Incidental Mutation 'R3116:Or2ag2b'
ID 264025
Institutional Source Beutler Lab
Gene Symbol Or2ag2b
Ensembl Gene ENSMUSG00000036744
Gene Name olfactory receptor family 2 subfamily AG member 2B
Synonyms 4933433E02Rik, Olfr701, GA_x6K02T2PBJ9-9195805-9196755, 4932441H21Rik, MOR283-1
MMRRC Submission 040589-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R3116 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 106413336-106419916 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 106417571 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 94 (F94I)
Ref Sequence ENSEMBL: ENSMUSP00000151783 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075414] [ENSMUST00000166880] [ENSMUST00000217739]
AlphaFold Q9D3U9
Predicted Effect probably damaging
Transcript: ENSMUST00000075414
AA Change: F94I

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000074868
Gene: ENSMUSG00000036744
AA Change: F94I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.9e-46 PFAM
Pfam:7tm_1 41 290 2.3e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000166880
AA Change: F94I

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000130958
Gene: ENSMUSG00000036744
AA Change: F94I

DomainStartEndE-ValueType
Pfam:7tm_1 41 290 5.8e-31 PFAM
Pfam:7tm_4 139 283 1.8e-44 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209339
Predicted Effect probably damaging
Transcript: ENSMUST00000217739
AA Change: F94I

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 A T 5: 8,946,610 (GRCm39) I37F possibly damaging Het
Aoc1l3 A G 6: 48,964,331 (GRCm39) Y113C probably damaging Het
Ccdc146 T C 5: 21,521,953 (GRCm39) N357S probably benign Het
Csmd3 A G 15: 47,520,995 (GRCm39) F2783S probably damaging Het
Desi2 T A 1: 178,072,008 (GRCm39) M104K probably damaging Het
Disp1 C T 1: 182,870,486 (GRCm39) V645I probably benign Het
Dock8 A T 19: 25,165,858 (GRCm39) H1914L probably benign Het
Fdft1 T C 14: 63,415,147 (GRCm39) I28M probably benign Het
Ffar3 T C 7: 30,555,231 (GRCm39) M30V probably benign Het
Grm3 A T 5: 9,620,752 (GRCm39) F164Y probably damaging Het
Ints5 T C 19: 8,872,136 (GRCm39) S32P possibly damaging Het
Itgam T A 7: 127,715,201 (GRCm39) S908R probably damaging Het
Kif20b C T 19: 34,947,480 (GRCm39) P1565L probably benign Het
Kntc1 A G 5: 123,940,121 (GRCm39) E1610G probably damaging Het
Krt24 T A 11: 99,173,262 (GRCm39) T298S possibly damaging Het
Magoh T C 4: 107,744,409 (GRCm39) V126A possibly damaging Het
Marchf6 G A 15: 31,486,265 (GRCm39) S362F probably benign Het
Meak7 G A 8: 120,495,056 (GRCm39) A234V probably benign Het
Mier3 T A 13: 111,843,182 (GRCm39) I178N probably damaging Het
Moxd1 G T 10: 24,177,429 (GRCm39) E582* probably null Het
Ncor2 A T 5: 125,101,230 (GRCm39) L2195Q probably damaging Het
Neil1 A T 9: 57,053,947 (GRCm39) D124E probably benign Het
Nhsl1 A T 10: 18,400,916 (GRCm39) Q714L probably damaging Het
Nipbl T A 15: 8,373,076 (GRCm39) M1057L probably benign Het
Npas3 G A 12: 54,114,508 (GRCm39) probably null Het
Oas1h C T 5: 120,999,679 (GRCm39) Q55* probably null Het
Or2a5 T C 6: 42,873,784 (GRCm39) V133A probably benign Het
Or52h9 C A 7: 104,202,295 (GRCm39) H56Q probably benign Het
Or5p61 T C 7: 107,759,029 (GRCm39) E17G probably benign Het
Or7d9 A T 9: 20,197,523 (GRCm39) H176L probably benign Het
Phactr2 C A 10: 13,137,645 (GRCm39) E166* probably null Het
Prkdc C T 16: 15,482,222 (GRCm39) L422F probably benign Het
Pum1 T C 4: 130,499,971 (GRCm39) V1051A probably damaging Het
Pxdn T C 12: 30,052,306 (GRCm39) S828P possibly damaging Het
Rad21 T A 15: 51,828,397 (GRCm39) E557V probably null Het
Rtn3 T G 19: 7,409,355 (GRCm39) N888H probably damaging Het
Slc12a5 T A 2: 164,838,101 (GRCm39) probably null Het
Slc7a11 T A 3: 50,338,588 (GRCm39) M274L probably benign Het
Tacc2 A G 7: 130,360,979 (GRCm39) N825S probably damaging Het
Tln2 T A 9: 67,262,421 (GRCm39) D610V probably benign Het
Tmed11 C T 5: 108,927,705 (GRCm39) V110M probably damaging Het
Tmem92 T C 11: 94,673,254 (GRCm39) D3G possibly damaging Het
Trp53rkb C T 2: 166,636,009 (GRCm39) probably benign Het
Wdr91 A G 6: 34,882,522 (GRCm39) L209P probably damaging Het
Zfp511 T A 7: 139,616,504 (GRCm39) D46E probably benign Het
Zfp804a C A 2: 82,089,761 (GRCm39) Q1197K probably damaging Het
Other mutations in Or2ag2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01476:Or2ag2b APN 7 106,417,827 (GRCm39) missense probably damaging 1.00
IGL01972:Or2ag2b APN 7 106,417,739 (GRCm39) missense probably benign 0.01
IGL02541:Or2ag2b APN 7 106,417,809 (GRCm39) missense probably benign 0.34
R0276:Or2ag2b UTSW 7 106,417,904 (GRCm39) missense probably benign 0.00
R0345:Or2ag2b UTSW 7 106,417,908 (GRCm39) missense probably benign 0.38
R0467:Or2ag2b UTSW 7 106,417,568 (GRCm39) missense possibly damaging 0.49
R1829:Or2ag2b UTSW 7 106,418,214 (GRCm39) missense probably benign
R3870:Or2ag2b UTSW 7 106,418,047 (GRCm39) nonsense probably null
R5267:Or2ag2b UTSW 7 106,418,015 (GRCm39) missense probably damaging 1.00
R6036:Or2ag2b UTSW 7 106,417,667 (GRCm39) missense probably damaging 1.00
R6036:Or2ag2b UTSW 7 106,417,667 (GRCm39) missense probably damaging 1.00
R7229:Or2ag2b UTSW 7 106,418,202 (GRCm39) missense probably damaging 0.97
R7230:Or2ag2b UTSW 7 106,417,386 (GRCm39) missense possibly damaging 0.78
R7231:Or2ag2b UTSW 7 106,417,650 (GRCm39) missense probably damaging 1.00
R7419:Or2ag2b UTSW 7 106,417,551 (GRCm39) missense possibly damaging 0.89
R7537:Or2ag2b UTSW 7 106,417,581 (GRCm39) missense probably damaging 1.00
R8468:Or2ag2b UTSW 7 106,418,046 (GRCm39) missense possibly damaging 0.66
R9246:Or2ag2b UTSW 7 106,417,938 (GRCm39) missense probably benign 0.00
R9300:Or2ag2b UTSW 7 106,418,111 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CTGTGCCACAGTTACAACCC -3'
(R):5'- TGTGTGACCTAGGGCACTAAG -3'

Sequencing Primer
(F):5'- CACAGTTACAACCCTGTACATGTTGG -3'
(R):5'- CACTAAGAGATGCTAGGATCCATG -3'
Posted On 2015-02-05