Incidental Mutation 'R2884:Gm19965'
ID 260946
Institutional Source Beutler Lab
Gene Symbol Gm19965
Ensembl Gene ENSMUSG00000094429
Gene Name predicted gene, 19965
Synonyms
MMRRC Submission 040472-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R2884 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 116730713-116751140 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 116749313 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 331 (N331K)
Ref Sequence ENSEMBL: ENSMUSP00000137019 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000179777]
AlphaFold J3QNY8
Predicted Effect probably benign
Transcript: ENSMUST00000179777
AA Change: N331K

PolyPhen 2 Score 0.138 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000137019
Gene: ENSMUSG00000094429
AA Change: N331K

DomainStartEndE-ValueType
KRAB 8 68 1.5e-36 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430548M08Rik G T 8: 120,872,250 (GRCm39) E59D possibly damaging Het
Arhgap27 T C 11: 103,251,669 (GRCm39) probably null Het
BC061237 A G 14: 44,738,627 (GRCm39) R9G possibly damaging Het
Brsk1 A G 7: 4,694,122 (GRCm39) probably benign Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Cspg4b G T 13: 113,505,725 (GRCm39) A2285S probably benign Het
Cspg4b A T 13: 113,457,216 (GRCm39) Q1087H probably damaging Het
Dnajb5 A T 4: 42,957,355 (GRCm39) D284V probably damaging Het
Dnmt3a A G 12: 3,946,132 (GRCm39) D329G probably damaging Het
Ecd C T 14: 20,370,841 (GRCm39) G626D probably damaging Het
Exoc3l4 A G 12: 111,394,956 (GRCm39) D551G possibly damaging Het
Fam227b A T 2: 125,942,846 (GRCm39) I317N probably benign Het
Fam3c G A 6: 22,329,581 (GRCm39) R49C probably damaging Het
Fcrl5 A G 3: 87,364,698 (GRCm39) Y566C probably damaging Het
Fras1 A G 5: 96,848,127 (GRCm39) N1779S probably benign Het
Grm7 G T 6: 110,623,309 (GRCm39) V161F probably damaging Het
H2ac8 A G 13: 23,755,047 (GRCm39) I79T probably damaging Het
H2-DMa A G 17: 34,356,121 (GRCm39) N41S probably damaging Het
Habp4 A T 13: 64,330,080 (GRCm39) R328S probably benign Het
Hexb C T 13: 97,320,208 (GRCm39) G272D probably damaging Het
Lilrb4a A T 10: 51,367,709 (GRCm39) N84Y probably benign Het
Mtnr1a A G 8: 45,540,305 (GRCm39) T89A probably benign Het
Myh13 T A 11: 67,228,469 (GRCm39) N336K probably benign Het
Naca T C 10: 127,877,547 (GRCm39) probably benign Het
Naif1 C T 2: 32,344,887 (GRCm39) P197L probably benign Het
Nprl3 A G 11: 32,198,163 (GRCm39) L179P probably damaging Het
Nup93 A G 8: 95,030,266 (GRCm39) Y375C probably damaging Het
Or52b4 A G 7: 102,184,439 (GRCm39) I162V probably benign Het
Pcdha12 G A 18: 37,153,757 (GRCm39) D159N probably damaging Het
Plekhs1 G A 19: 56,459,258 (GRCm39) G39R probably benign Het
Ppp4r3a T C 12: 101,034,936 (GRCm39) E53G probably damaging Het
Prss48 A T 3: 85,904,562 (GRCm39) M212K probably benign Het
Pth A T 7: 112,985,235 (GRCm39) L46Q probably damaging Het
Rin2 A T 2: 145,702,911 (GRCm39) T536S probably benign Het
Setx T G 2: 29,038,637 (GRCm39) C1707W probably damaging Het
Stau2 A T 1: 16,301,290 (GRCm39) F519Y possibly damaging Het
Syne2 T G 12: 76,010,533 (GRCm39) V2481G probably benign Het
Tpte C T 8: 22,825,439 (GRCm39) Q331* probably null Het
Ttn G T 2: 76,730,596 (GRCm39) probably benign Het
Utrn A T 10: 12,615,105 (GRCm39) probably null Het
Vmn2r82 A G 10: 79,232,082 (GRCm39) I694V probably benign Het
Vmn2r88 G A 14: 51,651,391 (GRCm39) C235Y probably damaging Het
Xrn2 T A 2: 146,889,576 (GRCm39) V653E probably damaging Het
Znrf3 A T 11: 5,239,693 (GRCm39) D58E probably damaging Het
Other mutations in Gm19965
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0993:Gm19965 UTSW 1 116,749,555 (GRCm39) missense probably benign 0.04
R1016:Gm19965 UTSW 1 116,749,031 (GRCm39) nonsense probably null
R1173:Gm19965 UTSW 1 116,748,550 (GRCm39) splice site probably benign
R1175:Gm19965 UTSW 1 116,748,550 (GRCm39) splice site probably benign
R1335:Gm19965 UTSW 1 116,732,349 (GRCm39) missense possibly damaging 0.79
R1773:Gm19965 UTSW 1 116,748,989 (GRCm39) nonsense probably null
R1802:Gm19965 UTSW 1 116,748,633 (GRCm39) nonsense probably null
R3435:Gm19965 UTSW 1 116,749,353 (GRCm39) missense possibly damaging 0.78
R4072:Gm19965 UTSW 1 116,748,801 (GRCm39) missense probably benign 0.17
R4585:Gm19965 UTSW 1 116,749,508 (GRCm39) missense probably benign 0.00
R4801:Gm19965 UTSW 1 116,749,626 (GRCm39) missense probably benign
R4802:Gm19965 UTSW 1 116,749,626 (GRCm39) missense probably benign
R5328:Gm19965 UTSW 1 116,749,148 (GRCm39) missense possibly damaging 0.78
R5856:Gm19965 UTSW 1 116,749,579 (GRCm39) missense probably benign
R5960:Gm19965 UTSW 1 116,749,201 (GRCm39) missense possibly damaging 0.67
R6185:Gm19965 UTSW 1 116,749,003 (GRCm39) missense possibly damaging 0.61
R6297:Gm19965 UTSW 1 116,750,410 (GRCm39) missense possibly damaging 0.82
R6374:Gm19965 UTSW 1 116,750,021 (GRCm39) missense probably benign 0.06
R6811:Gm19965 UTSW 1 116,731,809 (GRCm39) missense probably damaging 1.00
R6860:Gm19965 UTSW 1 116,748,609 (GRCm39) missense probably benign 0.19
R7076:Gm19965 UTSW 1 116,749,005 (GRCm39) missense
R7162:Gm19965 UTSW 1 116,750,095 (GRCm39) missense unknown
R7290:Gm19965 UTSW 1 116,748,921 (GRCm39) missense
R7473:Gm19965 UTSW 1 116,749,602 (GRCm39) missense unknown
R7643:Gm19965 UTSW 1 116,749,959 (GRCm39) missense unknown
R7919:Gm19965 UTSW 1 116,749,850 (GRCm39) nonsense probably null
R8187:Gm19965 UTSW 1 116,749,532 (GRCm39) nonsense probably null
R8306:Gm19965 UTSW 1 116,749,515 (GRCm39) missense
R8477:Gm19965 UTSW 1 116,730,854 (GRCm39) start gained probably benign
R8751:Gm19965 UTSW 1 116,749,867 (GRCm39) missense unknown
R8876:Gm19965 UTSW 1 116,749,776 (GRCm39) missense unknown
R9151:Gm19965 UTSW 1 116,748,942 (GRCm39) missense
R9389:Gm19965 UTSW 1 116,749,566 (GRCm39) missense
R9444:Gm19965 UTSW 1 116,732,393 (GRCm39) missense
R9696:Gm19965 UTSW 1 116,749,210 (GRCm39) missense
R9696:Gm19965 UTSW 1 116,730,838 (GRCm39) start gained probably benign
Z1088:Gm19965 UTSW 1 116,732,330 (GRCm39) missense probably benign 0.30
Predicted Primers PCR Primer
(F):5'- GCAGTTCCCTCAAAATCTACTCAGAG -3'
(R):5'- GAGGCATCCCTGTATATATCACAC -3'

Sequencing Primer
(F):5'- TGAGTTTATGGAAGCAATGAAACATG -3'
(R):5'- ACACATGTTCTAGTATACCAGCTATG -3'
Posted On 2015-01-23