Incidental Mutation 'R3116:Ffar3'
ID 264023
Institutional Source Beutler Lab
Gene Symbol Ffar3
Ensembl Gene ENSMUSG00000019429
Gene Name free fatty acid receptor 3
Synonyms LOC233080, Gpr41
MMRRC Submission 040589-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3116 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 30553755-30555603 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 30555231 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 30 (M30V)
Ref Sequence ENSEMBL: ENSMUSP00000140252 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052700] [ENSMUST00000094583] [ENSMUST00000185748]
AlphaFold Q3UFD7
Predicted Effect probably benign
Transcript: ENSMUST00000052700
SMART Domains Protein: ENSMUSP00000055564
Gene: ENSMUSG00000044453

DomainStartEndE-ValueType
Pfam:7tm_1 22 275 1.3e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000094583
AA Change: M30V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000092163
Gene: ENSMUSG00000019429
AA Change: M30V

DomainStartEndE-ValueType
low complexity region 12 25 N/A INTRINSIC
Pfam:7tm_1 27 272 2.9e-32 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000185748
AA Change: M30V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000140252
Gene: ENSMUSG00000019429
AA Change: M30V

DomainStartEndE-ValueType
low complexity region 12 25 N/A INTRINSIC
Pfam:7tm_1 27 272 9.1e-39 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele colonized with a model fermentative community are lean and exhibit decreased weight gain, increased intestinal transit rate, and reduced caloric extraction. Mice homozygous for a knock-out allele exhibit a slight increase in serum insulin when fed a high-fat diet. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 A T 5: 8,946,610 (GRCm39) I37F possibly damaging Het
Aoc1l3 A G 6: 48,964,331 (GRCm39) Y113C probably damaging Het
Ccdc146 T C 5: 21,521,953 (GRCm39) N357S probably benign Het
Csmd3 A G 15: 47,520,995 (GRCm39) F2783S probably damaging Het
Desi2 T A 1: 178,072,008 (GRCm39) M104K probably damaging Het
Disp1 C T 1: 182,870,486 (GRCm39) V645I probably benign Het
Dock8 A T 19: 25,165,858 (GRCm39) H1914L probably benign Het
Fdft1 T C 14: 63,415,147 (GRCm39) I28M probably benign Het
Grm3 A T 5: 9,620,752 (GRCm39) F164Y probably damaging Het
Ints5 T C 19: 8,872,136 (GRCm39) S32P possibly damaging Het
Itgam T A 7: 127,715,201 (GRCm39) S908R probably damaging Het
Kif20b C T 19: 34,947,480 (GRCm39) P1565L probably benign Het
Kntc1 A G 5: 123,940,121 (GRCm39) E1610G probably damaging Het
Krt24 T A 11: 99,173,262 (GRCm39) T298S possibly damaging Het
Magoh T C 4: 107,744,409 (GRCm39) V126A possibly damaging Het
Marchf6 G A 15: 31,486,265 (GRCm39) S362F probably benign Het
Meak7 G A 8: 120,495,056 (GRCm39) A234V probably benign Het
Mier3 T A 13: 111,843,182 (GRCm39) I178N probably damaging Het
Moxd1 G T 10: 24,177,429 (GRCm39) E582* probably null Het
Ncor2 A T 5: 125,101,230 (GRCm39) L2195Q probably damaging Het
Neil1 A T 9: 57,053,947 (GRCm39) D124E probably benign Het
Nhsl1 A T 10: 18,400,916 (GRCm39) Q714L probably damaging Het
Nipbl T A 15: 8,373,076 (GRCm39) M1057L probably benign Het
Npas3 G A 12: 54,114,508 (GRCm39) probably null Het
Oas1h C T 5: 120,999,679 (GRCm39) Q55* probably null Het
Or2a5 T C 6: 42,873,784 (GRCm39) V133A probably benign Het
Or2ag2b T A 7: 106,417,571 (GRCm39) F94I probably damaging Het
Or52h9 C A 7: 104,202,295 (GRCm39) H56Q probably benign Het
Or5p61 T C 7: 107,759,029 (GRCm39) E17G probably benign Het
Or7d9 A T 9: 20,197,523 (GRCm39) H176L probably benign Het
Phactr2 C A 10: 13,137,645 (GRCm39) E166* probably null Het
Prkdc C T 16: 15,482,222 (GRCm39) L422F probably benign Het
Pum1 T C 4: 130,499,971 (GRCm39) V1051A probably damaging Het
Pxdn T C 12: 30,052,306 (GRCm39) S828P possibly damaging Het
Rad21 T A 15: 51,828,397 (GRCm39) E557V probably null Het
Rtn3 T G 19: 7,409,355 (GRCm39) N888H probably damaging Het
Slc12a5 T A 2: 164,838,101 (GRCm39) probably null Het
Slc7a11 T A 3: 50,338,588 (GRCm39) M274L probably benign Het
Tacc2 A G 7: 130,360,979 (GRCm39) N825S probably damaging Het
Tln2 T A 9: 67,262,421 (GRCm39) D610V probably benign Het
Tmed11 C T 5: 108,927,705 (GRCm39) V110M probably damaging Het
Tmem92 T C 11: 94,673,254 (GRCm39) D3G possibly damaging Het
Trp53rkb C T 2: 166,636,009 (GRCm39) probably benign Het
Wdr91 A G 6: 34,882,522 (GRCm39) L209P probably damaging Het
Zfp511 T A 7: 139,616,504 (GRCm39) D46E probably benign Het
Zfp804a C A 2: 82,089,761 (GRCm39) Q1197K probably damaging Het
Other mutations in Ffar3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03080:Ffar3 APN 7 30,554,747 (GRCm39) missense probably damaging 0.99
IGL03167:Ffar3 APN 7 30,554,780 (GRCm39) missense probably damaging 1.00
R0555:Ffar3 UTSW 7 30,554,962 (GRCm39) nonsense probably null
R0751:Ffar3 UTSW 7 30,554,529 (GRCm39) missense probably damaging 1.00
R1184:Ffar3 UTSW 7 30,554,529 (GRCm39) missense probably damaging 1.00
R7276:Ffar3 UTSW 7 30,555,273 (GRCm39) missense possibly damaging 0.46
R8345:Ffar3 UTSW 7 30,554,789 (GRCm39) missense probably damaging 1.00
R9016:Ffar3 UTSW 7 30,554,454 (GRCm39) missense probably damaging 0.97
R9691:Ffar3 UTSW 7 30,555,119 (GRCm39) missense probably damaging 1.00
Z1176:Ffar3 UTSW 7 30,554,618 (GRCm39) missense probably damaging 1.00
Z1186:Ffar3 UTSW 7 30,555,495 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- CAGAAAACGTTCGATGCTCAC -3'
(R):5'- GCCTGATGGGTAAGAGTCTC -3'

Sequencing Primer
(F):5'- TCACCGCCGTCAGGAAGAG -3'
(R):5'- ATGGGTAAGAGTCTCCCAGTG -3'
Posted On 2015-02-05