Incidental Mutation 'R2904:Zfp160'
| ID |
261598 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp160
|
| Ensembl Gene |
ENSMUSG00000067942 |
| Gene Name |
zinc finger protein 160 |
| Synonyms |
6720480D16Rik, 6720480D16Rik |
| MMRRC Submission |
040491-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2904 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
21229203-21249119 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 21245911 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 154
(V154I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000155977
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000088811]
[ENSMUST00000231482]
[ENSMUST00000232320]
[ENSMUST00000232354]
[ENSMUST00000232473]
[ENSMUST00000232595]
[ENSMUST00000232663]
|
| AlphaFold |
E9Q459 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000088811
AA Change: V154I
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000086191
Gene: ENSMUSG00000067942
AA Change: V154I
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
8 |
68 |
1.91e-29 |
SMART |
|
low complexity region
|
100 |
110 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
146 |
168 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
174 |
196 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
202 |
224 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
230 |
252 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
258 |
280 |
1.72e-4 |
SMART |
|
ZnF_C2H2
|
286 |
308 |
4.94e-5 |
SMART |
|
ZnF_C2H2
|
314 |
336 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
342 |
364 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
370 |
392 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
398 |
420 |
6.42e-4 |
SMART |
|
ZnF_C2H2
|
426 |
448 |
9.08e-4 |
SMART |
|
ZnF_C2H2
|
454 |
476 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
482 |
504 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
510 |
532 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
538 |
560 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
566 |
588 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
594 |
616 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
622 |
644 |
1.13e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231482
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232320
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232354
AA Change: V154I
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232473
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232595
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232663
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.5%
|
| Validation Efficiency |
97% (30/31) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abraxas1 |
T |
C |
5: 100,957,673 (GRCm39) |
E182G |
probably benign |
Het |
| Acot4 |
C |
G |
12: 84,090,377 (GRCm39) |
T358S |
probably benign |
Het |
| Ap2a2 |
A |
G |
7: 141,199,391 (GRCm39) |
K433E |
probably damaging |
Het |
| Card11 |
T |
A |
5: 140,874,888 (GRCm39) |
D592V |
probably benign |
Het |
| Col12a1 |
G |
T |
9: 79,559,307 (GRCm39) |
S1860R |
probably damaging |
Het |
| Crisp1 |
C |
T |
17: 40,623,895 (GRCm39) |
|
probably null |
Het |
| Dzip1l |
A |
G |
9: 99,545,722 (GRCm39) |
E657G |
probably damaging |
Het |
| Gak |
T |
C |
5: 108,772,080 (GRCm39) |
N79S |
possibly damaging |
Het |
| Gm9791 |
T |
C |
3: 34,059,336 (GRCm39) |
|
noncoding transcript |
Het |
| Gmpr2 |
T |
C |
14: 55,910,215 (GRCm39) |
V15A |
probably damaging |
Het |
| Hectd4 |
T |
C |
5: 121,430,787 (GRCm39) |
|
probably benign |
Het |
| Ift56 |
T |
C |
6: 38,378,037 (GRCm39) |
V283A |
possibly damaging |
Het |
| Kalrn |
C |
T |
16: 33,810,180 (GRCm39) |
D2525N |
possibly damaging |
Het |
| Kdm4b |
G |
A |
17: 56,662,884 (GRCm39) |
G152S |
probably benign |
Het |
| Kdm6b |
G |
A |
11: 69,296,611 (GRCm39) |
T552I |
possibly damaging |
Het |
| Kdr |
T |
C |
5: 76,127,069 (GRCm39) |
Y307C |
probably damaging |
Het |
| Kif11 |
T |
C |
19: 37,392,103 (GRCm39) |
|
probably benign |
Het |
| Kirrel1 |
C |
T |
3: 86,996,458 (GRCm39) |
M380I |
probably null |
Het |
| Madd |
C |
T |
2: 91,006,017 (GRCm39) |
V20M |
probably damaging |
Het |
| Mkrn3 |
C |
A |
7: 62,068,207 (GRCm39) |
R528L |
probably benign |
Het |
| Myom2 |
T |
C |
8: 15,148,348 (GRCm39) |
V508A |
probably benign |
Het |
| Nav1 |
T |
C |
1: 135,512,976 (GRCm39) |
D28G |
probably benign |
Het |
| Nlrp4b |
T |
A |
7: 10,448,294 (GRCm39) |
W166R |
probably damaging |
Het |
| Or14j2 |
A |
T |
17: 37,885,705 (GRCm39) |
L203Q |
possibly damaging |
Het |
| Or5p59 |
T |
C |
7: 107,702,806 (GRCm39) |
Y97H |
probably benign |
Het |
| Rassf10 |
A |
T |
7: 112,553,756 (GRCm39) |
D119V |
possibly damaging |
Het |
| Smarcc1 |
A |
G |
9: 110,003,043 (GRCm39) |
N378D |
possibly damaging |
Het |
| Tas2r118 |
A |
G |
6: 23,969,801 (GRCm39) |
F87L |
possibly damaging |
Het |
| Tasor2 |
T |
C |
13: 3,632,185 (GRCm39) |
N772S |
possibly damaging |
Het |
| Trim21 |
A |
G |
7: 102,209,178 (GRCm39) |
W282R |
probably benign |
Het |
| Uggt2 |
T |
A |
14: 119,296,521 (GRCm39) |
Y447F |
possibly damaging |
Het |
|
| Other mutations in Zfp160 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00714:Zfp160
|
APN |
17 |
21,246,964 (GRCm39) |
missense |
probably benign |
|
|
IGL01019:Zfp160
|
APN |
17 |
21,241,088 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02430:Zfp160
|
APN |
17 |
21,245,792 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R0412:Zfp160
|
UTSW |
17 |
21,247,139 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0600:Zfp160
|
UTSW |
17 |
21,247,268 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2146:Zfp160
|
UTSW |
17 |
21,247,244 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2157:Zfp160
|
UTSW |
17 |
21,241,090 (GRCm39) |
missense |
probably benign |
0.23 |
|
R2411:Zfp160
|
UTSW |
17 |
21,246,007 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4249:Zfp160
|
UTSW |
17 |
21,246,000 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4896:Zfp160
|
UTSW |
17 |
21,240,343 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5106:Zfp160
|
UTSW |
17 |
21,247,023 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5342:Zfp160
|
UTSW |
17 |
21,240,995 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5352:Zfp160
|
UTSW |
17 |
21,247,114 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6193:Zfp160
|
UTSW |
17 |
21,247,124 (GRCm39) |
missense |
probably benign |
0.24 |
|
R6230:Zfp160
|
UTSW |
17 |
21,246,707 (GRCm39) |
missense |
probably benign |
0.38 |
|
R6753:Zfp160
|
UTSW |
17 |
21,240,996 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6928:Zfp160
|
UTSW |
17 |
21,261,724 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7040:Zfp160
|
UTSW |
17 |
21,246,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7255:Zfp160
|
UTSW |
17 |
21,245,749 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7497:Zfp160
|
UTSW |
17 |
21,246,455 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7510:Zfp160
|
UTSW |
17 |
21,246,655 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7540:Zfp160
|
UTSW |
17 |
21,245,922 (GRCm39) |
nonsense |
probably null |
|
|
R7627:Zfp160
|
UTSW |
17 |
21,247,270 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8169:Zfp160
|
UTSW |
17 |
21,247,298 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8240:Zfp160
|
UTSW |
17 |
21,246,350 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8330:Zfp160
|
UTSW |
17 |
21,246,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8367:Zfp160
|
UTSW |
17 |
21,245,804 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8802:Zfp160
|
UTSW |
17 |
21,246,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9183:Zfp160
|
UTSW |
17 |
21,240,354 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9556:Zfp160
|
UTSW |
17 |
21,247,031 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9695:Zfp160
|
UTSW |
17 |
21,245,746 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
Z1177:Zfp160
|
UTSW |
17 |
21,247,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAATGAAGCTAAGTCCATCAGCAG -3'
(R):5'- GTTTCTCACCAGTATGGATTCTTCG -3'
Sequencing Primer
(F):5'- AAGTCCATCAGCAGTGGTTC -3'
(R):5'- GGTGTGAATTCTGACTGAACACC -3'
|
| Posted On |
2015-01-23 |
Incidental Mutation