA Change: Q362L
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: Q362L
|Meta Mutation Damage Score||0.232|
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants are viable and fertile with normal immune system morphology and function. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Socs5||
(F):5'- CACCTTTGAAGCTACTGCACAG -3'
(R):5'- GCTCACAGAGAAGAGGTAGTCC -3'
(F):5'- GTCAACCCATTGTATAAGCTGGGAC -3'
(R):5'- GTAGTCCTCCTGTGCAGAGTC -3'