Incidental Mutation 'R3409:Or8c9'
ID 258421
Institutional Source Beutler Lab
Gene Symbol Or8c9
Ensembl Gene ENSMUSG00000058270
Gene Name olfactory receptor family 8 subfamily C member 9
Synonyms Olfr25, MOR170-4, GA_x6K02T2PVTD-32017922-32018863, MTPCR18
MMRRC Submission 040627-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R3409 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 38240788-38241855 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38241640 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 252 (S252R)
Ref Sequence ENSEMBL: ENSMUSP00000071393 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071449] [ENSMUST00000212354] [ENSMUST00000214155]
AlphaFold Q7TRD6
Predicted Effect possibly damaging
Transcript: ENSMUST00000071449
AA Change: S252R

PolyPhen 2 Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000071393
Gene: ENSMUSG00000058270
AA Change: S252R

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 3.1e-46 PFAM
Pfam:7tm_1 44 243 8e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000212354
AA Change: S249R

PolyPhen 2 Score 0.921 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214155
AA Change: S249R

PolyPhen 2 Score 0.921 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.3%
  • 10x: 96.4%
  • 20x: 91.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgra3 A G 5: 50,159,272 (GRCm39) V326A probably damaging Het
AI429214 C T 8: 37,461,071 (GRCm39) S73L probably benign Het
Atp13a4 G T 16: 29,232,567 (GRCm39) T923K probably damaging Het
Ccdc150 A G 1: 54,395,932 (GRCm39) D805G probably benign Het
Ccdc185 T G 1: 182,576,313 (GRCm39) Q125H possibly damaging Het
Ccdc88a T A 11: 29,436,006 (GRCm39) C10S probably damaging Het
Cpsf1 G T 15: 76,485,981 (GRCm39) Y396* probably null Het
Dnpep A G 1: 75,293,270 (GRCm39) V33A probably damaging Het
Fbn1 G A 2: 125,254,585 (GRCm39) A226V possibly damaging Het
Frmd4a A T 2: 4,157,839 (GRCm39) probably benign Het
Gipr A G 7: 18,893,719 (GRCm39) V318A possibly damaging Het
Gsdmc4 A G 15: 63,763,895 (GRCm39) S401P probably benign Het
H2-M10.6 T A 17: 37,124,893 (GRCm39) V270E probably damaging Het
Klhl7 G T 5: 24,343,319 (GRCm39) V212L probably damaging Het
Krt10 C A 11: 99,278,087 (GRCm39) R322L probably damaging Het
Lrrn4 A G 2: 132,721,781 (GRCm39) L12P unknown Het
Mast2 C G 4: 116,168,107 (GRCm39) E881Q possibly damaging Het
Nod1 G T 6: 54,921,902 (GRCm39) R139S probably benign Het
Notch3 C T 17: 32,369,676 (GRCm39) V772M possibly damaging Het
Nrxn1 G A 17: 90,515,795 (GRCm39) T19M probably damaging Het
Nudcd1 T C 15: 44,284,207 (GRCm39) M60V probably benign Het
Or10g1 T A 14: 52,647,818 (GRCm39) R170S possibly damaging Het
Or4c1 A G 2: 89,133,717 (GRCm39) F73S probably benign Het
Or4c115 T C 2: 88,927,668 (GRCm39) N201S possibly damaging Het
Or5b101 G C 19: 13,005,411 (GRCm39) A94G probably benign Het
Or5w8 T A 2: 87,688,005 (GRCm39) L162* probably null Het
Pcdhb6 A G 18: 37,468,945 (GRCm39) E622G probably damaging Het
Pitrm1 G A 13: 6,628,517 (GRCm39) A937T possibly damaging Het
Plxnb1 G A 9: 108,935,681 (GRCm39) probably null Het
Ripk3 T G 14: 56,025,698 (GRCm39) N54T probably damaging Het
Rpn2 C A 2: 157,132,572 (GRCm39) A108E possibly damaging Het
Scaf11 A G 15: 96,312,745 (GRCm39) V1432A probably damaging Het
Sec14l5 C T 16: 4,983,518 (GRCm39) probably null Het
Serpina3n A G 12: 104,377,536 (GRCm39) E263G possibly damaging Het
Six4 A G 12: 73,159,657 (GRCm39) F101S probably damaging Het
Slc12a1 A G 2: 124,996,071 (GRCm39) T75A probably benign Het
Slc26a9 T C 1: 131,691,682 (GRCm39) S642P probably benign Het
Smu1 T C 4: 40,752,008 (GRCm39) T183A probably benign Het
Sptb T G 12: 76,657,589 (GRCm39) K1311Q possibly damaging Het
Tal2 A G 4: 53,785,843 (GRCm39) N8S probably damaging Het
Tenm4 A G 7: 96,544,367 (GRCm39) T2128A probably damaging Het
Tmem67 A T 4: 12,073,952 (GRCm39) M288K probably benign Het
Ubr1 A C 2: 120,793,929 (GRCm39) I85S probably benign Het
Vmn2r90 G T 17: 17,953,638 (GRCm39) V601L probably benign Het
Zfhx4 C T 3: 5,468,418 (GRCm39) P2859S probably benign Het
Other mutations in Or8c9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01363:Or8c9 APN 9 38,240,999 (GRCm39) missense probably benign 0.01
IGL02044:Or8c9 APN 9 38,241,461 (GRCm39) missense probably benign 0.16
IGL02698:Or8c9 APN 9 38,241,506 (GRCm39) missense probably benign 0.03
IGL03084:Or8c9 APN 9 38,241,513 (GRCm39) missense probably damaging 0.97
IGL03355:Or8c9 APN 9 38,240,952 (GRCm39) missense probably benign 0.05
R0453:Or8c9 UTSW 9 38,241,467 (GRCm39) missense probably benign 0.36
R1584:Or8c9 UTSW 9 38,241,427 (GRCm39) missense possibly damaging 0.90
R1707:Or8c9 UTSW 9 38,241,197 (GRCm39) missense probably damaging 0.99
R1719:Or8c9 UTSW 9 38,241,803 (GRCm39) missense probably benign 0.23
R4810:Or8c9 UTSW 9 38,241,690 (GRCm39) missense probably benign 0.00
R6271:Or8c9 UTSW 9 38,241,578 (GRCm39) missense probably benign 0.09
R6621:Or8c9 UTSW 9 38,241,758 (GRCm39) missense probably damaging 1.00
R7220:Or8c9 UTSW 9 38,241,046 (GRCm39) missense probably damaging 1.00
R7562:Or8c9 UTSW 9 38,241,239 (GRCm39) missense probably damaging 1.00
R7609:Or8c9 UTSW 9 38,241,520 (GRCm39) missense possibly damaging 0.85
R7659:Or8c9 UTSW 9 38,241,012 (GRCm39) missense possibly damaging 0.69
R8375:Or8c9 UTSW 9 38,241,231 (GRCm39) missense probably benign
R8465:Or8c9 UTSW 9 38,241,410 (GRCm39) missense possibly damaging 0.91
X0019:Or8c9 UTSW 9 38,241,255 (GRCm39) missense probably damaging 1.00
X0027:Or8c9 UTSW 9 38,241,098 (GRCm39) missense probably benign 0.22
Predicted Primers PCR Primer
(F):5'- TCGGATCTCCTGCAGTAACACC -3'
(R):5'- GCAAACCAGCTCAAATTGTTTC -3'

Sequencing Primer
(F):5'- CACCTATCTCAATGAGCTTGTGAG -3'
(R):5'- ACCAGCTCAAATTGTTTCAATTAAC -3'
Posted On 2015-01-23