Incidental Mutation 'R0331:Kdm4b'
ID 26109
Institutional Source Beutler Lab
Gene Symbol Kdm4b
Ensembl Gene ENSMUSG00000024201
Gene Name lysine (K)-specific demethylase 4B
Synonyms Jmjd2b, 4732474L06Rik
MMRRC Submission 038540-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0331 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 56633062-56709870 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 56693289 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000084045 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025036] [ENSMUST00000086835]
AlphaFold Q91VY5
Predicted Effect probably benign
Transcript: ENSMUST00000025036
SMART Domains Protein: ENSMUSP00000025036
Gene: ENSMUSG00000024201

DomainStartEndE-ValueType
JmjN 14 56 5.88e-17 SMART
low complexity region 61 68 N/A INTRINSIC
JmjC 143 309 1.19e-59 SMART
low complexity region 349 361 N/A INTRINSIC
low complexity region 380 399 N/A INTRINSIC
low complexity region 443 449 N/A INTRINSIC
low complexity region 481 495 N/A INTRINSIC
low complexity region 511 537 N/A INTRINSIC
PHD 719 777 2.5e-5 SMART
PHD 839 895 7.07e-5 SMART
TUDOR 905 962 1.68e-9 SMART
TUDOR 963 1019 7.94e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000086835
SMART Domains Protein: ENSMUSP00000084045
Gene: ENSMUSG00000024201

DomainStartEndE-ValueType
JmjN 14 56 5.88e-17 SMART
low complexity region 61 68 N/A INTRINSIC
JmjC 143 309 1.19e-59 SMART
low complexity region 349 361 N/A INTRINSIC
low complexity region 380 399 N/A INTRINSIC
low complexity region 443 449 N/A INTRINSIC
low complexity region 481 495 N/A INTRINSIC
low complexity region 511 537 N/A INTRINSIC
PHD 712 770 2.5e-5 SMART
PHD 832 888 7.07e-5 SMART
TUDOR 898 954 2.31e-12 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132363
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.8%
  • 20x: 91.7%
Validation Efficiency 100% (81/81)
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted allele lacking demethylase activity exhibit no gross abnormalities. Mice homozygous for a conditional allele activated in mammary gland epithelial cells exhibit delayed mammary gland development with reduced branching. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700011L22Rik T A 8: 79,956,021 (GRCm39) T79S probably benign Het
Abtb1 T C 6: 88,817,684 (GRCm39) probably benign Het
Acot12 G A 13: 91,908,183 (GRCm39) probably null Het
Adamts4 T A 1: 171,078,541 (GRCm39) S54T probably benign Het
Adgrl4 T C 3: 151,203,577 (GRCm39) S96P probably benign Het
Aip G T 19: 4,168,247 (GRCm39) T40K probably damaging Het
Anapc4 A G 5: 53,012,984 (GRCm39) probably benign Het
Asz1 A G 6: 18,103,618 (GRCm39) probably benign Het
Atf7ip A G 6: 136,538,161 (GRCm39) T465A possibly damaging Het
Atp11a C T 8: 12,866,953 (GRCm39) Q127* probably null Het
Axin1 A G 17: 26,362,081 (GRCm39) R142G probably damaging Het
Bcat1 T A 6: 144,993,040 (GRCm39) E86V probably benign Het
Brd4 G A 17: 32,421,489 (GRCm39) P749L probably benign Het
C1ra G A 6: 124,496,394 (GRCm39) probably null Het
Capza2 A T 6: 17,665,102 (GRCm39) N237I probably benign Het
Cd2ap A T 17: 43,116,192 (GRCm39) V556E probably benign Het
Cfap65 G A 1: 74,968,460 (GRCm39) P124L probably damaging Het
Cfap65 G T 1: 74,968,461 (GRCm39) P124T probably damaging Het
Cftr T C 6: 18,235,225 (GRCm39) V488A possibly damaging Het
Ckmt1 A T 2: 121,193,337 (GRCm39) probably null Het
Cmya5 T G 13: 93,280,911 (GRCm39) E35A possibly damaging Het
Col7a1 A G 9: 108,796,570 (GRCm39) probably benign Het
Crmp1 C T 5: 37,422,657 (GRCm39) L155F possibly damaging Het
Cyp2d10 T A 15: 82,291,227 (GRCm39) T33S probably benign Het
Dhdh T C 7: 45,137,544 (GRCm39) K48E probably benign Het
Dlst T C 12: 85,165,586 (GRCm39) V103A probably damaging Het
Dohh C T 10: 81,223,646 (GRCm39) T233I probably benign Het
Dvl2 C A 11: 69,897,043 (GRCm39) probably benign Het
Eipr1 C T 12: 28,914,703 (GRCm39) Q286* probably null Het
Enpp6 C A 8: 47,535,484 (GRCm39) T343K probably damaging Het
Fbxw11 T A 11: 32,661,895 (GRCm39) F112I probably damaging Het
Gdpd4 T A 7: 97,622,215 (GRCm39) N231K probably benign Het
Gm6370 A T 5: 146,430,576 (GRCm39) T254S probably benign Het
Hapln4 G T 8: 70,537,159 (GRCm39) Q31H probably damaging Het
Hic1 T A 11: 75,056,316 (GRCm39) T858S possibly damaging Het
Isg20l2 T C 3: 87,839,092 (GRCm39) L101P probably damaging Het
Itga10 T C 3: 96,559,799 (GRCm39) Y485H probably damaging Het
Itgal T A 7: 126,905,853 (GRCm39) probably null Het
Itln1 T C 1: 171,359,117 (GRCm39) N62S probably damaging Het
Lct T C 1: 128,226,479 (GRCm39) probably benign Het
Lman2 A T 13: 55,500,829 (GRCm39) H123Q probably damaging Het
Lztr1 T A 16: 17,342,101 (GRCm39) probably benign Het
Myo3b G T 2: 69,925,605 (GRCm39) G24V probably damaging Het
Nacad T A 11: 6,549,441 (GRCm39) Q1250L possibly damaging Het
Ncor2 A T 5: 125,161,981 (GRCm39) M431K unknown Het
Nek9 T A 12: 85,374,149 (GRCm39) probably benign Het
Neu1 C A 17: 35,153,146 (GRCm39) N255K possibly damaging Het
Nf2 T A 11: 4,744,914 (GRCm39) T75S probably benign Het
Nipal4 T A 11: 46,041,040 (GRCm39) D385V probably damaging Het
Olah T A 2: 3,343,511 (GRCm39) N245I probably damaging Het
Or5p54 G T 7: 107,554,077 (GRCm39) L76F probably benign Het
Pag1 T A 3: 9,767,030 (GRCm39) T90S probably benign Het
Pald1 A G 10: 61,176,708 (GRCm39) probably null Het
Parva A G 7: 112,144,005 (GRCm39) M98V probably benign Het
Paxbp1 T A 16: 90,834,255 (GRCm39) D177V possibly damaging Het
Paxip1 A G 5: 27,970,230 (GRCm39) I587T probably damaging Het
Pclo T C 5: 14,730,390 (GRCm39) probably benign Het
Pdgfra T A 5: 75,355,713 (GRCm39) D1074E probably damaging Het
Pef1 A T 4: 130,021,241 (GRCm39) D265V probably damaging Het
Plekhh2 G A 17: 84,893,794 (GRCm39) E870K possibly damaging Het
Plscr4 G A 9: 92,364,695 (GRCm39) G40D probably damaging Het
Psg18 A G 7: 18,087,233 (GRCm39) Y142H probably benign Het
Ptchd3 A T 11: 121,733,017 (GRCm39) M636L probably benign Het
Rab2a A G 4: 8,572,559 (GRCm39) D51G probably benign Het
Rnf139 T A 15: 58,771,755 (GRCm39) D593E probably benign Het
Septin7 A G 9: 25,217,552 (GRCm39) N422S probably benign Het
Shprh T C 10: 11,069,914 (GRCm39) probably benign Het
Slc7a6os A G 8: 106,937,199 (GRCm39) I87T probably damaging Het
Slc7a7 A G 14: 54,615,381 (GRCm39) probably benign Het
Spc24 G T 9: 21,668,609 (GRCm39) N129K possibly damaging Het
Strip2 C T 6: 29,926,559 (GRCm39) T148I probably benign Het
Tmem150c A C 5: 100,234,132 (GRCm39) probably null Het
Trav13-5 A G 14: 54,033,205 (GRCm39) N38S probably benign Het
Ttn G T 2: 76,641,364 (GRCm39) Y11801* probably null Het
Usp37 A T 1: 74,493,223 (GRCm39) L688* probably null Het
Usp38 T C 8: 81,722,469 (GRCm39) I351V probably benign Het
Vav2 T A 2: 27,186,187 (GRCm39) M223L probably benign Het
Wdr36 A G 18: 32,985,968 (GRCm39) I557M possibly damaging Het
Wwc2 A T 8: 48,333,239 (GRCm39) M259K probably benign Het
Znfx1 G A 2: 166,888,898 (GRCm39) S770L probably benign Het
Other mutations in Kdm4b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01293:Kdm4b APN 17 56,660,019 (GRCm39) missense probably benign 0.28
IGL01408:Kdm4b APN 17 56,660,518 (GRCm39) splice site probably benign
IGL01610:Kdm4b APN 17 56,660,522 (GRCm39) splice site probably benign
IGL01936:Kdm4b APN 17 56,704,355 (GRCm39) missense probably damaging 1.00
IGL01964:Kdm4b APN 17 56,696,256 (GRCm39) splice site probably null
IGL02151:Kdm4b APN 17 56,703,234 (GRCm39) missense probably benign 0.05
IGL02596:Kdm4b APN 17 56,706,706 (GRCm39) missense probably benign 0.14
IGL02975:Kdm4b APN 17 56,682,996 (GRCm39) splice site probably null
IGL03172:Kdm4b APN 17 56,708,649 (GRCm39) missense probably damaging 0.98
Coelestinum UTSW 17 56,660,091 (GRCm39) missense probably benign 0.31
mistflower UTSW 17 56,696,564 (GRCm39) missense possibly damaging 0.65
R0193:Kdm4b UTSW 17 56,700,952 (GRCm39) missense probably benign 0.04
R0311:Kdm4b UTSW 17 56,693,200 (GRCm39) missense probably benign 0.42
R1109:Kdm4b UTSW 17 56,706,430 (GRCm39) missense probably damaging 0.99
R1499:Kdm4b UTSW 17 56,707,025 (GRCm39) missense probably damaging 1.00
R1895:Kdm4b UTSW 17 56,704,340 (GRCm39) missense probably damaging 1.00
R1985:Kdm4b UTSW 17 56,708,302 (GRCm39) missense probably damaging 1.00
R2087:Kdm4b UTSW 17 56,696,564 (GRCm39) missense possibly damaging 0.65
R2185:Kdm4b UTSW 17 56,700,750 (GRCm39) missense probably benign 0.00
R2904:Kdm4b UTSW 17 56,662,884 (GRCm39) missense probably benign 0.03
R3792:Kdm4b UTSW 17 56,662,944 (GRCm39) missense probably damaging 1.00
R3897:Kdm4b UTSW 17 56,703,955 (GRCm39) missense probably damaging 1.00
R4661:Kdm4b UTSW 17 56,706,459 (GRCm39) missense probably damaging 1.00
R4685:Kdm4b UTSW 17 56,708,675 (GRCm39) missense probably benign 0.06
R4716:Kdm4b UTSW 17 56,693,178 (GRCm39) missense probably benign 0.10
R4790:Kdm4b UTSW 17 56,708,618 (GRCm39) missense probably damaging 0.97
R4864:Kdm4b UTSW 17 56,660,091 (GRCm39) missense probably benign 0.31
R5700:Kdm4b UTSW 17 56,658,700 (GRCm39) missense possibly damaging 0.93
R5963:Kdm4b UTSW 17 56,706,732 (GRCm39) missense probably damaging 1.00
R6003:Kdm4b UTSW 17 56,703,916 (GRCm39) missense probably damaging 1.00
R6029:Kdm4b UTSW 17 56,703,576 (GRCm39) missense probably damaging 0.98
R6769:Kdm4b UTSW 17 56,658,754 (GRCm39) missense possibly damaging 0.54
R6771:Kdm4b UTSW 17 56,658,754 (GRCm39) missense possibly damaging 0.54
R6927:Kdm4b UTSW 17 56,706,435 (GRCm39) missense probably damaging 1.00
R7041:Kdm4b UTSW 17 56,703,592 (GRCm39) missense probably damaging 0.96
R7230:Kdm4b UTSW 17 56,676,155 (GRCm39) missense probably damaging 1.00
R7275:Kdm4b UTSW 17 56,703,333 (GRCm39) missense probably damaging 0.99
R7454:Kdm4b UTSW 17 56,696,639 (GRCm39) missense probably benign 0.00
R7455:Kdm4b UTSW 17 56,703,657 (GRCm39) missense probably damaging 0.98
R7457:Kdm4b UTSW 17 56,703,319 (GRCm39) missense probably damaging 1.00
R8171:Kdm4b UTSW 17 56,696,534 (GRCm39) missense probably damaging 0.99
R8367:Kdm4b UTSW 17 56,662,875 (GRCm39) missense probably damaging 1.00
R8524:Kdm4b UTSW 17 56,706,384 (GRCm39) missense probably damaging 1.00
R8810:Kdm4b UTSW 17 56,706,771 (GRCm39) missense probably damaging 1.00
R9260:Kdm4b UTSW 17 56,701,775 (GRCm39) missense probably benign
R9459:Kdm4b UTSW 17 56,706,509 (GRCm39) missense probably benign 0.15
R9466:Kdm4b UTSW 17 56,696,548 (GRCm39) missense probably benign 0.04
R9559:Kdm4b UTSW 17 56,693,228 (GRCm39) missense probably damaging 1.00
X0024:Kdm4b UTSW 17 56,708,278 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCCGAACGCTATGAGCAATGGAAG -3'
(R):5'- ACCTCTAACTAGGGACATGGGCAC -3'

Sequencing Primer
(F):5'- AAGCAAGGCCGTGACCTC -3'
(R):5'- GTCCACTCATCCTTAGGAGCAG -3'
Posted On 2013-04-16