Incidental Mutation 'R3705:Fam133b'
ID 258696
Institutional Source Beutler Lab
Gene Symbol Fam133b
Ensembl Gene ENSMUSG00000058503
Gene Name family with sequence similarity 133, member B
Synonyms 5830415L20Rik, 2900022K02Rik
MMRRC Submission 040698-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.537) question?
Stock # R3705 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 3593833-3620238 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 3611034 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143004 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115527] [ENSMUST00000197082] [ENSMUST00000199666]
AlphaFold Q9CVI2
Predicted Effect noncoding transcript
Transcript: ENSMUST00000083110
Predicted Effect probably benign
Transcript: ENSMUST00000115527
SMART Domains Protein: ENSMUSP00000111189
Gene: ENSMUSG00000058503

DomainStartEndE-ValueType
coiled coil region 40 82 N/A INTRINSIC
low complexity region 85 141 N/A INTRINSIC
low complexity region 145 166 N/A INTRINSIC
low complexity region 218 244 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195924
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196059
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196499
Predicted Effect probably benign
Transcript: ENSMUST00000197082
SMART Domains Protein: ENSMUSP00000142744
Gene: ENSMUSG00000058503

DomainStartEndE-ValueType
coiled coil region 40 82 N/A INTRINSIC
low complexity region 85 158 N/A INTRINSIC
low complexity region 201 227 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198598
Predicted Effect probably benign
Transcript: ENSMUST00000199666
SMART Domains Protein: ENSMUSP00000143004
Gene: ENSMUSG00000058503

DomainStartEndE-ValueType
coiled coil region 40 82 N/A INTRINSIC
low complexity region 86 109 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency 100% (46/46)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik1 T C 11: 48,838,803 (GRCm39) T595A possibly damaging Het
Abca12 T C 1: 71,324,864 (GRCm39) D1538G probably damaging Het
Asap3 TGAGGAGGAGGAGGAGGA TGAGGAGGAGGAGGAGGAGGA 4: 135,968,552 (GRCm39) probably benign Het
Bcap29 T C 12: 31,667,151 (GRCm39) H170R probably benign Het
Bltp1 T A 3: 37,041,730 (GRCm39) C2703S probably damaging Het
Brwd3 A G X: 107,804,021 (GRCm39) probably benign Het
Capn1 T C 19: 6,057,401 (GRCm39) E349G probably damaging Het
Cers3 G T 7: 66,435,823 (GRCm39) A261S probably benign Het
Csf3r A G 4: 125,926,078 (GRCm39) D221G possibly damaging Het
Cubn T A 2: 13,355,754 (GRCm39) H1826L probably damaging Het
Dnajc19 A G 3: 34,134,378 (GRCm39) probably null Het
Dync1h1 G A 12: 110,607,020 (GRCm39) V2566I possibly damaging Het
Ehd1 A G 19: 6,348,330 (GRCm39) D436G Het
Fam43b G C 4: 138,122,409 (GRCm39) R304G probably benign Het
Gpnmb T A 6: 49,028,799 (GRCm39) I439N possibly damaging Het
Grm1 G A 10: 10,658,473 (GRCm39) T339I possibly damaging Het
Gtpbp3 T G 8: 71,944,779 (GRCm39) S345A probably benign Het
Hdac4 A G 1: 91,862,416 (GRCm39) probably benign Het
Hfm1 A G 5: 107,040,705 (GRCm39) probably benign Het
Ift172 A G 5: 31,418,781 (GRCm39) probably null Het
Igfn1 T C 1: 135,896,147 (GRCm39) N1473S probably benign Het
Jak3 A G 8: 72,134,166 (GRCm39) K423E probably damaging Het
Kifc3 G A 8: 95,830,656 (GRCm39) probably benign Het
Lrrc8d T C 5: 105,961,341 (GRCm39) S584P probably damaging Het
Nipal4 T C 11: 46,052,678 (GRCm39) probably benign Het
Nisch A G 14: 30,898,702 (GRCm39) probably benign Het
Nmur2 T C 11: 55,931,300 (GRCm39) Y137C probably damaging Het
Nod2 T C 8: 89,379,948 (GRCm39) S150P probably benign Het
Or5w22 A G 2: 87,362,412 (GRCm39) I12V probably benign Het
Pdgfc T C 3: 81,111,751 (GRCm39) probably null Het
Phldb1 G T 9: 44,605,691 (GRCm39) H1323N probably damaging Het
Ppp1r14c A G 10: 3,373,524 (GRCm39) I112V possibly damaging Het
Pramel26 T C 4: 143,538,345 (GRCm39) T209A probably benign Het
Rcc1l A T 5: 134,183,030 (GRCm39) V414E probably damaging Het
Riok3 A G 18: 12,282,011 (GRCm39) M327V probably benign Het
Sf3b4 T C 3: 96,083,944 (GRCm39) probably benign Het
Spag6 A G 2: 18,715,368 (GRCm39) Y49C probably damaging Het
Syngap1 T C 17: 27,178,994 (GRCm39) S495P probably damaging Het
Tedc2 A G 17: 24,435,361 (GRCm39) S343P probably benign Het
Tenm2 T A 11: 35,959,153 (GRCm39) D1132V probably damaging Het
Tmem63a G A 1: 180,790,679 (GRCm39) D446N possibly damaging Het
Top1 G A 2: 160,544,744 (GRCm39) probably null Het
Tox3 G T 8: 90,975,533 (GRCm39) T366K possibly damaging Het
Tph2 G A 10: 114,955,798 (GRCm39) Q332* probably null Het
Zfr2 T G 10: 81,081,913 (GRCm39) V493G probably benign Het
Other mutations in Fam133b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01861:Fam133b APN 5 3,614,242 (GRCm39) splice site probably benign
IGL03026:Fam133b APN 5 3,609,646 (GRCm39) utr 3 prime probably benign
IGL03218:Fam133b APN 5 3,604,684 (GRCm39) nonsense probably null
R0433:Fam133b UTSW 5 3,608,560 (GRCm39) splice site probably benign
R1299:Fam133b UTSW 5 3,604,626 (GRCm39) splice site probably benign
R3176:Fam133b UTSW 5 3,608,522 (GRCm39) missense probably damaging 1.00
R3276:Fam133b UTSW 5 3,608,522 (GRCm39) missense probably damaging 1.00
R4722:Fam133b UTSW 5 3,593,949 (GRCm39) critical splice donor site probably null
R4799:Fam133b UTSW 5 3,607,815 (GRCm39) missense probably damaging 0.99
R6151:Fam133b UTSW 5 3,609,133 (GRCm39) missense probably null
R6709:Fam133b UTSW 5 3,619,059 (GRCm39) utr 3 prime probably benign
R6835:Fam133b UTSW 5 3,604,732 (GRCm39) missense possibly damaging 0.94
R8056:Fam133b UTSW 5 3,615,744 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- AAAGGCCTGTTGTCTTATGTGC -3'
(R):5'- GTGCTCACACACTGATCATCTC -3'

Sequencing Primer
(F):5'- CCTGTTGTCTTATGTGCAGATATGC -3'
(R):5'- ACAGCACCTGGTATTCCTAGG -3'
Posted On 2015-01-23