Incidental Mutation 'R3407:Vmn1r21'
ID 258312
Institutional Source Beutler Lab
Gene Symbol Vmn1r21
Ensembl Gene ENSMUSG00000115343
Gene Name vomeronasal 1 receptor 21
Synonyms V1rc28
MMRRC Submission 040625-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.121) question?
Stock # R3407 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 57820549-57821442 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 57820877 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Aspartic acid at position 189 (G189D)
Ref Sequence ENSEMBL: ENSMUSP00000154295 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081186] [ENSMUST00000203310] [ENSMUST00000203488] [ENSMUST00000226191]
AlphaFold Q8R2C6
Predicted Effect probably damaging
Transcript: ENSMUST00000081186
AA Change: G189D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000079950
Gene: ENSMUSG00000058588
AA Change: G189D

DomainStartEndE-ValueType
Pfam:V1R 28 293 5.9e-52 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203270
Predicted Effect probably damaging
Transcript: ENSMUST00000203310
AA Change: G189D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000145398
Gene: ENSMUSG00000115343
AA Change: G189D

DomainStartEndE-ValueType
Pfam:V1R 27 107 1.8e-14 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000203488
AA Change: G189D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000144978
Gene: ENSMUSG00000115343
AA Change: G189D

DomainStartEndE-ValueType
Pfam:V1R 28 105 2e-13 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226191
AA Change: G189D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 92.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg4 A T X: 56,013,487 (GRCm39) I2838F probably damaging Het
Agbl2 G A 2: 90,621,962 (GRCm39) V150I probably damaging Het
Ambra1 T C 2: 91,740,652 (GRCm39) S924P probably damaging Het
Arfgap3 T C 15: 83,206,808 (GRCm39) D260G probably benign Het
Bag3 AAAGG AAAGGAAGG 7: 128,147,493 (GRCm39) probably null Het
Bag3 TAAAG TAAAGAAAG 7: 128,147,492 (GRCm39) probably null Het
Cacnb3 T C 15: 98,539,068 (GRCm39) V167A probably benign Het
Carm1 C T 9: 21,497,478 (GRCm39) R347W probably damaging Het
Ccdc30 A T 4: 119,181,778 (GRCm39) F577I possibly damaging Het
Ces3a T A 8: 105,777,199 (GRCm39) V174E probably damaging Het
Cobl T C 11: 12,325,830 (GRCm39) Y215C probably damaging Het
Cybrd1 A T 2: 70,948,470 (GRCm39) M3L probably damaging Het
Dis3 A G 14: 99,336,212 (GRCm39) V98A probably benign Het
Dsg1c G A 18: 20,415,115 (GRCm39) probably null Het
Eif4a1 A T 11: 69,561,089 (GRCm39) V72E probably damaging Het
Fmn1 A T 2: 113,195,400 (GRCm39) I367F unknown Het
Fnbp1l A C 3: 122,345,799 (GRCm39) W229G probably damaging Het
Inka1 C T 9: 107,862,253 (GRCm39) R23Q probably damaging Het
Ints6 A T 14: 62,934,386 (GRCm39) I707K probably benign Het
Ipo8 T C 6: 148,723,207 (GRCm39) D70G probably benign Het
Kif20b T C 19: 34,927,900 (GRCm39) L1014P probably damaging Het
Kif9 T C 9: 110,348,208 (GRCm39) L677P probably damaging Het
Mbd1 A G 18: 74,410,438 (GRCm39) K414E possibly damaging Het
Mfsd1 T A 3: 67,504,046 (GRCm39) M346K possibly damaging Het
Mthfr T C 4: 148,139,518 (GRCm39) I66T probably damaging Het
Myh10 T G 11: 68,681,037 (GRCm39) L989R possibly damaging Het
Ncan G A 8: 70,564,801 (GRCm39) T271I probably damaging Het
Or10ag53 A C 2: 87,083,243 (GRCm39) T321P probably benign Het
Or9s23 A G 1: 92,501,675 (GRCm39) T261A probably damaging Het
Pate2 C T 9: 35,582,262 (GRCm39) T80I probably damaging Het
Pcdhb15 A G 18: 37,607,442 (GRCm39) T225A possibly damaging Het
Pde4dip C A 3: 97,661,784 (GRCm39) L640F probably damaging Het
Plch1 A G 3: 63,606,768 (GRCm39) probably benign Het
Pus3 C T 9: 35,478,021 (GRCm39) R418C probably damaging Het
Sall2 G T 14: 52,565,561 (GRCm39) N24K probably benign Het
Sh3bp4 G T 1: 89,072,769 (GRCm39) C539F possibly damaging Het
Smco3 A G 6: 136,808,425 (GRCm39) S150P probably benign Het
Spag17 G T 3: 99,992,615 (GRCm39) A1704S probably benign Het
Tecta A T 9: 42,249,150 (GRCm39) I1904N probably damaging Het
Ttn T A 2: 76,536,281 (GRCm39) K33280* probably null Het
Uggt2 T C 14: 119,328,682 (GRCm39) D90G probably benign Het
Zbtb10 A G 3: 9,329,926 (GRCm39) N428S probably damaging Het
Zfp407 G A 18: 84,576,997 (GRCm39) A1372V probably benign Het
Other mutations in Vmn1r21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00329:Vmn1r21 APN 6 57,821,049 (GRCm39) missense probably benign 0.05
IGL01366:Vmn1r21 APN 6 57,820,799 (GRCm39) missense probably benign 0.01
IGL01660:Vmn1r21 APN 6 57,821,222 (GRCm39) missense probably damaging 0.99
IGL02864:Vmn1r21 APN 6 57,820,661 (GRCm39) missense probably benign 0.13
IGL02961:Vmn1r21 APN 6 57,820,974 (GRCm39) missense probably benign 0.01
IGL03170:Vmn1r21 APN 6 57,820,847 (GRCm39) missense probably damaging 0.99
PIT4453001:Vmn1r21 UTSW 6 57,821,307 (GRCm39) missense probably benign 0.04
R1800:Vmn1r21 UTSW 6 57,820,799 (GRCm39) missense probably benign 0.01
R1928:Vmn1r21 UTSW 6 57,821,077 (GRCm39) nonsense probably null
R5566:Vmn1r21 UTSW 6 57,821,079 (GRCm39) missense probably benign 0.06
R6012:Vmn1r21 UTSW 6 57,820,891 (GRCm39) missense probably damaging 1.00
R6293:Vmn1r21 UTSW 6 57,821,255 (GRCm39) missense probably benign 0.19
R6473:Vmn1r21 UTSW 6 57,820,583 (GRCm39) missense probably damaging 0.99
R7128:Vmn1r21 UTSW 6 57,820,936 (GRCm39) missense probably damaging 0.97
R7489:Vmn1r21 UTSW 6 57,820,877 (GRCm39) missense probably damaging 1.00
R7559:Vmn1r21 UTSW 6 57,821,227 (GRCm39) missense probably damaging 0.99
R8002:Vmn1r21 UTSW 6 57,821,199 (GRCm39) missense probably benign 0.00
R8218:Vmn1r21 UTSW 6 57,820,910 (GRCm39) missense noncoding transcript
R8467:Vmn1r21 UTSW 6 57,821,441 (GRCm39) start codon destroyed probably null 1.00
R8922:Vmn1r21 UTSW 6 57,820,829 (GRCm39) missense probably damaging 1.00
R8930:Vmn1r21 UTSW 6 57,820,998 (GRCm39) missense probably benign 0.01
R8932:Vmn1r21 UTSW 6 57,820,998 (GRCm39) missense probably benign 0.01
R8961:Vmn1r21 UTSW 6 57,820,829 (GRCm39) missense probably damaging 1.00
R9154:Vmn1r21 UTSW 6 57,821,348 (GRCm39) missense probably benign 0.36
Z1176:Vmn1r21 UTSW 6 57,820,563 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGAAGTCCACCCAGTACATGAC -3'
(R):5'- TCCAGGCTGTCACAATCAG -3'

Sequencing Primer
(F):5'- TGACCACAAAGAAAACTACCAGGAG -3'
(R):5'- ACAATCAGTCCCAATACCTTCTTG -3'
Posted On 2015-01-23