Incidental Mutation 'R1261:Dnajc9'
| ID |
262743 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dnajc9
|
| Ensembl Gene |
ENSMUSG00000021811 |
| Gene Name |
DnaJ heat shock protein family (Hsp40) member C9 |
| Synonyms |
5330419I01Rik |
| MMRRC Submission |
039328-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1261 (G1)
|
| Quality Score |
137 |
|
Status
|
Not validated
|
| Chromosome |
14 |
| Chromosomal Location |
20434706-20438978 bp(-) (GRCm39) |
| Type of Mutation |
splice site (607 bp from exon) |
| DNA Base Change (assembly) |
G to A
at 20438765 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000055619
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022345]
[ENSMUST00000061444]
|
| AlphaFold |
Q91WN1 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000022345
|
| SMART Domains |
Protein: ENSMUSP00000022345
Gene: ENSMUSG00000021811
| Domain | Start | End | E-Value | Type |
|---|
|
DnaJ
|
14 |
74 |
2.76e-16 |
SMART |
|
coiled coil region
|
176 |
212 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000061444
|
| SMART Domains |
Protein: ENSMUSP00000055619
Gene: ENSMUSG00000049960
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Ribosomal_S16
|
24 |
84 |
9.9e-25 |
PFAM |
|
low complexity region
|
107 |
135 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000223844
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000223889
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000223950
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000224286
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.2%
- 10x: 96.1%
- 20x: 92.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 19 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aak1 |
T |
C |
6: 86,912,470 (GRCm39) |
V114A |
probably benign |
Het |
| Arhgef38 |
T |
C |
3: 132,866,624 (GRCm39) |
E171G |
possibly damaging |
Het |
| Arsi |
A |
G |
18: 61,049,743 (GRCm39) |
T209A |
probably damaging |
Het |
| Bmp3 |
A |
T |
5: 99,027,785 (GRCm39) |
R468S |
probably damaging |
Het |
| Cenpk |
T |
A |
13: 104,367,293 (GRCm39) |
V43E |
possibly damaging |
Het |
| Chmp7 |
C |
T |
14: 69,956,899 (GRCm39) |
M336I |
probably benign |
Het |
| Cul9 |
G |
T |
17: 46,836,708 (GRCm39) |
L1106M |
probably damaging |
Het |
| Enpp3 |
A |
T |
10: 24,650,832 (GRCm39) |
V768E |
probably damaging |
Het |
| Klk1b5 |
T |
C |
7: 43,494,714 (GRCm39) |
S66P |
probably damaging |
Het |
| Lrriq1 |
T |
C |
10: 103,069,998 (GRCm39) |
D6G |
possibly damaging |
Het |
| Myh7b |
A |
G |
2: 155,463,003 (GRCm39) |
K453R |
probably benign |
Het |
| Nipsnap3b |
G |
T |
4: 53,015,166 (GRCm39) |
G71V |
probably damaging |
Het |
| Oas1h |
A |
G |
5: 121,009,930 (GRCm39) |
E335G |
probably benign |
Het |
| Or5g25 |
A |
C |
2: 85,478,143 (GRCm39) |
I174S |
probably damaging |
Het |
| Rfwd3 |
C |
T |
8: 112,014,874 (GRCm39) |
R326Q |
probably damaging |
Het |
| Slc10a1 |
T |
A |
12: 81,014,604 (GRCm39) |
M39L |
probably damaging |
Het |
| Tas1r2 |
G |
A |
4: 139,382,599 (GRCm39) |
R79Q |
probably damaging |
Het |
| Thoc2l |
A |
G |
5: 104,668,501 (GRCm39) |
T1008A |
probably damaging |
Het |
| Tmprss11d |
T |
C |
5: 86,457,239 (GRCm39) |
D140G |
possibly damaging |
Het |
|
| Other mutations in Dnajc9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00923:Dnajc9
|
APN |
14 |
20,435,515 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01631:Dnajc9
|
APN |
14 |
20,438,176 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1257:Dnajc9
|
UTSW |
14 |
20,438,765 (GRCm39) |
splice site |
probably null |
|
|
R1258:Dnajc9
|
UTSW |
14 |
20,438,765 (GRCm39) |
splice site |
probably null |
|
|
R1765:Dnajc9
|
UTSW |
14 |
20,438,158 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1835:Dnajc9
|
UTSW |
14 |
20,438,402 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7218:Dnajc9
|
UTSW |
14 |
20,438,507 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7570:Dnajc9
|
UTSW |
14 |
20,438,712 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7600:Dnajc9
|
UTSW |
14 |
20,438,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7960:Dnajc9
|
UTSW |
14 |
20,438,764 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9631:Dnajc9
|
UTSW |
14 |
20,438,670 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9722:Dnajc9
|
UTSW |
14 |
20,438,279 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
|
| Posted On |
2015-02-04 |
Incidental Mutation