Incidental Mutation 'R3712:Mgll'
ID 259660
Institutional Source Beutler Lab
Gene Symbol Mgll
Ensembl Gene ENSMUSG00000033174
Gene Name monoglyceride lipase
Synonyms Magl
MMRRC Submission 040705-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.098) question?
Stock # R3712 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 88701397-88805342 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to C at 88741570 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000145364 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089449] [ENSMUST00000113581] [ENSMUST00000113582] [ENSMUST00000113585] [ENSMUST00000150180] [ENSMUST00000163271] [ENSMUST00000203824] [ENSMUST00000203608]
AlphaFold O35678
Predicted Effect probably benign
Transcript: ENSMUST00000089449
SMART Domains Protein: ENSMUSP00000086872
Gene: ENSMUSG00000033174

DomainStartEndE-ValueType
Pfam:Hydrolase_4 27 105 6e-29 PFAM
Pfam:Abhydrolase_5 43 270 1e-21 PFAM
Pfam:Abhydrolase_6 44 282 4.4e-26 PFAM
Pfam:DUF2305 55 186 1.7e-7 PFAM
Pfam:Lipase_3 56 163 1.6e-9 PFAM
Pfam:Abhydrolase_1 71 284 4.2e-14 PFAM
Pfam:Esterase 82 195 8.6e-8 PFAM
Pfam:Abhydrolase_3 88 273 8.8e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000113581
SMART Domains Protein: ENSMUSP00000109211
Gene: ENSMUSG00000033174

DomainStartEndE-ValueType
Pfam:Hydrolase_4 39 304 6.8e-70 PFAM
Pfam:Abhydrolase_5 43 298 1.1e-20 PFAM
Pfam:Abhydrolase_1 44 186 8.1e-13 PFAM
Pfam:Abhydrolase_6 44 310 4.4e-15 PFAM
Pfam:DUF2305 55 224 2.2e-8 PFAM
Pfam:Lipase_3 58 146 1.4e-8 PFAM
Pfam:Esterase 82 195 1.7e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000113582
SMART Domains Protein: ENSMUSP00000109212
Gene: ENSMUSG00000033174

DomainStartEndE-ValueType
Pfam:Hydrolase_4 27 105 4.4e-29 PFAM
Pfam:Abhydrolase_5 43 225 3.2e-18 PFAM
Pfam:Abhydrolase_6 44 184 1.3e-18 PFAM
Pfam:Lipase_3 55 163 1.2e-9 PFAM
Pfam:DUF2305 55 249 4.9e-8 PFAM
Pfam:Abhydrolase_1 71 220 1.1e-13 PFAM
Pfam:Esterase 81 222 4.8e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000113585
SMART Domains Protein: ENSMUSP00000109215
Gene: ENSMUSG00000033174

DomainStartEndE-ValueType
Pfam:Hydrolase_4 27 105 6e-29 PFAM
Pfam:Abhydrolase_5 43 270 1e-21 PFAM
Pfam:Abhydrolase_6 44 282 4.4e-26 PFAM
Pfam:DUF2305 55 186 1.7e-7 PFAM
Pfam:Lipase_3 56 163 1.6e-9 PFAM
Pfam:Abhydrolase_1 71 284 4.2e-14 PFAM
Pfam:Esterase 82 195 8.6e-8 PFAM
Pfam:Abhydrolase_3 88 273 8.8e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000150180
SMART Domains Protein: ENSMUSP00000145068
Gene: ENSMUSG00000033174

DomainStartEndE-ValueType
Pfam:Hydrolase_4 39 78 3.1e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000163271
SMART Domains Protein: ENSMUSP00000127374
Gene: ENSMUSG00000033174

DomainStartEndE-ValueType
Pfam:Hydrolase_4 43 121 3e-28 PFAM
Pfam:Abhydrolase_5 59 286 3.9e-21 PFAM
Pfam:Abhydrolase_6 60 298 1.1e-25 PFAM
Pfam:DUF2305 71 202 1.3e-7 PFAM
Pfam:Lipase_3 72 179 2.6e-9 PFAM
Pfam:Abhydrolase_1 87 300 1.1e-13 PFAM
Pfam:Esterase 98 211 2e-7 PFAM
Pfam:Abhydrolase_3 104 289 8.7e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203824
Predicted Effect probably benign
Transcript: ENSMUST00000203608
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 94.7%
Validation Efficiency 100% (59/59)
MGI Phenotype FUNCTION: This gene encodes a monoglyceride lipase, which catalyzes the hydrolysis of monoglycerides into fatty acids and glycerol. This enzyme is also thought to hydrolyze the endocannabinoid 2-arachidonoylglycerol. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit hypoalgesia, increased body temperature, and decreased fatty acid levels. Mice homozygous for a targeted allele exhibit impaired lipolysis and improved glucose homeostasis on a high-fat diet. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310079G19Rik C A 16: 88,424,411 (GRCm39) V27F unknown Het
Akr1c20 T C 13: 4,560,222 (GRCm39) E152G probably damaging Het
Alx4 G A 2: 93,473,134 (GRCm39) G44D possibly damaging Het
Arhgap31 T A 16: 38,422,895 (GRCm39) E1057V possibly damaging Het
Arhgef26 A T 3: 62,331,050 (GRCm39) D588V probably damaging Het
Bag2 T A 1: 33,785,997 (GRCm39) E108D probably benign Het
Ccdc162 C T 10: 41,463,375 (GRCm39) V183I probably benign Het
Ccdc83 A G 7: 89,885,563 (GRCm39) probably benign Het
Ccnyl1 G A 1: 64,753,827 (GRCm39) E137K probably damaging Het
Celsr2 T C 3: 108,308,155 (GRCm39) T1849A probably benign Het
Cep192 C A 18: 67,953,400 (GRCm39) D472E probably benign Het
Cep57l1 A G 10: 41,619,110 (GRCm39) Y86H probably damaging Het
Cep95 G T 11: 106,702,112 (GRCm39) E370* probably null Het
Cldn10 A G 14: 119,092,522 (GRCm39) T41A probably damaging Het
Clptm1l T A 13: 73,764,157 (GRCm39) Y426N probably benign Het
Dipk1b T C 2: 26,522,650 (GRCm39) L33S possibly damaging Het
Eps15 T C 4: 109,166,374 (GRCm39) V89A probably damaging Het
Fam53b A G 7: 132,361,654 (GRCm39) S125P probably damaging Het
Fbxo44 A T 4: 148,240,461 (GRCm39) W256R probably benign Het
Gnl2 T C 4: 124,940,067 (GRCm39) V313A probably damaging Het
Hyal4 A G 6: 24,756,513 (GRCm39) R244G probably damaging Het
Irf6 G T 1: 192,844,931 (GRCm39) W134L probably benign Het
Kcnu1 A G 8: 26,371,448 (GRCm39) T286A probably damaging Het
Lpcat2 T C 8: 93,644,798 (GRCm39) V529A possibly damaging Het
Lrfn2 A G 17: 49,378,188 (GRCm39) E423G possibly damaging Het
Lrp8 G T 4: 107,705,499 (GRCm39) R209L probably benign Het
Mix23 T C 16: 35,901,775 (GRCm39) probably null Het
Mta3 A G 17: 84,070,417 (GRCm39) I193V probably damaging Het
Nedd4l G A 18: 65,342,790 (GRCm39) V909I possibly damaging Het
Or10al5 T A 17: 38,063,271 (GRCm39) C175* probably null Het
Or3a1d A T 11: 74,238,023 (GRCm39) I129N probably damaging Het
Or5p66 A T 7: 107,885,663 (GRCm39) Y223* probably null Het
Or6c206 A T 10: 129,097,093 (GRCm39) K88* probably null Het
Orc1 T C 4: 108,461,218 (GRCm39) V526A probably damaging Het
Pard3b T C 1: 62,383,137 (GRCm39) S744P probably damaging Het
Pcnx3 G A 19: 5,733,367 (GRCm39) Q155* probably null Het
Pcnx3 C G 19: 5,733,368 (GRCm39) L1F probably null Het
Pdcd11 T A 19: 47,115,684 (GRCm39) probably benign Het
Pi4k2a G A 19: 42,079,131 (GRCm39) R64Q probably damaging Het
Pigt A G 2: 164,343,565 (GRCm39) D347G probably benign Het
Rbm27 T C 18: 42,425,177 (GRCm39) probably benign Het
Rpl7a-ps10 A G 9: 97,061,926 (GRCm39) E232G probably damaging Het
Rprd2 A G 3: 95,671,872 (GRCm39) L1177P probably damaging Het
Rrn3 T A 16: 13,601,959 (GRCm39) L71* probably null Het
Sbspon A G 1: 15,962,669 (GRCm39) C70R probably damaging Het
Smtn A T 11: 3,482,865 (GRCm39) probably null Het
Son A G 16: 91,453,614 (GRCm39) D787G probably damaging Het
Sphkap C T 1: 83,254,833 (GRCm39) S972N probably benign Het
Spopl C T 2: 23,427,392 (GRCm39) R221Q probably damaging Het
Srp14 A C 2: 118,309,440 (GRCm39) L58V probably null Het
Sun2 A G 15: 79,612,114 (GRCm39) S522P possibly damaging Het
Tectb C G 19: 55,169,431 (GRCm39) probably benign Het
Trdn T C 10: 33,033,162 (GRCm39) I129T probably benign Het
Trpv3 A G 11: 73,169,780 (GRCm39) K117R probably benign Het
Ubqlnl A T 7: 103,798,345 (GRCm39) I384N probably benign Het
Ush2a G A 1: 188,542,489 (GRCm39) G3352S probably benign Het
Vmn1r59 A T 7: 5,457,637 (GRCm39) I41K probably damaging Het
Vmn2r125 T A 4: 156,702,419 (GRCm39) Y68* probably null Het
Zpld1 A T 16: 55,046,799 (GRCm39) L390* probably null Het
Other mutations in Mgll
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03182:Mgll APN 6 88,800,173 (GRCm39) missense probably damaging 1.00
PIT4677001:Mgll UTSW 6 88,802,663 (GRCm39) missense possibly damaging 0.96
R0624:Mgll UTSW 6 88,702,799 (GRCm39) missense probably damaging 0.98
R1550:Mgll UTSW 6 88,790,871 (GRCm39) missense probably benign 0.00
R1779:Mgll UTSW 6 88,790,930 (GRCm39) nonsense probably null
R2230:Mgll UTSW 6 88,802,714 (GRCm39) missense possibly damaging 0.65
R4751:Mgll UTSW 6 88,702,093 (GRCm39) utr 5 prime probably benign
R5030:Mgll UTSW 6 88,795,647 (GRCm39) critical splice donor site probably null
R5216:Mgll UTSW 6 88,743,311 (GRCm39) nonsense probably null
R5523:Mgll UTSW 6 88,702,743 (GRCm39) missense probably benign 0.04
R6545:Mgll UTSW 6 88,802,685 (GRCm39) missense probably benign
R7251:Mgll UTSW 6 88,800,357 (GRCm39) missense probably benign 0.17
R7307:Mgll UTSW 6 88,791,103 (GRCm39) splice site probably null
R7745:Mgll UTSW 6 88,702,770 (GRCm39) missense possibly damaging 0.77
R8269:Mgll UTSW 6 88,790,930 (GRCm39) nonsense probably null
R8892:Mgll UTSW 6 88,743,306 (GRCm39) missense unknown
R9063:Mgll UTSW 6 88,802,690 (GRCm39) missense possibly damaging 0.62
Predicted Primers PCR Primer
(F):5'- AGCATAGGTCAGCTCCCATG -3'
(R):5'- AGGGAACATGAAAGGCCTTTC -3'

Sequencing Primer
(F):5'- TGGCTTTCCAGAGAGAAGGCC -3'
(R):5'- CTTTCTGCCAGCCTGGGTG -3'
Posted On 2015-01-23