Incidental Mutation 'R2909:Vmn2r91'
ID 261161
Institutional Source Beutler Lab
Gene Symbol Vmn2r91
Ensembl Gene ENSMUSG00000091206
Gene Name vomeronasal 2, receptor 91
Synonyms EG665210
MMRRC Submission 040496-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R2909 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 18305319-18356905 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 18356661 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 776 (E776G)
Ref Sequence ENSEMBL: ENSMUSP00000127465 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172359]
AlphaFold E9Q2U5
Predicted Effect probably damaging
Transcript: ENSMUST00000172359
AA Change: E776G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000127465
Gene: ENSMUSG00000091206
AA Change: E776G

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 83 462 2.2e-38 PFAM
Pfam:NCD3G 510 564 6.7e-20 PFAM
Pfam:7tm_3 597 832 2.1e-53 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr5 G A 2: 158,467,140 (GRCm39) G27R possibly damaging Het
Bltp1 A G 3: 37,002,102 (GRCm39) D1349G probably damaging Het
Chrm3 G T 13: 9,928,033 (GRCm39) D334E probably benign Het
Clic5 A C 17: 44,586,146 (GRCm39) T212P probably benign Het
Dapk1 G A 13: 60,864,631 (GRCm39) probably null Het
Dync2h1 A T 9: 7,049,114 (GRCm39) L3262H probably damaging Het
Epg5 G C 18: 78,026,691 (GRCm39) W1227C probably damaging Het
Fancm T C 12: 65,171,630 (GRCm39) S1757P probably damaging Het
Gm3604 G C 13: 62,516,832 (GRCm39) H509D probably benign Het
Gramd4 G T 15: 86,006,384 (GRCm39) E163* probably null Het
Hip1r T A 5: 124,138,656 (GRCm39) probably null Het
Ice1 G T 13: 70,744,292 (GRCm39) T2097K probably damaging Het
Il12a TCAC TC 3: 68,605,320 (GRCm39) probably null Het
Kbtbd7 A G 14: 79,665,922 (GRCm39) T585A probably benign Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Kcnq3 T C 15: 65,897,085 (GRCm39) T272A possibly damaging Het
Ly6l T G 15: 75,321,481 (GRCm39) probably null Het
Minar1 T C 9: 89,473,331 (GRCm39) N860S probably damaging Het
Mrps11 C A 7: 78,438,497 (GRCm39) A83E probably damaging Het
Or1af1 C T 2: 37,110,188 (GRCm39) P229L probably damaging Het
Pax7 T C 4: 139,556,007 (GRCm39) I156V possibly damaging Het
Plbd1 A T 6: 136,611,572 (GRCm39) V235D probably damaging Het
Pml T C 9: 58,154,526 (GRCm39) S76G possibly damaging Het
Ppp1r42 T A 1: 10,073,637 (GRCm39) probably benign Het
Rsl24d1 T C 9: 73,029,585 (GRCm39) L61S probably damaging Het
Rtp2 T C 16: 23,746,235 (GRCm39) E132G probably damaging Het
Sgk1 A G 10: 21,870,715 (GRCm39) I23V probably benign Het
Sharpin A G 15: 76,234,811 (GRCm39) probably benign Het
Sipa1l1 T A 12: 82,404,105 (GRCm39) Y533N probably benign Het
Slc12a9 T C 5: 137,330,463 (GRCm39) I81V probably benign Het
Stxbp5l G A 16: 37,028,548 (GRCm39) T505M possibly damaging Het
Tmem40 A G 6: 115,713,342 (GRCm39) probably null Het
Tnfrsf18 A T 4: 156,112,727 (GRCm39) N138Y probably damaging Het
Vmn2r87 A T 10: 130,314,865 (GRCm39) N240K probably damaging Het
Vmn2r92 T A 17: 18,405,377 (GRCm39) N840K possibly damaging Het
Vmn2r98 T C 17: 19,287,664 (GRCm39) I499T probably damaging Het
Other mutations in Vmn2r91
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00983:Vmn2r91 APN 17 18,325,820 (GRCm39) missense probably benign 0.00
IGL01121:Vmn2r91 APN 17 18,356,766 (GRCm39) missense possibly damaging 0.94
IGL01464:Vmn2r91 APN 17 18,327,864 (GRCm39) missense probably null 0.00
IGL02003:Vmn2r91 APN 17 18,327,921 (GRCm39) missense probably benign
IGL02709:Vmn2r91 APN 17 18,325,711 (GRCm39) missense possibly damaging 0.74
IGL02795:Vmn2r91 APN 17 18,305,539 (GRCm39) missense probably benign 0.01
IGL02813:Vmn2r91 APN 17 18,356,348 (GRCm39) missense possibly damaging 0.91
IGL02830:Vmn2r91 APN 17 18,356,884 (GRCm39) missense probably benign 0.01
IGL03130:Vmn2r91 APN 17 18,330,373 (GRCm39) splice site probably benign
BB006:Vmn2r91 UTSW 17 18,327,906 (GRCm39) missense probably damaging 1.00
BB016:Vmn2r91 UTSW 17 18,327,906 (GRCm39) missense probably damaging 1.00
R0164:Vmn2r91 UTSW 17 18,326,399 (GRCm39) missense probably benign 0.00
R0164:Vmn2r91 UTSW 17 18,326,399 (GRCm39) missense probably benign 0.00
R0393:Vmn2r91 UTSW 17 18,325,712 (GRCm39) missense probably damaging 1.00
R1142:Vmn2r91 UTSW 17 18,356,705 (GRCm39) missense probably damaging 1.00
R1603:Vmn2r91 UTSW 17 18,326,405 (GRCm39) missense probably benign 0.04
R1992:Vmn2r91 UTSW 17 18,356,142 (GRCm39) missense probably damaging 1.00
R2182:Vmn2r91 UTSW 17 18,325,691 (GRCm39) missense possibly damaging 0.94
R2424:Vmn2r91 UTSW 17 18,356,431 (GRCm39) nonsense probably null
R2512:Vmn2r91 UTSW 17 18,356,048 (GRCm39) missense probably benign
R2885:Vmn2r91 UTSW 17 18,325,628 (GRCm39) missense probably benign 0.00
R3009:Vmn2r91 UTSW 17 18,325,717 (GRCm39) missense probably benign 0.11
R3079:Vmn2r91 UTSW 17 18,355,973 (GRCm39) splice site probably null
R3080:Vmn2r91 UTSW 17 18,355,973 (GRCm39) splice site probably null
R3434:Vmn2r91 UTSW 17 18,330,370 (GRCm39) splice site probably benign
R3723:Vmn2r91 UTSW 17 18,305,540 (GRCm39) critical splice donor site probably null
R3829:Vmn2r91 UTSW 17 18,325,759 (GRCm39) missense probably damaging 1.00
R3845:Vmn2r91 UTSW 17 18,327,860 (GRCm39) missense probably benign 0.00
R3846:Vmn2r91 UTSW 17 18,327,860 (GRCm39) missense probably benign 0.00
R4118:Vmn2r91 UTSW 17 18,330,358 (GRCm39) missense probably damaging 1.00
R4285:Vmn2r91 UTSW 17 18,356,030 (GRCm39) missense probably benign 0.00
R4729:Vmn2r91 UTSW 17 18,327,906 (GRCm39) missense probably damaging 1.00
R4793:Vmn2r91 UTSW 17 18,325,658 (GRCm39) missense probably damaging 1.00
R4932:Vmn2r91 UTSW 17 18,356,751 (GRCm39) missense possibly damaging 0.84
R5016:Vmn2r91 UTSW 17 18,330,322 (GRCm39) nonsense probably null
R5018:Vmn2r91 UTSW 17 18,356,700 (GRCm39) missense probably damaging 1.00
R5605:Vmn2r91 UTSW 17 18,356,763 (GRCm39) missense probably damaging 1.00
R5815:Vmn2r91 UTSW 17 18,326,464 (GRCm39) missense probably benign 0.01
R6146:Vmn2r91 UTSW 17 18,356,518 (GRCm39) missense probably benign 0.07
R6187:Vmn2r91 UTSW 17 18,326,888 (GRCm39) missense probably benign 0.05
R6426:Vmn2r91 UTSW 17 18,355,865 (GRCm39) splice site probably null
R6450:Vmn2r91 UTSW 17 18,305,527 (GRCm39) missense probably damaging 0.98
R6767:Vmn2r91 UTSW 17 18,327,807 (GRCm39) missense probably damaging 0.98
R6986:Vmn2r91 UTSW 17 18,356,271 (GRCm39) missense probably benign 0.10
R7112:Vmn2r91 UTSW 17 18,325,880 (GRCm39) missense possibly damaging 0.83
R7178:Vmn2r91 UTSW 17 18,356,424 (GRCm39) missense probably damaging 1.00
R7330:Vmn2r91 UTSW 17 18,326,429 (GRCm39) missense probably damaging 1.00
R7368:Vmn2r91 UTSW 17 18,356,540 (GRCm39) missense possibly damaging 0.75
R7380:Vmn2r91 UTSW 17 18,356,838 (GRCm39) nonsense probably null
R7397:Vmn2r91 UTSW 17 18,356,060 (GRCm39) missense probably benign 0.02
R7625:Vmn2r91 UTSW 17 18,325,693 (GRCm39) missense probably damaging 1.00
R7739:Vmn2r91 UTSW 17 18,356,080 (GRCm39) missense probably benign 0.00
R7749:Vmn2r91 UTSW 17 18,356,540 (GRCm39) missense possibly damaging 0.75
R7755:Vmn2r91 UTSW 17 18,330,311 (GRCm39) missense possibly damaging 0.88
R7929:Vmn2r91 UTSW 17 18,327,906 (GRCm39) missense probably damaging 1.00
R7981:Vmn2r91 UTSW 17 18,327,887 (GRCm39) missense probably benign 0.02
R8211:Vmn2r91 UTSW 17 18,326,762 (GRCm39) missense probably damaging 1.00
R8325:Vmn2r91 UTSW 17 18,356,625 (GRCm39) missense probably damaging 1.00
R8781:Vmn2r91 UTSW 17 18,305,323 (GRCm39) missense possibly damaging 0.78
R8974:Vmn2r91 UTSW 17 18,325,636 (GRCm39) missense probably benign 0.27
R9047:Vmn2r91 UTSW 17 18,326,296 (GRCm39) missense probably benign 0.00
R9048:Vmn2r91 UTSW 17 18,356,122 (GRCm39) missense probably benign 0.00
R9109:Vmn2r91 UTSW 17 18,327,905 (GRCm39) missense probably damaging 1.00
R9211:Vmn2r91 UTSW 17 18,356,819 (GRCm39) nonsense probably null
R9555:Vmn2r91 UTSW 17 18,325,792 (GRCm39) missense possibly damaging 0.78
R9616:Vmn2r91 UTSW 17 18,356,305 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- GGTCCAAACTACATCATTCCTATCTG -3'
(R):5'- CAACAAGATAATGTAACACTTGGGACC -3'

Sequencing Primer
(F):5'- GGAATATGGATGGCAACTTCTCCAC -3'
(R):5'- CACTTGGGACCAAATATAAAGGC -3'
Posted On 2015-01-23