Incidental Mutation 'R0383:Upf3b'
ID 261846
Institutional Source Beutler Lab
Gene Symbol Upf3b
Ensembl Gene ENSMUSG00000036572
Gene Name UPF3 regulator of nonsense transcripts homolog B (yeast)
Synonyms UPF3X, RENT3B, 5730594O13Rik
MMRRC Submission 038589-MU
Accession Numbers
Essential gene? Not available question?
Stock # R0383 (G1)
Quality Score 201
Status Not validated
Chromosome X
Chromosomal Location 36355331-36373975 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 36368120 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 144 (I144T)
Ref Sequence ENSEMBL: ENSMUSP00000075614 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076265]
AlphaFold Q3ULL6
Predicted Effect probably benign
Transcript: ENSMUST00000076265
AA Change: I144T

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000075614
Gene: ENSMUSG00000036572
AA Change: I144T

DomainStartEndE-ValueType
Pfam:Smg4_UPF3 48 209 1.1e-57 PFAM
low complexity region 211 256 N/A INTRINSIC
low complexity region 278 294 N/A INTRINSIC
coiled coil region 333 400 N/A INTRINSIC
low complexity region 406 416 N/A INTRINSIC
PDB:2XB2|U 417 472 7e-26 PDB
Predicted Effect unknown
Transcript: ENSMUST00000130324
AA Change: I19T
SMART Domains Protein: ENSMUSP00000121631
Gene: ENSMUSG00000036572
AA Change: I19T

DomainStartEndE-ValueType
Pfam:Smg4_UPF3 1 85 1.5e-23 PFAM
low complexity region 87 132 N/A INTRINSIC
low complexity region 167 183 N/A INTRINSIC
coiled coil region 221 259 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133481
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 97.9%
  • 10x: 95.2%
  • 20x: 88.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous or hemizygous for a null mutation display impaired startle responses, prepulse inhibition, and cued and contextual fear conditioning behavior, limb grasping, decreased neuronal precursor proliferation, and increased neuronal precursor proliferation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 88 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730455P16Rik G T 11: 80,254,767 (GRCm39) Y351* probably null Het
Aadac G T 3: 59,943,368 (GRCm39) R91L possibly damaging Het
Adgrg1 T A 8: 95,738,370 (GRCm39) F621Y probably damaging Het
Ankmy1 G T 1: 92,812,775 (GRCm39) D511E probably benign Het
Anks4b A T 7: 119,782,097 (GRCm39) D376V probably damaging Het
Aox1 G T 1: 58,100,400 (GRCm39) C399F probably benign Het
Arfgef1 C T 1: 10,269,067 (GRCm39) probably null Het
Arhgef4 G A 1: 34,849,614 (GRCm39) V546M probably damaging Het
Cab39 T A 1: 85,765,020 (GRCm39) V98E probably damaging Het
Cacna1b T C 2: 24,651,856 (GRCm39) N108D probably damaging Het
Car15 C A 16: 17,654,617 (GRCm39) E134* probably null Het
Ccdc80 T G 16: 44,915,732 (GRCm39) Y163D probably damaging Het
Cdcp3 A G 7: 130,841,268 (GRCm39) M537V probably benign Het
Col22a1 C T 15: 71,740,853 (GRCm39) G513D unknown Het
Col8a1 T C 16: 57,452,805 (GRCm39) D66G probably damaging Het
Crot C A 5: 9,018,734 (GRCm39) S544I probably damaging Het
Cubn G T 2: 13,435,770 (GRCm39) P1062Q probably damaging Het
Dcc A T 18: 71,553,334 (GRCm39) V774E probably damaging Het
Dlgap5 T A 14: 47,647,818 (GRCm39) M240L probably benign Het
Dlx4 A G 11: 95,036,261 (GRCm39) V16A probably benign Het
Dnah17 G T 11: 117,958,373 (GRCm39) H2703Q probably benign Het
Duox2 A G 2: 122,122,291 (GRCm39) probably null Het
Fn1 C T 1: 71,636,844 (GRCm39) V168I probably damaging Het
Fpr-rs4 A T 17: 18,242,359 (GRCm39) D122V probably damaging Het
Gas2l2 A T 11: 83,313,923 (GRCm39) I463N probably benign Het
Ggta1 G T 2: 35,292,416 (GRCm39) P297Q probably damaging Het
Gpatch3 C A 4: 133,305,457 (GRCm39) R231S probably damaging Het
Gpc1 T C 1: 92,782,705 (GRCm39) Y151H probably damaging Het
Gpr141b A G 13: 19,913,317 (GRCm39) noncoding transcript Het
Gtf2e2 T C 8: 34,245,973 (GRCm39) W119R probably damaging Het
H2-M10.2 T C 17: 36,595,253 (GRCm39) I304V probably benign Het
Helq T C 5: 100,927,031 (GRCm39) K685R probably benign Het
Hps5 C T 7: 46,418,712 (GRCm39) probably null Het
Iars1 T C 13: 49,885,818 (GRCm39) C1186R probably damaging Het
Ift43 T C 12: 86,208,795 (GRCm39) V158A possibly damaging Het
Ift70b A G 2: 75,768,586 (GRCm39) Y56H probably damaging Het
Iqca1 A T 1: 90,070,429 (GRCm39) I141N probably damaging Het
Kat6b A G 14: 21,719,149 (GRCm39) N1276S probably benign Het
Kif19a A T 11: 114,656,340 (GRCm39) M1L possibly damaging Het
Kif1b T G 4: 149,286,969 (GRCm39) H1241P probably damaging Het
Kif26a T C 12: 112,144,510 (GRCm39) V1588A possibly damaging Het
Klb T A 5: 65,529,842 (GRCm39) probably null Het
Krtap26-1 A T 16: 88,444,131 (GRCm39) Y163* probably null Het
Lefty1 G T 1: 180,765,199 (GRCm39) E256* probably null Het
Lox T C 18: 52,662,271 (GRCm39) N44S possibly damaging Het
Marf1 C T 16: 13,960,398 (GRCm39) A549T probably damaging Het
Mctp1 A G 13: 76,949,663 (GRCm39) Y565C probably damaging Het
Megf6 C T 4: 154,349,783 (GRCm39) A961V probably benign Het
Mindy4 A G 6: 55,253,619 (GRCm39) K496R probably benign Het
Nalcn A T 14: 123,744,971 (GRCm39) H352Q probably benign Het
Ncoa5 T C 2: 164,851,310 (GRCm39) I188V possibly damaging Het
Notum G T 11: 120,545,282 (GRCm39) H426N probably benign Het
Or52r1 T A 7: 102,536,458 (GRCm39) I301F possibly damaging Het
Orm2 A T 4: 63,282,233 (GRCm39) D137V probably damaging Het
Pabpc2 G A 18: 39,908,448 (GRCm39) G571D probably damaging Het
Pabpc4 A G 4: 123,191,735 (GRCm39) N599S probably damaging Het
Pak1ip1 T C 13: 41,166,080 (GRCm39) V335A probably benign Het
Pcdhb11 A C 18: 37,556,446 (GRCm39) D592A probably damaging Het
Pmch C A 10: 87,927,120 (GRCm39) T41K possibly damaging Het
Polb G T 8: 23,130,011 (GRCm39) S187* probably null Het
Pter G T 2: 13,005,753 (GRCm39) G309* probably null Het
Ptprg T C 14: 12,219,024 (GRCm38) V406A possibly damaging Het
Ranbp3l A T 15: 9,063,184 (GRCm39) E467V possibly damaging Het
Rif1 T A 2: 51,975,153 (GRCm39) M354K probably damaging Het
Ripk4 C T 16: 97,549,312 (GRCm39) C248Y probably damaging Het
Slc6a15 T C 10: 103,253,914 (GRCm39) W617R probably damaging Het
Smyd5 C T 6: 85,417,155 (GRCm39) Q178* probably null Het
St18 T A 1: 6,873,248 (GRCm39) F328I probably damaging Het
Supt20 T A 3: 54,610,570 (GRCm39) L124* probably null Het
Tarbp1 T A 8: 127,174,223 (GRCm39) H861L probably benign Het
Tars1 A G 15: 11,390,411 (GRCm39) M356T probably benign Het
Tbc1d10a A G 11: 4,162,819 (GRCm39) T221A probably damaging Het
Tead3 A G 17: 28,553,672 (GRCm39) probably null Het
Tprg1 A G 16: 25,240,985 (GRCm39) T254A probably damaging Het
Trank1 C A 9: 111,220,545 (GRCm39) N2427K probably benign Het
Tufm T C 7: 126,089,036 (GRCm39) S380P probably damaging Het
Tyrobp C T 7: 30,114,042 (GRCm39) R68C probably damaging Het
Ubl4b T C 3: 107,462,143 (GRCm39) E39G possibly damaging Het
Uggt2 A T 14: 119,286,863 (GRCm39) F661I probably damaging Het
Usp54 A T 14: 20,611,320 (GRCm39) D1165E probably benign Het
Vmn2r81 C T 10: 79,129,281 (GRCm39) T724I possibly damaging Het
Vsig1 A G X: 139,837,062 (GRCm39) I247M possibly damaging Het
Zfp110 C A 7: 12,583,187 (GRCm39) L612I probably benign Het
Zfp318 C A 17: 46,724,222 (GRCm39) T2075K probably damaging Het
Zfp37 A G 4: 62,110,122 (GRCm39) M1T probably null Het
Zfp605 T A 5: 110,276,720 (GRCm39) C613S probably damaging Het
Zfp729a G A 13: 67,769,792 (GRCm39) P146S possibly damaging Het
Zfp85 T C 13: 67,896,791 (GRCm39) N427S probably benign Het
Other mutations in Upf3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01147:Upf3b APN X 36,360,586 (GRCm39) missense probably damaging 0.96
X0011:Upf3b UTSW X 36,363,312 (GRCm39) missense probably damaging 0.99
Predicted Primers
Posted On 2015-02-04