Incidental Mutation 'R0285:Tmem144'
ID261827
Institutional Source Beutler Lab
Gene Symbol Tmem144
Ensembl Gene ENSMUSG00000027956
Gene Nametransmembrane protein 144
Synonyms5730537D05Rik, 1110057I03Rik
MMRRC Submission 038506-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.081) question?
Stock #R0285 (G1)
Quality Score225
Status Validated
Chromosome3
Chromosomal Location79812564-79852773 bp(-) (GRCm38)
Type of Mutationstart gained
DNA Base Change (assembly) G to A at 79839273 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000141832 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029568] [ENSMUST00000168038] [ENSMUST00000192341] [ENSMUST00000193410]
Predicted Effect probably benign
Transcript: ENSMUST00000029568
SMART Domains Protein: ENSMUSP00000029568
Gene: ENSMUSG00000027956

DomainStartEndE-ValueType
Pfam:DUF1632 11 266 3.7e-107 PFAM
Pfam:Sugar_transport 238 348 3.6e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000104273
Predicted Effect probably benign
Transcript: ENSMUST00000168038
SMART Domains Protein: ENSMUSP00000127837
Gene: ENSMUSG00000027956

DomainStartEndE-ValueType
Pfam:TMEM144 9 347 9.1e-142 PFAM
Pfam:Sugar_transport 238 348 4.9e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000192341
Predicted Effect probably benign
Transcript: ENSMUST00000193410
SMART Domains Protein: ENSMUSP00000141832
Gene: ENSMUSG00000027956

DomainStartEndE-ValueType
Pfam:DUF1632 11 137 7.3e-58 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194338
Meta Mutation Damage Score 0.0976 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 96.1%
  • 20x: 92.9%
Validation Efficiency 99% (80/81)
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700011I03Rik G A 18: 57,533,865 G5S probably damaging Het
Acy3 A G 19: 3,988,193 E162G probably benign Het
Angptl1 T C 1: 156,845,215 S204P probably benign Het
Atf6b C T 17: 34,650,396 probably benign Het
Card11 G A 5: 140,887,101 S619F probably damaging Het
Ccl11 G A 11: 82,062,258 V81I probably damaging Het
Cds1 T C 5: 101,797,038 I126T probably damaging Het
Chd1 A G 17: 17,374,680 probably benign Het
Cndp1 C A 18: 84,618,238 V384F possibly damaging Het
Cuta A G 17: 26,939,449 probably null Het
Diaph3 G A 14: 87,115,024 T47I possibly damaging Het
Dopey1 A T 9: 86,512,639 S598C probably damaging Het
Dsp A G 13: 38,172,794 M217V probably benign Het
Esyt1 T A 10: 128,512,218 I898F possibly damaging Het
Fam189a2 G A 19: 23,979,385 probably benign Het
Fam205a1 G A 4: 42,850,236 T640M probably benign Het
Fam84b T C 15: 60,822,967 H310R probably benign Het
Fgd3 A T 13: 49,263,948 W680R possibly damaging Het
Folh1 A G 7: 86,742,165 probably benign Het
Fuk G C 8: 110,893,717 H235Q probably benign Het
Gadl1 C A 9: 116,030,738 probably benign Het
Garem1 A G 18: 21,129,612 M715T probably benign Het
Gpd2 A T 2: 57,338,955 D257V probably benign Het
Hdac7 A G 15: 97,798,222 probably null Het
Heatr5b A G 17: 78,808,453 M858T probably benign Het
Inpp4b A T 8: 82,034,516 probably benign Het
Iqgap3 G T 3: 88,096,990 C461F probably benign Het
Lamb1 C A 12: 31,326,645 C559* probably null Het
Lrrc31 T C 3: 30,684,948 N308S probably benign Het
Ly75 T C 2: 60,318,319 Y1222C probably damaging Het
Map3k10 C A 7: 27,673,900 R42L probably benign Het
Meioc A G 11: 102,672,191 T72A probably benign Het
Miox C T 15: 89,336,274 L189F possibly damaging Het
Mmp11 T C 10: 75,925,668 Y366C probably damaging Het
N4bp2 T A 5: 65,806,559 D650E probably benign Het
Ncoa6 TGC TGCGC 2: 155,408,291 probably null Het
Ncoa6 T C 2: 155,415,701 M641V probably damaging Het
Nol4l G A 2: 153,483,853 probably benign Het
Notch1 T G 2: 26,460,861 D2089A possibly damaging Het
Olfr1156 A G 2: 87,950,131 I34T probably damaging Het
Olfr1419 A G 19: 11,871,138 L26P probably damaging Het
Olfr1449 A T 19: 12,935,172 M145L probably benign Het
Olfr155 G A 4: 43,854,398 V30M possibly damaging Het
Olfr493 A G 7: 108,346,499 S161P probably benign Het
Olfr649 A T 7: 104,189,324 Y294* probably null Het
Olfr930 T A 9: 38,930,774 I201N possibly damaging Het
Otof C T 5: 30,379,533 probably null Het
Paox T C 7: 140,129,140 F324L probably damaging Het
Pycr1 A T 11: 120,640,316 I277N probably benign Het
R3hcc1l A T 19: 42,576,129 H627L probably damaging Het
Rab21 G A 10: 115,290,863 S193L probably benign Het
Ralgds T G 2: 28,550,569 probably null Het
Rbm42 A G 7: 30,645,840 S169P possibly damaging Het
Rfpl4 A G 7: 5,110,378 V262A probably benign Het
Rhobtb3 A G 13: 75,877,509 I496T possibly damaging Het
Rnf31 G A 14: 55,601,389 A901T probably damaging Het
Ryr2 T C 13: 11,716,977 D2359G probably damaging Het
Sgo2b A C 8: 63,928,789 Y336* probably null Het
Slc16a7 T A 10: 125,294,631 I62L probably benign Het
Slc22a21 A T 11: 53,959,196 probably benign Het
Slc25a21 A G 12: 56,858,025 probably null Het
Slc5a4b T C 10: 76,062,283 I532M probably damaging Het
Srrm4 C A 5: 116,467,789 probably benign Het
Stxbp1 C A 2: 32,823,542 E27D probably benign Het
Sult2a5 T A 7: 13,628,760 Y131N probably damaging Het
Svopl T C 6: 37,984,522 Q492R probably benign Het
Tmem87a A G 2: 120,394,424 S119P probably benign Het
Tmprss11c A G 5: 86,271,430 L90P probably damaging Het
Tmprss6 T A 15: 78,452,868 D346V probably damaging Het
Ubr4 A C 4: 139,440,801 S2820R probably damaging Het
Usp4 T C 9: 108,378,564 V607A probably benign Het
Usp45 A G 4: 21,798,603 probably null Het
Vill C T 9: 119,070,827 probably benign Het
Vmn1r13 C A 6: 57,209,994 T46N probably benign Het
Vmn2r107 A G 17: 20,345,611 T63A probably benign Het
Vmn2r82 T A 10: 79,396,557 W797R probably damaging Het
Washc2 T A 6: 116,221,839 D287E probably damaging Het
Xpc G A 6: 91,498,064 L660F probably damaging Het
Other mutations in Tmem144
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00594:Tmem144 APN 3 79839167 missense probably benign 0.19
IGL01924:Tmem144 APN 3 79839194 missense probably damaging 1.00
IGL02080:Tmem144 APN 3 79822759 splice site probably benign
IGL02191:Tmem144 APN 3 79826852 missense possibly damaging 0.59
IGL02880:Tmem144 APN 3 79827622 missense probably benign 0.00
PIT4486001:Tmem144 UTSW 3 79826867 missense probably benign 0.00
R0080:Tmem144 UTSW 3 79839273 start gained probably benign
R0081:Tmem144 UTSW 3 79839273 start gained probably benign
R0164:Tmem144 UTSW 3 79839273 start gained probably benign
R0172:Tmem144 UTSW 3 79839273 start gained probably benign
R0173:Tmem144 UTSW 3 79839273 start gained probably benign
R0284:Tmem144 UTSW 3 79839273 start gained probably benign
R0288:Tmem144 UTSW 3 79839273 start gained probably benign
R0445:Tmem144 UTSW 3 79825354 missense probably benign 0.01
R0549:Tmem144 UTSW 3 79822744 missense probably damaging 1.00
R0687:Tmem144 UTSW 3 79839273 start gained probably benign
R1720:Tmem144 UTSW 3 79825299 missense probably damaging 1.00
R1748:Tmem144 UTSW 3 79825287 missense probably damaging 0.99
R1937:Tmem144 UTSW 3 79825304 missense probably damaging 0.99
R1955:Tmem144 UTSW 3 79826857 missense probably benign 0.13
R1978:Tmem144 UTSW 3 79825400 splice site probably null
R2025:Tmem144 UTSW 3 79827711 splice site probably null
R5241:Tmem144 UTSW 3 79814124 missense probably benign 0.13
R6674:Tmem144 UTSW 3 79839183 missense possibly damaging 0.91
R6862:Tmem144 UTSW 3 79832099 missense probably benign
Predicted Primers
Posted On2015-02-04