Mutagenetix > Incidental Mutation

Incidental Mutation 'R2878:Vmn2r56'

260170

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r56

Ensembl Gene

ENSMUSG00000090762

Gene Name

vomeronasal 2, receptor 56

Synonyms

EG629079

MMRRC Submission

040466-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

R2878 (G1)

Quality Score

148

Status

Validated

Chromosome

Chromosomal Location

12427787-12468785 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 12444954 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Arginine at position 433 (M433R)

Ref Sequence

ENSEMBL: ENSMUSP00000129566 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000163852]

AlphaFold

A0A3B2WBA1

Predicted Effect

probably benign
Transcript: ENSMUST00000163852
AA Change: M433R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000129566
Gene: ENSMUSG00000090762
AA Change: M433R

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	5	397	1.9e-55	PFAM
Pfam:NCD3G	439	492	6.4e-20	PFAM
Pfam:7tm_3	523	760	1.3e-53	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.6%
10x: 97.3%
20x: 95.2%

Validation Efficiency

92% (58/63)

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	C	T	11: 9,241,889 (GRCm39)	L1251F	possibly damaging	Het
Accsl	A	T	2: 93,689,755 (GRCm39)	M384K	probably damaging	Het
Adgrg7	A	G	16: 56,570,817 (GRCm39)	F404L	probably benign	Het
Akr1c20	G	A	13: 4,557,774 (GRCm39)	T251M	probably damaging	Het
Amph	G	A	13: 19,288,437 (GRCm39)	V309I	possibly damaging	Het
Ano2	T	G	6: 125,840,481 (GRCm39)	F384C	probably damaging	Het
Aplf	G	A	6: 87,645,409 (GRCm39)	R32*	probably null	Het
Arhgef18	A	G	8: 3,482,759 (GRCm39)	M155V	probably benign	Het
Atg2b	A	T	12: 105,630,268 (GRCm39)	Y374*	probably null	Het
Camkmt	T	C	17: 85,738,979 (GRCm39)		probably benign	Het
Capn2	T	A	1: 182,344,798 (GRCm39)	E41V	probably benign	Het
Cd53	T	C	3: 106,674,732 (GRCm39)	T112A	probably benign	Het
Cyp2a4	G	A	7: 26,011,612 (GRCm39)	E278K	possibly damaging	Het
Dact2	A	T	17: 14,416,176 (GRCm39)	S675T	probably damaging	Het
Dync1li2	A	C	8: 105,156,047 (GRCm39)	Y265D	probably damaging	Het
Eml4	T	A	17: 83,717,603 (GRCm39)	H58Q	probably benign	Het
F13b	T	C	1: 139,429,485 (GRCm39)	M1T	probably null	Het
Fam83b	A	G	9: 76,398,092 (GRCm39)	F1004L	probably damaging	Het
Fbxo48	A	G	11: 16,903,382 (GRCm39)	K3E	possibly damaging	Het
Fbxw13	A	G	9: 109,010,534 (GRCm39)	F368S	probably damaging	Het
Fbxw19	A	T	9: 109,315,038 (GRCm39)	W175R	probably damaging	Het
Fibcd1	G	A	2: 31,728,678 (GRCm39)	P60S	probably benign	Het
Fscb	A	T	12: 64,519,348 (GRCm39)	V706E	unknown	Het
Gfm2	A	G	13: 97,289,757 (GRCm39)	R181G	possibly damaging	Het
Gm17546	A	T	15: 95,727,805 (GRCm39)		probably benign	Het
Grin1	A	G	2: 25,187,641 (GRCm39)	V594A	probably damaging	Het
Itpripl1	A	G	2: 126,983,534 (GRCm39)	V196A	probably benign	Het
Kcns1	A	G	2: 164,006,682 (GRCm39)	I427T	probably damaging	Het
Map3k19	T	A	1: 127,751,530 (GRCm39)	E607V	possibly damaging	Het
Map3k4	T	C	17: 12,482,954 (GRCm39)	S588G	probably benign	Het
Mslnl	G	A	17: 25,961,908 (GRCm39)	V128M	probably damaging	Het
Naa80	A	T	9: 107,460,367 (GRCm39)	E87D	possibly damaging	Het
Nebl	C	A	2: 17,439,740 (GRCm39)	D178Y	probably damaging	Het
Nfatc3	C	A	8: 106,818,776 (GRCm39)	T498K	probably damaging	Het
Nfkb2	G	A	19: 46,295,880 (GRCm39)	R158H	possibly damaging	Het
Obscn	T	C	11: 58,947,014 (GRCm39)	E4337G	possibly damaging	Het
Or5b106	A	G	19: 13,123,771 (GRCm39)	L84P	probably benign	Het
Palb2	A	G	7: 121,713,652 (GRCm39)	V877A	probably damaging	Het
Rbm6	T	C	9: 107,729,649 (GRCm39)	E333G	probably damaging	Het
Rem2	A	G	14: 54,713,819 (GRCm39)	T31A	possibly damaging	Het
Ric1	A	G	19: 29,579,730 (GRCm39)	D1224G	possibly damaging	Het
Rp1	A	G	1: 4,418,362 (GRCm39)	S917P	probably damaging	Het
Scn2a	G	A	2: 65,518,715 (GRCm39)	G363D	probably damaging	Het
Shcbp1l	A	T	1: 153,313,264 (GRCm39)		probably benign	Het
Skor2	G	T	18: 76,948,419 (GRCm39)	E714*	probably null	Het
Slc15a1	T	A	14: 121,703,345 (GRCm39)	K545N	probably benign	Het
Slc1a2	T	A	2: 102,591,512 (GRCm39)	M414K	probably damaging	Het
Slc7a8	A	G	14: 54,997,143 (GRCm39)	S70P	probably damaging	Het
Spopfm1	G	T	3: 94,173,787 (GRCm39)	C265F	possibly damaging	Het
Taf1a	A	G	1: 183,179,173 (GRCm39)	E117G	probably damaging	Het
Trem2	A	G	17: 48,658,141 (GRCm39)	D135G	probably benign	Het
Ttn	T	C	2: 76,567,409 (GRCm39)	D27828G	probably damaging	Het
Ulk4	T	C	9: 121,089,105 (GRCm39)	D258G	probably benign	Het
Unc80	TGTATTCCAGGCG	TG	1: 66,710,735 (GRCm39)		probably benign	Het
Wdr45	C	T	X: 7,593,611 (GRCm39)	P271S	probably damaging	Het
Zfp410	A	C	12: 84,378,411 (GRCm39)	N245T	probably damaging	Het

Other mutations in Vmn2r56

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00902:Vmn2r56	APN	7	12,449,426 (GRCm39)	missense	probably benign	0.38
IGL01060:Vmn2r56	APN	7	12,447,016 (GRCm39)	missense	probably damaging	0.97
IGL01433:Vmn2r56	APN	7	12,449,541 (GRCm39)	missense	probably benign
IGL01859:Vmn2r56	APN	7	12,449,932 (GRCm39)	missense	probably damaging	1.00
IGL01874:Vmn2r56	APN	7	12,449,602 (GRCm39)	missense	probably benign	0.03
IGL02208:Vmn2r56	APN	7	12,449,408 (GRCm39)	missense	probably benign	0.01
PIT4445001:Vmn2r56	UTSW	7	12,449,153 (GRCm39)	critical splice donor site	probably null
R0077:Vmn2r56	UTSW	7	12,449,332 (GRCm39)	missense	probably benign	0.01
R0278:Vmn2r56	UTSW	7	12,449,644 (GRCm39)	missense	probably damaging	0.99
R0512:Vmn2r56	UTSW	7	12,449,350 (GRCm39)	missense	probably benign
R0658:Vmn2r56	UTSW	7	12,444,235 (GRCm39)	missense	probably benign	0.10
R0789:Vmn2r56	UTSW	7	12,466,762 (GRCm39)	missense	probably damaging	1.00
R1534:Vmn2r56	UTSW	7	12,427,954 (GRCm39)	missense	probably benign
R1731:Vmn2r56	UTSW	7	12,466,972 (GRCm39)	missense	probably benign
R1817:Vmn2r56	UTSW	7	12,449,542 (GRCm39)	missense	probably benign
R2047:Vmn2r56	UTSW	7	12,466,918 (GRCm39)	missense	probably damaging	1.00
R2139:Vmn2r56	UTSW	7	12,446,890 (GRCm39)	nonsense	probably null
R2160:Vmn2r56	UTSW	7	12,428,146 (GRCm39)	missense	probably benign	0.43
R2449:Vmn2r56	UTSW	7	12,428,082 (GRCm39)	missense	possibly damaging	0.67
R2877:Vmn2r56	UTSW	7	12,444,954 (GRCm39)	missense	probably benign
R4910:Vmn2r56	UTSW	7	12,449,462 (GRCm39)	missense	possibly damaging	0.64
R5072:Vmn2r56	UTSW	7	12,427,983 (GRCm39)	missense	probably benign	0.40
R5340:Vmn2r56	UTSW	7	12,449,799 (GRCm39)	missense	probably damaging	1.00
R5697:Vmn2r56	UTSW	7	12,449,917 (GRCm39)	missense	probably damaging	1.00
R5798:Vmn2r56	UTSW	7	12,446,892 (GRCm39)	missense	probably benign	0.00
R6166:Vmn2r56	UTSW	7	12,427,947 (GRCm39)	missense	probably damaging	1.00
R6290:Vmn2r56	UTSW	7	12,428,809 (GRCm39)	missense	probably damaging	1.00
R6458:Vmn2r56	UTSW	7	12,427,984 (GRCm39)	missense	probably damaging	0.99
R6751:Vmn2r56	UTSW	7	12,428,719 (GRCm39)	missense	probably benign
R6978:Vmn2r56	UTSW	7	12,449,333 (GRCm39)	missense	probably benign	0.01
R7090:Vmn2r56	UTSW	7	12,449,254 (GRCm39)	missense	probably damaging	1.00
R7200:Vmn2r56	UTSW	7	12,444,259 (GRCm39)	missense	probably damaging	1.00
R7861:Vmn2r56	UTSW	7	12,449,351 (GRCm39)	missense	probably benign	0.00
R8222:Vmn2r56	UTSW	7	12,444,960 (GRCm39)	missense	probably benign
R8282:Vmn2r56	UTSW	7	12,449,601 (GRCm39)	nonsense	probably null
R8786:Vmn2r56	UTSW	7	12,449,393 (GRCm39)	missense	probably damaging	1.00
R8970:Vmn2r56	UTSW	7	12,428,632 (GRCm39)	missense	probably damaging	1.00
R9230:Vmn2r56	UTSW	7	12,444,237 (GRCm39)	missense	possibly damaging	0.70
RF002:Vmn2r56	UTSW	7	12,428,757 (GRCm39)	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- GGCTCCTACGTCAATAATTGAAG -3'
(R):5'- ATCAGGTTTTGCAGGTCTCCC -3'

Sequencing Primer
(F):5'- AGTAAATGCTGCTGCTCCAG -3'
(R):5'- GCAGGTCTCCCATATATTAGAGGAC -3'

Posted On

2015-01-23