Incidental Mutation 'R3713:Foxred1'
ID 259747
Institutional Source Beutler Lab
Gene Symbol Foxred1
Ensembl Gene ENSMUSG00000039048
Gene Name FAD-dependent oxidoreductase domain containing 1
Synonyms TEG-23, Tex23
MMRRC Submission 040706-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R3713 (G1)
Quality Score 137
Status Validated
Chromosome 9
Chromosomal Location 35115502-35122351 bp(-) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) A to G at 35122186 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 1 (M1T)
Ref Sequence ENSEMBL: ENSMUSP00000123496 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034541] [ENSMUST00000043805] [ENSMUST00000127996] [ENSMUST00000132799] [ENSMUST00000135054] [ENSMUST00000138692] [ENSMUST00000139703] [ENSMUST00000142595] [ENSMUST00000151658] [ENSMUST00000154691] [ENSMUST00000138287]
AlphaFold Q3TQB2
Predicted Effect probably benign
Transcript: ENSMUST00000034541
SMART Domains Protein: ENSMUSP00000034541
Gene: ENSMUSG00000032042

DomainStartEndE-ValueType
Pfam:SRP-alpha_N 27 301 4.4e-69 PFAM
SRP54_N 318 395 4.04e-6 SMART
AAA 415 568 9.65e-10 SMART
SRP54 416 635 3.47e-78 SMART
Predicted Effect probably null
Transcript: ENSMUST00000043805
AA Change: M1T
SMART Domains Protein: ENSMUSP00000038924
Gene: ENSMUSG00000039048
AA Change: M1T

DomainStartEndE-ValueType
low complexity region 3 20 N/A INTRINSIC
Pfam:DAO 65 462 2.8e-50 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000127996
AA Change: M1T
SMART Domains Protein: ENSMUSP00000118037
Gene: ENSMUSG00000039048
AA Change: M1T

DomainStartEndE-ValueType
low complexity region 3 20 N/A INTRINSIC
Pfam:DAO 65 456 1.8e-62 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130072
Predicted Effect probably benign
Transcript: ENSMUST00000132799
SMART Domains Protein: ENSMUSP00000115104
Gene: ENSMUSG00000032042

DomainStartEndE-ValueType
Pfam:SRP54 3 132 8.6e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000135054
SMART Domains Protein: ENSMUSP00000115301
Gene: ENSMUSG00000039048

DomainStartEndE-ValueType
Pfam:DAO 3 140 1.1e-10 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000138692
AA Change: M1T
SMART Domains Protein: ENSMUSP00000120556
Gene: ENSMUSG00000039048
AA Change: M1T

DomainStartEndE-ValueType
low complexity region 3 20 N/A INTRINSIC
low complexity region 29 43 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000139703
AA Change: M1T
SMART Domains Protein: ENSMUSP00000122535
Gene: ENSMUSG00000039048
AA Change: M1T

DomainStartEndE-ValueType
low complexity region 3 20 N/A INTRINSIC
Pfam:DAO 65 184 1.6e-15 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000142595
AA Change: M1T
SMART Domains Protein: ENSMUSP00000117147
Gene: ENSMUSG00000039048
AA Change: M1T

DomainStartEndE-ValueType
low complexity region 3 20 N/A INTRINSIC
Pfam:DAO 65 187 3.4e-15 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000151658
AA Change: M1T
SMART Domains Protein: ENSMUSP00000120284
Gene: ENSMUSG00000039048
AA Change: M1T

DomainStartEndE-ValueType
low complexity region 3 20 N/A INTRINSIC
Pfam:DAO 65 121 5.8e-9 PFAM
low complexity region 128 138 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000154691
AA Change: M1T
SMART Domains Protein: ENSMUSP00000123496
Gene: ENSMUSG00000039048
AA Change: M1T

DomainStartEndE-ValueType
low complexity region 3 20 N/A INTRINSIC
low complexity region 29 43 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140177
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143039
Predicted Effect probably benign
Transcript: ENSMUST00000138287
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154005
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151082
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216618
Meta Mutation Damage Score 0.9476 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 97.0%
  • 20x: 94.0%
Validation Efficiency 100% (67/67)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310079G19Rik T C 16: 88,424,081 (GRCm39) M137V probably benign Het
Aak1 T A 6: 86,932,172 (GRCm39) I381N probably benign Het
Abcd4 C T 12: 84,658,533 (GRCm39) M223I probably benign Het
Adgrf2 A G 17: 43,023,979 (GRCm39) V164A probably damaging Het
Ahdc1 G A 4: 132,793,297 (GRCm39) A1513T possibly damaging Het
Akap13 T C 7: 75,235,929 (GRCm39) M168T probably damaging Het
Aox1 C T 1: 58,095,374 (GRCm39) T196I probably benign Het
Aqr A G 2: 113,949,150 (GRCm39) probably benign Het
Astn1 A G 1: 158,495,102 (GRCm39) E1042G possibly damaging Het
Azi2 A G 9: 117,876,508 (GRCm39) D8G possibly damaging Het
Bcam T C 7: 19,498,118 (GRCm39) T302A probably benign Het
Cct6b A T 11: 82,651,183 (GRCm39) I110N probably damaging Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Ceacam5 G A 7: 17,493,263 (GRCm39) S762N possibly damaging Het
Cecr2 T C 6: 120,735,221 (GRCm39) L819P probably damaging Het
Cers3 G T 7: 66,435,823 (GRCm39) A261S probably benign Het
Chd2 A G 7: 73,121,538 (GRCm39) probably benign Het
Col7a1 G T 9: 108,793,508 (GRCm39) G1357* probably null Het
Cux1 A G 5: 136,594,397 (GRCm39) probably benign Het
Cwh43 A T 5: 73,595,835 (GRCm39) I535F probably damaging Het
Dexi A T 16: 10,360,553 (GRCm39) M1K probably null Het
Dnah12 T C 14: 26,534,747 (GRCm39) V2081A probably benign Het
Efcab5 A T 11: 77,007,008 (GRCm39) L872Q probably damaging Het
Enpp7 A G 11: 118,881,344 (GRCm39) Y163C probably damaging Het
Fam221a T C 6: 49,349,548 (GRCm39) Y38H probably damaging Het
Fscn3 C T 6: 28,428,091 (GRCm39) T26I possibly damaging Het
Galp A T 7: 6,216,836 (GRCm39) D72V probably damaging Het
Gm9843 A G 16: 76,200,419 (GRCm39) noncoding transcript Het
Grm7 G T 6: 110,623,309 (GRCm39) V161F probably damaging Het
Lmbrd1 T C 1: 24,732,076 (GRCm39) Y98H probably damaging Het
Lrrc63 T G 14: 75,344,776 (GRCm39) Y437S probably benign Het
Macc1 A G 12: 119,410,576 (GRCm39) E448G probably benign Het
Madcam1 A G 10: 79,504,194 (GRCm39) H404R probably benign Het
Mink1 G T 11: 70,499,776 (GRCm39) R773L possibly damaging Het
Mroh2b A G 15: 4,973,131 (GRCm39) I1045V probably benign Het
Mroh3 T C 1: 136,113,714 (GRCm39) T692A probably benign Het
Myo15a A T 11: 60,370,057 (GRCm39) E939V possibly damaging Het
Naip2 A G 13: 100,298,410 (GRCm39) F542S probably damaging Het
Napsa A G 7: 44,230,852 (GRCm39) Y73C probably damaging Het
Ndst4 A T 3: 125,355,154 (GRCm39) H354L possibly damaging Het
Neil1 A T 9: 57,054,254 (GRCm39) V22E probably damaging Het
Nol4 T C 18: 23,172,994 (GRCm39) I36V probably damaging Het
Nprl3 G A 11: 32,205,464 (GRCm39) T111I probably damaging Het
Or12k8 A G 2: 36,975,517 (GRCm39) M81T possibly damaging Het
Or1e26 A T 11: 73,479,731 (GRCm39) Y278N probably damaging Het
Or4p22 C A 2: 88,317,787 (GRCm39) T237N probably damaging Het
Pald1 G A 10: 61,178,144 (GRCm39) T624I possibly damaging Het
Pcdhb13 C T 18: 37,576,786 (GRCm39) P388L probably damaging Het
Pcdhga6 T C 18: 37,840,976 (GRCm39) V232A probably damaging Het
Pde6b A G 5: 108,570,928 (GRCm39) I388V probably damaging Het
Phactr2 C A 10: 13,264,476 (GRCm39) probably benign Het
Prdx5 T C 19: 6,885,477 (GRCm39) D56G probably damaging Het
Ptprh A T 7: 4,574,969 (GRCm39) I350N probably damaging Het
Rangap1 C A 15: 81,594,661 (GRCm39) E389D probably benign Het
Reln A G 5: 22,109,732 (GRCm39) V3126A probably damaging Het
Rpl21 G A 5: 146,771,847 (GRCm39) G59S possibly damaging Het
Rsph6a G A 7: 18,791,475 (GRCm39) V215M probably damaging Het
Smcp T C 3: 92,491,431 (GRCm39) K139E unknown Het
Stag1 A G 9: 100,771,671 (GRCm39) T699A probably benign Het
Tars3 G A 7: 65,338,700 (GRCm39) probably null Het
Tle1 G T 4: 72,044,659 (GRCm39) H459Q possibly damaging Het
Ttn G A 2: 76,561,363 (GRCm39) P27302S probably damaging Het
Ttn C T 2: 76,571,610 (GRCm39) V26428I probably damaging Het
Usp53 T C 3: 122,742,968 (GRCm39) E656G probably benign Het
Vmn1r218 A T 13: 23,321,081 (GRCm39) N63Y probably damaging Het
Vmn1r79 A G 7: 11,910,139 (GRCm39) N40S possibly damaging Het
Wdr35 A G 12: 9,077,648 (GRCm39) D1107G possibly damaging Het
Zfp101 A G 17: 33,600,880 (GRCm39) M292T probably benign Het
Zfp108 T A 7: 23,961,270 (GRCm39) C620* probably null Het
Zscan4b T C 7: 10,635,818 (GRCm39) T170A probably benign Het
Other mutations in Foxred1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02163:Foxred1 APN 9 35,117,192 (GRCm39) missense probably damaging 1.00
IGL02314:Foxred1 APN 9 35,117,264 (GRCm39) missense probably damaging 1.00
IGL02379:Foxred1 APN 9 35,121,282 (GRCm39) missense probably benign 0.44
IGL02558:Foxred1 APN 9 35,121,429 (GRCm39) missense probably damaging 1.00
PIT4494001:Foxred1 UTSW 9 35,120,355 (GRCm39) missense possibly damaging 0.95
R0220:Foxred1 UTSW 9 35,120,749 (GRCm39) missense probably damaging 1.00
R0605:Foxred1 UTSW 9 35,116,178 (GRCm39) missense possibly damaging 0.68
R0763:Foxred1 UTSW 9 35,118,769 (GRCm39) splice site probably null
R1136:Foxred1 UTSW 9 35,116,333 (GRCm39) missense probably benign 0.25
R1449:Foxred1 UTSW 9 35,120,738 (GRCm39) missense probably damaging 1.00
R1757:Foxred1 UTSW 9 35,122,130 (GRCm39) missense probably benign 0.16
R2157:Foxred1 UTSW 9 35,116,659 (GRCm39) missense probably damaging 1.00
R2434:Foxred1 UTSW 9 35,116,954 (GRCm39) missense probably damaging 0.99
R4012:Foxred1 UTSW 9 35,117,571 (GRCm39) missense possibly damaging 0.48
R4666:Foxred1 UTSW 9 35,122,151 (GRCm39) intron probably benign
R4934:Foxred1 UTSW 9 35,121,210 (GRCm39) intron probably benign
R5488:Foxred1 UTSW 9 35,121,266 (GRCm39) missense probably damaging 1.00
R5489:Foxred1 UTSW 9 35,121,266 (GRCm39) missense probably damaging 1.00
R5828:Foxred1 UTSW 9 35,121,492 (GRCm39) intron probably benign
R5840:Foxred1 UTSW 9 35,121,435 (GRCm39) missense probably damaging 0.99
R7037:Foxred1 UTSW 9 35,118,844 (GRCm39) missense probably benign 0.04
R7599:Foxred1 UTSW 9 35,116,932 (GRCm39) missense probably damaging 1.00
R9722:Foxred1 UTSW 9 35,117,300 (GRCm39) missense possibly damaging 0.95
R9795:Foxred1 UTSW 9 35,122,152 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- AGAGCCATACACTTGCCTCG -3'
(R):5'- TGACCAATAGCACACAGGG -3'

Sequencing Primer
(F):5'- AGCTAACTCGCTGTCCCG -3'
(R):5'- ACACAGGGGCGGGACTC -3'
Posted On 2015-01-23