Incidental Mutation 'R3408:Tmem150b'
ID 258368
Institutional Source Beutler Lab
Gene Symbol Tmem150b
Ensembl Gene ENSMUSG00000046456
Gene Name transmembrane protein 150B
Synonyms Tmem224
MMRRC Submission 040626-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.191) question?
Stock # R3408 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 4709831-4728248 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 4727339 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 55 (F55L)
Ref Sequence ENSEMBL: ENSMUSP00000083550 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086363] [ENSMUST00000086364]
AlphaFold Q8R218
Predicted Effect probably damaging
Transcript: ENSMUST00000086363
AA Change: F55L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000083549
Gene: ENSMUSG00000046456
AA Change: F55L

DomainStartEndE-ValueType
Pfam:Frag1 4 207 7.1e-52 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000086364
AA Change: F55L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000083550
Gene: ENSMUSG00000046456
AA Change: F55L

DomainStartEndE-ValueType
Pfam:Frag1 4 114 1.5e-28 PFAM
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 95.8%
  • 20x: 89.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430550D23Rik C T 2: 155,845,840 (GRCm39) V6I probably benign Het
Adam17 T A 12: 21,379,119 (GRCm39) K643N probably damaging Het
Adgrg4 A T X: 56,013,487 (GRCm39) I2838F probably damaging Het
Aox1 G A 1: 58,382,827 (GRCm39) V1036I probably benign Het
Bag3 AAAGG AAAGGAAGG 7: 128,147,493 (GRCm39) probably null Het
Cacnb3 T C 15: 98,539,068 (GRCm39) V167A probably benign Het
Clasrp C A 7: 19,319,165 (GRCm39) probably benign Het
E2f7 C T 10: 110,620,578 (GRCm39) T865M possibly damaging Het
Eef2 GCCC GCCCC 10: 81,014,601 (GRCm39) probably null Het
Ephb3 T A 16: 21,038,254 (GRCm39) Y341N probably damaging Het
Frem1 A T 4: 82,930,223 (GRCm39) V241E probably damaging Het
Gpi1 A G 7: 33,902,104 (GRCm39) V500A probably damaging Het
Ilk A T 7: 105,390,181 (GRCm39) M155L probably benign Het
Ipo8 T C 6: 148,723,207 (GRCm39) D70G probably benign Het
Macf1 T C 4: 123,275,574 (GRCm39) Q6283R probably damaging Het
Mfsd1 T A 3: 67,504,046 (GRCm39) M346K possibly damaging Het
Mideas C T 12: 84,203,245 (GRCm39) G886S probably benign Het
Mroh2a GCCC GC 1: 88,159,979 (GRCm39) probably null Het
Myo7a A T 7: 97,730,294 (GRCm39) F758Y probably benign Het
Nalcn T A 14: 123,834,029 (GRCm39) S49C probably null Het
Ncan G A 8: 70,564,801 (GRCm39) T271I probably damaging Het
Nr5a2 C T 1: 136,868,236 (GRCm39) A299T probably benign Het
Or10ag60 A T 2: 87,438,220 (GRCm39) I163L probably benign Het
Or4g16 A T 2: 111,136,850 (GRCm39) Q100L probably damaging Het
Or51q1c G T 7: 103,652,550 (GRCm39) E23* probably null Het
Or9s23 A G 1: 92,501,675 (GRCm39) T261A probably damaging Het
Piwil4 T C 9: 14,637,259 (GRCm39) T352A probably damaging Het
Plch1 A G 3: 63,606,768 (GRCm39) probably benign Het
Plekhg5 A G 4: 152,192,749 (GRCm39) T559A probably damaging Het
Rfx2 G T 17: 57,110,526 (GRCm39) D153E probably benign Het
Sh3bp4 G T 1: 89,072,769 (GRCm39) C539F possibly damaging Het
Slco1b2 A T 6: 141,621,982 (GRCm39) H479L probably benign Het
Spmip9 C T 6: 70,892,690 (GRCm39) S19N possibly damaging Het
Vmn1r60 A T 7: 5,548,148 (GRCm39) probably null Het
Vmn2r80 C T 10: 79,004,227 (GRCm39) L147F possibly damaging Het
Vps50 A T 6: 3,600,212 (GRCm39) K890N probably damaging Het
Other mutations in Tmem150b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00590:Tmem150b APN 7 4,726,896 (GRCm39) missense probably benign 0.01
R1769:Tmem150b UTSW 7 4,727,365 (GRCm39) missense probably damaging 1.00
R1888:Tmem150b UTSW 7 4,712,044 (GRCm39) missense probably benign 0.31
R1888:Tmem150b UTSW 7 4,712,044 (GRCm39) missense probably benign 0.31
R2197:Tmem150b UTSW 7 4,719,353 (GRCm39) missense probably benign 0.07
R3872:Tmem150b UTSW 7 4,727,360 (GRCm39) nonsense probably null
R4820:Tmem150b UTSW 7 4,726,871 (GRCm39) missense probably damaging 1.00
R5412:Tmem150b UTSW 7 4,719,368 (GRCm39) missense probably null 0.54
R6280:Tmem150b UTSW 7 4,727,373 (GRCm39) missense probably benign 0.00
R7427:Tmem150b UTSW 7 4,719,209 (GRCm39) missense probably benign 0.29
R7658:Tmem150b UTSW 7 4,723,758 (GRCm39) missense probably benign 0.00
R8015:Tmem150b UTSW 7 4,719,327 (GRCm39) missense probably null 1.00
R8209:Tmem150b UTSW 7 4,723,691 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- ATGGACTCTGGGTCTGAGAG -3'
(R):5'- CAATCGCTGTGGTTAATGGTTC -3'

Sequencing Primer
(F):5'- CTAGACTCCTGGGTGTGAGGAAG -3'
(R):5'- TTCTGTGGACCTCAACGAAG -3'
Posted On 2015-01-23