Incidental Mutation 'R2876:Or5g26'
ID 260543
Institutional Source Beutler Lab
Gene Symbol Or5g26
Ensembl Gene ENSMUSG00000075212
Gene Name olfactory receptor family 5 subfamily G member 26
Synonyms MOR175-1, Olfr154, 912-93, Olfr4-3, OR93, GA_x6K02T2Q125-47143827-47142871
MMRRC Submission 040464-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R2876 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 85493721-85494799 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 85494034 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 248 (V248A)
Ref Sequence ENSEMBL: ENSMUSP00000097502 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099918]
AlphaFold Q9QY00
Predicted Effect probably damaging
Transcript: ENSMUST00000099918
AA Change: V248A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000097502
Gene: ENSMUSG00000075212
AA Change: V248A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.2e-49 PFAM
Pfam:7tm_1 41 290 1.7e-17 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 95% (42/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730507C01Rik C A 12: 18,583,644 (GRCm39) Q235K possibly damaging Het
Abcc1 A T 16: 14,275,824 (GRCm39) H906L probably benign Het
Acot6 T G 12: 84,148,036 (GRCm39) D97E possibly damaging Het
Acvr2a T A 2: 48,782,190 (GRCm39) M241K probably damaging Het
Adamts9 T C 6: 92,772,891 (GRCm39) probably benign Het
Adgb T G 10: 10,298,463 (GRCm39) T422P probably damaging Het
Adrm1 A G 2: 179,817,411 (GRCm39) T293A probably damaging Het
Ankfn1 A G 11: 89,282,462 (GRCm39) V395A possibly damaging Het
Atp2b1 A G 10: 98,835,607 (GRCm39) M451V probably damaging Het
Ccdc152 T C 15: 3,327,663 (GRCm39) N38S probably damaging Het
Cdh23 A T 10: 60,143,275 (GRCm39) N3017K probably damaging Het
Cenpf A G 1: 189,390,841 (GRCm39) M997T probably benign Het
Gcc2 A G 10: 58,126,124 (GRCm39) E1344G probably damaging Het
Gen1 A C 12: 11,292,069 (GRCm39) S573R probably benign Het
Ilvbl C A 10: 78,418,890 (GRCm39) Q410K probably benign Het
Ints11 C A 4: 155,971,882 (GRCm39) probably benign Het
Itfg1 T C 8: 86,507,139 (GRCm39) probably benign Het
Lrrc27 C T 7: 138,808,600 (GRCm39) probably benign Het
Maml3 G A 3: 51,597,480 (GRCm39) A422V possibly damaging Het
Masp2 T A 4: 148,692,458 (GRCm39) I317K probably benign Het
Or13n4 A T 7: 106,423,664 (GRCm39) V23E probably benign Het
Or2ag18 C G 7: 106,405,204 (GRCm39) S155T probably benign Het
Papln T A 12: 83,825,701 (GRCm39) S661T probably damaging Het
Pi4ka A G 16: 17,185,414 (GRCm39) S229P possibly damaging Het
Piezo2 A G 18: 63,186,106 (GRCm39) S1688P probably damaging Het
Pzp T C 6: 128,468,513 (GRCm39) T1005A probably damaging Het
Rad1 T C 15: 10,490,417 (GRCm39) V128A probably benign Het
Rhbdd1 A G 1: 82,346,090 (GRCm39) D215G probably benign Het
Rnft2 G A 5: 118,331,686 (GRCm39) R417C probably damaging Het
Scn2a A C 2: 65,546,241 (GRCm39) I935L possibly damaging Het
Sdc4 T C 2: 164,273,211 (GRCm39) D33G possibly damaging Het
Slco1c1 T C 6: 141,505,582 (GRCm39) S454P probably damaging Het
Spidr A T 16: 15,730,453 (GRCm39) probably null Het
Srp72 T A 5: 77,143,767 (GRCm39) probably benign Het
Ttll4 A G 1: 74,725,597 (GRCm39) probably null Het
Ttn C T 2: 76,750,684 (GRCm39) S3455N probably damaging Het
Vcan T A 13: 89,852,356 (GRCm39) E868V probably damaging Het
Vmn2r89 G T 14: 51,692,541 (GRCm39) G115C possibly damaging Het
Zbed6 C T 1: 133,584,598 (GRCm39) C913Y probably damaging Het
Zscan29 T C 2: 120,994,581 (GRCm39) Y468C probably damaging Het
Other mutations in Or5g26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00309:Or5g26 APN 2 85,494,700 (GRCm39) missense probably benign 0.23
IGL01745:Or5g26 APN 2 85,493,921 (GRCm39) missense possibly damaging 0.76
R1937:Or5g26 UTSW 2 85,494,341 (GRCm39) missense probably benign
R2086:Or5g26 UTSW 2 85,494,090 (GRCm39) missense probably benign
R3881:Or5g26 UTSW 2 85,494,769 (GRCm39) missense probably benign 0.00
R4801:Or5g26 UTSW 2 85,494,622 (GRCm39) missense probably damaging 1.00
R4802:Or5g26 UTSW 2 85,494,622 (GRCm39) missense probably damaging 1.00
R6010:Or5g26 UTSW 2 85,494,374 (GRCm39) missense probably benign 0.00
R6944:Or5g26 UTSW 2 85,494,195 (GRCm39) missense probably benign 0.00
R7089:Or5g26 UTSW 2 85,494,518 (GRCm39) missense possibly damaging 0.79
R7443:Or5g26 UTSW 2 85,493,912 (GRCm39) missense probably damaging 1.00
R7453:Or5g26 UTSW 2 85,494,524 (GRCm39) missense probably benign
R7736:Or5g26 UTSW 2 85,494,758 (GRCm39) missense probably damaging 1.00
R7853:Or5g26 UTSW 2 85,494,689 (GRCm39) missense probably benign
R9719:Or5g26 UTSW 2 85,494,608 (GRCm39) missense probably benign 0.30
Z1088:Or5g26 UTSW 2 85,493,960 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TCTTGAAAGCTGTAGCAAAACTGC -3'
(R):5'- TGTGGTCCAAATCTCATCAATCAC -3'

Sequencing Primer
(F):5'- GCAAAACTGCTTTTCAAATGTCCTG -3'
(R):5'- CTGGCATGTGCAAATACTCAG -3'
Posted On 2015-01-23