Incidental Mutation 'R3122:Tnfsf15'
ID 264094
Institutional Source Beutler Lab
Gene Symbol Tnfsf15
Ensembl Gene ENSMUSG00000050395
Gene Name tumor necrosis factor (ligand) superfamily, member 15
Synonyms TL1A, VEGI, TL1
MMRRC Submission 040595-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R3122 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 63642837-63663296 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 63652522 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 96 (E96D)
Ref Sequence ENSEMBL: ENSMUSP00000050144 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062246]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000062246
AA Change: E96D

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000050144
Gene: ENSMUSG00000050395
AA Change: E96D

DomainStartEndE-ValueType
transmembrane domain 56 78 N/A INTRINSIC
TNF 114 270 1.25e-28 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency 100% (48/48)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
PHENOTYPE: Homozygous targeted mutants display decreased clinical severity in experimental autoimmune encephalomyelitis (EAE) and collagen-induced arthritis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam18 T C 8: 25,118,248 (GRCm39) N8S possibly damaging Het
Ago3 A G 4: 126,311,165 (GRCm39) I16T probably benign Het
Alms1 C A 6: 85,644,945 (GRCm39) probably benign Het
Brdt A G 5: 107,525,011 (GRCm39) T851A probably damaging Het
Capn7 A T 14: 31,081,167 (GRCm39) I395F probably damaging Het
Ccbe1 A G 18: 66,199,900 (GRCm39) M274T probably benign Het
Ccdc146 T C 5: 21,499,591 (GRCm39) R864G possibly damaging Het
Ccdc17 G T 4: 116,456,749 (GRCm39) probably benign Het
Ccdc85a C A 11: 28,533,499 (GRCm39) C15F unknown Het
Cpt1c A G 7: 44,609,345 (GRCm39) Y715H probably damaging Het
Dmwd T A 7: 18,814,620 (GRCm39) F423L probably damaging Het
Dock3 C G 9: 106,788,542 (GRCm39) A1598P probably damaging Het
Ext2 A G 2: 93,644,170 (GRCm39) L37P probably damaging Het
Fam120a T C 13: 49,045,562 (GRCm39) D758G possibly damaging Het
Foxn4 T C 5: 114,396,776 (GRCm39) T236A probably damaging Het
Gm9776 A T 13: 94,495,194 (GRCm39) probably benign Het
Grik1 A T 16: 87,803,361 (GRCm39) M277K probably damaging Het
H2-T23 T A 17: 36,341,855 (GRCm39) M248L probably benign Het
Hephl1 A G 9: 15,000,265 (GRCm39) F329S possibly damaging Het
Kif13a G A 13: 46,918,072 (GRCm39) probably benign Het
Knl1 T A 2: 118,899,425 (GRCm39) H375Q probably benign Het
Lox A G 18: 52,658,177 (GRCm39) F332S probably damaging Het
Ltf G A 9: 110,851,968 (GRCm39) C135Y probably damaging Het
Madd A G 2: 91,006,554 (GRCm39) Y347H probably damaging Het
Mboat1 T C 13: 30,422,031 (GRCm39) Y387H probably damaging Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Naip1 T C 13: 100,545,503 (GRCm39) T1342A probably damaging Het
Naip6 T C 13: 100,453,031 (GRCm39) D10G probably benign Het
Nudt8 A G 19: 4,052,015 (GRCm39) R209G possibly damaging Het
Or4c31 G T 2: 88,291,853 (GRCm39) M75I probably damaging Het
Or56a3 T C 7: 104,735,385 (GRCm39) V154A probably benign Het
Or8k35 A T 2: 86,424,954 (GRCm39) Y73N possibly damaging Het
Orc4 G A 2: 48,827,501 (GRCm39) P31S probably benign Het
Phactr1 T A 13: 43,213,049 (GRCm39) S131T possibly damaging Het
Phactr3 A G 2: 177,973,411 (GRCm39) I475V probably damaging Het
Pip T A 6: 41,828,819 (GRCm39) N121K probably damaging Het
Pla2g4d T C 2: 120,109,384 (GRCm39) R222G probably benign Het
Rbm42 A G 7: 30,349,152 (GRCm39) probably benign Het
Sowahb T C 5: 93,191,261 (GRCm39) D486G possibly damaging Het
Svep1 C T 4: 58,087,845 (GRCm39) V1745I possibly damaging Het
Vmn1r217 A G 13: 23,298,249 (GRCm39) S218P probably damaging Het
Vmn2r129 G T 4: 156,686,692 (GRCm39) noncoding transcript Het
Vmn2r71 T G 7: 85,264,828 (GRCm39) Y53* probably null Het
Wapl A G 14: 34,451,172 (GRCm39) I729M possibly damaging Het
Wrnip1 A G 13: 32,986,744 (GRCm39) D175G probably benign Het
Zscan2 G A 7: 80,513,092 (GRCm39) A26T probably benign Het
Other mutations in Tnfsf15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00674:Tnfsf15 APN 4 63,652,483 (GRCm39) splice site probably benign
IGL00743:Tnfsf15 APN 4 63,652,518 (GRCm39) missense probably benign 0.00
IGL03189:Tnfsf15 APN 4 63,648,289 (GRCm39) splice site probably benign
R0158:Tnfsf15 UTSW 4 63,648,229 (GRCm39) missense possibly damaging 0.95
R1824:Tnfsf15 UTSW 4 63,651,588 (GRCm39) missense probably benign 0.03
R4595:Tnfsf15 UTSW 4 63,648,180 (GRCm39) nonsense probably null
R5025:Tnfsf15 UTSW 4 63,648,125 (GRCm39) missense probably benign 0.01
R6123:Tnfsf15 UTSW 4 63,663,162 (GRCm39) missense probably benign 0.00
R6376:Tnfsf15 UTSW 4 63,663,267 (GRCm39) missense probably damaging 0.98
R7104:Tnfsf15 UTSW 4 63,647,887 (GRCm39) missense probably damaging 1.00
R7173:Tnfsf15 UTSW 4 63,647,889 (GRCm39) missense probably damaging 1.00
R9448:Tnfsf15 UTSW 4 63,663,305 (GRCm39) missense possibly damaging 0.46
Predicted Primers PCR Primer
(F):5'- ATGTAGTCAGAGCACTGTTTTGC -3'
(R):5'- TCTAGAAAAGGTGTGCAGAGCC -3'

Sequencing Primer
(F):5'- AGTGGGGGAGGAGCCTCAC -3'
(R):5'- CGAGAGGCAAGATTCCCAC -3'
Posted On 2015-02-05