Incidental Mutation 'R3410:Or5b101'
ID 258505
Institutional Source Beutler Lab
Gene Symbol Or5b101
Ensembl Gene ENSMUSG00000094755
Gene Name olfactory receptor family 5 subfamily B member 101
Synonyms Olfr1453, GA_x6K02T2RE5P-3357666-3356743, MOR202-6
MMRRC Submission 040628-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R3410 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 13004768-13005691 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to C at 13005411 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Glycine at position 94 (A94G)
Ref Sequence ENSEMBL: ENSMUSP00000085071 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087773]
AlphaFold Q8VFX0
Predicted Effect probably benign
Transcript: ENSMUST00000087773
AA Change: A94G

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000085071
Gene: ENSMUSG00000094755
AA Change: A94G

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 6.6e-50 PFAM
Pfam:7tm_1 39 288 2.6e-20 PFAM
Meta Mutation Damage Score 0.0929 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 100% (59/59)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adad2 T C 8: 120,342,708 (GRCm39) V418A probably benign Het
Adamts16 T C 13: 70,901,345 (GRCm39) T911A probably benign Het
Adgra1 T C 7: 139,427,619 (GRCm39) F62S possibly damaging Het
Adgra3 A G 5: 50,159,272 (GRCm39) V326A probably damaging Het
Adgrg6 A G 10: 14,316,114 (GRCm39) F569S probably benign Het
Alcam T C 16: 52,130,261 (GRCm39) T30A probably null Het
Arnt2 G A 7: 83,924,655 (GRCm39) R391W probably damaging Het
Ascc3 T C 10: 50,576,196 (GRCm39) V817A probably damaging Het
Atp13a4 G T 16: 29,232,567 (GRCm39) T923K probably damaging Het
Atp5po C T 16: 91,725,794 (GRCm39) R64H probably damaging Het
Ccdc185 T G 1: 182,576,313 (GRCm39) Q125H possibly damaging Het
Ccdc88a T A 11: 29,436,006 (GRCm39) C10S probably damaging Het
Cct2 T C 10: 116,897,968 (GRCm39) N73S probably benign Het
Clock G A 5: 76,377,401 (GRCm39) Q633* probably null Het
Col6a2 T C 10: 76,439,193 (GRCm39) I826V probably benign Het
Cpsf1 G T 15: 76,485,981 (GRCm39) Y396* probably null Het
Dnah1 A T 14: 30,991,774 (GRCm39) M3076K possibly damaging Het
Dxo A G 17: 35,057,825 (GRCm39) N177D probably damaging Het
Fbxw28 A T 9: 109,167,472 (GRCm39) V95E possibly damaging Het
Galnt6 T C 15: 100,597,018 (GRCm39) N383D probably damaging Het
Gpat2 G A 2: 127,270,211 (GRCm39) V75M probably damaging Het
Grik5 T C 7: 24,762,397 (GRCm39) D198G probably benign Het
Gsdmc4 A G 15: 63,763,895 (GRCm39) S401P probably benign Het
Gspt1 A T 16: 11,047,109 (GRCm39) D435E probably damaging Het
Hsf2 T C 10: 57,381,378 (GRCm39) S266P probably damaging Het
Jade2 T C 11: 51,708,050 (GRCm39) D721G probably benign Het
Klhl7 G T 5: 24,343,319 (GRCm39) V212L probably damaging Het
Klra17 T A 6: 129,851,809 (GRCm39) N21I probably damaging Het
L3mbtl3 T C 10: 26,215,197 (GRCm39) N196S unknown Het
Lama3 G C 18: 12,546,915 (GRCm39) probably null Het
Mcm5 T C 8: 75,848,272 (GRCm39) M507T possibly damaging Het
Mycbp2 T C 14: 103,372,553 (GRCm39) R814G probably damaging Het
Nlrp4b A G 7: 10,449,456 (GRCm39) E186G probably damaging Het
Nlrp4c A G 7: 6,095,569 (GRCm39) K816E possibly damaging Het
Nod1 G T 6: 54,921,902 (GRCm39) R139S probably benign Het
Nudcd1 T C 15: 44,284,207 (GRCm39) M60V probably benign Het
Or5p63 G A 7: 107,811,490 (GRCm39) P82L possibly damaging Het
Or5p69 A T 7: 107,967,551 (GRCm39) I285F possibly damaging Het
Or8g28 G T 9: 39,169,897 (GRCm39) Q24K possibly damaging Het
Ovol2 A G 2: 144,159,796 (GRCm39) S82P probably benign Het
Ppl T C 16: 4,925,381 (GRCm39) E86G possibly damaging Het
Ptch1 T G 13: 63,672,773 (GRCm39) E944A probably benign Het
Ripk4 T C 16: 97,545,157 (GRCm39) T497A probably benign Het
Scml4 A G 10: 42,833,667 (GRCm39) Y327C probably damaging Het
Serpina3n A G 12: 104,377,536 (GRCm39) E263G possibly damaging Het
Six4 A G 12: 73,159,657 (GRCm39) F101S probably damaging Het
Sltm T G 9: 70,493,240 (GRCm39) L728V probably damaging Het
Sptb T G 12: 76,657,589 (GRCm39) K1311Q possibly damaging Het
Sycp1 T C 3: 102,748,357 (GRCm39) K812E possibly damaging Het
Tenm4 T C 7: 96,501,737 (GRCm39) Y1314H probably damaging Het
Tmem67 A T 4: 12,073,952 (GRCm39) M288K probably benign Het
Toporsl T C 4: 52,610,970 (GRCm39) S288P probably benign Het
Ttn A C 2: 76,772,749 (GRCm39) N2415K possibly damaging Het
Vmn2r65 T C 7: 84,595,896 (GRCm39) I263V probably benign Het
Vmn2r89 A T 14: 51,693,628 (GRCm39) E326V probably damaging Het
Wdr81 A G 11: 75,343,758 (GRCm39) I503T probably damaging Het
Other mutations in Or5b101
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00914:Or5b101 APN 19 13,004,955 (GRCm39) missense probably damaging 0.98
IGL01137:Or5b101 APN 19 13,005,394 (GRCm39) missense possibly damaging 0.52
IGL01894:Or5b101 APN 19 13,005,649 (GRCm39) missense probably damaging 1.00
IGL02579:Or5b101 APN 19 13,004,892 (GRCm39) missense probably damaging 0.99
PIT4418001:Or5b101 UTSW 19 13,005,095 (GRCm39) nonsense probably null
R0099:Or5b101 UTSW 19 13,005,165 (GRCm39) missense probably damaging 1.00
R0211:Or5b101 UTSW 19 13,005,646 (GRCm39) missense possibly damaging 0.95
R0211:Or5b101 UTSW 19 13,005,646 (GRCm39) missense possibly damaging 0.95
R0395:Or5b101 UTSW 19 13,005,663 (GRCm39) missense probably damaging 1.00
R0453:Or5b101 UTSW 19 13,005,295 (GRCm39) missense probably damaging 0.97
R0847:Or5b101 UTSW 19 13,005,095 (GRCm39) nonsense probably null
R1227:Or5b101 UTSW 19 13,005,217 (GRCm39) missense probably benign
R1823:Or5b101 UTSW 19 13,005,181 (GRCm39) missense probably benign 0.06
R2509:Or5b101 UTSW 19 13,005,058 (GRCm39) missense probably damaging 1.00
R2899:Or5b101 UTSW 19 13,005,058 (GRCm39) missense probably damaging 1.00
R2964:Or5b101 UTSW 19 13,005,412 (GRCm39) missense probably benign 0.38
R2965:Or5b101 UTSW 19 13,005,412 (GRCm39) missense probably benign 0.38
R3157:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R3158:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R3409:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R3411:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R3425:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R4018:Or5b101 UTSW 19 13,005,189 (GRCm39) missense probably benign
R4668:Or5b101 UTSW 19 13,005,445 (GRCm39) missense probably benign 0.00
R4805:Or5b101 UTSW 19 13,005,661 (GRCm39) missense probably benign 0.04
R5180:Or5b101 UTSW 19 13,004,776 (GRCm39) missense probably benign 0.01
R5391:Or5b101 UTSW 19 13,005,150 (GRCm39) missense probably damaging 1.00
R5557:Or5b101 UTSW 19 13,005,004 (GRCm39) missense probably benign 0.01
R5740:Or5b101 UTSW 19 13,004,926 (GRCm39) missense probably benign 0.24
R7472:Or5b101 UTSW 19 13,005,439 (GRCm39) missense probably benign
R7832:Or5b101 UTSW 19 13,005,360 (GRCm39) missense probably benign 0.02
R7970:Or5b101 UTSW 19 13,005,058 (GRCm39) missense probably damaging 1.00
R8044:Or5b101 UTSW 19 13,004,829 (GRCm39) missense probably damaging 1.00
R8229:Or5b101 UTSW 19 13,005,561 (GRCm39) missense possibly damaging 0.55
R8474:Or5b101 UTSW 19 13,005,357 (GRCm39) missense probably damaging 1.00
R8951:Or5b101 UTSW 19 13,004,827 (GRCm39) missense
R8957:Or5b101 UTSW 19 13,004,881 (GRCm39) missense probably benign 0.03
R9046:Or5b101 UTSW 19 13,005,115 (GRCm39) missense probably benign 0.01
R9059:Or5b101 UTSW 19 13,005,277 (GRCm39) missense probably damaging 1.00
R9131:Or5b101 UTSW 19 13,005,360 (GRCm39) missense probably benign 0.02
R9266:Or5b101 UTSW 19 13,005,648 (GRCm39) missense probably damaging 1.00
R9269:Or5b101 UTSW 19 13,004,994 (GRCm39) missense probably benign
Z1088:Or5b101 UTSW 19 13,005,391 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TTCACAGAAGGAGAGACTTAATGC -3'
(R):5'- CACCCTTATAGGAAATCTTGGGC -3'

Sequencing Primer
(F):5'- AGGAGAGACTTAATGCATCCATAG -3'
(R):5'- CCCTTATAGGAAATCTTGGGCTGATC -3'
Posted On 2015-01-23