Incidental Mutation 'R0334:Or2ag2'
ID 26122
Institutional Source Beutler Lab
Gene Symbol Or2ag2
Ensembl Gene ENSMUSG00000109354
Gene Name olfactory receptor family 2 subfamily AG member 2
Synonyms MOR283-11, GA_x6K02T2PBJ9-9271198-9270248, Olfr706
MMRRC Submission 038543-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.289) question?
Stock # R0334 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 106485072-106486022 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 106485622 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 134 (V134A)
Ref Sequence ENSEMBL: ENSMUSP00000150075 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052535] [ENSMUST00000088687] [ENSMUST00000208759] [ENSMUST00000209025] [ENSMUST00000210644] [ENSMUST00000213251] [ENSMUST00000213918] [ENSMUST00000214112]
AlphaFold Q9EPF8
Predicted Effect probably benign
Transcript: ENSMUST00000052535
AA Change: V134A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000057180
Gene: ENSMUSG00000064223
AA Change: V134A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 4.1e-43 PFAM
Pfam:7tm_1 41 290 9.1e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000088687
SMART Domains Protein: ENSMUSP00000086062
Gene: ENSMUSG00000069390

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2.2e-58 PFAM
Pfam:7TM_GPCR_Srsx 35 303 9.1e-9 PFAM
Pfam:7tm_1 41 290 1.4e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000208759
Predicted Effect probably benign
Transcript: ENSMUST00000209025
AA Change: V134A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000210644
Predicted Effect probably benign
Transcript: ENSMUST00000213251
Predicted Effect probably benign
Transcript: ENSMUST00000213918
AA Change: V134A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214495
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216085
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216099
Predicted Effect probably benign
Transcript: ENSMUST00000214112
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.4%
  • 20x: 93.6%
Validation Efficiency 99% (68/69)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aggf1 T C 13: 95,508,105 (GRCm39) N87S probably benign Het
Ap2b1 T C 11: 83,258,700 (GRCm39) probably benign Het
Arfgef3 A G 10: 18,468,029 (GRCm39) Y1724H probably damaging Het
Arhgef10l G A 4: 140,311,237 (GRCm39) Q243* probably null Het
Atp8a2 A T 14: 59,928,961 (GRCm39) F1031Y probably damaging Het
Bmp8b A G 4: 123,008,553 (GRCm39) probably null Het
Brinp2 G T 1: 158,123,155 (GRCm39) T37K probably benign Het
Bsph1 T A 7: 13,184,864 (GRCm39) L9* probably null Het
C6 T G 15: 4,784,849 (GRCm39) N238K probably benign Het
Cbs T C 17: 31,838,130 (GRCm39) D373G probably damaging Het
Clec4a3 T C 6: 122,946,329 (GRCm39) F191S possibly damaging Het
Cpz A G 5: 35,661,025 (GRCm39) V530A probably damaging Het
Ctsc G T 7: 87,927,550 (GRCm39) S47I possibly damaging Het
Cyp7b1 T G 3: 18,157,960 (GRCm39) Y53S probably damaging Het
Dach1 C T 14: 98,406,184 (GRCm39) G188R probably damaging Het
Defb4 T C 8: 19,251,220 (GRCm39) I29T probably benign Het
Disc1 A T 8: 125,987,836 (GRCm39) probably null Het
Dnah2 A G 11: 69,327,662 (GRCm39) M3429T probably damaging Het
Dnah7a A T 1: 53,472,213 (GRCm39) I3518N possibly damaging Het
Dnah8 A T 17: 31,090,325 (GRCm39) H4609L probably damaging Het
Evi5 C A 5: 107,968,401 (GRCm39) C182F probably damaging Het
Fam149b G A 14: 20,413,492 (GRCm39) R237H probably damaging Het
Fut8 T A 12: 77,440,536 (GRCm39) D174E possibly damaging Het
Ghr T C 15: 3,370,580 (GRCm39) probably benign Het
Gm10801 G C 2: 98,494,352 (GRCm39) R143T possibly damaging Het
Gpr176 T C 2: 118,110,189 (GRCm39) S357G probably benign Het
Grwd1 A T 7: 45,476,601 (GRCm39) probably null Het
H2-T24 A G 17: 36,325,772 (GRCm39) V273A possibly damaging Het
Hdac4 A C 1: 91,883,760 (GRCm39) probably benign Het
Herc3 A G 6: 58,895,802 (GRCm39) T1017A probably damaging Het
Hsd11b1 T C 1: 192,924,476 (GRCm39) probably benign Het
Igsf23 T C 7: 19,675,678 (GRCm39) S143G probably benign Het
Kbtbd12 T A 6: 88,594,888 (GRCm39) Y314F probably damaging Het
Kcnmb2 A G 3: 32,252,508 (GRCm39) probably null Het
Kdm5b A G 1: 134,532,260 (GRCm39) I479M probably damaging Het
Kidins220 A G 12: 25,058,068 (GRCm39) T600A probably damaging Het
Mrgprb2 A C 7: 48,202,077 (GRCm39) I216S probably damaging Het
Muc21 A G 17: 35,933,614 (GRCm39) probably benign Het
Myo1g A G 11: 6,461,084 (GRCm39) probably benign Het
Nrxn3 T C 12: 89,780,412 (GRCm39) probably null Het
Or8b54 A T 9: 38,686,535 (GRCm39) probably null Het
Or8g26 A G 9: 39,095,980 (GRCm39) I169V probably benign Het
Pdia5 A T 16: 35,284,760 (GRCm39) S66T possibly damaging Het
Plec T C 15: 76,062,206 (GRCm39) E2604G probably damaging Het
Plekha6 G T 1: 133,209,918 (GRCm39) A654S probably benign Het
Pnpla2 G A 7: 141,039,433 (GRCm39) probably null Het
Pramel19 T C 4: 101,798,781 (GRCm39) F251L probably benign Het
Prb1c T A 6: 132,341,021 (GRCm39) Q17L unknown Het
Prkdc A G 16: 15,554,663 (GRCm39) D2128G probably benign Het
Rabggta A T 14: 55,958,268 (GRCm39) L131Q probably damaging Het
Rbks A T 5: 31,781,863 (GRCm39) Y312* probably null Het
Rnf139 A G 15: 58,771,322 (GRCm39) Y449C probably damaging Het
Sanbr A G 11: 23,567,129 (GRCm39) probably benign Het
Sbno1 A G 5: 124,524,931 (GRCm39) V1058A possibly damaging Het
Sema3a A T 5: 13,607,268 (GRCm39) N321I probably damaging Het
Slit3 T A 11: 35,469,928 (GRCm39) V310E probably damaging Het
Slitrk5 T C 14: 111,918,256 (GRCm39) S627P probably benign Het
Stat2 T A 10: 128,113,736 (GRCm39) F172I probably damaging Het
Tchh C A 3: 93,352,923 (GRCm39) R788S unknown Het
Tnks T A 8: 35,320,413 (GRCm39) K753* probably null Het
Trank1 T A 9: 111,194,421 (GRCm39) V815D probably benign Het
Trank1 T A 9: 111,222,008 (GRCm39) I2915N probably damaging Het
Trpc6 T C 9: 8,610,344 (GRCm39) S271P probably damaging Het
Trpm5 T C 7: 142,640,613 (GRCm39) Q213R probably benign Het
Ulk3 C T 9: 57,501,510 (GRCm39) probably benign Het
Usp31 T C 7: 121,258,185 (GRCm39) D694G probably damaging Het
Wnt3a A G 11: 59,147,144 (GRCm39) S181P probably damaging Het
Yipf3 T C 17: 46,559,238 (GRCm39) F22S possibly damaging Het
Zbtb40 A T 4: 136,713,867 (GRCm39) H1094Q probably damaging Het
Other mutations in Or2ag2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02311:Or2ag2 APN 7 106,485,101 (GRCm39) missense probably benign 0.00
IGL03093:Or2ag2 APN 7 106,485,410 (GRCm39) missense probably benign 0.02
IGL03354:Or2ag2 APN 7 106,485,307 (GRCm39) missense probably benign 0.07
R1577:Or2ag2 UTSW 7 106,485,217 (GRCm39) missense probably benign 0.03
R4083:Or2ag2 UTSW 7 106,485,851 (GRCm39) missense probably damaging 0.97
R4399:Or2ag2 UTSW 7 106,485,660 (GRCm39) missense probably damaging 1.00
R4421:Or2ag2 UTSW 7 106,485,660 (GRCm39) missense probably damaging 1.00
R5202:Or2ag2 UTSW 7 106,485,803 (GRCm39) missense possibly damaging 0.90
R6031:Or2ag2 UTSW 7 106,485,134 (GRCm39) missense possibly damaging 0.93
R6031:Or2ag2 UTSW 7 106,485,134 (GRCm39) missense possibly damaging 0.93
R6375:Or2ag2 UTSW 7 106,485,221 (GRCm39) missense probably benign
R6475:Or2ag2 UTSW 7 106,485,604 (GRCm39) missense probably benign 0.00
R7665:Or2ag2 UTSW 7 106,485,880 (GRCm39) missense possibly damaging 0.95
R7742:Or2ag2 UTSW 7 106,485,829 (GRCm39) missense probably damaging 1.00
R7956:Or2ag2 UTSW 7 106,485,178 (GRCm39) missense possibly damaging 0.88
R8678:Or2ag2 UTSW 7 106,485,280 (GRCm39) missense probably damaging 1.00
Z1088:Or2ag2 UTSW 7 106,485,503 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TCTACACAGGACAGCTTCAGCAAAG -3'
(R):5'- TTGTCATCACAGTGGATGCCCG -3'

Sequencing Primer
(F):5'- TTCAGCAAAGGCAGGATCTC -3'
(R):5'- ATGTACCTCCTACTGAGGCAG -3'
Posted On 2013-04-16