Incidental Mutation 'R3115:Or2a5'
ID 263967
Institutional Source Beutler Lab
Gene Symbol Or2a5
Ensembl Gene ENSMUSG00000043119
Gene Name olfactory receptor family 2 subfamily A member 5
Synonyms Olfr448, MOR261-13, GA_x6K02T2P3E9-4663051-4662119
MMRRC Submission 040588-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # R3115 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 42873387-42874319 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 42873784 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 133 (V133A)
Ref Sequence ENSEMBL: ENSMUSP00000148884 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058668] [ENSMUST00000213952] [ENSMUST00000214529]
AlphaFold Q8VES9
Predicted Effect probably benign
Transcript: ENSMUST00000058668
AA Change: V133A

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000059195
Gene: ENSMUSG00000043119
AA Change: V133A

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 1.8e-61 PFAM
Pfam:7tm_1 40 289 5.3e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213952
AA Change: V133A

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
Predicted Effect probably benign
Transcript: ENSMUST00000214529
AA Change: V133A

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
Meta Mutation Damage Score 0.1110 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.1%
Validation Efficiency 96% (47/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 A G 8: 87,266,653 (GRCm39) probably null Het
Abcc9 T C 6: 142,634,755 (GRCm39) T170A probably benign Het
Agbl2 T C 2: 90,636,245 (GRCm39) S594P possibly damaging Het
Aoc1l3 A G 6: 48,964,331 (GRCm39) Y113C probably damaging Het
Atf7 C T 15: 102,442,858 (GRCm39) S417N probably benign Het
Cacng7 T C 7: 3,387,450 (GRCm39) V111A probably benign Het
Chrm4 A G 2: 91,757,705 (GRCm39) T38A probably benign Het
Cnot1 T C 8: 96,470,906 (GRCm39) E1314G possibly damaging Het
Dcx A G X: 142,706,105 (GRCm39) Y229H probably damaging Het
Espl1 T A 15: 102,231,639 (GRCm39) F1945Y possibly damaging Het
Glul T C 1: 153,783,038 (GRCm39) F204L possibly damaging Het
Grm2 A G 9: 106,524,822 (GRCm39) V631A probably damaging Het
Ifi205 T A 1: 173,855,901 (GRCm39) Y43F possibly damaging Het
Irs3 A G 5: 137,642,118 (GRCm39) L440P probably benign Het
Itpr1 A G 6: 108,383,070 (GRCm39) D1466G possibly damaging Het
Jarid2 T C 13: 45,049,942 (GRCm39) S257P probably damaging Het
Knl1 C A 2: 118,900,872 (GRCm39) L858M possibly damaging Het
Krt24 T A 11: 99,173,262 (GRCm39) T298S possibly damaging Het
Lrriq1 C T 10: 103,006,294 (GRCm39) R1277Q probably benign Het
Mgp A C 6: 136,849,683 (GRCm39) Y92D probably damaging Het
Micu3 A G 8: 40,835,208 (GRCm39) H521R probably benign Het
Mier3 T A 13: 111,843,182 (GRCm39) I178N probably damaging Het
Moxd1 G T 10: 24,177,429 (GRCm39) E582* probably null Het
Mprip T A 11: 59,656,229 (GRCm39) probably null Het
Mybph A G 1: 134,122,476 (GRCm39) I174V probably benign Het
Mynn C T 3: 30,661,959 (GRCm39) T347M probably damaging Het
Nhsl1 A T 10: 18,400,916 (GRCm39) Q714L probably damaging Het
Nr1d2 A T 14: 18,215,504 (GRCm38) probably null Het
Or10g3 T C 14: 52,610,397 (GRCm39) T38A probably damaging Het
Or52h9 C A 7: 104,202,295 (GRCm39) H56Q probably benign Het
Or5p61 T C 7: 107,759,029 (GRCm39) E17G probably benign Het
Pcdha4 T C 18: 37,086,603 (GRCm39) V262A probably benign Het
Pde4d T A 13: 110,084,792 (GRCm39) M519K probably damaging Het
Phactr2 C A 10: 13,137,645 (GRCm39) E166* probably null Het
Prdx4 C T X: 154,113,407 (GRCm39) R167Q probably damaging Het
Prkdc C T 16: 15,482,222 (GRCm39) L422F probably benign Het
Prph T A 15: 98,953,337 (GRCm39) F84I probably damaging Het
Rnmt A G 18: 68,447,079 (GRCm39) E321G probably benign Het
Serpinb13 A T 1: 106,910,568 (GRCm39) E64V probably null Het
Slc12a4 A T 8: 106,686,091 (GRCm39) S81T probably damaging Het
Slc47a1 A G 11: 61,258,506 (GRCm39) L179P possibly damaging Het
Sp140l2 C G 1: 85,235,106 (GRCm39) probably benign Het
Spata31e5 A C 1: 28,815,410 (GRCm39) V874G possibly damaging Het
Sycp2l C A 13: 41,302,274 (GRCm39) T456K probably benign Het
Tenm2 A G 11: 35,914,193 (GRCm39) L2447P probably damaging Het
Tll1 A G 8: 64,506,900 (GRCm39) C614R probably damaging Het
Usp5 T C 6: 124,792,560 (GRCm39) Y826C probably damaging Het
Vmn2r71 A C 7: 85,272,866 (GRCm39) D560A probably damaging Het
Wdr91 A G 6: 34,882,522 (GRCm39) L209P probably damaging Het
Zfp511 T A 7: 139,616,504 (GRCm39) D46E probably benign Het
Zfp81 C T 17: 33,553,537 (GRCm39) A426T possibly damaging Het
Zscan22 T C 7: 12,641,217 (GRCm39) I328T probably benign Het
Other mutations in Or2a5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00937:Or2a5 APN 6 42,873,568 (GRCm39) missense probably damaging 1.00
IGL02888:Or2a5 APN 6 42,874,263 (GRCm39) missense probably damaging 1.00
R0830:Or2a5 UTSW 6 42,873,532 (GRCm39) missense probably benign 0.06
R1173:Or2a5 UTSW 6 42,874,285 (GRCm39) missense probably benign 0.11
R1846:Or2a5 UTSW 6 42,874,254 (GRCm39) missense probably damaging 0.99
R1913:Or2a5 UTSW 6 42,873,687 (GRCm39) missense probably damaging 0.97
R2178:Or2a5 UTSW 6 42,873,732 (GRCm39) missense probably benign
R3116:Or2a5 UTSW 6 42,873,784 (GRCm39) missense probably benign 0.01
R4717:Or2a5 UTSW 6 42,874,158 (GRCm39) missense probably damaging 1.00
R5358:Or2a5 UTSW 6 42,873,454 (GRCm39) missense probably benign 0.11
R6249:Or2a5 UTSW 6 42,874,238 (GRCm39) missense probably damaging 0.98
R6860:Or2a5 UTSW 6 42,873,750 (GRCm39) missense probably benign 0.35
R7122:Or2a5 UTSW 6 42,874,024 (GRCm39) missense probably damaging 0.99
R8924:Or2a5 UTSW 6 42,873,964 (GRCm39) missense probably damaging 1.00
R8988:Or2a5 UTSW 6 42,874,201 (GRCm39) missense
R9507:Or2a5 UTSW 6 42,873,835 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TCTGGCTTGACTGCAGACTC -3'
(R):5'- TGTCAGCACAGACCAACTTAAG -3'

Sequencing Primer
(F):5'- GGCCATCGTCGATATTTCATATG -3'
(R):5'- TCAGCACAGACCAACTTAAGGACAG -3'
Posted On 2015-02-05