Incidental Mutation 'R0324:Plk2'
ID 26383
Institutional Source Beutler Lab
Gene Symbol Plk2
Ensembl Gene ENSMUSG00000021701
Gene Name polo like kinase 2
Synonyms Snk
MMRRC Submission 038534-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0324 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 110531580-110537378 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 110534242 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Lysine at position 274 (R274K)
Ref Sequence ENSEMBL: ENSMUSP00000022212 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022212]
AlphaFold P53351
Predicted Effect probably benign
Transcript: ENSMUST00000022212
AA Change: R274K

PolyPhen 2 Score 0.079 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000022212
Gene: ENSMUSG00000021701
AA Change: R274K

DomainStartEndE-ValueType
low complexity region 54 62 N/A INTRINSIC
S_TKc 79 331 7.08e-97 SMART
Blast:STYKc 335 383 9e-7 BLAST
low complexity region 448 464 N/A INTRINSIC
Pfam:POLO_box 508 569 2.5e-19 PFAM
Pfam:POLO_box 604 673 1.3e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223756
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224489
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225156
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225340
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 96.1%
  • 20x: 93.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
PHENOTYPE: Inactivation of this gene results in impaired embryonic growth and placental defects due to increased cell proliferation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010I14Rik T C 17: 9,219,989 (GRCm39) L357S probably benign Het
1700129C05Rik C T 14: 59,380,256 (GRCm39) R14H probably damaging Het
Aatf A G 11: 84,402,965 (GRCm39) probably null Het
Abca13 T A 11: 9,247,669 (GRCm39) M2472K possibly damaging Het
Abcd3 C A 3: 121,562,816 (GRCm39) Q540H probably null Het
Adam17 C T 12: 21,399,939 (GRCm39) V156I probably benign Het
Adam26a A G 8: 44,021,490 (GRCm39) S667P probably benign Het
Adcy10 A G 1: 165,391,818 (GRCm39) K1333E probably benign Het
Apob G A 12: 8,060,521 (GRCm39) R2968Q probably benign Het
Arap3 G A 18: 38,106,278 (GRCm39) P1522S possibly damaging Het
Catsper1 A T 19: 5,386,573 (GRCm39) S269C probably damaging Het
Cd209d A T 8: 3,928,258 (GRCm39) S42R probably benign Het
Cntln T A 4: 85,010,932 (GRCm39) V1049E probably damaging Het
Cracr2b T C 7: 141,043,659 (GRCm39) F87L probably damaging Het
Crb3 T C 17: 57,372,133 (GRCm39) L60P probably damaging Het
Crispld1 T C 1: 17,819,815 (GRCm39) V271A probably benign Het
Cyp2c66 G T 19: 39,165,135 (GRCm39) R372L probably benign Het
Deup1 G A 9: 15,493,829 (GRCm39) R438W probably benign Het
Dnah6 C T 6: 73,150,541 (GRCm39) E741K possibly damaging Het
Epha4 T C 1: 77,360,188 (GRCm39) E703G probably damaging Het
Evc2 G A 5: 37,550,443 (GRCm39) R819H probably damaging Het
Fam217a A C 13: 35,094,944 (GRCm39) C272G possibly damaging Het
Fndc7 T C 3: 108,784,015 (GRCm39) probably null Het
Foxs1 C T 2: 152,774,607 (GRCm39) G149S probably benign Het
Galnt13 T C 2: 54,744,628 (GRCm39) V109A probably benign Het
Hmgxb4 G A 8: 75,725,556 (GRCm39) M7I probably benign Het
Klk1b1 T A 7: 43,620,165 (GRCm39) C209* probably null Het
Klra10 A G 6: 130,249,613 (GRCm39) probably null Het
Kntc1 A T 5: 123,916,175 (GRCm39) K701N probably damaging Het
Lpgat1 T A 1: 191,481,754 (GRCm39) L114Q probably damaging Het
Mecom T A 3: 30,017,261 (GRCm39) Q468L probably damaging Het
Med15 T C 16: 17,515,476 (GRCm39) T70A probably damaging Het
Msh6 T A 17: 88,294,048 (GRCm39) Y934* probably null Het
Mtus1 T C 8: 41,537,432 (GRCm39) T95A probably benign Het
Mylk3 C A 8: 86,079,535 (GRCm39) R444S probably damaging Het
Nbea A G 3: 55,965,369 (GRCm39) probably null Het
Nbeal1 T C 1: 60,332,032 (GRCm39) V2242A probably damaging Het
Nhp2 A G 11: 51,513,334 (GRCm39) T85A possibly damaging Het
Nlk A G 11: 78,463,257 (GRCm39) S413P possibly damaging Het
Nmbr A G 10: 14,636,192 (GRCm39) I54V possibly damaging Het
Nmur2 A T 11: 55,931,346 (GRCm39) C122S probably damaging Het
Nudt13 G T 14: 20,361,583 (GRCm39) V220L probably damaging Het
Or5m13 G A 2: 85,748,295 (GRCm39) V9M probably benign Het
Pclo G A 5: 14,719,447 (GRCm39) G1195R unknown Het
Pcsk7 A G 9: 45,824,309 (GRCm39) H276R possibly damaging Het
Pdss2 T C 10: 43,269,924 (GRCm39) S256P probably damaging Het
Pgf G T 12: 85,218,198 (GRCm39) H116N probably benign Het
Pglyrp2 T C 17: 32,637,302 (GRCm39) D242G probably benign Het
Ppp6r3 G T 19: 3,514,693 (GRCm39) P141T probably benign Het
Prss54 T C 8: 96,292,295 (GRCm39) T95A probably benign Het
Rab3il1 A G 19: 10,005,653 (GRCm39) D149G probably damaging Het
Rasgef1c T C 11: 49,852,057 (GRCm39) probably null Het
Rhpn1 T C 15: 75,583,437 (GRCm39) M334T probably damaging Het
Rigi T C 4: 40,213,766 (GRCm39) T586A probably benign Het
Robo2 C T 16: 73,764,739 (GRCm39) V630M probably damaging Het
Rptor C T 11: 119,783,467 (GRCm39) R1154W probably damaging Het
Scnn1g A G 7: 121,339,778 (GRCm39) I192M possibly damaging Het
Sit1 G A 4: 43,482,815 (GRCm39) Q115* probably null Het
Slc13a2 T C 11: 78,295,350 (GRCm39) N141S probably damaging Het
Slc19a2 C A 1: 164,084,344 (GRCm39) T78K probably damaging Het
Snx14 A G 9: 88,287,291 (GRCm39) probably null Het
Stil T A 4: 114,896,346 (GRCm39) C944S probably benign Het
Tex56 A G 13: 35,108,596 (GRCm39) N26S probably benign Het
Tnfaip2 A G 12: 111,419,893 (GRCm39) N675S probably damaging Het
Trim30c A G 7: 104,032,516 (GRCm39) I270T possibly damaging Het
Ugt2a3 C T 5: 87,474,932 (GRCm39) probably null Het
Vmn1r213 A T 13: 23,195,588 (GRCm39) probably benign Het
Vmn2r8 A C 5: 108,945,807 (GRCm39) probably null Het
Vps13c T C 9: 67,871,591 (GRCm39) F3253L possibly damaging Het
Zbtb16 G T 9: 48,576,575 (GRCm39) Q502K possibly damaging Het
Zfp143 A G 7: 109,676,354 (GRCm39) K218E possibly damaging Het
Zfp946 A G 17: 22,673,417 (GRCm39) N57S probably benign Het
Zfp985 T C 4: 147,667,314 (GRCm39) Y61H probably benign Het
Zkscan1 G A 5: 138,095,785 (GRCm39) R246Q probably damaging Het
Zpld1 A G 16: 55,071,978 (GRCm39) F94L probably damaging Het
Zswim5 G T 4: 116,844,103 (GRCm39) W1047L probably damaging Het
Other mutations in Plk2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00513:Plk2 APN 13 110,535,298 (GRCm39) missense probably benign 0.18
IGL00586:Plk2 APN 13 110,532,912 (GRCm39) missense possibly damaging 0.61
IGL00798:Plk2 APN 13 110,534,568 (GRCm39) missense probably benign 0.00
IGL01450:Plk2 APN 13 110,532,858 (GRCm39) missense probably damaging 1.00
IGL01722:Plk2 APN 13 110,535,976 (GRCm39) missense probably benign 0.00
IGL01937:Plk2 APN 13 110,535,588 (GRCm39) missense possibly damaging 0.80
IGL01945:Plk2 APN 13 110,535,588 (GRCm39) missense possibly damaging 0.80
IGL01993:Plk2 APN 13 110,535,731 (GRCm39) missense probably damaging 1.00
IGL02231:Plk2 APN 13 110,536,603 (GRCm39) missense probably benign 0.01
IGL03059:Plk2 APN 13 110,535,668 (GRCm39) missense probably benign 0.42
Mite UTSW 13 110,532,570 (GRCm39) nonsense probably null
R0189:Plk2 UTSW 13 110,535,997 (GRCm39) missense probably damaging 1.00
R1108:Plk2 UTSW 13 110,536,023 (GRCm39) missense probably damaging 0.99
R1422:Plk2 UTSW 13 110,536,023 (GRCm39) missense probably damaging 0.99
R1513:Plk2 UTSW 13 110,536,622 (GRCm39) missense probably benign 0.45
R2987:Plk2 UTSW 13 110,534,243 (GRCm39) missense probably benign 0.03
R4050:Plk2 UTSW 13 110,536,400 (GRCm39) missense probably damaging 1.00
R4211:Plk2 UTSW 13 110,532,871 (GRCm39) missense probably damaging 0.98
R4278:Plk2 UTSW 13 110,532,637 (GRCm39) missense probably benign 0.15
R4777:Plk2 UTSW 13 110,534,307 (GRCm39) missense probably benign
R5121:Plk2 UTSW 13 110,535,958 (GRCm39) missense probably benign 0.01
R5677:Plk2 UTSW 13 110,535,591 (GRCm39) missense possibly damaging 0.83
R6240:Plk2 UTSW 13 110,536,568 (GRCm39) missense probably damaging 1.00
R6240:Plk2 UTSW 13 110,536,008 (GRCm39) missense probably damaging 1.00
R6436:Plk2 UTSW 13 110,532,570 (GRCm39) nonsense probably null
R6596:Plk2 UTSW 13 110,534,296 (GRCm39) missense probably benign 0.37
R6776:Plk2 UTSW 13 110,536,325 (GRCm39) missense probably benign
R6938:Plk2 UTSW 13 110,533,214 (GRCm39) nonsense probably null
R7556:Plk2 UTSW 13 110,533,122 (GRCm39) splice site probably null
R8927:Plk2 UTSW 13 110,535,750 (GRCm39) missense probably damaging 1.00
R8928:Plk2 UTSW 13 110,535,750 (GRCm39) missense probably damaging 1.00
R9043:Plk2 UTSW 13 110,533,194 (GRCm39) missense probably damaging 0.97
R9063:Plk2 UTSW 13 110,532,920 (GRCm39) missense possibly damaging 0.67
R9512:Plk2 UTSW 13 110,536,673 (GRCm39) missense probably damaging 0.96
R9546:Plk2 UTSW 13 110,535,301 (GRCm39) missense possibly damaging 0.84
Z1177:Plk2 UTSW 13 110,531,793 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- CATCTGGGCCTTAGGCTGTGTAATG -3'
(R):5'- TGGAAATCTGGAACTGTGTGGCAAC -3'

Sequencing Primer
(F):5'- AGGCTGTGTAATGTAAGTAAATGC -3'
(R):5'- CAGGACGATGACACTCAATTTTACAG -3'
Posted On 2013-04-16