Mutagenetix > Incidental Mutation

Incidental Mutation 'R1405:Prl3a1'

262770

Institutional Source

Beutler Lab

Gene Symbol

Prl3a1

Ensembl Gene

ENSMUSG00000038883

Gene Name

prolactin family 3, subfamily a, member 1

Synonyms

Prlpi, PLP-I, 1600016E11Rik, PLP-H, Plpi

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

R1405 (G1)

Quality Score

138

Status

Not validated

Chromosome

Chromosomal Location

27443472-27460669 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 27459051 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000046522 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049463]

AlphaFold

Q78Y73

Predicted Effect

probably null
Transcript: ENSMUST00000049463

SMART Domains

Protein: ENSMUSP00000046522
Gene: ENSMUSG00000038883

Domain	Start	End	E-Value	Type
Pfam:Hormone_1	16	227	2.3e-59	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223739

Coding Region Coverage

1x: 99.0%
3x: 96.7%
10x: 83.5%
20x: 53.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arap1	G	A	7: 101,047,643 (GRCm39)		probably null	Het
Asb8	G	A	15: 98,039,248 (GRCm39)	H51Y	possibly damaging	Het
Capn10	T	G	1: 92,872,744 (GRCm39)	V490G	probably benign	Het
Ccdc146	G	A	5: 21,604,730 (GRCm39)	S36L	probably benign	Het
Celsr1	C	T	15: 85,789,635 (GRCm39)		probably null	Het
Clvs2	C	A	10: 33,389,256 (GRCm39)	*328L	probably null	Het
Cul9	C	G	17: 46,833,101 (GRCm39)	A1326P	probably damaging	Het
Dstn	A	G	2: 143,780,356 (GRCm39)	K19E	probably damaging	Het
Ehmt2	T	A	17: 35,125,553 (GRCm39)	H134Q	probably benign	Het
Faah	G	A	4: 115,858,345 (GRCm39)	P411S	probably damaging	Het
Fn1	A	G	1: 71,681,237 (GRCm39)	F364L	probably damaging	Het
Gmnc	A	T	16: 26,779,196 (GRCm39)	N270K	possibly damaging	Het
Grip2	A	T	6: 91,765,133 (GRCm39)		probably null	Het
Hmg20a	A	T	9: 56,384,587 (GRCm39)	Q119L	possibly damaging	Het
Ipo7	T	C	7: 109,629,048 (GRCm39)	I106T	probably benign	Het
Ipo7	C	T	7: 109,638,456 (GRCm39)	P241L	probably damaging	Het
Katnb1	T	C	8: 95,824,801 (GRCm39)	Y574H	probably damaging	Het
Larp6	A	C	9: 60,644,849 (GRCm39)	M330L	probably benign	Het
Lrrc8e	T	C	8: 4,281,754 (GRCm39)	Y30H	probably damaging	Het
Nop56	T	C	2: 130,119,868 (GRCm39)	V420A	probably benign	Het
Nrg1	T	C	8: 32,407,855 (GRCm39)	D126G	probably benign	Het
Prdm1	T	A	10: 44,315,961 (GRCm39)	N725I	probably damaging	Het
Psmd2	T	C	16: 20,471,034 (GRCm39)	L59P	possibly damaging	Het
Ptgdr2	T	C	19: 10,918,395 (GRCm39)	V304A	probably benign	Het
Rasa3	A	G	8: 13,638,027 (GRCm39)	V339A	possibly damaging	Het
Sec24c	G	A	14: 20,742,593 (GRCm39)		probably null	Het
Serpinb9e	A	G	13: 33,444,009 (GRCm39)	D343G	probably benign	Het
Sfi1	TCGC	TC	11: 3,096,254 (GRCm39)		probably null	Het
Sfi1	CCTCTC	CCTCTCTC	11: 3,127,419 (GRCm39)		probably benign	Het
Stab1	A	C	14: 30,870,958 (GRCm39)	V1297G	probably benign	Het
Stk4	C	T	2: 163,942,448 (GRCm39)	T360M	probably benign	Het
Tmprss2	G	A	16: 97,398,005 (GRCm39)	T57I	probably benign	Het
Tnrc6a	A	G	7: 122,770,301 (GRCm39)	D697G	probably damaging	Het
Vwa5b2	T	A	16: 20,423,066 (GRCm39)	D1021E	probably benign	Het
Wdr46	C	A	17: 34,168,057 (GRCm39)	P543Q	probably damaging	Het
Zfp1005	T	A	2: 150,109,620 (GRCm39)	Y103*	probably null	Het
Zfp287	T	A	11: 62,619,137 (GRCm39)	D119V	probably damaging	Het
Zxdc	A	G	6: 90,361,225 (GRCm39)	S737G	possibly damaging	Het

Other mutations in Prl3a1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02216:Prl3a1	APN	13	27,454,127 (GRCm39)	missense	probably benign	0.13
IGL02648:Prl3a1	APN	13	27,454,218 (GRCm39)	missense	probably benign	0.00
R1405:Prl3a1	UTSW	13	27,459,051 (GRCm39)	splice site	probably null
R1596:Prl3a1	UTSW	13	27,443,600 (GRCm39)	start gained	probably benign
R1823:Prl3a1	UTSW	13	27,454,177 (GRCm39)	missense	probably damaging	0.99
R1952:Prl3a1	UTSW	13	27,454,136 (GRCm39)	missense	possibly damaging	0.91
R2059:Prl3a1	UTSW	13	27,454,127 (GRCm39)	missense	probably benign	0.13
R5843:Prl3a1	UTSW	13	27,454,093 (GRCm39)	missense	probably damaging	1.00
R6222:Prl3a1	UTSW	13	27,460,097 (GRCm39)	missense	probably benign	0.05
R6664:Prl3a1	UTSW	13	27,454,194 (GRCm39)	nonsense	probably null
R7077:Prl3a1	UTSW	13	27,460,086 (GRCm39)	missense	probably benign	0.35
R7846:Prl3a1	UTSW	13	27,456,442 (GRCm39)	missense	probably damaging	1.00
R9049:Prl3a1	UTSW	13	27,460,167 (GRCm39)	missense	probably damaging	1.00
R9616:Prl3a1	UTSW	13	27,459,118 (GRCm39)	missense

Predicted Primers

Posted On

2015-02-04