Incidental Mutation 'R0708:Glra3'
ID 262022
Institutional Source Beutler Lab
Gene Symbol Glra3
Ensembl Gene ENSMUSG00000038257
Gene Name glycine receptor, alpha 3 subunit
Synonyms
MMRRC Submission 038891-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0708 (G1)
Quality Score 125
Status Not validated
Chromosome 8
Chromosomal Location 56393495-56583105 bp(+) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) C to T at 56578399 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000000275 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000275] [ENSMUST00000000275]
AlphaFold Q91XP5
Predicted Effect probably benign
Transcript: ENSMUST00000000275
SMART Domains Protein: ENSMUSP00000000275
Gene: ENSMUSG00000038257

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
Pfam:Neur_chan_LBD 59 269 3.7e-55 PFAM
Pfam:Neur_chan_memb 276 434 1.4e-35 PFAM
PDB:2M6I|E 437 474 1e-12 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000000275
SMART Domains Protein: ENSMUSP00000000275
Gene: ENSMUSG00000038257

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
Pfam:Neur_chan_LBD 59 269 3.7e-55 PFAM
Pfam:Neur_chan_memb 276 434 1.4e-35 PFAM
PDB:2M6I|E 437 474 1e-12 PDB
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the glycine receptor subfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
PHENOTYPE: Homozygous null mice are fertile and display decreased inflammatory pain sensitization without any gross abnormalities in the brain or spinal cord. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Brdt A T 5: 107,506,766 (GRCm39) K450* probably null Het
Cand2 G A 6: 115,780,766 (GRCm39) E1217K probably damaging Het
Col9a1 A T 1: 24,276,342 (GRCm39) Q750L possibly damaging Het
Dnah6 A T 6: 73,189,605 (GRCm39) S14R probably benign Het
Enox1 A G 14: 77,830,352 (GRCm39) N319S probably benign Het
Frs2 G A 10: 116,909,997 (GRCm39) T455M probably damaging Het
Gmppa T C 1: 75,419,218 (GRCm39) F375S probably damaging Het
Hectd4 G A 5: 121,424,526 (GRCm39) probably null Het
Hgf C A 5: 16,771,761 (GRCm39) C129* probably null Het
Insc T A 7: 114,444,381 (GRCm39) V456E probably damaging Het
Ints14 G A 9: 64,891,266 (GRCm39) V416I probably benign Het
Klk1b11 T C 7: 43,647,152 (GRCm39) F29L possibly damaging Het
Ogfod1 C T 8: 94,765,673 (GRCm39) L79F possibly damaging Het
Or8d2b T A 9: 38,788,571 (GRCm39) V33E probably damaging Het
Orc3 A T 4: 34,597,368 (GRCm39) I224N probably damaging Het
Papss2 T C 19: 32,614,616 (GRCm39) F111L probably damaging Het
Poc1b A G 10: 98,990,992 (GRCm39) D291G probably null Het
Prl8a8 A T 13: 27,695,528 (GRCm39) M72K possibly damaging Het
Ptpn7 C A 1: 135,062,285 (GRCm39) T77K probably damaging Het
Ptpro T C 6: 137,363,251 (GRCm39) S462P probably benign Het
Rab3gap2 T A 1: 184,982,123 (GRCm39) S392T probably damaging Het
Sema4d A G 13: 51,866,755 (GRCm39) V245A probably benign Het
Sgcb A T 5: 73,798,225 (GRCm39) probably null Het
Slc24a1 T A 9: 64,855,172 (GRCm39) K578N unknown Het
Sptbn1 A T 11: 30,064,739 (GRCm39) V1920E probably damaging Het
Tecr A T 8: 84,299,738 (GRCm39) I101N probably damaging Het
Tectb T C 19: 55,179,984 (GRCm39) F277L probably benign Het
Tgs1 T A 4: 3,586,152 (GRCm39) L343H probably benign Het
Thbs4 C A 13: 92,909,694 (GRCm39) G368W probably damaging Het
Zfp558 T C 9: 18,368,123 (GRCm39) S222G possibly damaging Het
Other mutations in Glra3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00835:Glra3 APN 8 56,394,012 (GRCm39) splice site probably benign
IGL01301:Glra3 APN 8 56,393,997 (GRCm39) missense probably benign 0.00
IGL01772:Glra3 APN 8 56,542,090 (GRCm39) missense probably benign 0.22
IGL02280:Glra3 APN 8 56,394,006 (GRCm39) missense possibly damaging 0.67
IGL02386:Glra3 APN 8 56,542,063 (GRCm39) missense probably benign 0.12
IGL02508:Glra3 APN 8 56,538,179 (GRCm39) missense probably benign 0.10
IGL03094:Glra3 APN 8 56,578,207 (GRCm39) missense probably benign
ANU18:Glra3 UTSW 8 56,393,997 (GRCm39) missense probably benign 0.00
R0532:Glra3 UTSW 8 56,578,111 (GRCm39) missense probably benign
R0710:Glra3 UTSW 8 56,578,399 (GRCm39) utr 3 prime probably benign
R0927:Glra3 UTSW 8 56,578,239 (GRCm39) missense possibly damaging 0.65
R1125:Glra3 UTSW 8 56,492,789 (GRCm39) missense possibly damaging 0.69
R1138:Glra3 UTSW 8 56,542,011 (GRCm39) splice site probably null
R1717:Glra3 UTSW 8 56,393,942 (GRCm39) missense probably benign 0.07
R1718:Glra3 UTSW 8 56,393,942 (GRCm39) missense probably benign 0.07
R1848:Glra3 UTSW 8 56,393,942 (GRCm39) missense probably benign 0.07
R1933:Glra3 UTSW 8 56,393,942 (GRCm39) missense probably benign 0.07
R1934:Glra3 UTSW 8 56,393,942 (GRCm39) missense probably benign 0.07
R2042:Glra3 UTSW 8 56,515,494 (GRCm39) missense probably benign 0.36
R2571:Glra3 UTSW 8 56,563,516 (GRCm39) missense probably benign 0.41
R3123:Glra3 UTSW 8 56,578,244 (GRCm39) missense possibly damaging 0.94
R3124:Glra3 UTSW 8 56,578,244 (GRCm39) missense possibly damaging 0.94
R4585:Glra3 UTSW 8 56,542,028 (GRCm39) missense probably damaging 1.00
R4593:Glra3 UTSW 8 56,393,916 (GRCm39) missense probably damaging 1.00
R4981:Glra3 UTSW 8 56,444,270 (GRCm39) missense possibly damaging 0.69
R5277:Glra3 UTSW 8 56,444,242 (GRCm39) missense possibly damaging 0.79
R5356:Glra3 UTSW 8 56,393,936 (GRCm39) missense probably benign 0.00
R6214:Glra3 UTSW 8 56,444,291 (GRCm39) splice site probably null
R6941:Glra3 UTSW 8 56,393,961 (GRCm39) missense probably benign 0.00
R7976:Glra3 UTSW 8 56,565,911 (GRCm39) critical splice donor site probably null
R8354:Glra3 UTSW 8 56,578,345 (GRCm39) nonsense probably null
R8401:Glra3 UTSW 8 56,542,124 (GRCm39) missense probably damaging 1.00
R8909:Glra3 UTSW 8 56,444,159 (GRCm39) critical splice acceptor site probably null
R9399:Glra3 UTSW 8 56,542,079 (GRCm39) missense probably damaging 0.99
R9515:Glra3 UTSW 8 56,578,299 (GRCm39) missense probably damaging 1.00
R9598:Glra3 UTSW 8 56,393,718 (GRCm39) start gained probably benign
R9731:Glra3 UTSW 8 56,542,058 (GRCm39) missense probably damaging 1.00
R9801:Glra3 UTSW 8 56,563,563 (GRCm39) missense probably damaging 1.00
Z1176:Glra3 UTSW 8 56,515,535 (GRCm39) missense probably benign 0.12
Predicted Primers
Posted On 2015-02-04