Incidental Mutation 'R3121:Or6c6'
ID 263235
Institutional Source Beutler Lab
Gene Symbol Or6c6
Ensembl Gene ENSMUSG00000095075
Gene Name olfactory receptor family 6 subfamily C member 6
Synonyms MOR110-8, GA_x6K02T2PULF-11031172-11032116, Olfr782
MMRRC Submission 040594-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R3121 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 129186434-129187378 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 129186552 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 40 (N40S)
Ref Sequence ENSEMBL: ENSMUSP00000150951 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077024] [ENSMUST00000213970]
AlphaFold Q7TRI2
Predicted Effect possibly damaging
Transcript: ENSMUST00000077024
AA Change: N40S

PolyPhen 2 Score 0.736 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000076282
Gene: ENSMUSG00000095075
AA Change: N40S

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1e-48 PFAM
Pfam:7tm_1 39 288 8.5e-23 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213970
AA Change: N40S

PolyPhen 2 Score 0.736 (Sensitivity: 0.85; Specificity: 0.92)
Meta Mutation Damage Score 0.3853 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg5 A T 17: 84,966,091 (GRCm39) M423K probably benign Het
Adamtsl1 T A 4: 86,255,246 (GRCm39) W780R probably damaging Het
Ago3 A G 4: 126,311,165 (GRCm39) I16T probably benign Het
Amph T A 13: 19,297,316 (GRCm39) L354* probably null Het
Ankk1 G A 9: 49,338,267 (GRCm39) L9F probably benign Het
Brdt A G 5: 107,525,011 (GRCm39) T851A probably damaging Het
Bzw2 A C 12: 36,170,788 (GRCm39) probably null Het
Capn7 A T 14: 31,081,167 (GRCm39) I395F probably damaging Het
Ccdc146 T C 5: 21,499,591 (GRCm39) R864G possibly damaging Het
Ccdc50 G T 16: 27,228,139 (GRCm39) R102L possibly damaging Het
Cep83 T C 10: 94,622,700 (GRCm39) V592A probably damaging Het
Cgn G A 3: 94,685,792 (GRCm39) probably benign Het
Cidec C A 6: 113,405,086 (GRCm39) V195L probably benign Het
Cntln A G 4: 84,923,289 (GRCm39) probably benign Het
Cntrob A T 11: 69,213,526 (GRCm39) L88* probably null Het
Dnah17 C T 11: 117,931,912 (GRCm39) V3687M probably damaging Het
Dst T C 1: 34,328,729 (GRCm39) I4599T probably damaging Het
Dtl A T 1: 191,285,175 (GRCm39) Y320* probably null Het
Fam98b A G 2: 117,098,408 (GRCm39) T293A probably damaging Het
Farp1 G A 14: 121,460,138 (GRCm39) probably benign Het
Fat2 G T 11: 55,202,622 (GRCm39) P151T probably damaging Het
Fbxl17 A T 17: 63,778,419 (GRCm39) M497K probably damaging Het
Foxn4 T C 5: 114,396,776 (GRCm39) T236A probably damaging Het
Gm525 C T 11: 88,979,374 (GRCm39) probably benign Het
Golga4 C A 9: 118,386,448 (GRCm39) T1190K possibly damaging Het
H2-T23 T A 17: 36,341,855 (GRCm39) M248L probably benign Het
Homez T C 14: 55,094,778 (GRCm39) E310G probably benign Het
Hydin A G 8: 111,233,138 (GRCm39) I1746V probably benign Het
Igkv1-35 T A 6: 69,988,641 (GRCm39) H6L probably benign Het
Kcnt2 T C 1: 140,356,622 (GRCm39) S354P probably damaging Het
Khdc4 A G 3: 88,596,599 (GRCm39) T127A probably damaging Het
Klra4 G T 6: 130,040,141 (GRCm39) Q44K probably benign Het
L3mbtl3 A G 10: 26,220,119 (GRCm39) probably benign Het
Lamb1 C T 12: 31,337,528 (GRCm39) R372C probably damaging Het
Magea14 A T X: 51,057,968 (GRCm39) Y239* probably null Het
Map3k9 A G 12: 81,790,698 (GRCm39) I285T probably damaging Het
Or4a47 T A 2: 89,665,858 (GRCm39) I144L probably benign Het
Pcdhb16 A T 18: 37,611,271 (GRCm39) Q77L possibly damaging Het
Pramel20 T A 4: 143,297,583 (GRCm39) M1K probably null Het
Proser3 A G 7: 30,239,796 (GRCm39) V436A probably benign Het
Relch A G 1: 105,653,524 (GRCm39) N834S probably benign Het
Resf1 T A 6: 149,230,741 (GRCm39) C1262* probably null Het
Sec24b C T 3: 129,795,953 (GRCm39) probably null Het
Slc2a2 A G 3: 28,775,898 (GRCm39) Q336R probably benign Het
Sowahb T C 5: 93,191,261 (GRCm39) D486G possibly damaging Het
Spidr T C 16: 15,958,724 (GRCm39) K13E probably damaging Het
Tiam2 T A 17: 3,489,977 (GRCm39) M786K probably benign Het
Tktl2 T A 8: 66,964,808 (GRCm39) V122E probably damaging Het
Wapl A G 14: 34,451,172 (GRCm39) I729M possibly damaging Het
Zbbx T C 3: 74,989,153 (GRCm39) T317A possibly damaging Het
Zfp976 A G 7: 42,262,938 (GRCm39) C300R probably damaging Het
Other mutations in Or6c6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01286:Or6c6 APN 10 129,186,519 (GRCm39) missense probably damaging 1.00
IGL01469:Or6c6 APN 10 129,186,449 (GRCm39) missense probably benign
IGL01980:Or6c6 APN 10 129,187,386 (GRCm39) utr 3 prime probably benign
IGL03309:Or6c6 APN 10 129,187,178 (GRCm39) missense probably benign 0.01
R0449:Or6c6 UTSW 10 129,187,103 (GRCm39) missense probably benign 0.00
R1994:Or6c6 UTSW 10 129,186,561 (GRCm39) missense probably damaging 1.00
R6421:Or6c6 UTSW 10 129,187,370 (GRCm39) nonsense probably null
R7268:Or6c6 UTSW 10 129,187,263 (GRCm39) missense possibly damaging 0.60
R7399:Or6c6 UTSW 10 129,186,426 (GRCm39) start gained probably benign
R7647:Or6c6 UTSW 10 129,187,326 (GRCm39) missense probably benign
R8384:Or6c6 UTSW 10 129,186,695 (GRCm39) nonsense probably null
R8795:Or6c6 UTSW 10 129,187,194 (GRCm39) missense probably damaging 0.99
R9224:Or6c6 UTSW 10 129,186,450 (GRCm39) missense probably benign
R9375:Or6c6 UTSW 10 129,186,989 (GRCm39) missense probably damaging 1.00
R9478:Or6c6 UTSW 10 129,186,960 (GRCm39) missense possibly damaging 0.70
X0027:Or6c6 UTSW 10 129,187,202 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAAACTGACTTTGTAACATATCCCC -3'
(R):5'- CTGTGACTCCCAGCAAAAGAATG -3'

Sequencing Primer
(F):5'- GTTTTCTAGCCCAAAATATCCAGGG -3'
(R):5'- TGAAAAACAACTGAGCTGCAC -3'
Posted On 2015-02-05