Incidental Mutation 'R3157:Cd300e'
ID 263552
Institutional Source Beutler Lab
Gene Symbol Cd300e
Ensembl Gene ENSMUSG00000048498
Gene Name CD300E molecule
Synonyms Trem5, Cd300le, Clm2
MMRRC Submission 040608-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3157 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 114942743-114953003 bp(-) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) A to C at 114952849 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Arginine at position 1 (M1R)
Ref Sequence ENSEMBL: ENSMUSP00000054883 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062787]
AlphaFold Q8K249
Predicted Effect probably null
Transcript: ENSMUST00000062787
AA Change: M1R
SMART Domains Protein: ENSMUSP00000054883
Gene: ENSMUSG00000048498
AA Change: M1R

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
IG 21 128 6.26e-5 SMART
low complexity region 129 144 N/A INTRINSIC
transmembrane domain 171 193 N/A INTRINSIC
Meta Mutation Damage Score 0.9150 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.5%
  • 20x: 95.6%
Validation Efficiency 98% (47/48)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adarb2 A T 13: 8,747,669 (GRCm39) K408N probably benign Het
Aoc2 A T 11: 101,220,102 (GRCm39) N696I probably damaging Het
Ap1g2 A T 14: 55,336,731 (GRCm39) I747N probably damaging Het
Arhgap27 T A 11: 103,224,663 (GRCm39) probably null Het
Bmp1 G T 14: 70,729,547 (GRCm39) N541K possibly damaging Het
Cacna1c T A 6: 118,728,485 (GRCm39) T320S probably benign Het
Ccr4 G T 9: 114,321,350 (GRCm39) N238K probably benign Het
Cep95 A G 11: 106,700,013 (GRCm39) probably benign Het
Cfap54 T C 10: 92,834,918 (GRCm39) I1096V probably benign Het
D630003M21Rik A C 2: 158,037,392 (GRCm39) probably benign Het
Dmpk A G 7: 18,826,944 (GRCm39) T579A probably benign Het
Dock8 T C 19: 25,127,195 (GRCm39) Y1058H probably benign Het
Dscam T C 16: 96,479,710 (GRCm39) T1146A probably benign Het
Fnip2 T C 3: 79,474,901 (GRCm39) T4A probably damaging Het
Galnt12 A G 4: 47,104,264 (GRCm39) D174G probably damaging Het
Gxylt1 A G 15: 93,142,913 (GRCm39) I384T probably benign Het
Hmcn2 A G 2: 31,290,267 (GRCm39) N2367D probably damaging Het
Hydin A G 8: 110,994,005 (GRCm39) K13R unknown Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 53,032,934 (GRCm39) 74 probably benign Het
Kcns1 G A 2: 164,006,865 (GRCm39) A366V probably damaging Het
Kif5a A T 10: 127,081,310 (GRCm39) I208N probably damaging Het
Klrb1c G T 6: 128,761,702 (GRCm39) T134K possibly damaging Het
Med14 G A X: 12,550,330 (GRCm39) probably benign Het
Mgat4d T C 8: 84,081,450 (GRCm39) Y68H probably benign Het
Mmp11 C T 10: 75,762,948 (GRCm39) probably benign Het
Ncapg T A 5: 45,833,400 (GRCm39) D295E probably benign Het
Npas2 C T 1: 39,386,690 (GRCm39) T653M possibly damaging Het
Nps A G 7: 134,873,989 (GRCm39) D53G probably benign Het
Ociad1 A T 5: 73,467,688 (GRCm39) R155* probably null Het
Or5b101 G C 19: 13,005,411 (GRCm39) A94G probably benign Het
Pcdha2 A G 18: 37,073,145 (GRCm39) T259A probably damaging Het
Pced1a A G 2: 130,261,687 (GRCm39) M322T probably benign Het
Pcgf6 T C 19: 47,028,475 (GRCm39) probably benign Het
Pigg C T 5: 108,462,014 (GRCm39) T115I probably damaging Het
Plcd4 G A 1: 74,590,313 (GRCm39) probably null Het
Prss52 G T 14: 64,350,992 (GRCm39) W259L probably damaging Het
Rasal2 A G 1: 156,986,225 (GRCm39) probably benign Het
Rec8 A G 14: 55,862,763 (GRCm39) E574G probably damaging Het
Sectm1a A G 11: 120,959,603 (GRCm39) I175T probably benign Het
Slc16a8 T C 15: 79,136,375 (GRCm39) I276V probably damaging Het
Slc8a3 C A 12: 81,361,766 (GRCm39) R351L probably damaging Het
Slc9b1 G A 3: 135,077,606 (GRCm39) G100E probably damaging Het
Smu1 T A 4: 40,754,529 (GRCm39) R123S possibly damaging Het
Synpr C T 14: 13,493,614 (GRCm38) A64V possibly damaging Het
Tmem132a C T 19: 10,836,901 (GRCm39) W680* probably null Het
Tpt1 G A 14: 76,083,840 (GRCm39) probably benign Het
Trav18 A G 14: 54,069,152 (GRCm39) T65A probably benign Het
Ttll4 T C 1: 74,736,770 (GRCm39) L1165P possibly damaging Het
Other mutations in Cd300e
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3158_Cd300e_594 UTSW 11 114,952,849 (GRCm39) start codon destroyed probably null
PIT4472001:Cd300e UTSW 11 114,945,336 (GRCm39) missense possibly damaging 0.83
R1234:Cd300e UTSW 11 114,946,192 (GRCm39) missense probably damaging 0.96
R1772:Cd300e UTSW 11 114,945,344 (GRCm39) missense probably benign 0.21
R3158:Cd300e UTSW 11 114,952,849 (GRCm39) start codon destroyed probably null
R6191:Cd300e UTSW 11 114,945,359 (GRCm39) missense possibly damaging 0.92
R6283:Cd300e UTSW 11 114,945,380 (GRCm39) missense probably benign 0.04
R7406:Cd300e UTSW 11 114,946,128 (GRCm39) missense probably damaging 1.00
R8994:Cd300e UTSW 11 114,946,348 (GRCm39) missense probably damaging 1.00
R9407:Cd300e UTSW 11 114,946,171 (GRCm39) missense probably damaging 1.00
X0060:Cd300e UTSW 11 114,946,318 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GATGGATGCTGGACTACACTG -3'
(R):5'- TCTGAAGCGATTCTCACTCATC -3'

Sequencing Primer
(F):5'- TGCTGGACTACACTGATAGATAAAG -3'
(R):5'- ACAAGAAGGTGGTTGCCT -3'
Posted On 2015-02-05