Incidental Mutation 'R2881:Zfp871'
| ID |
260334 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp871
|
| Ensembl Gene |
ENSMUSG00000024298 |
| Gene Name |
zinc finger protein 871 |
| Synonyms |
9030612M13Rik |
| MMRRC Submission |
040469-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R2881 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
32984470-33007261 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 32994407 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Arginine
at position 256
(K256R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127178
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000057501]
[ENSMUST00000159086]
|
| AlphaFold |
G5E905 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000057501
AA Change: K237R
PolyPhen 2
Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000050501
Gene: ENSMUSG00000024298
AA Change: K237R
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
1 |
42 |
1.32e0 |
SMART |
|
ZnF_C2H2
|
174 |
196 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
202 |
224 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
230 |
252 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
258 |
280 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
286 |
308 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
314 |
336 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
342 |
364 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
370 |
392 |
2.79e-4 |
SMART |
|
ZnF_C2H2
|
398 |
420 |
1.23e-5 |
SMART |
|
ZnF_C2H2
|
426 |
448 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
454 |
476 |
5.42e-2 |
SMART |
|
ZnF_C2H2
|
482 |
504 |
8.6e-5 |
SMART |
|
ZnF_C2H2
|
510 |
532 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
538 |
560 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
566 |
588 |
2.86e-1 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159086
AA Change: K256R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000127178
Gene: ENSMUSG00000024298
AA Change: K256R
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
61 |
2.18e-15 |
SMART |
|
ZnF_C2H2
|
193 |
215 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
221 |
243 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
249 |
271 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
277 |
299 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
305 |
327 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
333 |
355 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
361 |
383 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
389 |
411 |
2.79e-4 |
SMART |
|
ZnF_C2H2
|
417 |
439 |
1.23e-5 |
SMART |
|
ZnF_C2H2
|
445 |
467 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
473 |
495 |
5.42e-2 |
SMART |
|
ZnF_C2H2
|
501 |
523 |
8.6e-5 |
SMART |
|
ZnF_C2H2
|
529 |
551 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
557 |
579 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
585 |
607 |
2.86e-1 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000168337
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Atp4a |
G |
A |
7: 30,419,650 (GRCm39) |
R671Q |
probably benign |
Het |
| Atp9a |
T |
C |
2: 168,548,134 (GRCm39) |
Y7C |
probably damaging |
Het |
| Bsn |
C |
T |
9: 107,990,266 (GRCm39) |
A1829T |
possibly damaging |
Het |
| Camta2 |
A |
T |
11: 70,570,490 (GRCm39) |
|
probably null |
Het |
| Ces1d |
C |
A |
8: 93,921,659 (GRCm39) |
G35W |
probably damaging |
Het |
| Chd3 |
T |
C |
11: 69,242,946 (GRCm39) |
D1425G |
probably damaging |
Het |
| Coasy |
G |
A |
11: 100,976,675 (GRCm39) |
V482I |
possibly damaging |
Het |
| Cyp2j9 |
A |
T |
4: 96,462,249 (GRCm39) |
V344E |
probably damaging |
Het |
| Dhx30 |
A |
T |
9: 109,927,913 (GRCm39) |
Y73* |
probably null |
Het |
| Ewsr1 |
C |
A |
11: 5,028,523 (GRCm39) |
|
probably benign |
Het |
| Faap100 |
T |
C |
11: 120,265,185 (GRCm39) |
T564A |
probably damaging |
Het |
| Galc |
A |
G |
12: 98,179,355 (GRCm39) |
M518T |
probably benign |
Het |
| Gpatch8 |
A |
G |
11: 102,370,743 (GRCm39) |
Y932H |
unknown |
Het |
| Hace1 |
T |
A |
10: 45,547,230 (GRCm39) |
M471K |
probably benign |
Het |
| Irf2bpl |
T |
A |
12: 86,929,551 (GRCm39) |
D374V |
probably damaging |
Het |
| Lcor |
A |
G |
19: 41,571,488 (GRCm39) |
E227G |
probably damaging |
Het |
| Nbea |
A |
G |
3: 55,554,779 (GRCm39) |
V2623A |
probably benign |
Het |
| Or4a47 |
T |
C |
2: 89,675,328 (GRCm39) |
|
probably null |
Het |
| Or5ac24 |
A |
T |
16: 59,165,215 (GRCm39) |
L283Q |
probably damaging |
Het |
| Pex5l |
T |
A |
3: 33,047,152 (GRCm39) |
|
probably null |
Het |
| Pira13 |
T |
A |
7: 3,828,640 (GRCm39) |
M1L |
probably null |
Het |
| Plxnb1 |
T |
A |
9: 108,943,480 (GRCm39) |
S1908T |
probably damaging |
Het |
| Sgo2b |
T |
C |
8: 64,380,570 (GRCm39) |
Y754C |
probably damaging |
Het |
| She |
T |
A |
3: 89,739,231 (GRCm39) |
C141S |
probably benign |
Het |
| Tex15 |
T |
A |
8: 34,064,935 (GRCm39) |
L1455* |
probably null |
Het |
| Tfec |
T |
A |
6: 16,835,232 (GRCm39) |
H182L |
probably benign |
Het |
| Tgm6 |
T |
C |
2: 129,979,359 (GRCm39) |
V163A |
probably benign |
Het |
| Vmn2r88 |
G |
T |
14: 51,656,146 (GRCm39) |
C794F |
probably damaging |
Het |
| Zfp998 |
A |
T |
13: 66,579,329 (GRCm39) |
C385S |
probably damaging |
Het |
|
| Other mutations in Zfp871 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00849:Zfp871
|
APN |
17 |
32,994,873 (GRCm39) |
missense |
probably benign |
|
|
IGL00963:Zfp871
|
APN |
17 |
32,993,726 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL01687:Zfp871
|
APN |
17 |
32,994,618 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02170:Zfp871
|
APN |
17 |
32,994,662 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL02399:Zfp871
|
APN |
17 |
32,993,329 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0304:Zfp871
|
UTSW |
17 |
32,993,408 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1215:Zfp871
|
UTSW |
17 |
32,994,946 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1444:Zfp871
|
UTSW |
17 |
32,993,900 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1754:Zfp871
|
UTSW |
17 |
32,994,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1913:Zfp871
|
UTSW |
17 |
32,994,891 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2018:Zfp871
|
UTSW |
17 |
32,993,751 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2180:Zfp871
|
UTSW |
17 |
32,994,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4422:Zfp871
|
UTSW |
17 |
32,993,808 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4422:Zfp871
|
UTSW |
17 |
32,993,807 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4979:Zfp871
|
UTSW |
17 |
32,994,829 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5564:Zfp871
|
UTSW |
17 |
32,994,842 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6228:Zfp871
|
UTSW |
17 |
32,994,858 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6232:Zfp871
|
UTSW |
17 |
32,994,494 (GRCm39) |
frame shift |
probably null |
|
|
R6233:Zfp871
|
UTSW |
17 |
32,994,494 (GRCm39) |
frame shift |
probably null |
|
|
R6234:Zfp871
|
UTSW |
17 |
32,994,494 (GRCm39) |
frame shift |
probably null |
|
|
R6474:Zfp871
|
UTSW |
17 |
32,994,647 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7237:Zfp871
|
UTSW |
17 |
32,994,289 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7809:Zfp871
|
UTSW |
17 |
32,993,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8830:Zfp871
|
UTSW |
17 |
32,993,901 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9219:Zfp871
|
UTSW |
17 |
32,993,914 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAACTGAATCCAACGCATG -3'
(R):5'- TGACGAAGACTATAGATATGGCC -3'
Sequencing Primer
(F):5'- GCCACACTGCTTACATTCATAAGGTG -3'
(R):5'- AGCCCTTTGAGTGTAAGCAG -3'
|
| Posted On |
2015-01-23 |
Incidental Mutation