Mutagenetix > Incidental Mutation

Incidental Mutation 'R3158:Vmn2r37'

263582

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r37

Ensembl Gene

ENSMUSG00000066828

Gene Name

vomeronasal 2, receptor 37

Synonyms

V2r14

MMRRC Submission

040609-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R3158 (G1)

Quality Score

112

Status

Not validated

Chromosome

Chromosomal Location

9208548-9226652 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 9220713 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Isoleucine at position 383 (M383I)

Ref Sequence

ENSEMBL: ENSMUSP00000072566 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072787]

AlphaFold

F8VQD3

Predicted Effect

probably benign
Transcript: ENSMUST00000072787
AA Change: M383I

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000072566
Gene: ENSMUSG00000066828
AA Change: M383I

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	157	469	2.9e-26	PFAM
Pfam:NCD3G	512	563	1.1e-16	PFAM
Pfam:7tm_3	550	783	1.7e-53	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.1%
20x: 94.4%

Validation Efficiency

97% (35/36)

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aoc2	A	T	11: 101,220,102 (GRCm39)	N696I	probably damaging	Het
Ccr4	G	T	9: 114,321,350 (GRCm39)	N238K	probably benign	Het
Cd300e	A	C	11: 114,952,849 (GRCm39)	M1R	probably null	Het
Cep95	A	G	11: 106,700,013 (GRCm39)		probably benign	Het
Cfap54	T	C	10: 92,834,918 (GRCm39)	I1096V	probably benign	Het
Clca4b	C	A	3: 144,617,878 (GRCm39)	V742L	probably benign	Het
Diaph3	A	T	14: 86,893,892 (GRCm39)	I39N	possibly damaging	Het
Dll3	A	T	7: 27,993,520 (GRCm39)	D566E	possibly damaging	Het
Dmpk	A	G	7: 18,826,944 (GRCm39)	T579A	probably benign	Het
E330034G19Rik	A	T	14: 24,346,965 (GRCm39)	Y84F	possibly damaging	Het
Eya1	G	A	1: 14,374,691 (GRCm39)		probably benign	Het
Fat4	A	G	3: 38,944,940 (GRCm39)	T1278A	possibly damaging	Het
Galnt12	A	G	4: 47,104,264 (GRCm39)	D174G	probably damaging	Het
Gm20939	T	A	17: 95,184,721 (GRCm39)	H456Q	probably damaging	Het
Gm7853	A	G	14: 35,811,358 (GRCm39)		noncoding transcript	Het
Hsd3b5	G	A	3: 98,529,375 (GRCm39)	A85V	probably benign	Het
Itga11	A	G	9: 62,676,560 (GRCm39)	K916R	probably benign	Het
Kcnh8	GAGACCAACGAGCAGCTGATGCTTCAGA	GAGA	17: 53,032,934 (GRCm39)	74	probably benign	Het
Krt6a	T	C	15: 101,599,801 (GRCm39)	Y437C	probably damaging	Het
Lrp5	A	G	19: 3,665,849 (GRCm39)	S707P	probably damaging	Het
Med14	G	A	X: 12,550,330 (GRCm39)		probably benign	Het
Mmp11	C	T	10: 75,762,948 (GRCm39)		probably benign	Het
Mtus2	A	G	5: 148,168,637 (GRCm39)	H950R	probably damaging	Het
Myo1g	G	T	11: 6,464,527 (GRCm39)	T511K	possibly damaging	Het
Myo7a	A	G	7: 97,701,499 (GRCm39)	F2154S	probably damaging	Het
Or11h4	A	G	14: 50,974,271 (GRCm39)	V116A	probably benign	Het
Or5b101	G	C	19: 13,005,411 (GRCm39)	A94G	probably benign	Het
Or8h8	C	T	2: 86,752,950 (GRCm39)	E309K	probably benign	Het
Prss52	G	T	14: 64,350,992 (GRCm39)	W259L	probably damaging	Het
Sbk2	G	A	7: 4,960,526 (GRCm39)	R215*	probably null	Het
Sectm1a	A	G	11: 120,959,603 (GRCm39)	I175T	probably benign	Het
Smu1	T	A	4: 40,754,529 (GRCm39)	R123S	possibly damaging	Het
Stk3	A	G	15: 35,008,387 (GRCm39)	S178P	possibly damaging	Het
Tle6	T	C	10: 81,431,038 (GRCm39)		probably null	Het

Other mutations in Vmn2r37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01346:Vmn2r37	APN	7	9,209,680 (GRCm39)	missense	probably benign	0.05
IGL01909:Vmn2r37	APN	7	9,219,032 (GRCm39)	nonsense	probably null
IGL02281:Vmn2r37	APN	7	9,220,881 (GRCm39)	missense	possibly damaging	0.95
IGL02282:Vmn2r37	APN	7	9,209,761 (GRCm39)	missense	probably benign	0.19
IGL02513:Vmn2r37	APN	7	9,220,934 (GRCm39)	missense	probably benign	0.14
R0136:Vmn2r37	UTSW	7	9,220,782 (GRCm39)	nonsense	probably null
R2051:Vmn2r37	UTSW	7	9,220,792 (GRCm39)	missense	probably damaging	1.00
R2262:Vmn2r37	UTSW	7	9,220,943 (GRCm39)	missense	probably damaging	0.99
R4084:Vmn2r37	UTSW	7	9,218,984 (GRCm39)	missense	probably benign
R4114:Vmn2r37	UTSW	7	9,213,092 (GRCm39)	critical splice acceptor site	probably null
R5231:Vmn2r37	UTSW	7	9,209,594 (GRCm39)	missense	possibly damaging	0.94
R5462:Vmn2r37	UTSW	7	9,220,973 (GRCm39)	missense	probably damaging	1.00
R6437:Vmn2r37	UTSW	7	9,220,850 (GRCm39)	missense	probably damaging	0.98
R7104:Vmn2r37	UTSW	7	9,219,045 (GRCm39)	missense	probably damaging	1.00
R7116:Vmn2r37	UTSW	7	9,220,898 (GRCm39)	missense	probably benign	0.00
R7381:Vmn2r37	UTSW	7	9,213,032 (GRCm39)	missense	probably benign	0.21
R8775:Vmn2r37	UTSW	7	9,218,991 (GRCm39)	nonsense	probably null
R8775-TAIL:Vmn2r37	UTSW	7	9,218,991 (GRCm39)	nonsense	probably null
R8869:Vmn2r37	UTSW	7	9,209,854 (GRCm39)	missense	possibly damaging	0.50
R8884:Vmn2r37	UTSW	7	9,218,916 (GRCm39)	missense	probably benign
RF004:Vmn2r37	UTSW	7	9,220,686 (GRCm39)	missense	probably damaging	0.97
Z1177:Vmn2r37	UTSW	7	9,212,996 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGTCATCTGAAAGACTCTAAACAAC -3'
(R):5'- CCCCACCATGGTGTGATTTC -3'

Sequencing Primer
(F):5'- GACTCTAAACAACTATGCAAGTGAAG -3'
(R):5'- CAGACATGGTTCCATCTCAG -3'

Posted On

2015-02-05