Incidental Mutation 'R2873:Cd101'
ID 260382
Institutional Source Beutler Lab
Gene Symbol Cd101
Ensembl Gene ENSMUSG00000086564
Gene Name CD101 antigen
Synonyms LOC381460, Igsf2
MMRRC Submission 040461-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2873 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 100900845-100936872 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 100911164 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 831 (D831E)
Ref Sequence ENSEMBL: ENSMUSP00000126027 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000147399] [ENSMUST00000167086]
AlphaFold A8E0Y8
Predicted Effect probably benign
Transcript: ENSMUST00000147399
AA Change: D835E

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000116643
Gene: ENSMUSG00000086564
AA Change: D835E

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
IG 28 143 4.96e-8 SMART
IG 153 266 4.74e-5 SMART
IG_like 274 379 2.19e-1 SMART
IG 289 395 3.25e-3 SMART
IG 417 533 4.85e-11 SMART
IG 545 659 1.52e-3 SMART
IG 680 805 3.16e-1 SMART
IG_like 827 927 2.95e-1 SMART
IG 856 955 1.04e-1 SMART
transmembrane domain 971 993 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000167086
AA Change: D831E

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000126027
Gene: ENSMUSG00000086564
AA Change: D831E

DomainStartEndE-ValueType
IG 24 139 4.96e-8 SMART
IG 149 262 4.74e-5 SMART
IG_like 270 375 2.19e-1 SMART
IG 285 391 3.25e-3 SMART
IG 413 529 4.85e-11 SMART
IG 541 655 1.52e-3 SMART
IG 676 801 3.16e-1 SMART
IG_like 823 923 2.95e-1 SMART
IG 852 951 1.04e-1 SMART
transmembrane domain 967 989 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 100% (81/81)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced Gr-1+ cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b A G 11: 109,846,002 (GRCm39) C811R possibly damaging Het
Acvr1 G A 2: 58,367,808 (GRCm39) Q118* probably null Het
Als2 A G 1: 59,250,296 (GRCm39) S483P probably damaging Het
Ankrd40 T C 11: 94,224,771 (GRCm39) V60A possibly damaging Het
Armc2 C T 10: 41,842,696 (GRCm39) probably null Het
Atp12a A G 14: 56,624,407 (GRCm39) R952G possibly damaging Het
Atp13a2 T C 4: 140,730,294 (GRCm39) I773T probably benign Het
Atp6v1g1 A G 4: 63,468,258 (GRCm39) Y87C probably benign Het
Ccdc162 G T 10: 41,531,095 (GRCm39) T537N possibly damaging Het
Ccdc59 A T 10: 105,677,388 (GRCm39) K9M possibly damaging Het
Ch25h T A 19: 34,452,210 (GRCm39) H106L probably benign Het
Chek2 C A 5: 111,011,202 (GRCm39) Y333* probably null Het
Cimap1d G A 10: 79,481,487 (GRCm39) T14I probably benign Het
Csmd2 T C 4: 128,451,511 (GRCm39) F113S unknown Het
Cyp4a14 C A 4: 115,344,498 (GRCm39) G456W probably damaging Het
Cyp4a30b A G 4: 115,315,559 (GRCm39) H260R possibly damaging Het
Dennd2b A T 7: 109,156,637 (GRCm39) Y38N probably benign Het
Eif4enif1 C T 11: 3,192,586 (GRCm39) P805S probably damaging Het
Fan1 A G 7: 64,012,938 (GRCm39) I668T probably benign Het
Flnc A G 6: 29,447,542 (GRCm39) D1115G probably damaging Het
Ftdc1 A T 16: 58,434,342 (GRCm39) I125K probably benign Het
Gbp11 C T 5: 105,478,866 (GRCm39) D191N probably benign Het
Gm5519 A C 19: 33,802,410 (GRCm39) D151A possibly damaging Het
Grid2ip C A 5: 143,343,684 (GRCm39) Q127K probably benign Het
Hdhd2 T C 18: 77,042,702 (GRCm39) F44L probably damaging Het
Hmcn1 A T 1: 150,614,467 (GRCm39) V1313D possibly damaging Het
Kpna7 T C 5: 144,930,745 (GRCm39) T367A probably benign Het
Matr3 T A 18: 35,705,349 (GRCm39) S91R probably benign Het
Mdm1 A G 10: 117,986,847 (GRCm39) T267A probably benign Het
Mlxip A G 5: 123,590,730 (GRCm39) M878V probably benign Het
Mtor T A 4: 148,624,487 (GRCm39) M2089K probably benign Het
Myo9b G A 8: 71,786,981 (GRCm39) R721Q probably benign Het
Ndufs1 A G 1: 63,203,882 (GRCm39) probably benign Het
Nlrp4b C T 7: 10,444,170 (GRCm39) Q40* probably null Het
Nomo1 C A 7: 45,696,361 (GRCm39) T293N probably damaging Het
Notch1 A G 2: 26,350,247 (GRCm39) C2298R possibly damaging Het
Notum A G 11: 120,551,022 (GRCm39) V48A probably benign Het
Or10g1 T G 14: 52,648,318 (GRCm39) T4P probably benign Het
Or10z1 T C 1: 174,078,092 (GRCm39) S134G probably benign Het
Or6c211 A T 10: 129,505,628 (GRCm39) C253* probably null Het
Ostc T C 3: 130,497,157 (GRCm39) N80S probably damaging Het
Palmd T C 3: 116,717,400 (GRCm39) R366G possibly damaging Het
Parp1 A G 1: 180,401,230 (GRCm39) D45G probably damaging Het
Pcdhga9 T A 18: 37,870,524 (GRCm39) Y118N possibly damaging Het
Pes1 C A 11: 3,926,834 (GRCm39) T372K probably benign Het
Plcl1 A T 1: 55,736,309 (GRCm39) D550V probably benign Het
Plekhg5 T A 4: 152,191,960 (GRCm39) C433S probably benign Het
Plin2 A G 4: 86,586,915 (GRCm39) M1T probably null Het
Pms2 G A 5: 143,848,732 (GRCm39) probably benign Het
Ppp1r7 T A 1: 93,285,585 (GRCm39) probably null Het
Psmb8 T C 17: 34,419,144 (GRCm39) I146T probably damaging Het
Ptger4 T C 15: 5,264,286 (GRCm39) R457G probably benign Het
Pzp A T 6: 128,462,519 (GRCm39) probably null Het
Ralgds A G 2: 28,438,781 (GRCm39) probably null Het
Rnf6 T C 5: 146,147,215 (GRCm39) Y601C probably benign Het
Sgk2 A G 2: 162,836,449 (GRCm39) probably benign Het
Shoc1 A C 4: 59,093,850 (GRCm39) L226R probably damaging Het
Slc39a8 T A 3: 135,592,554 (GRCm39) probably null Het
Slc4a4 G T 5: 89,283,623 (GRCm39) V481L probably damaging Het
Slc5a8 A G 10: 88,740,825 (GRCm39) I247V probably benign Het
Slit3 G T 11: 35,435,620 (GRCm39) E184* probably null Het
Sppl2c C T 11: 104,078,141 (GRCm39) P314S probably benign Het
St7 C T 6: 17,819,276 (GRCm39) P60L probably damaging Het
Tafa2 A T 10: 123,540,270 (GRCm39) H42L possibly damaging Het
Tbc1d8 A G 1: 39,444,398 (GRCm39) F187S probably damaging Het
Tet2 C T 3: 133,192,715 (GRCm39) G573E probably damaging Het
Tnni3k C T 3: 154,644,387 (GRCm39) probably null Het
Trpa1 A G 1: 14,957,844 (GRCm39) C705R probably damaging Het
Usp9y T A Y: 1,310,502 (GRCm39) probably benign Het
Vmn2r68 A C 7: 84,882,834 (GRCm39) M306R probably benign Het
Vwa7 G A 17: 35,240,218 (GRCm39) M395I probably damaging Het
Ybx3 G A 6: 131,347,376 (GRCm39) A253V probably damaging Het
Zfp53 A T 17: 21,728,340 (GRCm39) E124D probably benign Het
Other mutations in Cd101
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00958:Cd101 APN 3 100,911,018 (GRCm39) missense probably damaging 1.00
IGL01443:Cd101 APN 3 100,910,887 (GRCm39) missense probably benign
IGL02000:Cd101 APN 3 100,919,398 (GRCm39) missense probably benign 0.11
IGL02178:Cd101 APN 3 100,901,082 (GRCm39) missense probably damaging 1.00
IGL02224:Cd101 APN 3 100,924,318 (GRCm39) missense probably benign
IGL02450:Cd101 APN 3 100,901,054 (GRCm39) missense probably damaging 0.99
IGL02502:Cd101 APN 3 100,919,141 (GRCm39) missense probably damaging 0.99
IGL02536:Cd101 APN 3 100,910,913 (GRCm39) missense probably damaging 1.00
IGL02749:Cd101 APN 3 100,927,715 (GRCm39) missense probably damaging 1.00
IGL02818:Cd101 APN 3 100,919,245 (GRCm39) missense probably damaging 1.00
IGL02829:Cd101 APN 3 100,925,881 (GRCm39) splice site probably benign
IGL02902:Cd101 APN 3 100,926,310 (GRCm39) splice site probably benign
tax_day UTSW 3 100,911,021 (GRCm39) missense possibly damaging 0.86
R0069:Cd101 UTSW 3 100,915,533 (GRCm39) missense probably benign 0.08
R0069:Cd101 UTSW 3 100,915,533 (GRCm39) missense probably benign 0.08
R0411:Cd101 UTSW 3 100,925,843 (GRCm39) splice site probably null
R0486:Cd101 UTSW 3 100,915,408 (GRCm39) missense possibly damaging 0.94
R0556:Cd101 UTSW 3 100,927,970 (GRCm39) missense probably damaging 1.00
R0726:Cd101 UTSW 3 100,927,938 (GRCm39) missense possibly damaging 0.95
R0966:Cd101 UTSW 3 100,915,538 (GRCm39) missense probably benign 0.13
R1344:Cd101 UTSW 3 100,926,091 (GRCm39) nonsense probably null
R1418:Cd101 UTSW 3 100,926,091 (GRCm39) nonsense probably null
R1547:Cd101 UTSW 3 100,926,267 (GRCm39) missense possibly damaging 0.94
R1551:Cd101 UTSW 3 100,919,329 (GRCm39) missense probably damaging 0.99
R1845:Cd101 UTSW 3 100,936,764 (GRCm39) splice site probably null
R1919:Cd101 UTSW 3 100,926,233 (GRCm39) missense probably damaging 1.00
R1976:Cd101 UTSW 3 100,915,377 (GRCm39) missense probably damaging 0.96
R2260:Cd101 UTSW 3 100,924,261 (GRCm39) missense possibly damaging 0.82
R2679:Cd101 UTSW 3 100,901,079 (GRCm39) missense probably benign 0.00
R3606:Cd101 UTSW 3 100,927,913 (GRCm39) missense probably damaging 1.00
R4201:Cd101 UTSW 3 100,926,001 (GRCm39) missense probably damaging 1.00
R4202:Cd101 UTSW 3 100,926,001 (GRCm39) missense probably damaging 1.00
R4205:Cd101 UTSW 3 100,926,001 (GRCm39) missense probably damaging 1.00
R4349:Cd101 UTSW 3 100,920,630 (GRCm39) missense possibly damaging 0.93
R4574:Cd101 UTSW 3 100,920,469 (GRCm39) missense probably benign 0.02
R4601:Cd101 UTSW 3 100,901,204 (GRCm39) missense possibly damaging 0.84
R4820:Cd101 UTSW 3 100,929,471 (GRCm39) missense probably benign 0.01
R4910:Cd101 UTSW 3 100,901,205 (GRCm39) missense probably benign 0.13
R5014:Cd101 UTSW 3 100,911,139 (GRCm39) missense probably damaging 0.99
R5081:Cd101 UTSW 3 100,911,021 (GRCm39) missense possibly damaging 0.86
R5396:Cd101 UTSW 3 100,926,126 (GRCm39) missense probably damaging 1.00
R5425:Cd101 UTSW 3 100,926,002 (GRCm39) missense probably damaging 1.00
R6193:Cd101 UTSW 3 100,927,778 (GRCm39) missense probably damaging 1.00
R6210:Cd101 UTSW 3 100,925,959 (GRCm39) missense probably damaging 1.00
R6732:Cd101 UTSW 3 100,915,515 (GRCm39) missense probably benign 0.01
R6830:Cd101 UTSW 3 100,901,012 (GRCm39) missense probably benign 0.12
R6897:Cd101 UTSW 3 100,920,376 (GRCm39) missense probably damaging 1.00
R6940:Cd101 UTSW 3 100,911,018 (GRCm39) missense probably damaging 1.00
R7335:Cd101 UTSW 3 100,926,045 (GRCm39) missense probably benign 0.01
R7565:Cd101 UTSW 3 100,926,108 (GRCm39) missense probably benign 0.00
R7880:Cd101 UTSW 3 100,915,182 (GRCm39) missense probably benign 0.00
R8121:Cd101 UTSW 3 100,927,898 (GRCm39) missense probably damaging 1.00
R8233:Cd101 UTSW 3 100,900,989 (GRCm39) missense unknown
R8900:Cd101 UTSW 3 100,926,062 (GRCm39) missense probably benign 0.19
R8960:Cd101 UTSW 3 100,910,817 (GRCm39) missense probably benign 0.01
R9260:Cd101 UTSW 3 100,920,599 (GRCm39) missense probably benign 0.16
R9335:Cd101 UTSW 3 100,915,431 (GRCm39) missense probably benign 0.18
R9663:Cd101 UTSW 3 100,911,222 (GRCm39) missense probably benign 0.21
X0018:Cd101 UTSW 3 100,925,948 (GRCm39) missense possibly damaging 0.95
X0023:Cd101 UTSW 3 100,926,171 (GRCm39) missense probably benign
X0058:Cd101 UTSW 3 100,927,737 (GRCm39) missense probably damaging 1.00
Z1177:Cd101 UTSW 3 100,924,456 (GRCm39) missense probably benign 0.02
Z1177:Cd101 UTSW 3 100,919,232 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TCCATTTCCACCCGATGCAG -3'
(R):5'- TGAGATCTCCCAGTGGAAATG -3'

Sequencing Primer
(F):5'- ACCCGATGCAGCTTCAGGAC -3'
(R):5'- CTCCCAGTGGAAATGATAGGGCTC -3'
Posted On 2015-01-23