Incidental Mutation 'R3712:Or5p66'
ID 259664
Institutional Source Beutler Lab
Gene Symbol Or5p66
Ensembl Gene ENSMUSG00000109884
Gene Name olfactory receptor family 5 subfamily P member 66
Synonyms Olfr490, GA_x6K02T2PBJ9-10617173-10616229, MOR204-17
MMRRC Submission 040705-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.164) question?
Stock # R3712 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 107885387-107886331 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 107885663 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 223 (Y223*)
Ref Sequence ENSEMBL: ENSMUSP00000147922 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000210114] [ENSMUST00000211345]
AlphaFold Q8VFD2
Predicted Effect probably null
Transcript: ENSMUST00000074550
AA Change: Y223*
SMART Domains Protein: ENSMUSP00000074137
Gene: ENSMUSG00000093808
AA Change: Y223*

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 4e-53 PFAM
Pfam:7tm_1 44 293 5e-23 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000210114
AA Change: Y223*
Predicted Effect probably null
Transcript: ENSMUST00000211345
AA Change: Y223*
Meta Mutation Damage Score 0.9710 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 94.7%
Validation Efficiency 100% (59/59)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310079G19Rik C A 16: 88,424,411 (GRCm39) V27F unknown Het
Akr1c20 T C 13: 4,560,222 (GRCm39) E152G probably damaging Het
Alx4 G A 2: 93,473,134 (GRCm39) G44D possibly damaging Het
Arhgap31 T A 16: 38,422,895 (GRCm39) E1057V possibly damaging Het
Arhgef26 A T 3: 62,331,050 (GRCm39) D588V probably damaging Het
Bag2 T A 1: 33,785,997 (GRCm39) E108D probably benign Het
Ccdc162 C T 10: 41,463,375 (GRCm39) V183I probably benign Het
Ccdc83 A G 7: 89,885,563 (GRCm39) probably benign Het
Ccnyl1 G A 1: 64,753,827 (GRCm39) E137K probably damaging Het
Celsr2 T C 3: 108,308,155 (GRCm39) T1849A probably benign Het
Cep192 C A 18: 67,953,400 (GRCm39) D472E probably benign Het
Cep57l1 A G 10: 41,619,110 (GRCm39) Y86H probably damaging Het
Cep95 G T 11: 106,702,112 (GRCm39) E370* probably null Het
Cldn10 A G 14: 119,092,522 (GRCm39) T41A probably damaging Het
Clptm1l T A 13: 73,764,157 (GRCm39) Y426N probably benign Het
Dipk1b T C 2: 26,522,650 (GRCm39) L33S possibly damaging Het
Eps15 T C 4: 109,166,374 (GRCm39) V89A probably damaging Het
Fam53b A G 7: 132,361,654 (GRCm39) S125P probably damaging Het
Fbxo44 A T 4: 148,240,461 (GRCm39) W256R probably benign Het
Gnl2 T C 4: 124,940,067 (GRCm39) V313A probably damaging Het
Hyal4 A G 6: 24,756,513 (GRCm39) R244G probably damaging Het
Irf6 G T 1: 192,844,931 (GRCm39) W134L probably benign Het
Kcnu1 A G 8: 26,371,448 (GRCm39) T286A probably damaging Het
Lpcat2 T C 8: 93,644,798 (GRCm39) V529A possibly damaging Het
Lrfn2 A G 17: 49,378,188 (GRCm39) E423G possibly damaging Het
Lrp8 G T 4: 107,705,499 (GRCm39) R209L probably benign Het
Mgll T C 6: 88,741,570 (GRCm39) probably benign Het
Mix23 T C 16: 35,901,775 (GRCm39) probably null Het
Mta3 A G 17: 84,070,417 (GRCm39) I193V probably damaging Het
Nedd4l G A 18: 65,342,790 (GRCm39) V909I possibly damaging Het
Or10al5 T A 17: 38,063,271 (GRCm39) C175* probably null Het
Or3a1d A T 11: 74,238,023 (GRCm39) I129N probably damaging Het
Or6c206 A T 10: 129,097,093 (GRCm39) K88* probably null Het
Orc1 T C 4: 108,461,218 (GRCm39) V526A probably damaging Het
Pard3b T C 1: 62,383,137 (GRCm39) S744P probably damaging Het
Pcnx3 G A 19: 5,733,367 (GRCm39) Q155* probably null Het
Pcnx3 C G 19: 5,733,368 (GRCm39) L1F probably null Het
Pdcd11 T A 19: 47,115,684 (GRCm39) probably benign Het
Pi4k2a G A 19: 42,079,131 (GRCm39) R64Q probably damaging Het
Pigt A G 2: 164,343,565 (GRCm39) D347G probably benign Het
Rbm27 T C 18: 42,425,177 (GRCm39) probably benign Het
Rpl7a-ps10 A G 9: 97,061,926 (GRCm39) E232G probably damaging Het
Rprd2 A G 3: 95,671,872 (GRCm39) L1177P probably damaging Het
Rrn3 T A 16: 13,601,959 (GRCm39) L71* probably null Het
Sbspon A G 1: 15,962,669 (GRCm39) C70R probably damaging Het
Smtn A T 11: 3,482,865 (GRCm39) probably null Het
Son A G 16: 91,453,614 (GRCm39) D787G probably damaging Het
Sphkap C T 1: 83,254,833 (GRCm39) S972N probably benign Het
Spopl C T 2: 23,427,392 (GRCm39) R221Q probably damaging Het
Srp14 A C 2: 118,309,440 (GRCm39) L58V probably null Het
Sun2 A G 15: 79,612,114 (GRCm39) S522P possibly damaging Het
Tectb C G 19: 55,169,431 (GRCm39) probably benign Het
Trdn T C 10: 33,033,162 (GRCm39) I129T probably benign Het
Trpv3 A G 11: 73,169,780 (GRCm39) K117R probably benign Het
Ubqlnl A T 7: 103,798,345 (GRCm39) I384N probably benign Het
Ush2a G A 1: 188,542,489 (GRCm39) G3352S probably benign Het
Vmn1r59 A T 7: 5,457,637 (GRCm39) I41K probably damaging Het
Vmn2r125 T A 4: 156,702,419 (GRCm39) Y68* probably null Het
Zpld1 A T 16: 55,046,799 (GRCm39) L390* probably null Het
Other mutations in Or5p66
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0395:Or5p66 UTSW 7 107,885,478 (GRCm39) missense probably benign 0.00
R0634:Or5p66 UTSW 7 107,885,503 (GRCm39) missense probably benign 0.00
R0940:Or5p66 UTSW 7 107,886,264 (GRCm39) missense probably benign 0.01
R1990:Or5p66 UTSW 7 107,885,566 (GRCm39) nonsense probably null
R1991:Or5p66 UTSW 7 107,885,566 (GRCm39) nonsense probably null
R2860:Or5p66 UTSW 7 107,886,169 (GRCm39) missense probably damaging 0.98
R2861:Or5p66 UTSW 7 107,886,169 (GRCm39) missense probably damaging 0.98
R4735:Or5p66 UTSW 7 107,885,520 (GRCm39) missense probably benign
R4895:Or5p66 UTSW 7 107,885,802 (GRCm39) missense probably damaging 0.97
R4976:Or5p66 UTSW 7 107,885,818 (GRCm39) missense probably damaging 1.00
R5686:Or5p66 UTSW 7 107,885,949 (GRCm39) missense probably damaging 1.00
R5719:Or5p66 UTSW 7 107,885,599 (GRCm39) missense probably damaging 0.97
R5883:Or5p66 UTSW 7 107,885,451 (GRCm39) missense probably damaging 1.00
R5911:Or5p66 UTSW 7 107,885,605 (GRCm39) missense probably damaging 1.00
R6452:Or5p66 UTSW 7 107,886,100 (GRCm39) missense probably damaging 1.00
R7018:Or5p66 UTSW 7 107,885,551 (GRCm39) missense probably benign 0.34
R7233:Or5p66 UTSW 7 107,885,923 (GRCm39) missense probably benign 0.36
R8085:Or5p66 UTSW 7 107,885,620 (GRCm39) missense probably benign 0.01
R8166:Or5p66 UTSW 7 107,885,904 (GRCm39) missense probably benign 0.06
R8919:Or5p66 UTSW 7 107,886,289 (GRCm39) missense probably damaging 1.00
R9209:Or5p66 UTSW 7 107,885,526 (GRCm39) missense probably benign 0.06
R9612:Or5p66 UTSW 7 107,885,487 (GRCm39) missense probably benign
R9789:Or5p66 UTSW 7 107,885,898 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AGTGGGTTCAACATGGGAAC -3'
(R):5'- GGATCCTACATTGCTGGGTTTC -3'

Sequencing Primer
(F):5'- GGAACCACAACCATGTAGAACACAG -3'
(R):5'- ATCCTACATTGCTGGGTTTCTTAATG -3'
Posted On 2015-01-23