Incidental Mutation 'R3160:Socs5'
ID258136
Institutional Source Beutler Lab
Gene Symbol Socs5
Ensembl Gene ENSMUSG00000037104
Gene Namesuppressor of cytokine signaling 5
SynonymsCish5, 1810018L08Rik, SOCS-5
MMRRC Submission 040611-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R3160 (G1)
Quality Score225
Status Not validated
Chromosome17
Chromosomal Location87107679-87137583 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 87134718 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Leucine at position 362 (Q362L)
Ref Sequence ENSEMBL: ENSMUSP00000038591 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041369]
Predicted Effect probably damaging
Transcript: ENSMUST00000041369
AA Change: Q362L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000038591
Gene: ENSMUSG00000037104
AA Change: Q362L

DomainStartEndE-ValueType
Pfam:SOCS 145 197 8.4e-20 PFAM
low complexity region 258 270 N/A INTRINSIC
SH2 379 465 4.59e-18 SMART
SOCS 475 518 1.65e-19 SMART
SOCS_box 481 517 3.74e-10 SMART
Meta Mutation Damage Score 0.232 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants are viable and fertile with normal immune system morphology and function. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700074P13Rik A G 6: 40,926,069 M123T probably benign Het
Adcy9 A G 16: 4,311,588 L715P probably damaging Het
Amer2 A G 14: 60,378,551 D65G probably damaging Het
Btnl2 T C 17: 34,358,065 W65R probably damaging Het
Camk1g T C 1: 193,359,807 T45A possibly damaging Het
Ccdc181 T A 1: 164,280,296 S183T probably damaging Het
Cep350 T C 1: 155,863,164 H2311R probably benign Het
Copa T A 1: 172,091,233 C127S probably damaging Het
Crbn T C 6: 106,790,866 Q221R probably benign Het
Dapk2 T G 9: 66,254,611 V267G probably damaging Het
Decr1 T A 4: 15,930,972 D120V probably damaging Het
Dennd1c C T 17: 57,066,562 G637D possibly damaging Het
Disp1 T C 1: 183,087,242 K1205E probably benign Het
Dnajc13 G T 9: 104,219,898 N510K possibly damaging Het
Hnrnpu T C 1: 178,331,125 probably benign Het
Iqgap1 G A 7: 80,752,338 A393V probably benign Het
Irak2 G T 6: 113,672,760 A119S probably benign Het
Itgb2l A G 16: 96,437,389 L70P probably damaging Het
Itsn1 C A 16: 91,853,044 S202* probably null Het
Mill2 A C 7: 18,856,174 E127A probably benign Het
Msh6 T C 17: 87,985,481 Y555H probably damaging Het
Myo18b A C 5: 112,692,728 S2400A probably damaging Het
Naa25 A G 5: 121,435,072 probably null Het
Nop2 A G 6: 125,134,592 N96S probably benign Het
Olfr1263 T G 2: 90,015,021 Y30* probably null Het
Olfr156 T A 4: 43,820,544 K272N probably benign Het
Olfr30 T C 11: 58,455,227 T241A probably damaging Het
Olfr739 T A 14: 50,425,031 C171S probably damaging Het
Pde5a T A 3: 122,781,628 L356* probably null Het
Ralgapa1 A T 12: 55,709,586 N1075K probably damaging Het
Rps2 G T 17: 24,720,978 A129S probably benign Het
Serinc2 A G 4: 130,260,735 S175P probably benign Het
Srbd1 A T 17: 86,130,215 D233E probably benign Het
Srgap3 A G 6: 112,729,658 V826A probably benign Het
Tns2 A G 15: 102,113,336 E1118G possibly damaging Het
Topaz1 T C 9: 122,749,381 I452T probably benign Het
Tuba8 A G 6: 121,222,738 D127G possibly damaging Het
Tulp4 A G 17: 6,198,708 M1V probably null Het
Urb1 A G 16: 90,797,903 L247P probably damaging Het
Usp32 A G 11: 85,025,536 W861R probably damaging Het
Vmn1r48 G A 6: 90,036,378 T155I probably benign Het
Vmn2r117 A G 17: 23,460,378 L624P probably damaging Het
Vstm5 T G 9: 15,257,298 S53A probably benign Het
Yeats2 T C 16: 20,193,645 V531A probably damaging Het
Other mutations in Socs5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02426:Socs5 APN 17 87134892 missense probably damaging 1.00
IGL02553:Socs5 APN 17 87134991 missense probably damaging 1.00
PIT1430001:Socs5 UTSW 17 87133616 splice site probably benign
R0909:Socs5 UTSW 17 87133773 missense probably benign 0.11
R1595:Socs5 UTSW 17 87134195 missense probably damaging 1.00
R2397:Socs5 UTSW 17 87134949 missense probably damaging 1.00
R3162:Socs5 UTSW 17 87134718 missense probably damaging 1.00
R5264:Socs5 UTSW 17 87134341 missense probably damaging 1.00
R5483:Socs5 UTSW 17 87134974 missense probably damaging 1.00
R6604:Socs5 UTSW 17 87135125 missense probably damaging 1.00
X0011:Socs5 UTSW 17 87134940 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CACCTTTGAAGCTACTGCACAG -3'
(R):5'- GCTCACAGAGAAGAGGTAGTCC -3'

Sequencing Primer
(F):5'- GTCAACCCATTGTATAAGCTGGGAC -3'
(R):5'- GTAGTCCTCCTGTGCAGAGTC -3'
Posted On2015-01-23