Incidental Mutation 'R2900:Zfp566'
| ID |
261441 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp566
|
| Ensembl Gene |
ENSMUSG00000078768 |
| Gene Name |
zinc finger protein 566 |
| Synonyms |
2700043M03Rik |
| MMRRC Submission |
040488-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.110)
|
| Stock # |
R2900 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
29776762-29789935 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 29777668 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 171
(D171G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000086164
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000088785]
[ENSMUST00000182746]
|
| AlphaFold |
Q8VCI1 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000088785
AA Change: D171G
PolyPhen 2
Score 0.886 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000086164
Gene: ENSMUSG00000078768
AA Change: D171G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
6 |
67 |
1.19e-16 |
SMART |
|
ZnF_C2H2
|
167 |
189 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
195 |
217 |
2.05e-2 |
SMART |
|
ZnF_C2H2
|
223 |
245 |
3.21e-4 |
SMART |
|
ZnF_C2H2
|
251 |
273 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
279 |
301 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
307 |
329 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
335 |
357 |
1.95e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000182248
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182746
|
| SMART Domains |
Protein: ENSMUSP00000138567
Gene: ENSMUSG00000058447
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
6 |
56 |
1.44e-15 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ak9 |
C |
T |
10: 41,300,751 (GRCm39) |
H1654Y |
unknown |
Het |
| Bahd1 |
C |
T |
2: 118,746,887 (GRCm39) |
P169S |
probably damaging |
Het |
| Cmtm1 |
A |
G |
8: 105,036,176 (GRCm39) |
V151A |
possibly damaging |
Het |
| Coro6 |
A |
G |
11: 77,358,639 (GRCm39) |
I233V |
probably benign |
Het |
| Cyp26b1 |
C |
T |
6: 84,553,623 (GRCm39) |
R252H |
possibly damaging |
Het |
| Dcdc2a |
C |
A |
13: 25,304,481 (GRCm39) |
D351E |
probably benign |
Het |
| Flnc |
T |
C |
6: 29,448,584 (GRCm39) |
F1274S |
probably damaging |
Het |
| Fut7 |
A |
G |
2: 25,313,923 (GRCm39) |
K33E |
probably benign |
Het |
| Gpsm1 |
G |
T |
2: 26,235,174 (GRCm39) |
V480L |
probably benign |
Het |
| Hoxc9 |
A |
T |
15: 102,890,185 (GRCm39) |
H34L |
probably benign |
Het |
| Ighv1-4 |
A |
G |
12: 114,450,788 (GRCm39) |
S107P |
probably benign |
Het |
| Itsn2 |
T |
C |
12: 4,680,713 (GRCm39) |
|
probably benign |
Het |
| Kcnma1 |
T |
C |
14: 23,853,228 (GRCm39) |
T109A |
probably damaging |
Het |
| Med18 |
G |
A |
4: 132,187,128 (GRCm39) |
R124C |
probably damaging |
Het |
| Ms4a6d |
C |
T |
19: 11,567,508 (GRCm39) |
G23D |
probably damaging |
Het |
| Pan2 |
T |
A |
10: 128,144,211 (GRCm39) |
D135E |
probably benign |
Het |
| Pdlim1 |
C |
T |
19: 40,211,519 (GRCm39) |
C258Y |
probably damaging |
Het |
| Ppp6r2 |
C |
A |
15: 89,166,198 (GRCm39) |
P734H |
probably damaging |
Het |
| Slc15a4 |
A |
G |
5: 127,681,600 (GRCm39) |
|
probably null |
Het |
| Stat5a |
G |
A |
11: 100,764,957 (GRCm39) |
V227M |
probably benign |
Het |
| Strip2 |
A |
T |
6: 29,939,034 (GRCm39) |
|
probably null |
Het |
| Syn2 |
C |
T |
6: 115,214,295 (GRCm39) |
T173I |
possibly damaging |
Het |
| Thbd |
C |
A |
2: 148,248,134 (GRCm39) |
*578L |
probably null |
Het |
| Tnfrsf11a |
T |
C |
1: 105,754,786 (GRCm39) |
I286T |
probably benign |
Het |
| Zfp938 |
T |
C |
10: 82,061,340 (GRCm39) |
R427G |
possibly damaging |
Het |
|
| Other mutations in Zfp566 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00160:Zfp566
|
APN |
7 |
29,777,936 (GRCm39) |
missense |
probably benign |
0.34 |
|
IGL02165:Zfp566
|
APN |
7 |
29,777,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1442:Zfp566
|
UTSW |
7 |
29,777,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1666:Zfp566
|
UTSW |
7 |
29,777,901 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1855:Zfp566
|
UTSW |
7 |
29,777,927 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4654:Zfp566
|
UTSW |
7 |
29,777,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4752:Zfp566
|
UTSW |
7 |
29,777,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7243:Zfp566
|
UTSW |
7 |
29,777,701 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7625:Zfp566
|
UTSW |
7 |
29,777,930 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8145:Zfp566
|
UTSW |
7 |
29,777,785 (GRCm39) |
missense |
probably benign |
0.22 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTCTGGTGAGGTCAGAACC -3'
(R):5'- ATCATCAACCGTGACGACGTG -3'
Sequencing Primer
(F):5'- TTTGAGCCACTACTGAAGGC -3'
(R):5'- GTGCCCACTCTCAGTCAGTG -3'
|
| Posted On |
2015-01-23 |
Incidental Mutation