Incidental Mutation 'R3711:Or6c206'
ID 259613
Institutional Source Beutler Lab
Gene Symbol Or6c206
Ensembl Gene ENSMUSG00000095483
Gene Name olfactory receptor family 6 subfamily C member 206
Synonyms GA_x6K02T2PULF-10947193-10948131, MOR111-12, Olfr776
MMRRC Submission 040704-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R3711 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 129096832-129097770 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 129097093 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 88 (K88*)
Ref Sequence ENSEMBL: ENSMUSP00000150656 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073704] [ENSMUST00000204573] [ENSMUST00000213512]
AlphaFold Q7TRI3
Predicted Effect probably null
Transcript: ENSMUST00000073704
AA Change: K88*
SMART Domains Protein: ENSMUSP00000073383
Gene: ENSMUSG00000095483
AA Change: K88*

DomainStartEndE-ValueType
Pfam:7tm_4 29 307 8.3e-50 PFAM
Pfam:7tm_1 39 288 3.9e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000204573
SMART Domains Protein: ENSMUSP00000145475
Gene: ENSMUSG00000062914

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 1.4e-42 PFAM
Pfam:7tm_1 38 287 1.5e-22 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000213512
AA Change: K88*
Meta Mutation Damage Score 0.9583 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency 98% (51/52)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b A G 11: 109,837,081 (GRCm39) V1138A possibly damaging Het
Adgrv1 A T 13: 81,567,594 (GRCm39) I5193K probably benign Het
Adnp A T 2: 168,026,743 (GRCm39) I184N probably damaging Het
Ahnak T G 19: 8,985,262 (GRCm39) V2182G probably benign Het
Aif1l T A 2: 31,859,763 (GRCm39) F94L probably damaging Het
Aspm G A 1: 139,385,838 (GRCm39) G494D probably benign Het
Atic T A 1: 71,617,738 (GRCm39) S563T probably benign Het
Bahcc1 A T 11: 120,165,923 (GRCm39) I1060F probably benign Het
Cd27 A G 6: 125,210,281 (GRCm39) Y189H probably damaging Het
Dnm2 C A 9: 21,417,669 (GRCm39) probably benign Het
Exo1 A G 1: 175,721,395 (GRCm39) T345A probably benign Het
Fbf1 T C 11: 116,052,299 (GRCm39) H53R possibly damaging Het
Fbf1 A G 11: 116,054,179 (GRCm39) I29T probably damaging Het
Gm14399 G A 2: 174,973,303 (GRCm39) R151* probably null Het
Gsdma T A 11: 98,557,045 (GRCm39) Y53* probably null Het
Hid1 A T 11: 115,249,601 (GRCm39) L208Q probably damaging Het
Kif4-ps A G 12: 101,112,312 (GRCm39) E147G probably damaging Het
Kif7 A T 7: 79,360,640 (GRCm39) V245D probably benign Het
Klhdc4 A G 8: 122,524,794 (GRCm39) V378A probably benign Het
Lrfn2 A G 17: 49,378,188 (GRCm39) E423G possibly damaging Het
Lrp4 T A 2: 91,332,299 (GRCm39) N1665K probably benign Het
Mast3 C A 8: 71,232,251 (GRCm39) R1242L probably benign Het
Mon1b T C 8: 114,365,779 (GRCm39) M369T possibly damaging Het
Mta3 A G 17: 84,070,417 (GRCm39) I193V probably damaging Het
Narf G T 11: 121,137,764 (GRCm39) E224* probably null Het
Nedd4l G A 18: 65,342,790 (GRCm39) V909I possibly damaging Het
Nmnat3 T A 9: 98,292,276 (GRCm39) Y108N probably damaging Het
Npr2 A T 4: 43,643,378 (GRCm39) Y534F probably benign Het
Obox5 A T 7: 15,492,713 (GRCm39) M223L probably benign Het
Optc A T 1: 133,832,819 (GRCm39) S94T probably benign Het
Or10al5 T A 17: 38,063,271 (GRCm39) C175* probably null Het
Or1l4 A G 2: 37,091,285 (GRCm39) T11A probably benign Het
Or5d47 A T 2: 87,804,066 (GRCm39) N314K probably benign Het
Or8w1 T C 2: 87,466,025 (GRCm39) D22G probably benign Het
Rbm27 T C 18: 42,425,177 (GRCm39) probably benign Het
Spopl C T 2: 23,427,392 (GRCm39) R221Q probably damaging Het
Stab2 A G 10: 86,702,572 (GRCm39) L423P probably damaging Het
Sun5 A G 2: 153,709,468 (GRCm39) V74A probably benign Het
Tanc2 A G 11: 105,689,516 (GRCm39) Y226C probably damaging Het
Tlr6 T C 5: 65,111,152 (GRCm39) D585G possibly damaging Het
Tmt1a3 A T 15: 100,232,961 (GRCm39) M51L probably benign Het
Tnrc6c A G 11: 117,613,950 (GRCm39) T863A probably benign Het
Ush2a G A 1: 188,542,489 (GRCm39) G3352S probably benign Het
Wt1 G A 2: 104,993,773 (GRCm39) probably benign Het
Ythdc2 C T 18: 44,966,240 (GRCm39) L159F probably damaging Het
Zc3h6 A G 2: 128,859,251 (GRCm39) N1094S probably benign Het
Zdbf2 T C 1: 63,347,830 (GRCm39) S2070P possibly damaging Het
Zfp648 T A 1: 154,080,304 (GRCm39) S154R probably benign Het
Zfp748 A G 13: 67,688,915 (GRCm39) C782R probably damaging Het
Zfp992 C T 4: 146,551,976 (GRCm39) H566Y probably damaging Het
Other mutations in Or6c206
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01444:Or6c206 APN 10 129,097,204 (GRCm39) missense probably damaging 1.00
IGL01956:Or6c206 APN 10 129,096,911 (GRCm39) missense possibly damaging 0.88
IGL03299:Or6c206 APN 10 129,097,196 (GRCm39) missense probably benign 0.26
IGL03388:Or6c206 APN 10 129,097,312 (GRCm39) missense probably benign 0.00
IGL02802:Or6c206 UTSW 10 129,097,136 (GRCm39) splice site probably null
R1538:Or6c206 UTSW 10 129,097,082 (GRCm39) missense probably damaging 0.99
R3712:Or6c206 UTSW 10 129,097,093 (GRCm39) nonsense probably null
R4201:Or6c206 UTSW 10 129,097,646 (GRCm39) missense probably benign 0.19
R4202:Or6c206 UTSW 10 129,097,646 (GRCm39) missense probably benign 0.19
R4726:Or6c206 UTSW 10 129,097,045 (GRCm39) missense possibly damaging 0.84
R5029:Or6c206 UTSW 10 129,097,707 (GRCm39) missense probably benign 0.15
R5623:Or6c206 UTSW 10 129,096,901 (GRCm39) missense probably benign 0.17
R7566:Or6c206 UTSW 10 129,097,469 (GRCm39) missense probably damaging 1.00
R7678:Or6c206 UTSW 10 129,096,937 (GRCm39) missense probably damaging 0.98
R9149:Or6c206 UTSW 10 129,097,184 (GRCm39) missense probably damaging 1.00
R9291:Or6c206 UTSW 10 129,097,202 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CACACCAGAAGTCCAGGTTG -3'
(R):5'- AGAAATCCTGCCAGCCATG -3'

Sequencing Primer
(F):5'- AGAAGTCCAGGTTGTGATTTTTATCC -3'
(R):5'- AATCCTGCCAGCCATGAGGTG -3'
Posted On 2015-01-23