Mutagenetix > Incidental Mutation

Incidental Mutation 'ANU74:Vmn2r14'

262693

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r14

Ensembl Gene

ENSMUSG00000091059

Gene Name

vomeronasal 2, receptor 14

Synonyms

EG231591

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.469) question?

Stock #

ANU74

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

109362822-109372488 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 109366910 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 437 (S437T)

Ref Sequence

ENSEMBL: ENSMUSP00000128015 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170341]

AlphaFold

E9Q759

Predicted Effect

probably benign
Transcript: ENSMUST00000170341
AA Change: S437T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000128015
Gene: ENSMUSG00000091059
AA Change: S437T

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:ANF_receptor	76	466	8.3e-31	PFAM
Pfam:NCD3G	507	561	1.1e-17	PFAM
Pfam:7tm_3	594	829	1.2e-55	PFAM

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.2%
20x: 95.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgra3	G	A	5: 50,118,380 (GRCm39)	S1056L	probably benign	Het
Ankrd26	A	T	6: 118,529,736 (GRCm39)	D236E	probably benign	Het
Capn15	C	T	17: 26,184,460 (GRCm39)	W7*	probably null	Het
Celsr2	G	A	3: 108,319,815 (GRCm39)	T999M	probably damaging	Het
Chrd	T	A	16: 20,560,069 (GRCm39)	M912K	possibly damaging	Het
Col9a1	A	G	1: 24,224,409 (GRCm39)	D197G	unknown	Het
Csf1r	A	G	18: 61,250,463 (GRCm39)	E431G	probably benign	Het
Eloc	A	G	1: 16,713,574 (GRCm39)	F115L	possibly damaging	Het
Fap	T	C	2: 62,378,113 (GRCm39)	D193G	probably damaging	Het
Fscn2	T	C	11: 120,253,162 (GRCm39)	Y210H	probably damaging	Het
Fut9	G	C	4: 25,620,802 (GRCm39)	T4R	probably benign	Het
Grb2	A	T	11: 115,536,733 (GRCm39)	D131E	probably benign	Het
Hecw2	T	C	1: 53,964,853 (GRCm39)	T658A	probably benign	Het
Helz2	T	C	2: 180,876,627 (GRCm39)	E1289G	probably benign	Het
Hyou1	A	G	9: 44,292,560 (GRCm39)	N92D	possibly damaging	Het
Irf8	A	C	8: 121,466,608 (GRCm39)	I18L	possibly damaging	Het
Kif12	GGGGC	GGGGCCTCCACCCGGCGGGC	4: 63,089,660 (GRCm39)		probably benign	Het
Kif12	GC	"GCCTCCACCCGGCGGTC,GCC"	4: 63,089,663 (GRCm39)		probably null	Het
Lamc2	A	C	1: 153,007,581 (GRCm39)	D864E	probably benign	Het
Map3k4	A	G	17: 12,451,863 (GRCm39)	V1475A	probably damaging	Het
Mapk8ip3	A	C	17: 25,119,551 (GRCm39)	M1030R	possibly damaging	Het
Mat1a	A	G	14: 40,833,099 (GRCm39)	D94G	probably benign	Het
Myh15	T	A	16: 48,993,295 (GRCm39)	D1643E	possibly damaging	Het
Myo15b	T	C	11: 115,769,239 (GRCm39)	F55L	probably damaging	Het
Nhlh2	A	T	3: 101,919,970 (GRCm39)	M1L	probably benign	Het
Nup214	T	C	2: 31,924,978 (GRCm39)	S1836P	probably damaging	Het
Olr1	G	A	6: 129,477,032 (GRCm39)	R78C	possibly damaging	Het
Or5m9	T	A	2: 85,877,655 (GRCm39)	Y276*	probably null	Het
Pam16	C	A	16: 4,434,497 (GRCm39)	V98F	probably damaging	Het
Pelp1	C	T	11: 70,285,913 (GRCm39)	V652I	probably damaging	Het
Pole	A	G	5: 110,437,236 (GRCm39)	H67R	probably benign	Het
Rbms1	G	T	2: 60,628,060 (GRCm39)	A60E	probably damaging	Het
Recql4	A	T	15: 76,589,957 (GRCm39)	M789K	possibly damaging	Het
Rrn3	T	C	16: 13,629,397 (GRCm39)	F571S	possibly damaging	Het
Ryr3	T	C	2: 112,661,575 (GRCm39)		probably null	Het
Sec61b	C	A	4: 47,474,922 (GRCm39)	N26K	possibly damaging	Het
Serinc1	T	C	10: 57,395,938 (GRCm39)	E284G	probably benign	Het
Slc30a9	G	A	5: 67,507,195 (GRCm39)	D496N	probably damaging	Het
Slc44a4	G	A	17: 35,140,554 (GRCm39)	R249H	probably damaging	Het
Slc6a13	A	C	6: 121,311,835 (GRCm39)	D404A	probably benign	Het
Spata18	A	G	5: 73,828,456 (GRCm39)	E225G	probably damaging	Het
Sspo	G	A	6: 48,437,893 (GRCm39)	G1351S	probably damaging	Het
Tgm3	T	C	2: 129,890,310 (GRCm39)	V691A	probably damaging	Het
Tns3	C	T	11: 8,442,149 (GRCm39)	R738Q	probably benign	Het
Tyk2	A	T	9: 21,027,454 (GRCm39)	I506N	probably damaging	Het
Ube2v1	G	A	2: 167,452,264 (GRCm39)	T113I	probably damaging	Het
Vmn1r177	A	G	7: 23,565,645 (GRCm39)	V77A	possibly damaging	Het
Vmn2r78	G	C	7: 86,570,273 (GRCm39)	V264L	possibly damaging	Het
Zfp956	T	G	6: 47,940,507 (GRCm39)	Y289D	probably benign	Het

Other mutations in Vmn2r14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01472:Vmn2r14	APN	5	109,364,180 (GRCm39)	nonsense	probably null
IGL01504:Vmn2r14	APN	5	109,369,285 (GRCm39)	missense	probably benign	0.01
IGL01828:Vmn2r14	APN	5	109,372,443 (GRCm39)	missense	possibly damaging	0.71
IGL02093:Vmn2r14	APN	5	109,368,275 (GRCm39)	missense	possibly damaging	0.94
IGL02103:Vmn2r14	APN	5	109,372,349 (GRCm39)	missense	probably damaging	0.96
IGL02123:Vmn2r14	APN	5	109,367,933 (GRCm39)	missense	probably damaging	1.00
IGL02145:Vmn2r14	APN	5	109,368,454 (GRCm39)	nonsense	probably null
IGL02676:Vmn2r14	APN	5	109,367,882 (GRCm39)	missense	probably benign	0.03
IGL02720:Vmn2r14	APN	5	109,369,305 (GRCm39)	missense	probably damaging	1.00
IGL02877:Vmn2r14	APN	5	109,368,054 (GRCm39)	missense	probably damaging	0.99
IGL02974:Vmn2r14	APN	5	109,369,292 (GRCm39)	missense	possibly damaging	0.55
IGL03151:Vmn2r14	APN	5	109,364,260 (GRCm39)	missense	probably damaging	1.00
IGL03297:Vmn2r14	APN	5	109,363,973 (GRCm39)	missense	probably damaging	1.00
IGL03386:Vmn2r14	APN	5	109,368,350 (GRCm39)	missense	possibly damaging	0.90
IGL03394:Vmn2r14	APN	5	109,367,702 (GRCm39)	missense	probably null	0.83
R0316:Vmn2r14	UTSW	5	109,366,762 (GRCm39)	missense	probably benign	0.07
R0755:Vmn2r14	UTSW	5	109,364,226 (GRCm39)	missense	possibly damaging	0.81
R1219:Vmn2r14	UTSW	5	109,372,440 (GRCm39)	missense	probably benign	0.17
R1321:Vmn2r14	UTSW	5	109,364,117 (GRCm39)	missense	probably benign	0.08
R1465:Vmn2r14	UTSW	5	109,368,195 (GRCm39)	missense	possibly damaging	0.47
R1465:Vmn2r14	UTSW	5	109,368,195 (GRCm39)	missense	possibly damaging	0.47
R1509:Vmn2r14	UTSW	5	109,363,862 (GRCm39)	missense	probably benign	0.00
R1551:Vmn2r14	UTSW	5	109,369,283 (GRCm39)	missense	probably damaging	1.00
R1628:Vmn2r14	UTSW	5	109,367,838 (GRCm39)	missense	probably benign	0.00
R1668:Vmn2r14	UTSW	5	109,366,913 (GRCm39)	nonsense	probably null
R2013:Vmn2r14	UTSW	5	109,369,109 (GRCm39)	missense	probably benign	0.00
R2201:Vmn2r14	UTSW	5	109,366,698 (GRCm39)	splice site	probably null
R2417:Vmn2r14	UTSW	5	109,372,329 (GRCm39)	missense	probably benign	0.00
R3029:Vmn2r14	UTSW	5	109,363,776 (GRCm39)	missense	probably damaging	1.00
R3120:Vmn2r14	UTSW	5	109,372,431 (GRCm39)	missense	probably null	0.00
R3729:Vmn2r14	UTSW	5	109,364,095 (GRCm39)	missense	probably damaging	1.00
R3762:Vmn2r14	UTSW	5	109,368,033 (GRCm39)	missense	probably benign	0.02
R3943:Vmn2r14	UTSW	5	109,363,930 (GRCm39)	missense	probably damaging	1.00
R3944:Vmn2r14	UTSW	5	109,363,930 (GRCm39)	missense	probably damaging	1.00
R4222:Vmn2r14	UTSW	5	109,364,149 (GRCm39)	missense	probably benign	0.00
R4224:Vmn2r14	UTSW	5	109,364,149 (GRCm39)	missense	probably benign	0.00
R4239:Vmn2r14	UTSW	5	109,364,277 (GRCm39)	critical splice acceptor site	probably null
R4240:Vmn2r14	UTSW	5	109,364,277 (GRCm39)	critical splice acceptor site	probably null
R4782:Vmn2r14	UTSW	5	109,369,370 (GRCm39)	missense	probably benign	0.01
R4832:Vmn2r14	UTSW	5	109,363,976 (GRCm39)	missense	probably damaging	1.00
R4884:Vmn2r14	UTSW	5	109,369,384 (GRCm39)	splice site	probably null
R4896:Vmn2r14	UTSW	5	109,368,246 (GRCm39)	missense	probably benign	0.19
R5004:Vmn2r14	UTSW	5	109,368,246 (GRCm39)	missense	probably benign	0.19
R5117:Vmn2r14	UTSW	5	109,363,961 (GRCm39)	missense	probably benign	0.16
R5285:Vmn2r14	UTSW	5	109,365,442 (GRCm39)	missense	probably damaging	0.98
R5413:Vmn2r14	UTSW	5	109,369,154 (GRCm39)	missense	probably benign	0.29
R5569:Vmn2r14	UTSW	5	109,368,261 (GRCm39)	missense	probably benign	0.44
R5701:Vmn2r14	UTSW	5	109,367,816 (GRCm39)	missense	probably damaging	1.00
R5726:Vmn2r14	UTSW	5	109,365,486 (GRCm39)	missense	possibly damaging	0.95
R5763:Vmn2r14	UTSW	5	109,363,724 (GRCm39)	missense	possibly damaging	0.49
R5872:Vmn2r14	UTSW	5	109,369,222 (GRCm39)	missense	probably benign
R5985:Vmn2r14	UTSW	5	109,368,082 (GRCm39)	missense	possibly damaging	0.89
R6268:Vmn2r14	UTSW	5	109,369,283 (GRCm39)	missense	possibly damaging	0.87
R6273:Vmn2r14	UTSW	5	109,369,133 (GRCm39)	missense	probably benign	0.44
R6409:Vmn2r14	UTSW	5	109,364,096 (GRCm39)	missense	probably benign	0.09
R6944:Vmn2r14	UTSW	5	109,364,140 (GRCm39)	missense	probably benign	0.06
R6944:Vmn2r14	UTSW	5	109,363,925 (GRCm39)	missense	probably benign	0.22
R7608:Vmn2r14	UTSW	5	109,369,276 (GRCm39)	missense	probably benign	0.03
R7740:Vmn2r14	UTSW	5	109,368,324 (GRCm39)	missense	probably benign	0.41
R7768:Vmn2r14	UTSW	5	109,368,086 (GRCm39)	missense	probably benign	0.01
R7804:Vmn2r14	UTSW	5	109,368,324 (GRCm39)	missense	probably benign	0.41
R7872:Vmn2r14	UTSW	5	109,369,219 (GRCm39)	missense	probably benign	0.02
R7993:Vmn2r14	UTSW	5	109,363,862 (GRCm39)	missense	probably benign	0.00
R8006:Vmn2r14	UTSW	5	109,368,324 (GRCm39)	missense	probably benign	0.41
R8007:Vmn2r14	UTSW	5	109,368,324 (GRCm39)	missense	probably benign	0.41
R8187:Vmn2r14	UTSW	5	109,368,420 (GRCm39)	missense	probably benign	0.03
R8369:Vmn2r14	UTSW	5	109,369,342 (GRCm39)	missense	probably damaging	1.00
R8463:Vmn2r14	UTSW	5	109,369,340 (GRCm39)	missense	probably benign	0.30
R8968:Vmn2r14	UTSW	5	109,365,533 (GRCm39)	missense	probably benign	0.01
R9008:Vmn2r14	UTSW	5	109,367,893 (GRCm39)	missense	probably benign	0.00
R9030:Vmn2r14	UTSW	5	109,368,054 (GRCm39)	missense	probably damaging	0.99
R9039:Vmn2r14	UTSW	5	109,367,902 (GRCm39)	nonsense	probably null
R9150:Vmn2r14	UTSW	5	109,367,783 (GRCm39)	missense	probably damaging	1.00
R9164:Vmn2r14	UTSW	5	109,364,087 (GRCm39)	missense	probably damaging	1.00
R9216:Vmn2r14	UTSW	5	109,369,112 (GRCm39)	missense	probably benign	0.01
R9225:Vmn2r14	UTSW	5	109,369,288 (GRCm39)	missense	probably damaging	1.00
R9245:Vmn2r14	UTSW	5	109,368,176 (GRCm39)	missense	possibly damaging	0.89
R9342:Vmn2r14	UTSW	5	109,368,428 (GRCm39)	missense	probably damaging	1.00
R9472:Vmn2r14	UTSW	5	109,367,962 (GRCm39)	missense	probably benign	0.00
R9678:Vmn2r14	UTSW	5	109,364,041 (GRCm39)	missense	probably damaging	1.00
R9774:Vmn2r14	UTSW	5	109,369,126 (GRCm39)	missense	probably benign	0.07
Z1177:Vmn2r14	UTSW	5	109,367,741 (GRCm39)	missense	probably benign	0.33

Predicted Primers

PCR Primer
(F):5'- ACTCACTGATGATCCTCCTGTGGC -3'
(R):5'- GAAAACCACGAATGATTGAGACTGCAC -3'

Sequencing Primer
(F):5'- GCCCAGTCCAAGTCTTCAG -3'
(R):5'- AAAGGTCCACAACCATTCTTTTC -3'

Posted On

2015-02-04