Mutagenetix > Incidental Mutation

Incidental Mutation 'T0975:Zmym1'

262145

Institutional Source

Beutler Lab

Gene Symbol

Zmym1

Ensembl Gene

ENSMUSG00000043872

Gene Name

zinc finger, MYM domain containing 1

Synonyms

5830412B09Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.194) question?

Stock #

T0975 (G3) of strain 714

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

126940887-126954945 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 126941740 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Asparagine at position 785 (D785N)

Ref Sequence

ENSEMBL: ENSMUSP00000101705 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055013] [ENSMUST00000106099] [ENSMUST00000106102]

AlphaFold

Q3TJB1

Predicted Effect

probably benign
Transcript: ENSMUST00000055013
AA Change: D883N

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000050669
Gene: ENSMUSG00000043872
AA Change: D883N

Domain	Start	End	E-Value	Type
Pfam:zf-FCS	6	46	2.4e-8	PFAM
Pfam:zf-FCS	53	96	1.6e-10	PFAM
low complexity region	155	168	N/A	INTRINSIC
low complexity region	229	243	N/A	INTRINSIC
Pfam:DUF4371	335	569	4.9e-55	PFAM
Pfam:Dimer_Tnp_hAT	870	959	5.1e-18	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000106099
AA Change: D785N

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000101705
Gene: ENSMUSG00000043872
AA Change: D785N

Domain	Start	End	E-Value	Type
Pfam:zf-FCS	6	46	3.3e-9	PFAM
Pfam:zf-FCS	53	96	4.6e-10	PFAM
low complexity region	155	168	N/A	INTRINSIC
Pfam:DUF4371	237	471	2.8e-52	PFAM
Pfam:Dimer_Tnp_hAT	772	861	5.3e-18	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000106102
AA Change: D883N

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000101708
Gene: ENSMUSG00000043872
AA Change: D883N

Domain	Start	End	E-Value	Type
Pfam:zf-FCS	6	46	7.8e-9	PFAM
Pfam:zf-FCS	53	96	1.1e-9	PFAM
low complexity region	155	168	N/A	INTRINSIC
low complexity region	229	243	N/A	INTRINSIC
Pfam:DUF4371	335	569	7.4e-52	PFAM
Pfam:Dimer_Tnp_hAT	870	959	1.7e-17	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000117934

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124429

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137236

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000152607

Coding Region Coverage

1x: 99.4%
3x: 98.7%
10x: 97.0%
20x: 93.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930556J24Rik	TAA	TAAA	11: 3,887,945 (GRCm39)		probably null	Het
4930556J24Rik	C	T	11: 3,926,324 (GRCm39)	A27T	unknown	Het
Ago3	C	T	4: 126,298,056 (GRCm39)	V155I	probably benign	Het
Ago3	G	A	4: 126,298,103 (GRCm39)	A139V	probably benign	Het
Ago3	C	T	4: 126,298,098 (GRCm39)	A141T	probably benign	Het
Ahdc1	ACCTCCT	ACCTCCTCCT	4: 132,790,065 (GRCm39)		probably benign	Het
Azin2	A	G	4: 128,839,927 (GRCm39)	Y222H	probably benign	Het
Bpifb5	C	A	2: 154,071,384 (GRCm39)		probably null	Het
Castor1	G	C	11: 4,170,445 (GRCm39)	G147A	probably benign	Het
Ccdc157	C	T	11: 4,096,246 (GRCm39)	A455T	probably damaging	Het
Ccng1	A	C	11: 40,644,871 (GRCm39)	S9A	probably benign	Het
Cfh	T	C	1: 140,082,336 (GRCm39)	T164A	probably benign	Het
Cherp	TTGGACCTGGACCTGGACCTGGACCTGGA	TTGGACCTGGACCTGGACCTGGA	8: 73,215,878 (GRCm39)		probably benign	Het
Chrng	T	C	1: 87,138,348 (GRCm39)	S380P	probably benign	Het
Clspn	ACGGCGGCGGCGGCG	ACGGCGGCGGCGGCGGCGGCG	4: 126,460,230 (GRCm39)		probably benign	Het
Ctrc	T	TA	4: 141,572,507 (GRCm39)		probably null	Het
Cxxc1	C	T	18: 74,353,992 (GRCm39)	R593C	probably damaging	Het
Dlgap1	T	C	17: 70,823,950 (GRCm39)	S312P	possibly damaging	Het
Dnah10	A	G	5: 124,840,130 (GRCm39)	S1255G	probably benign	Het
Dpep1	A	T	8: 123,927,727 (GRCm39)	S388C	probably damaging	Het
Emid1	T	C	11: 5,094,386 (GRCm39)	T42A	probably damaging	Het
Emid1	A	C	11: 5,078,884 (GRCm39)	L353V	probably benign	Het
Epn3	A	G	11: 94,382,733 (GRCm39)		probably null	Het
Fam124b	T	C	1: 80,190,843 (GRCm39)	E180G	probably benign	Het
Fam135b	T	G	15: 71,335,734 (GRCm39)	T487P	probably damaging	Het
Gja4	G	C	4: 127,206,024 (GRCm39)	H246Q	probably benign	Het
Gm9972	GA	GAA	11: 42,927,597 (GRCm39)		probably null	Het
Hmmr	G	C	11: 40,614,243 (GRCm39)	N148K	probably damaging	Het
Homez	C	T	14: 55,094,796 (GRCm39)	R304K	possibly damaging	Het
Ifngr1	G	A	10: 19,485,221 (GRCm39)	V407M	probably damaging	Het
Inpp5j	G	T	11: 3,452,527 (GRCm39)	T241N	possibly damaging	Het
Kif12	GGGGC	GGGGCCTCCACCCGGCGGGC	4: 63,089,660 (GRCm39)		probably benign	Het
Kremen1	C	T	11: 5,145,105 (GRCm39)	A424T	probably benign	Het
Mat2b	G	A	11: 40,570,918 (GRCm39)	T302I	probably benign	Het
Mtmr3	C	T	11: 4,438,441 (GRCm39)	R671K	probably benign	Het
Nacad	A	G	11: 6,551,632 (GRCm39)	C520R	probably benign	Het
Nacad	GCAGGGTCAGGGTC	GCAGGGTCAGGGTCAGGGTC	11: 6,549,750 (GRCm39)		probably benign	Het
Nacad	T	C	11: 6,551,622 (GRCm39)	N523S	probably benign	Het
Nefh	G	A	11: 4,890,151 (GRCm39)	P823S	probably benign	Het
Nfrkb	G	C	9: 31,308,379 (GRCm39)	A230P	probably benign	Het
Nlrp4a	A	G	7: 26,149,062 (GRCm39)	E223G	probably damaging	Het
Notch3	T	A	17: 32,365,391 (GRCm39)	Y1107F	probably damaging	Het
Or10ak9	G	T	4: 118,726,500 (GRCm39)	R174M	probably benign	Het
Or13g1	A	T	7: 85,955,492 (GRCm39)	Y276*	probably null	Het
Or6c35	A	G	10: 129,169,314 (GRCm39)	D188G	probably benign	Het
Osm	A	G	11: 4,189,588 (GRCm39)	D124G	probably benign	Het
Plekhm2	TTCCTCCTCCT	TTCCTCCT	4: 141,359,292 (GRCm39)		probably benign	Het
Pomgnt1	C	T	4: 115,994,624 (GRCm39)		probably benign	Het
Spen	A	G	4: 141,201,664 (GRCm39)	V2321A	probably benign	Het
Sytl1	TCTGC	TC	4: 132,984,305 (GRCm39)		probably benign	Het
Tcn2	G	C	11: 3,873,487 (GRCm39)	F286L	possibly damaging	Het
Tg	T	C	15: 66,560,712 (GRCm39)	S10P	probably benign	Het
Tmprss7	C	T	16: 45,501,096 (GRCm39)	R235Q	probably benign	Het
Tns3	G	A	11: 8,499,100 (GRCm39)		probably benign	Het
Tns3	G	T	11: 8,401,146 (GRCm39)	L1051M	probably benign	Het
Tns3	T	G	11: 8,429,518 (GRCm39)	E806A	probably benign	Het
Toe1	T	C	4: 116,663,290 (GRCm39)	I62M	probably benign	Het
Txnrd2	A	G	16: 18,294,315 (GRCm39)	H436R	probably damaging	Het
Ubr4	C	T	4: 139,179,092 (GRCm39)	P2001S	probably damaging	Het
Vmn2r23	T	A	6: 123,690,120 (GRCm39)	M332K	probably benign	Het
Zbtb8a	GG	GGATG	4: 129,253,812 (GRCm39)		probably benign	Het
Zbtb8a	T	C	4: 129,254,005 (GRCm39)	H163R	probably benign	Het
Zfyve21	A	G	12: 111,794,067 (GRCm39)	D206G	probably damaging	Het
Zkscan4	AGAGGAG	AGAG	13: 21,663,370 (GRCm39)		probably benign	Het
Zpld2	GTG	GTGCTG	4: 133,929,940 (GRCm39)		probably benign	Het

Other mutations in Zmym1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01140:Zmym1	APN	4	126,943,435 (GRCm39)	missense	probably damaging	1.00
IGL02326:Zmym1	APN	4	126,941,553 (GRCm39)	missense	probably damaging	1.00
IGL02392:Zmym1	APN	4	126,942,256 (GRCm39)	missense	probably damaging	1.00
IGL02431:Zmym1	APN	4	126,941,557 (GRCm39)	nonsense	probably null
IGL02512:Zmym1	APN	4	126,942,465 (GRCm39)	missense	probably damaging	1.00
IGL03303:Zmym1	APN	4	126,942,927 (GRCm39)	missense	probably damaging	1.00
BB009:Zmym1	UTSW	4	126,944,578 (GRCm39)	missense	possibly damaging	0.77
BB019:Zmym1	UTSW	4	126,944,578 (GRCm39)	missense	possibly damaging	0.77
R0195:Zmym1	UTSW	4	126,941,704 (GRCm39)	missense	possibly damaging	0.85
R0266:Zmym1	UTSW	4	126,941,818 (GRCm39)	missense	possibly damaging	0.86
R0416:Zmym1	UTSW	4	126,952,613 (GRCm39)	missense	probably benign	0.00
R1374:Zmym1	UTSW	4	126,943,404 (GRCm39)	missense	probably damaging	1.00
R1480:Zmym1	UTSW	4	126,942,405 (GRCm39)	missense	probably damaging	0.99
R1704:Zmym1	UTSW	4	126,942,177 (GRCm39)	missense	probably damaging	1.00
R1806:Zmym1	UTSW	4	126,941,872 (GRCm39)	missense	probably damaging	1.00
R1815:Zmym1	UTSW	4	126,942,814 (GRCm39)	missense	possibly damaging	0.76
R2124:Zmym1	UTSW	4	126,943,363 (GRCm39)	missense	probably benign	0.05
R2169:Zmym1	UTSW	4	126,947,996 (GRCm39)	splice site	probably null
R4027:Zmym1	UTSW	4	126,943,672 (GRCm39)	missense	probably benign	0.08
R4410:Zmym1	UTSW	4	126,941,897 (GRCm39)	nonsense	probably null
R4572:Zmym1	UTSW	4	126,944,628 (GRCm39)	missense	probably benign	0.39
R4788:Zmym1	UTSW	4	126,948,090 (GRCm39)	missense	probably benign	0.10
R5120:Zmym1	UTSW	4	126,945,230 (GRCm39)	splice site	probably null
R5130:Zmym1	UTSW	4	126,942,451 (GRCm39)	missense	probably damaging	1.00
R5615:Zmym1	UTSW	4	126,943,191 (GRCm39)	missense	probably damaging	1.00
R6190:Zmym1	UTSW	4	126,941,677 (GRCm39)	missense	probably damaging	0.99
R7426:Zmym1	UTSW	4	126,943,191 (GRCm39)	missense	possibly damaging	0.81
R7464:Zmym1	UTSW	4	126,952,728 (GRCm39)	nonsense	probably null
R7540:Zmym1	UTSW	4	126,942,550 (GRCm39)	missense	probably benign
R7779:Zmym1	UTSW	4	126,948,038 (GRCm39)	missense	probably benign
R7807:Zmym1	UTSW	4	126,941,667 (GRCm39)	missense	probably damaging	1.00
R7876:Zmym1	UTSW	4	126,941,496 (GRCm39)	missense	probably damaging	0.98
R7932:Zmym1	UTSW	4	126,944,578 (GRCm39)	missense	possibly damaging	0.77
R8183:Zmym1	UTSW	4	126,952,649 (GRCm39)	missense	probably benign	0.07
R8276:Zmym1	UTSW	4	126,948,051 (GRCm39)	missense	probably damaging	0.99
R8744:Zmym1	UTSW	4	126,945,165 (GRCm39)	missense	probably damaging	1.00
R8798:Zmym1	UTSW	4	126,943,664 (GRCm39)	missense	possibly damaging	0.90
R9199:Zmym1	UTSW	4	126,944,623 (GRCm39)	missense	possibly damaging	0.80
R9385:Zmym1	UTSW	4	126,952,683 (GRCm39)	missense	probably damaging	1.00
T0722:Zmym1	UTSW	4	126,943,466 (GRCm39)	missense	probably benign	0.05
T0722:Zmym1	UTSW	4	126,942,043 (GRCm39)	missense	probably benign	0.01
T0722:Zmym1	UTSW	4	126,941,740 (GRCm39)	missense	probably benign	0.00
T0975:Zmym1	UTSW	4	126,943,466 (GRCm39)	missense	probably benign	0.05
T0975:Zmym1	UTSW	4	126,942,043 (GRCm39)	missense	probably benign	0.01

Predicted Primers

Posted On

2015-02-04