Incidental Mutation 'R3714:Or10ab4'
ID 259792
Institutional Source Beutler Lab
Gene Symbol Or10ab4
Ensembl Gene ENSMUSG00000043855
Gene Name olfactory receptor family 10 subfamily AB member 4
Synonyms Olfr479, MOR267-15, GA_x6K02T2PBJ9-10384085-10385068
MMRRC Submission 040707-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.099) question?
Stock # R3714 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 107654191-107655174 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 107654642 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 151 (F151S)
Ref Sequence ENSEMBL: ENSMUSP00000149060 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063151] [ENSMUST00000209805] [ENSMUST00000214599]
AlphaFold Q7TRV1
Predicted Effect probably damaging
Transcript: ENSMUST00000063151
AA Change: F151S

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000056631
Gene: ENSMUSG00000043855
AA Change: F151S

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 7.5e-45 PFAM
Pfam:7tm_1 39 301 1.9e-15 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000209805
AA Change: F151S

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000214599
AA Change: F151S

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik1 T C 11: 48,838,803 (GRCm39) T595A possibly damaging Het
Abcd4 C T 12: 84,658,533 (GRCm39) M223I probably benign Het
Adck5 G A 15: 76,478,138 (GRCm39) V229I probably damaging Het
Afg2a G A 3: 37,487,358 (GRCm39) V407I probably benign Het
Ankk1 T G 9: 49,333,013 (GRCm39) D157A possibly damaging Het
Atp1a2 A G 1: 172,106,551 (GRCm39) I817T probably damaging Het
Ccdc87 A G 19: 4,890,287 (GRCm39) S260G probably benign Het
Cers3 G T 7: 66,435,823 (GRCm39) A261S probably benign Het
Cibar2 C T 8: 120,901,576 (GRCm39) R43H probably damaging Het
Cntnap5c C T 17: 58,199,062 (GRCm39) Q119* probably null Het
Cpb2 T A 14: 75,520,657 (GRCm39) probably null Het
Ddx47 T A 6: 134,996,025 (GRCm39) I329K probably damaging Het
Elavl3 G T 9: 21,929,895 (GRCm39) D336E probably benign Het
Fcsk G T 8: 111,613,891 (GRCm39) D723E probably damaging Het
Fras1 T C 5: 96,793,829 (GRCm39) probably null Het
Garem1 T A 18: 21,281,947 (GRCm39) E136D probably damaging Het
Haus6 A G 4: 86,521,104 (GRCm39) I178T probably benign Het
Igkv3-2 T G 6: 70,675,480 (GRCm39) V10G possibly damaging Het
Jrkl A C 9: 13,244,236 (GRCm39) I475R possibly damaging Het
Lcmt1 C T 7: 123,003,683 (GRCm39) H146Y probably damaging Het
Lipk A G 19: 34,017,829 (GRCm39) N289S probably damaging Het
Mb A G 15: 76,901,789 (GRCm39) V102A probably benign Het
Mc4r T A 18: 66,992,892 (GRCm39) N74Y probably damaging Het
Mink1 G T 11: 70,499,776 (GRCm39) R773L possibly damaging Het
Mroh2b A G 15: 4,973,131 (GRCm39) I1045V probably benign Het
Myo15a A T 11: 60,370,057 (GRCm39) E939V possibly damaging Het
Ndufs7 T C 10: 80,088,255 (GRCm39) I14T probably benign Het
Nlrp4b T C 7: 10,448,808 (GRCm39) V337A probably benign Het
Npm2 T C 14: 70,890,060 (GRCm39) probably null Het
Or2h2c A G 17: 37,422,227 (GRCm39) Y216H probably damaging Het
Or4a68 G A 2: 89,269,727 (GRCm39) L299F probably damaging Het
Prdm9 T A 17: 15,777,623 (GRCm39) K154* probably null Het
Prkch C T 12: 73,822,290 (GRCm39) P630S probably damaging Het
Ptprn T C 1: 75,229,411 (GRCm39) probably null Het
Rnf31 T A 14: 55,840,851 (GRCm39) D884E probably damaging Het
Semp2l2a T G 8: 13,886,736 (GRCm39) I452L probably benign Het
Slc22a27 A T 19: 7,903,815 (GRCm39) N107K possibly damaging Het
Tln1 G T 4: 43,540,597 (GRCm39) A1468D probably damaging Het
Tmem185b T A 1: 119,454,781 (GRCm39) F181I possibly damaging Het
Tmem63a G A 1: 180,790,679 (GRCm39) D446N possibly damaging Het
Trappc11 T C 8: 47,958,351 (GRCm39) probably benign Het
Vmn1r218 A T 13: 23,321,081 (GRCm39) N63Y probably damaging Het
Vps37c A G 19: 10,683,632 (GRCm39) D18G probably damaging Het
Other mutations in Or10ab4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01120:Or10ab4 APN 7 107,654,774 (GRCm39) missense probably damaging 0.96
IGL01320:Or10ab4 APN 7 107,654,188 (GRCm39) utr 5 prime probably benign
IGL01322:Or10ab4 APN 7 107,654,188 (GRCm39) utr 5 prime probably benign
R0396:Or10ab4 UTSW 7 107,655,170 (GRCm39) missense probably benign 0.11
R0539:Or10ab4 UTSW 7 107,655,029 (GRCm39) missense probably damaging 1.00
R2129:Or10ab4 UTSW 7 107,655,111 (GRCm39) missense probably benign 0.25
R2246:Or10ab4 UTSW 7 107,654,989 (GRCm39) missense probably benign 0.00
R2247:Or10ab4 UTSW 7 107,654,989 (GRCm39) missense probably benign 0.00
R3149:Or10ab4 UTSW 7 107,654,989 (GRCm39) missense probably benign 0.00
R3709:Or10ab4 UTSW 7 107,655,004 (GRCm39) missense possibly damaging 0.63
R4326:Or10ab4 UTSW 7 107,654,362 (GRCm39) missense probably damaging 1.00
R4962:Or10ab4 UTSW 7 107,654,647 (GRCm39) missense probably benign 0.27
R5053:Or10ab4 UTSW 7 107,654,741 (GRCm39) missense probably benign 0.10
R5976:Or10ab4 UTSW 7 107,655,005 (GRCm39) missense possibly damaging 0.89
R6151:Or10ab4 UTSW 7 107,655,106 (GRCm39) missense probably benign
R6939:Or10ab4 UTSW 7 107,654,312 (GRCm39) missense possibly damaging 0.87
R7271:Or10ab4 UTSW 7 107,654,423 (GRCm39) missense probably damaging 1.00
R8956:Or10ab4 UTSW 7 107,655,160 (GRCm39) missense probably benign 0.13
R9250:Or10ab4 UTSW 7 107,655,014 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTCCCTGAATGTGCTACCCAG -3'
(R):5'- ATGCCTCCCCTGTACAGAAG -3'

Sequencing Primer
(F):5'- GAATGTGCTACCCAGATGTTTTTC -3'
(R):5'- CCCTGTACAGAAGGCATTTTTAC -3'
Posted On 2015-01-23