Incidental Mutation 'R3108:Ccnb1'
ID 263679
Institutional Source Beutler Lab
Gene Symbol Ccnb1
Ensembl Gene ENSMUSG00000041431
Gene Name cyclin B1
Synonyms Ccnb1-rs13, Cycb-4
MMRRC Submission 040582-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R3108 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 100915247-100922994 bp(-) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to T at 100918132 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000133962 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072119] [ENSMUST00000091295] [ENSMUST00000174038] [ENSMUST00000174038]
AlphaFold P24860
Predicted Effect probably null
Transcript: ENSMUST00000072119
SMART Domains Protein: ENSMUSP00000071989
Gene: ENSMUSG00000041431

DomainStartEndE-ValueType
low complexity region 80 110 N/A INTRINSIC
low complexity region 149 160 N/A INTRINSIC
CYCLIN 204 288 3.88e-26 SMART
Cyclin_C 297 415 4.18e-37 SMART
CYCLIN 301 382 3.65e-22 SMART
Predicted Effect probably null
Transcript: ENSMUST00000091295
SMART Domains Protein: ENSMUSP00000088841
Gene: ENSMUSG00000041431

DomainStartEndE-ValueType
low complexity region 80 110 N/A INTRINSIC
CYCLIN 143 227 3.88e-26 SMART
Cyclin_C 236 354 4.18e-37 SMART
CYCLIN 240 321 3.65e-22 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128279
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134080
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142056
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147790
Predicted Effect probably null
Transcript: ENSMUST00000174038
SMART Domains Protein: ENSMUSP00000133962
Gene: ENSMUSG00000041431

DomainStartEndE-ValueType
low complexity region 80 110 N/A INTRINSIC
low complexity region 149 160 N/A INTRINSIC
CYCLIN 204 288 3.88e-26 SMART
Cyclin_C 297 378 3.18e-10 SMART
CYCLIN 301 384 8.4e-13 SMART
Predicted Effect probably null
Transcript: ENSMUST00000174038
SMART Domains Protein: ENSMUSP00000133962
Gene: ENSMUSG00000041431

DomainStartEndE-ValueType
low complexity region 80 110 N/A INTRINSIC
low complexity region 149 160 N/A INTRINSIC
CYCLIN 204 288 3.88e-26 SMART
Cyclin_C 297 378 3.18e-10 SMART
CYCLIN 301 384 8.4e-13 SMART
Meta Mutation Damage Score 0.9600 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 100% (32/32)
MGI Phenotype PHENOTYPE: Homozygous mutation of this gene is embryonic lethal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd2 C T 7: 78,973,333 (GRCm39) S104L probably benign Het
Adcy1 A G 11: 7,119,453 (GRCm39) Y1032C probably damaging Het
Ap4e1 T C 2: 126,898,226 (GRCm39) probably null Het
Cfap54 T C 10: 92,830,545 (GRCm39) N1197S probably benign Het
Cnot1 A G 8: 96,462,377 (GRCm39) V1691A probably damaging Het
Dclk2 G A 3: 86,827,342 (GRCm39) P46S probably damaging Het
Dennd4a A G 9: 64,819,669 (GRCm39) K1760R probably benign Het
Drd4 T A 7: 140,872,195 (GRCm39) V82E possibly damaging Het
Dtx2 G A 5: 136,050,670 (GRCm39) V323M probably benign Het
Espl1 A G 15: 102,221,424 (GRCm39) I944V probably damaging Het
Fat1 G A 8: 45,498,210 (GRCm39) probably null Het
Igkv11-125 T C 6: 67,890,855 (GRCm39) F58L possibly damaging Het
Mrgprb1 A G 7: 48,097,076 (GRCm39) S279P possibly damaging Het
Muc5b C T 7: 141,412,496 (GRCm39) T1814M unknown Het
Nkpd1 G A 7: 19,256,903 (GRCm39) M227I probably damaging Het
Ntrk3 C T 7: 78,110,263 (GRCm39) V324M probably benign Het
Nup155 C A 15: 8,146,790 (GRCm39) T210K probably null Het
Or52s1b T A 7: 102,822,293 (GRCm39) M184L probably damaging Het
Or9s18 T C 13: 65,300,875 (GRCm39) V279A possibly damaging Het
Pak4 A T 7: 28,263,769 (GRCm39) Y322* probably null Het
Raph1 G A 1: 60,532,545 (GRCm39) A696V probably benign Het
Satb1 A T 17: 52,089,810 (GRCm39) Y346N possibly damaging Het
Serpina1a A T 12: 103,820,100 (GRCm39) I382N probably damaging Het
Slc34a3 G T 2: 25,119,257 (GRCm39) Q538K probably benign Het
Slf1 C T 13: 77,274,840 (GRCm39) probably benign Het
Ston1 G T 17: 88,943,583 (GRCm39) E330* probably null Het
Trhde C T 10: 114,427,971 (GRCm39) E442K probably damaging Het
Unc45a A G 7: 79,981,294 (GRCm39) probably benign Het
Zfp169 A G 13: 48,643,472 (GRCm39) S552P possibly damaging Het
Zfp229 T A 17: 21,965,797 (GRCm39) C676S probably damaging Het
Other mutations in Ccnb1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00897:Ccnb1 APN 13 100,922,419 (GRCm39) splice site probably benign
IGL01775:Ccnb1 APN 13 100,920,017 (GRCm39) missense probably benign 0.36
IGL01874:Ccnb1 APN 13 100,920,001 (GRCm39) missense probably damaging 1.00
IGL02108:Ccnb1 APN 13 100,917,665 (GRCm39) critical splice donor site probably null
IGL02170:Ccnb1 APN 13 100,919,994 (GRCm39) nonsense probably null
IGL02372:Ccnb1 APN 13 100,917,824 (GRCm39) missense probably damaging 1.00
IGL02755:Ccnb1 APN 13 100,918,168 (GRCm39) missense possibly damaging 0.89
IGL03142:Ccnb1 APN 13 100,920,039 (GRCm39) missense probably damaging 1.00
R0025:Ccnb1 UTSW 13 100,916,289 (GRCm39) missense probably damaging 1.00
R0499:Ccnb1 UTSW 13 100,916,642 (GRCm39) critical splice acceptor site probably null
R2249:Ccnb1 UTSW 13 100,917,827 (GRCm39) missense possibly damaging 0.79
R4934:Ccnb1 UTSW 13 100,918,209 (GRCm39) missense possibly damaging 0.49
R5126:Ccnb1 UTSW 13 100,918,283 (GRCm39) missense possibly damaging 0.88
R5127:Ccnb1 UTSW 13 100,918,283 (GRCm39) missense possibly damaging 0.88
R5180:Ccnb1 UTSW 13 100,918,283 (GRCm39) missense possibly damaging 0.88
R5181:Ccnb1 UTSW 13 100,918,283 (GRCm39) missense possibly damaging 0.88
R5325:Ccnb1 UTSW 13 100,918,283 (GRCm39) missense possibly damaging 0.88
R7024:Ccnb1 UTSW 13 100,922,888 (GRCm39) critical splice donor site probably null
R7583:Ccnb1 UTSW 13 100,916,262 (GRCm39) missense probably benign 0.06
R7632:Ccnb1 UTSW 13 100,918,209 (GRCm39) missense probably benign 0.32
R7833:Ccnb1 UTSW 13 100,917,859 (GRCm39) missense probably damaging 1.00
R9634:Ccnb1 UTSW 13 100,920,112 (GRCm39) missense probably benign 0.01
R9769:Ccnb1 UTSW 13 100,917,393 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTTACCTCCCAAGAAAGGATTCAG -3'
(R):5'- GGTCTTTATGGACACCGATGG -3'

Sequencing Primer
(F):5'- CTCCCAAGAAAGGATTCAGTTTCAGG -3'
(R):5'- CTTTATGGACACCGATGGTAGATG -3'
Posted On 2015-02-05