Incidental Mutation 'R2885:Fcrl5'
ID 260999
Institutional Source Beutler Lab
Gene Symbol Fcrl5
Ensembl Gene ENSMUSG00000048031
Gene Name Fc receptor-like 5
Synonyms Fcrh3, BXMAS1-like protein 2, mBXMH2
MMRRC Submission 040473-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R2885 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 87343084-87407985 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 87364698 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 566 (Y566C)
Ref Sequence ENSEMBL: ENSMUSP00000136046 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049926] [ENSMUST00000166297] [ENSMUST00000178261] [ENSMUST00000193229] [ENSMUST00000194102]
AlphaFold Q68SN8
Predicted Effect probably benign
Transcript: ENSMUST00000049926
AA Change: Y566C

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000050151
Gene: ENSMUSG00000048031
AA Change: Y566C

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IG 40 113 2.08e-1 SMART
IGc2 128 188 6.16e-4 SMART
IG_like 213 296 4.41e1 SMART
IGc2 316 380 3.97e-7 SMART
IG_like 410 473 2.94e-1 SMART
transmembrane domain 495 517 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000166297
AA Change: Y478C

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000131176
Gene: ENSMUSG00000048031
AA Change: Y478C

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IGc2 40 100 6.16e-4 SMART
IG_like 125 208 4.41e1 SMART
IGc2 228 292 3.97e-7 SMART
IG_like 322 385 2.94e-1 SMART
transmembrane domain 407 429 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000178261
AA Change: Y566C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000136046
Gene: ENSMUSG00000048031
AA Change: Y566C

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
IG 40 113 2.08e-1 SMART
IGc2 128 188 6.16e-4 SMART
IG_like 213 296 4.41e1 SMART
IGc2 316 380 3.97e-7 SMART
IG_like 410 473 2.94e-1 SMART
transmembrane domain 495 517 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000193229
AA Change: Y478C

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000141311
Gene: ENSMUSG00000048031
AA Change: Y478C

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IGc2 40 100 6.16e-4 SMART
IG_like 125 208 4.41e1 SMART
IGc2 228 292 3.97e-7 SMART
IG_like 322 385 2.94e-1 SMART
transmembrane domain 407 429 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000194102
AA Change: Y566C

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000142210
Gene: ENSMUSG00000048031
AA Change: Y566C

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IG 40 113 2.08e-1 SMART
IGc2 128 188 6.16e-4 SMART
IG_like 213 296 4.41e1 SMART
IGc2 316 380 3.97e-7 SMART
IG_like 410 473 2.94e-1 SMART
transmembrane domain 495 517 N/A INTRINSIC
Meta Mutation Damage Score 0.6598 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency 100% (37/37)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alpk3 A G 7: 80,749,940 (GRCm39) S1453G probably damaging Het
Arhgap27 T C 11: 103,251,669 (GRCm39) probably null Het
Casp1 A T 9: 5,299,851 (GRCm39) H108L probably benign Het
Cerk A G 15: 86,027,084 (GRCm39) F142S probably damaging Het
Cmip A G 8: 118,111,704 (GRCm39) N145S probably benign Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Cyp4b1 C T 4: 115,492,849 (GRCm39) D287N probably damaging Het
Dlx2 G A 2: 71,375,808 (GRCm39) R172* probably null Het
Dnah11 G A 12: 117,951,162 (GRCm39) Q1145* probably null Het
Dock2 A T 11: 34,580,593 (GRCm39) I659N probably damaging Het
Dync2h1 G C 9: 7,102,329 (GRCm39) F2690L probably damaging Het
Ift57 T C 16: 49,584,114 (GRCm39) V289A probably damaging Het
Lrrc46 G A 11: 96,925,806 (GRCm39) R219C probably damaging Het
Mapk1 A G 16: 16,844,309 (GRCm39) N269S probably benign Het
Mrgprb1 A T 7: 48,097,469 (GRCm39) Y148N probably damaging Het
Mzt2 G T 16: 15,680,780 (GRCm39) A3E unknown Het
Naif1 C T 2: 32,344,887 (GRCm39) P197L probably benign Het
Obscn A T 11: 58,977,574 (GRCm39) V1959E probably damaging Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Phf12 T C 11: 77,914,595 (GRCm39) I130T possibly damaging Het
Plekhg3 T C 12: 76,611,735 (GRCm39) V338A probably benign Het
Prl3b1 A T 13: 27,433,505 (GRCm39) N220I probably damaging Het
Rusc2 A G 4: 43,415,456 (GRCm39) Q254R probably benign Het
Ryr1 G T 7: 28,774,223 (GRCm39) R2404S probably damaging Het
Setdb1 A G 3: 95,247,506 (GRCm39) I463T probably benign Het
Setx T G 2: 29,038,637 (GRCm39) C1707W probably damaging Het
Siglec1 A G 2: 130,914,667 (GRCm39) F1483S possibly damaging Het
Sis G A 3: 72,816,506 (GRCm39) P1515S probably benign Het
Sit1 C T 4: 43,483,314 (GRCm39) R50H possibly damaging Het
Smc6 T C 12: 11,326,294 (GRCm39) V97A probably damaging Het
Ttc39d A G 17: 80,524,144 (GRCm39) S268G probably benign Het
Ube2frt A G 12: 36,140,574 (GRCm39) probably benign Het
Utrn A T 10: 12,615,105 (GRCm39) probably null Het
Vmn2r60 T A 7: 41,790,403 (GRCm39) D463E possibly damaging Het
Vmn2r91 A T 17: 18,325,628 (GRCm39) Y82F probably benign Het
Zfp709 A T 8: 72,643,549 (GRCm39) D325V probably benign Het
Znrf3 A T 11: 5,239,693 (GRCm39) D58E probably damaging Het
Other mutations in Fcrl5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01743:Fcrl5 APN 3 87,351,598 (GRCm39) missense probably damaging 0.96
IGL01868:Fcrl5 APN 3 87,351,014 (GRCm39) missense possibly damaging 0.58
IGL01939:Fcrl5 APN 3 87,353,606 (GRCm39) missense probably damaging 0.99
IGL02817:Fcrl5 APN 3 87,343,220 (GRCm39) missense probably benign 0.35
IGL03106:Fcrl5 APN 3 87,343,190 (GRCm39) splice site probably null
R0381:Fcrl5 UTSW 3 87,353,767 (GRCm39) missense probably damaging 1.00
R0523:Fcrl5 UTSW 3 87,365,099 (GRCm39) missense possibly damaging 0.72
R0646:Fcrl5 UTSW 3 87,349,320 (GRCm39) missense probably benign 0.00
R1231:Fcrl5 UTSW 3 87,349,486 (GRCm39) missense probably benign 0.13
R1353:Fcrl5 UTSW 3 87,355,669 (GRCm39) missense probably damaging 1.00
R1711:Fcrl5 UTSW 3 87,364,721 (GRCm39) missense possibly damaging 0.61
R1714:Fcrl5 UTSW 3 87,353,713 (GRCm39) missense probably damaging 1.00
R1719:Fcrl5 UTSW 3 87,364,704 (GRCm39) missense probably damaging 0.98
R2084:Fcrl5 UTSW 3 87,351,537 (GRCm39) missense probably benign 0.24
R2358:Fcrl5 UTSW 3 87,353,726 (GRCm39) missense probably damaging 0.99
R2884:Fcrl5 UTSW 3 87,364,698 (GRCm39) missense probably damaging 1.00
R3085:Fcrl5 UTSW 3 87,353,771 (GRCm39) missense probably damaging 1.00
R3153:Fcrl5 UTSW 3 87,350,987 (GRCm39) missense probably benign 0.09
R4288:Fcrl5 UTSW 3 87,349,531 (GRCm39) missense probably benign 0.09
R4289:Fcrl5 UTSW 3 87,349,531 (GRCm39) missense probably benign 0.09
R4614:Fcrl5 UTSW 3 87,355,733 (GRCm39) missense probably damaging 1.00
R4719:Fcrl5 UTSW 3 87,351,496 (GRCm39) missense probably damaging 1.00
R4788:Fcrl5 UTSW 3 87,364,495 (GRCm39) missense probably damaging 1.00
R4920:Fcrl5 UTSW 3 87,351,480 (GRCm39) missense probably damaging 1.00
R4972:Fcrl5 UTSW 3 87,361,957 (GRCm39) missense probably benign 0.00
R5373:Fcrl5 UTSW 3 87,353,698 (GRCm39) missense probably benign 0.01
R5374:Fcrl5 UTSW 3 87,353,698 (GRCm39) missense probably benign 0.01
R5963:Fcrl5 UTSW 3 87,351,480 (GRCm39) missense probably damaging 1.00
R5975:Fcrl5 UTSW 3 87,349,410 (GRCm39) missense probably benign 0.00
R6022:Fcrl5 UTSW 3 87,363,070 (GRCm39) missense probably benign 0.42
R6267:Fcrl5 UTSW 3 87,355,631 (GRCm39) missense probably damaging 1.00
R6372:Fcrl5 UTSW 3 87,351,501 (GRCm39) nonsense probably null
R6393:Fcrl5 UTSW 3 87,355,634 (GRCm39) missense probably damaging 1.00
R7088:Fcrl5 UTSW 3 87,365,141 (GRCm39) makesense probably null
R7175:Fcrl5 UTSW 3 87,353,645 (GRCm39) missense probably benign 0.37
R7210:Fcrl5 UTSW 3 87,353,719 (GRCm39) missense possibly damaging 0.85
R7217:Fcrl5 UTSW 3 87,351,081 (GRCm39) missense probably damaging 1.00
R7243:Fcrl5 UTSW 3 87,349,552 (GRCm39) missense probably benign
R7776:Fcrl5 UTSW 3 87,351,502 (GRCm39) missense possibly damaging 0.84
R7813:Fcrl5 UTSW 3 87,350,930 (GRCm39) missense probably benign 0.09
R8357:Fcrl5 UTSW 3 87,351,567 (GRCm39) missense probably damaging 0.99
R8457:Fcrl5 UTSW 3 87,351,567 (GRCm39) missense probably damaging 0.99
R9257:Fcrl5 UTSW 3 87,343,195 (GRCm39) missense probably benign 0.11
R9276:Fcrl5 UTSW 3 87,343,138 (GRCm39) start gained probably benign
R9748:Fcrl5 UTSW 3 87,364,469 (GRCm39) missense possibly damaging 0.93
X0054:Fcrl5 UTSW 3 87,353,606 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCCTGTATAGAACTGCAGCC -3'
(R):5'- ACTCCAAACAATGTAGGTGCAAG -3'

Sequencing Primer
(F):5'- CTGGTCTCGGGGTAATCACAAGATAC -3'
(R):5'- TGCAAGTTAAGGAATCCTAGCGTCC -3'
Posted On 2015-01-23