Incidental Mutation 'R2894:Ccl4'
ID 260711
Institutional Source Beutler Lab
Gene Symbol Ccl4
Ensembl Gene ENSMUSG00000018930
Gene Name C-C motif chemokine ligand 4
Synonyms MIP-1B, MIP-1 beta, Mip1b, AT744.1, Act-2, Scya4
MMRRC Submission 040482-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.173) question?
Stock # R2894 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 83553410-83555509 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) C to A at 83554329 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000019074 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019074]
AlphaFold P14097
Predicted Effect probably null
Transcript: ENSMUST00000019074
SMART Domains Protein: ENSMUSP00000019074
Gene: ENSMUSG00000018930

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
SCY 31 89 9.92e-32 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 C T 6: 128,557,349 (GRCm39) A115T probably benign Het
Acox3 A G 5: 35,757,192 (GRCm39) I344V probably benign Het
Ank2 T C 3: 127,041,892 (GRCm39) probably null Het
Cdh15 G A 8: 123,583,374 (GRCm39) R59H probably benign Het
Cdk5rap2 T C 4: 70,208,110 (GRCm39) K779E probably benign Het
Cenpu C A 8: 47,029,384 (GRCm39) N212K probably damaging Het
Dcun1d2 A T 8: 13,328,649 (GRCm39) I86N probably damaging Het
Dnah1 T A 14: 31,020,718 (GRCm39) E1217V possibly damaging Het
Dusp15 T C 2: 152,791,005 (GRCm39) I31V probably benign Het
Ern2 A C 7: 121,780,810 (GRCm39) S114A possibly damaging Het
F11 A G 8: 45,701,675 (GRCm39) S353P probably damaging Het
Fmo6 C T 1: 162,750,293 (GRCm39) W254* probably null Het
Gm16494 T C 17: 47,327,632 (GRCm39) E84G unknown Het
Kdr A G 5: 76,107,496 (GRCm39) F1016L probably damaging Het
Lrrc37a G A 11: 103,388,690 (GRCm39) T2245I unknown Het
Mdga1 T C 17: 30,071,478 (GRCm39) Y381C probably damaging Het
Msh3 G T 13: 92,478,868 (GRCm39) A367D probably benign Het
Nadk A G 4: 155,671,817 (GRCm39) N232S possibly damaging Het
Or51e1 A G 7: 102,358,882 (GRCm39) T139A probably damaging Het
Or7g29 A T 9: 19,286,588 (GRCm39) Y196* probably null Het
Per2 C A 1: 91,373,325 (GRCm39) Q154H probably damaging Het
Pik3ap1 G A 19: 41,364,500 (GRCm39) A73V probably benign Het
Pramel16 A T 4: 143,675,692 (GRCm39) M378K probably damaging Het
Rad18 G A 6: 112,652,734 (GRCm39) Q288* probably null Het
Rarb T C 14: 16,435,146 (GRCm38) D300G probably damaging Het
Ruvbl1 C T 6: 88,456,114 (GRCm39) R63W possibly damaging Het
Setdb2 T C 14: 59,663,916 (GRCm39) N77S probably benign Het
Slc22a19 C A 19: 7,670,169 (GRCm39) K228N probably benign Het
Thoc6 A G 17: 23,888,009 (GRCm39) S292P probably damaging Het
Tmem126b A T 7: 90,120,121 (GRCm39) S83R probably damaging Het
Tmem232 C T 17: 65,757,408 (GRCm39) E262K probably damaging Het
Vmn2r60 T C 7: 41,785,220 (GRCm39) V144A probably benign Het
Vpreb3 C T 10: 75,779,056 (GRCm39) probably benign Het
Vwa8 A G 14: 79,275,578 (GRCm39) N787S probably damaging Het
Other mutations in Ccl4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03217:Ccl4 APN 11 83,553,504 (GRCm39) missense unknown
R0302:Ccl4 UTSW 11 83,554,280 (GRCm39) splice site probably benign
R0328:Ccl4 UTSW 11 83,554,383 (GRCm39) missense probably damaging 0.98
R1342:Ccl4 UTSW 11 83,554,402 (GRCm39) splice site probably benign
R4934:Ccl4 UTSW 11 83,553,504 (GRCm39) missense unknown
R6334:Ccl4 UTSW 11 83,553,504 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TCTCATTCTGGGTGGATGACC -3'
(R):5'- ACACTTTACTGCCCATCCAG -3'

Sequencing Primer
(F):5'- TGACCATAGATTTCAGGGACCATG -3'
(R):5'- ATGACCTCACTGTTCTTTGGCAGAG -3'
Posted On 2015-01-23