Incidental Mutation 'R3401:Tead2'
| ID |
259187 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tead2
|
| Ensembl Gene |
ENSMUSG00000030796 |
| Gene Name |
TEA domain family member 2 |
| Synonyms |
TEF-4, TEAD-2, Etdf |
| MMRRC Submission |
040620-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R3401 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
44865216-44882892 bp(+) (GRCm39) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
T to A
at 44873097 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000147727
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000033060]
[ENSMUST00000097216]
[ENSMUST00000107801]
[ENSMUST00000209343]
[ENSMUST00000209437]
[ENSMUST00000209678]
[ENSMUST00000210447]
[ENSMUST00000211744]
|
| AlphaFold |
P48301 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000033060
|
| SMART Domains |
Protein: ENSMUSP00000033060
Gene: ENSMUSG00000030796
| Domain | Start | End | E-Value | Type |
|---|
|
TEA
|
36 |
107 |
4.84e-52 |
SMART |
|
low complexity region
|
201 |
217 |
N/A |
INTRINSIC |
|
PDB:3L15|B
|
218 |
445 |
1e-143 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000097216
|
| SMART Domains |
Protein: ENSMUSP00000103430
Gene: ENSMUSG00000030796
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
11 |
38 |
N/A |
INTRINSIC |
|
Pfam:TEA
|
40 |
402 |
1.8e-137 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107801
|
| SMART Domains |
Protein: ENSMUSP00000103431
Gene: ENSMUSG00000030796
| Domain | Start | End | E-Value | Type |
|---|
|
TEA
|
36 |
107 |
4.84e-52 |
SMART |
|
low complexity region
|
201 |
217 |
N/A |
INTRINSIC |
|
PDB:3L15|B
|
218 |
445 |
1e-143 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000209343
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000209437
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000209678
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000209708
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000210814
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000211778
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000210447
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000210570
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000209818
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000211138
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000211744
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.3%
|
| Validation Efficiency |
100% (30/30) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a functionally null allele of this gene exhibit no gross abnormalities and are fertile. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 27 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| B3gat1 |
C |
A |
9: 26,667,149 (GRCm39) |
T127K |
probably damaging |
Het |
| Cactin |
G |
A |
10: 81,161,709 (GRCm39) |
R747H |
probably benign |
Het |
| Cul5 |
A |
T |
9: 53,532,512 (GRCm39) |
M747K |
probably benign |
Het |
| Dennd4c |
C |
T |
4: 86,692,780 (GRCm39) |
P97S |
probably damaging |
Het |
| Dnah3 |
A |
G |
7: 119,566,879 (GRCm39) |
V2449A |
probably benign |
Het |
| Eif1ad |
T |
C |
19: 5,418,276 (GRCm39) |
V20A |
probably benign |
Het |
| Faim2 |
C |
T |
15: 99,418,229 (GRCm39) |
V119I |
probably damaging |
Het |
| Fli1 |
G |
A |
9: 32,372,570 (GRCm39) |
S156L |
probably damaging |
Het |
| Gucy1a2 |
T |
A |
9: 3,635,154 (GRCm39) |
D399E |
probably benign |
Het |
| Hip1r |
A |
G |
5: 124,135,046 (GRCm39) |
E394G |
probably damaging |
Het |
| Htr2a |
T |
C |
14: 74,882,499 (GRCm39) |
S162P |
probably damaging |
Het |
| Naip5 |
G |
A |
13: 100,358,411 (GRCm39) |
Q942* |
probably null |
Het |
| Ndrg3 |
C |
T |
2: 156,790,208 (GRCm39) |
V92M |
probably damaging |
Het |
| Nlrp4d |
A |
T |
7: 10,096,781 (GRCm39) |
N906K |
probably damaging |
Het |
| Pkd2 |
A |
G |
5: 104,628,193 (GRCm39) |
I422M |
possibly damaging |
Het |
| Polr3b |
C |
T |
10: 84,535,355 (GRCm39) |
T888M |
probably damaging |
Het |
| Ppp1r37 |
C |
T |
7: 19,266,712 (GRCm39) |
A392T |
probably damaging |
Het |
| Ralgapa1 |
T |
C |
12: 55,705,922 (GRCm39) |
T2323A |
possibly damaging |
Het |
| Sntg2 |
A |
G |
12: 30,338,171 (GRCm39) |
|
probably benign |
Het |
| Stard9 |
A |
G |
2: 120,534,170 (GRCm39) |
I3476V |
probably damaging |
Het |
| Tma16 |
C |
T |
8: 66,936,823 (GRCm39) |
|
probably null |
Het |
| Tmem74 |
C |
T |
15: 43,730,417 (GRCm39) |
V209M |
probably damaging |
Het |
| Trim25 |
T |
C |
11: 88,901,707 (GRCm39) |
M334T |
probably benign |
Het |
| Uprt |
A |
G |
X: 103,549,864 (GRCm39) |
D310G |
probably damaging |
Het |
| Vmn2r68 |
TCC |
TC |
7: 84,870,758 (GRCm39) |
|
probably null |
Het |
| Zfp157 |
T |
A |
5: 138,455,273 (GRCm39) |
N490K |
probably benign |
Het |
| Zhx1 |
T |
C |
15: 57,917,745 (GRCm39) |
E167G |
probably benign |
Het |
|
| Other mutations in Tead2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01365:Tead2
|
APN |
7 |
44,866,675 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01887:Tead2
|
APN |
7 |
44,881,734 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02378:Tead2
|
APN |
7 |
44,867,571 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02441:Tead2
|
APN |
7 |
44,866,845 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02716:Tead2
|
APN |
7 |
44,881,720 (GRCm39) |
nonsense |
probably null |
|
|
IGL02939:Tead2
|
APN |
7 |
44,869,858 (GRCm39) |
splice site |
probably benign |
|
|
IGL03302:Tead2
|
APN |
7 |
44,882,323 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0325:Tead2
|
UTSW |
7 |
44,875,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0611:Tead2
|
UTSW |
7 |
44,866,674 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2571:Tead2
|
UTSW |
7 |
44,875,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3847:Tead2
|
UTSW |
7 |
44,881,752 (GRCm39) |
splice site |
probably null |
|
|
R3849:Tead2
|
UTSW |
7 |
44,881,752 (GRCm39) |
splice site |
probably null |
|
|
R3850:Tead2
|
UTSW |
7 |
44,881,752 (GRCm39) |
splice site |
probably null |
|
|
R5729:Tead2
|
UTSW |
7 |
44,870,166 (GRCm39) |
unclassified |
probably benign |
|
|
R5932:Tead2
|
UTSW |
7 |
44,882,323 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5956:Tead2
|
UTSW |
7 |
44,870,138 (GRCm39) |
unclassified |
probably benign |
|
|
R6208:Tead2
|
UTSW |
7 |
44,867,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6729:Tead2
|
UTSW |
7 |
44,866,658 (GRCm39) |
missense |
probably benign |
|
|
R7152:Tead2
|
UTSW |
7 |
44,869,871 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8120:Tead2
|
UTSW |
7 |
44,865,752 (GRCm39) |
intron |
probably benign |
|
|
R8272:Tead2
|
UTSW |
7 |
44,878,166 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8379:Tead2
|
UTSW |
7 |
44,867,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8719:Tead2
|
UTSW |
7 |
44,882,316 (GRCm39) |
unclassified |
probably benign |
|
|
R9278:Tead2
|
UTSW |
7 |
44,880,776 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9362:Tead2
|
UTSW |
7 |
44,881,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tead2
|
UTSW |
7 |
44,866,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCTCATGGTTGGGACTAACTG -3'
(R):5'- TTGACTACTCGGTTGTGCC -3'
Sequencing Primer
(F):5'- GGAGTTCAGGCTTTATGGCAC -3'
(R):5'- TACTCGGTTGTGCCCAGCTG -3'
|
| Posted On |
2015-01-23 |
Incidental Mutation