Incidental Mutation 'R3103:Vmn2r61'
ID 262899
Institutional Source Beutler Lab
Gene Symbol Vmn2r61
Ensembl Gene ENSMUSG00000090967
Gene Name vomeronasal 2, receptor 61
Synonyms Gprc2a-rs2, Casr-rs2, EG637873
MMRRC Submission 040577-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R3103 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 41909477-41950179 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 41916067 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 227 (S227T)
Ref Sequence ENSEMBL: ENSMUSP00000129576 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166131]
AlphaFold L7N2B8
Predicted Effect possibly damaging
Transcript: ENSMUST00000166131
AA Change: S227T

PolyPhen 2 Score 0.728 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000129576
Gene: ENSMUSG00000090967
AA Change: S227T

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 471 4e-42 PFAM
Pfam:NCD3G 514 567 1.9e-21 PFAM
Pfam:7tm_3 600 835 6.2e-52 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206855
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp7 A G 7: 28,310,409 (GRCm39) probably null Het
Adap2 G T 11: 80,047,859 (GRCm39) C105F probably damaging Het
Bace2 T C 16: 97,223,201 (GRCm39) probably null Het
Bpifc A G 10: 85,829,286 (GRCm39) S94P probably damaging Het
C2cd3 A G 7: 100,044,459 (GRCm39) D347G possibly damaging Het
Cad T C 5: 31,219,018 (GRCm39) V613A possibly damaging Het
Ccdc47 T C 11: 106,093,667 (GRCm39) H6R probably benign Het
Celsr3 A G 9: 108,714,338 (GRCm39) T1956A probably benign Het
Cep128 T A 12: 90,986,118 (GRCm39) D1006V probably damaging Het
Cog3 T C 14: 75,984,641 (GRCm39) probably null Het
Csmd1 C T 8: 15,967,405 (GRCm39) V3153M probably damaging Het
Ctnna2 T C 6: 77,630,127 (GRCm39) E122G possibly damaging Het
Cts8 T A 13: 61,398,772 (GRCm39) I245F probably damaging Het
Ddx27 T A 2: 166,868,166 (GRCm39) V333E probably damaging Het
Dmpk A G 7: 18,821,579 (GRCm39) Y279C probably damaging Het
Dpagt1 A G 9: 44,239,292 (GRCm39) I111V probably benign Het
Dvl2 C A 11: 69,899,695 (GRCm39) P546T possibly damaging Het
Fat4 G T 3: 38,946,089 (GRCm39) A1661S probably benign Het
Gcm1 A G 9: 77,971,734 (GRCm39) N225S probably damaging Het
Gcnt2 A T 13: 41,072,082 (GRCm39) M242L probably benign Het
Golgb1 A G 16: 36,715,211 (GRCm39) R226G probably damaging Het
Gpr63 G A 4: 25,007,353 (GRCm39) V26I probably benign Het
Grik2 A G 10: 49,116,868 (GRCm39) L631P probably damaging Het
Hapln3 T C 7: 78,771,484 (GRCm39) D135G probably benign Het
Il31ra C A 13: 112,666,885 (GRCm39) V398F probably damaging Het
Ipp G T 4: 116,381,446 (GRCm39) R315L possibly damaging Het
Kcmf1 A G 6: 72,838,830 (GRCm39) L32P probably damaging Het
Klf17 T A 4: 117,617,805 (GRCm39) Q184L possibly damaging Het
Lrp2 C T 2: 69,262,328 (GRCm39) V4442I probably benign Het
Lrrfip2 A T 9: 111,051,278 (GRCm39) E293D probably damaging Het
Oit3 A G 10: 59,274,713 (GRCm39) I29T probably damaging Het
Or1a1 G A 11: 74,086,901 (GRCm39) D191N probably benign Het
Or1j21 T C 2: 36,683,574 (GRCm39) C109R possibly damaging Het
Or51h1 T C 7: 102,308,688 (GRCm39) V220A probably benign Het
Plb1 T A 5: 32,485,373 (GRCm39) M842K possibly damaging Het
Ppt1 T C 4: 122,730,100 (GRCm39) C18R probably benign Het
Pstpip2 T C 18: 77,959,477 (GRCm39) Y191H probably damaging Het
Ryr1 C T 7: 28,774,373 (GRCm39) V2361I probably damaging Het
Serpinb11 A G 1: 107,305,338 (GRCm39) N238S probably benign Het
Skor2 A T 18: 76,946,973 (GRCm39) K232* probably null Het
Slc13a5 A T 11: 72,148,214 (GRCm39) W231R probably damaging Het
Svs5 A T 2: 164,175,313 (GRCm39) E55V probably benign Het
Tfcp2 A T 15: 100,423,481 (GRCm39) W142R probably damaging Het
Trpc2 A T 7: 101,744,441 (GRCm39) I738F possibly damaging Het
Zfhx4 A G 3: 5,464,386 (GRCm39) T1540A probably damaging Het
Zfp616 A G 11: 73,962,561 (GRCm39) T74A probably benign Het
Other mutations in Vmn2r61
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00158:Vmn2r61 APN 7 41,950,175 (GRCm39) missense possibly damaging 0.96
IGL00824:Vmn2r61 APN 7 41,916,438 (GRCm39) missense probably benign 0.03
IGL00903:Vmn2r61 APN 7 41,949,935 (GRCm39) missense probably damaging 1.00
IGL01125:Vmn2r61 APN 7 41,909,550 (GRCm39) missense probably damaging 1.00
IGL01393:Vmn2r61 APN 7 41,916,258 (GRCm39) missense probably benign 0.08
IGL01712:Vmn2r61 APN 7 41,909,661 (GRCm39) missense probably damaging 0.98
IGL01822:Vmn2r61 APN 7 41,950,130 (GRCm39) missense probably benign 0.18
IGL01835:Vmn2r61 APN 7 41,950,015 (GRCm39) missense probably benign 0.12
IGL01844:Vmn2r61 APN 7 41,909,639 (GRCm39) missense probably benign 0.00
IGL01953:Vmn2r61 APN 7 41,949,613 (GRCm39) missense probably damaging 1.00
IGL02032:Vmn2r61 APN 7 41,949,466 (GRCm39) missense probably damaging 0.99
IGL02054:Vmn2r61 APN 7 41,926,158 (GRCm39) critical splice donor site probably null
IGL02569:Vmn2r61 APN 7 41,926,070 (GRCm39) missense probably damaging 1.00
IGL02697:Vmn2r61 APN 7 41,924,892 (GRCm39) missense possibly damaging 0.55
IGL02958:Vmn2r61 APN 7 41,949,361 (GRCm39) missense probably benign
IGL03290:Vmn2r61 APN 7 41,915,408 (GRCm39) missense probably benign 0.00
IGL03337:Vmn2r61 APN 7 41,916,509 (GRCm39) missense possibly damaging 0.58
IGL03369:Vmn2r61 APN 7 41,909,517 (GRCm39) missense probably benign
IGL03402:Vmn2r61 APN 7 41,909,679 (GRCm39) missense probably benign
R0026:Vmn2r61 UTSW 7 41,924,898 (GRCm39) missense possibly damaging 0.64
R0319:Vmn2r61 UTSW 7 41,949,941 (GRCm39) missense probably damaging 0.99
R0433:Vmn2r61 UTSW 7 41,915,335 (GRCm39) missense probably benign 0.02
R0555:Vmn2r61 UTSW 7 41,915,442 (GRCm39) missense probably benign 0.02
R0691:Vmn2r61 UTSW 7 41,949,844 (GRCm39) missense probably damaging 1.00
R1701:Vmn2r61 UTSW 7 41,949,935 (GRCm39) missense probably damaging 1.00
R1718:Vmn2r61 UTSW 7 41,950,121 (GRCm39) missense probably benign
R1835:Vmn2r61 UTSW 7 41,916,076 (GRCm39) nonsense probably null
R1920:Vmn2r61 UTSW 7 41,949,710 (GRCm39) missense possibly damaging 0.73
R2069:Vmn2r61 UTSW 7 41,949,425 (GRCm39) missense probably benign 0.06
R2326:Vmn2r61 UTSW 7 41,916,287 (GRCm39) missense probably damaging 1.00
R2402:Vmn2r61 UTSW 7 41,949,529 (GRCm39) missense possibly damaging 0.90
R3107:Vmn2r61 UTSW 7 41,916,491 (GRCm39) missense possibly damaging 0.82
R4426:Vmn2r61 UTSW 7 41,950,159 (GRCm39) missense probably benign
R4426:Vmn2r61 UTSW 7 41,950,157 (GRCm39) missense probably benign
R4484:Vmn2r61 UTSW 7 41,950,120 (GRCm39) missense probably benign
R4748:Vmn2r61 UTSW 7 41,916,565 (GRCm39) missense probably damaging 0.96
R4835:Vmn2r61 UTSW 7 41,916,459 (GRCm39) missense possibly damaging 0.52
R4863:Vmn2r61 UTSW 7 41,950,132 (GRCm39) missense probably benign 0.03
R4923:Vmn2r61 UTSW 7 41,916,520 (GRCm39) missense probably damaging 1.00
R4968:Vmn2r61 UTSW 7 41,949,478 (GRCm39) missense probably benign 0.14
R5114:Vmn2r61 UTSW 7 41,949,953 (GRCm39) missense possibly damaging 0.92
R5297:Vmn2r61 UTSW 7 41,909,646 (GRCm39) missense probably benign
R5497:Vmn2r61 UTSW 7 41,924,906 (GRCm39) missense possibly damaging 0.95
R5508:Vmn2r61 UTSW 7 41,916,242 (GRCm39) missense possibly damaging 0.52
R5587:Vmn2r61 UTSW 7 41,949,911 (GRCm39) missense probably damaging 1.00
R5615:Vmn2r61 UTSW 7 41,949,917 (GRCm39) missense probably damaging 1.00
R5615:Vmn2r61 UTSW 7 41,916,677 (GRCm39) missense probably benign 0.00
R5782:Vmn2r61 UTSW 7 41,949,253 (GRCm39) missense probably damaging 1.00
R6136:Vmn2r61 UTSW 7 41,916,455 (GRCm39) missense probably damaging 1.00
R6207:Vmn2r61 UTSW 7 41,909,616 (GRCm39) missense probably benign 0.01
R6265:Vmn2r61 UTSW 7 41,915,915 (GRCm39) missense probably benign 0.01
R6272:Vmn2r61 UTSW 7 41,949,242 (GRCm39) missense probably damaging 1.00
R6355:Vmn2r61 UTSW 7 41,916,659 (GRCm39) missense probably benign 0.00
R6469:Vmn2r61 UTSW 7 41,915,283 (GRCm39) nonsense probably null
R6554:Vmn2r61 UTSW 7 41,926,139 (GRCm39) missense probably damaging 1.00
R6699:Vmn2r61 UTSW 7 41,949,580 (GRCm39) missense probably benign
R6768:Vmn2r61 UTSW 7 41,949,748 (GRCm39) missense probably damaging 1.00
R6824:Vmn2r61 UTSW 7 41,949,403 (GRCm39) missense probably benign 0.10
R6930:Vmn2r61 UTSW 7 41,949,364 (GRCm39) missense probably benign 0.02
R7053:Vmn2r61 UTSW 7 41,916,557 (GRCm39) missense probably damaging 0.96
R7238:Vmn2r61 UTSW 7 41,916,629 (GRCm39) missense possibly damaging 0.73
R7332:Vmn2r61 UTSW 7 41,909,534 (GRCm39) missense probably benign 0.00
R7359:Vmn2r61 UTSW 7 41,915,407 (GRCm39) missense probably benign 0.11
R7553:Vmn2r61 UTSW 7 41,916,205 (GRCm39) missense not run
R7710:Vmn2r61 UTSW 7 41,916,472 (GRCm39) missense probably damaging 1.00
R7732:Vmn2r61 UTSW 7 41,916,097 (GRCm39) missense probably benign
R7839:Vmn2r61 UTSW 7 41,916,032 (GRCm39) missense probably damaging 0.97
R7916:Vmn2r61 UTSW 7 41,949,935 (GRCm39) missense probably damaging 1.00
R8026:Vmn2r61 UTSW 7 41,916,141 (GRCm39) missense probably benign 0.02
R8440:Vmn2r61 UTSW 7 41,916,080 (GRCm39) missense probably benign 0.02
R8499:Vmn2r61 UTSW 7 41,949,700 (GRCm39) missense probably damaging 0.99
R8771:Vmn2r61 UTSW 7 41,916,194 (GRCm39) missense probably damaging 0.99
R8847:Vmn2r61 UTSW 7 41,950,010 (GRCm39) missense probably damaging 1.00
R8986:Vmn2r61 UTSW 7 41,915,325 (GRCm39) nonsense probably null
R9290:Vmn2r61 UTSW 7 41,915,385 (GRCm39) missense probably benign 0.27
R9311:Vmn2r61 UTSW 7 41,950,092 (GRCm39) missense possibly damaging 0.92
R9324:Vmn2r61 UTSW 7 41,916,619 (GRCm39) missense probably benign 0.00
R9476:Vmn2r61 UTSW 7 41,949,593 (GRCm39) missense probably damaging 1.00
R9521:Vmn2r61 UTSW 7 41,916,626 (GRCm39) missense probably damaging 0.99
R9619:Vmn2r61 UTSW 7 41,926,136 (GRCm39) missense probably damaging 0.98
R9729:Vmn2r61 UTSW 7 41,949,917 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r61 UTSW 7 41,949,388 (GRCm39) missense possibly damaging 0.93
Z1176:Vmn2r61 UTSW 7 41,916,166 (GRCm39) missense probably benign 0.00
Z1176:Vmn2r61 UTSW 7 41,909,585 (GRCm39) missense possibly damaging 0.46
Predicted Primers PCR Primer
(F):5'- AGACTGGGAATTTGTCTTATGCC -3'
(R):5'- ACAGTTGTGCAATATGTCGC -3'

Sequencing Primer
(F):5'- GATATCTCTTCAGCTAACTTTTGGAC -3'
(R):5'- GTTGTGCAATATGTCGCATTAAACC -3'
Posted On 2015-02-05