Mutagenetix > Incidental Mutation

Incidental Mutation 'R1213:Moxd2'

262442

Institutional Source

Beutler Lab

Gene Symbol

Moxd2

Ensembl Gene

ENSMUSG00000029885

Gene Name

monooxygenase, DBH-like 2

Synonyms

Dbhl1

MMRRC Submission

039282-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

R1213 (G1)

Quality Score

196

Status

Not validated

Chromosome

Chromosomal Location

40855728-40864428 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to G at 40868831 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000100078 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031937] [ENSMUST00000063523] [ENSMUST00000103262]

AlphaFold

Q7TT41

Predicted Effect

probably benign
Transcript: ENSMUST00000031937

SMART Domains

Protein: ENSMUSP00000031937
Gene: ENSMUSG00000029885

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
DoH	66	156	1.43e-12	SMART
Pfam:Cu2_monooxygen	192	316	8.3e-39	PFAM
Pfam:Cu2_monoox_C	336	493	1.8e-37	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000063523

SMART Domains

Protein: ENSMUSP00000069833
Gene: ENSMUSG00000051936

Domain	Start	End	E-Value	Type
Tryp_SPc	22	234	4.49e-36	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000103262

SMART Domains

Protein: ENSMUSP00000100078
Gene: ENSMUSG00000076461

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:V-set	22	116	8.4e-10	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000192446

Coding Region Coverage

1x: 99.4%
3x: 98.3%
10x: 95.2%
20x: 87.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agfg1	T	C	1: 82,853,055 (GRCm39)	S142P	probably damaging	Het
Appl1	G	A	14: 26,665,950 (GRCm39)	A388V	probably benign	Het
Atp11a	A	G	8: 12,892,859 (GRCm39)	R70G	probably benign	Het
Atrnl1	G	A	19: 57,626,894 (GRCm39)	V167I	probably benign	Het
Bfar	T	C	16: 13,505,308 (GRCm39)	I106T	possibly damaging	Het
Cbx8	T	C	11: 118,930,359 (GRCm39)		probably null	Het
Cd80	T	C	16: 38,294,245 (GRCm39)	S43P	probably damaging	Het
Fat4	G	A	3: 38,944,520 (GRCm39)	A1138T	probably benign	Het
Fcgbpl1	T	C	7: 27,857,098 (GRCm39)	S2149P	probably damaging	Het
Fmo3	C	A	1: 162,795,392 (GRCm39)	G148W	probably damaging	Het
Ftdc2	A	T	16: 58,458,057 (GRCm39)	Y81*	probably null	Het
Krt78	T	C	15: 101,860,245 (GRCm39)	M224V	probably benign	Het
Or13n4	T	A	7: 106,423,404 (GRCm39)	T110S	possibly damaging	Het
Or2y14	T	A	11: 49,405,421 (GRCm39)	*319K	probably null	Het
Or6d15	A	G	6: 116,559,827 (GRCm39)	S27P	probably benign	Het
Pax6	G	A	2: 105,516,258 (GRCm39)	G179R	probably benign	Het
Rbm12	G	A	2: 155,939,412 (GRCm39)	Q287*	probably null	Het
Rtel1	T	A	2: 180,993,128 (GRCm39)	H703Q	probably benign	Het
Spag17	A	G	3: 100,002,954 (GRCm39)	R1893G	probably benign	Het
Synpo	A	G	18: 60,735,525 (GRCm39)	V807A	possibly damaging	Het

Other mutations in Moxd2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00885:Moxd2	APN	6	40,861,113 (GRCm39)	splice site	probably benign
IGL02113:Moxd2	APN	6	40,862,338 (GRCm39)	missense	probably benign	0.06
IGL02223:Moxd2	APN	6	40,861,967 (GRCm39)	missense	probably damaging	1.00
IGL03204:Moxd2	APN	6	40,864,239 (GRCm39)	missense	probably benign	0.04
IGL03385:Moxd2	APN	6	40,855,952 (GRCm39)	missense	probably damaging	1.00
R0084:Moxd2	UTSW	6	40,856,342 (GRCm39)	missense	probably null	0.01
R1326:Moxd2	UTSW	6	40,857,288 (GRCm39)	missense	probably benign	0.00
R1652:Moxd2	UTSW	6	40,864,337 (GRCm39)	missense	probably damaging	1.00
R1940:Moxd2	UTSW	6	40,860,466 (GRCm39)	missense	probably damaging	1.00
R2040:Moxd2	UTSW	6	40,861,887 (GRCm39)	splice site	probably null
R2088:Moxd2	UTSW	6	40,861,901 (GRCm39)	missense	probably damaging	1.00
R3018:Moxd2	UTSW	6	40,855,820 (GRCm39)	missense	probably benign	0.01
R3962:Moxd2	UTSW	6	40,862,331 (GRCm39)	missense	probably benign
R4248:Moxd2	UTSW	6	40,855,933 (GRCm39)	missense	probably damaging	1.00
R4438:Moxd2	UTSW	6	40,860,996 (GRCm39)	missense	probably damaging	1.00
R4715:Moxd2	UTSW	6	40,864,181 (GRCm39)	missense	probably damaging	1.00
R4732:Moxd2	UTSW	6	40,855,793 (GRCm39)	missense	probably benign
R4733:Moxd2	UTSW	6	40,855,793 (GRCm39)	missense	probably benign
R4760:Moxd2	UTSW	6	40,868,537 (GRCm39)	missense	probably benign	0.06
R4851:Moxd2	UTSW	6	40,855,756 (GRCm39)	missense	probably damaging	1.00
R5087:Moxd2	UTSW	6	40,856,270 (GRCm39)	missense	probably damaging	1.00
R5187:Moxd2	UTSW	6	40,856,271 (GRCm39)	missense	probably benign	0.18
R5339:Moxd2	UTSW	6	40,862,354 (GRCm39)	missense	probably damaging	1.00
R5452:Moxd2	UTSW	6	40,859,048 (GRCm39)	splice site	probably null
R5860:Moxd2	UTSW	6	40,857,341 (GRCm39)	missense	probably damaging	1.00
R5973:Moxd2	UTSW	6	40,855,744 (GRCm39)	missense	probably damaging	0.96
R6015:Moxd2	UTSW	6	40,860,688 (GRCm39)	missense	probably damaging	1.00
R6316:Moxd2	UTSW	6	40,860,481 (GRCm39)	missense	probably damaging	1.00
R7500:Moxd2	UTSW	6	40,868,746 (GRCm39)	missense	probably benign
R7561:Moxd2	UTSW	6	40,864,337 (GRCm39)	missense	probably damaging	1.00
R7840:Moxd2	UTSW	6	40,862,378 (GRCm39)	missense	possibly damaging	0.95
R8042:Moxd2	UTSW	6	40,862,301 (GRCm39)	missense	probably benign	0.40
R9147:Moxd2	UTSW	6	40,860,978 (GRCm39)	missense	probably damaging	1.00
R9148:Moxd2	UTSW	6	40,860,978 (GRCm39)	missense	probably damaging	1.00
R9169:Moxd2	UTSW	6	40,860,490 (GRCm39)	missense	possibly damaging	0.94
R9259:Moxd2	UTSW	6	40,860,969 (GRCm39)	missense	probably damaging	1.00
R9291:Moxd2	UTSW	6	40,857,362 (GRCm39)	missense	probably damaging	1.00
R9448:Moxd2	UTSW	6	40,864,160 (GRCm39)	missense	probably benign	0.01
R9522:Moxd2	UTSW	6	40,857,375 (GRCm39)	missense	probably benign	0.13
R9635:Moxd2	UTSW	6	40,863,000 (GRCm39)	missense	possibly damaging	0.93
X0052:Moxd2	UTSW	6	40,859,462 (GRCm39)	missense	probably benign

Predicted Primers

Posted On

2015-02-04