Incidental Mutation 'R3147:H1f5'
ID 264294
Institutional Source Beutler Lab
Gene Symbol H1f5
Ensembl Gene ENSMUSG00000058773
Gene Name H1.5 linker histone, cluster member
Synonyms Hist1h1b, H1f5, H1s-3, H1B, H1.5
MMRRC Submission 040599-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.388) question?
Stock # R3147 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 21964053-21964795 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 21964285 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000139663 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080511] [ENSMUST00000189457]
AlphaFold P43276
Predicted Effect unknown
Transcript: ENSMUST00000080511
AA Change: K147R
SMART Domains Protein: ENSMUSP00000079356
Gene: ENSMUSG00000058773
AA Change: K147R

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
H15 34 99 5.02e-24 SMART
low complexity region 116 223 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000189457
SMART Domains Protein: ENSMUSP00000139663
Gene: ENSMUSG00000101972

DomainStartEndE-ValueType
H3 34 136 1.5e-75 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype FUNCTION: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Sep 2015]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933436I01Rik T C X: 66,964,984 (GRCm39) D12G probably benign Het
Alg2 A T 4: 47,472,259 (GRCm39) V183D probably damaging Het
Amy1 T C 3: 113,363,697 (GRCm39) probably benign Het
Asb15 G T 6: 24,566,258 (GRCm39) A404S probably damaging Het
Atf2 T C 2: 73,681,283 (GRCm39) probably null Het
Atosa A G 9: 74,916,120 (GRCm39) I240V probably benign Het
Baalc A T 15: 38,812,568 (GRCm39) E106V possibly damaging Het
Catsperd G T 17: 56,971,039 (GRCm39) C701F possibly damaging Het
Cc2d2a T A 5: 43,866,497 (GRCm39) I769N probably damaging Het
Ccdc158 T C 5: 92,805,822 (GRCm39) N311S probably damaging Het
Dbx1 C A 7: 49,286,297 (GRCm39) R56L probably damaging Het
Eif4enif1 T A 11: 3,194,003 (GRCm39) probably null Het
Elmod3 T G 6: 72,563,485 (GRCm39) T48P probably benign Het
Erbb2 T C 11: 98,324,865 (GRCm39) S820P probably damaging Het
Gimap8 T C 6: 48,627,440 (GRCm39) V138A probably damaging Het
Il6ra G T 3: 89,793,235 (GRCm39) P305Q probably benign Het
Kcng3 A G 17: 83,895,749 (GRCm39) V239A possibly damaging Het
Kcnrg T C 14: 61,845,140 (GRCm39) F60S probably damaging Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Lama1 A G 17: 68,044,653 (GRCm39) D184G probably damaging Het
Lhcgr A T 17: 89,065,771 (GRCm39) L206Q probably damaging Het
Lhx3 T C 2: 26,091,277 (GRCm39) D344G probably benign Het
Marf1 A G 16: 13,943,843 (GRCm39) V1380A possibly damaging Het
Mtcl2 T G 2: 156,862,284 (GRCm39) K1548N possibly damaging Het
Mtfr1 T C 3: 19,271,374 (GRCm39) V182A probably benign Het
Or14a259 A G 7: 86,013,092 (GRCm39) L151S probably benign Het
Or5p64 C T 7: 107,854,883 (GRCm39) G154D possibly damaging Het
Rsf1 CG CGACGGAGGAG 7: 97,229,115 (GRCm39) probably benign Het
Snx4 A C 16: 33,108,094 (GRCm39) D296A probably benign Het
Sox7 A T 14: 64,186,083 (GRCm39) Y373F probably damaging Het
Tuba1b T C 15: 98,830,386 (GRCm39) T145A probably benign Het
Usp32 T A 11: 84,919,913 (GRCm39) N718I probably damaging Het
Wapl G A 14: 34,447,106 (GRCm39) V648M probably damaging Het
Zfp85 C T 13: 67,900,612 (GRCm39) V10M probably damaging Het
Zgrf1 A G 3: 127,377,797 (GRCm39) N1014S possibly damaging Het
Other mutations in H1f5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03026:H1f5 APN 13 21,964,117 (GRCm39) unclassified probably benign
R1104:H1f5 UTSW 13 21,964,451 (GRCm39) missense possibly damaging 0.66
R1295:H1f5 UTSW 13 21,964,169 (GRCm39) missense probably benign 0.23
R3120:H1f5 UTSW 13 21,964,215 (GRCm39) missense probably benign 0.23
R4222:H1f5 UTSW 13 21,964,147 (GRCm39) unclassified probably benign
R4597:H1f5 UTSW 13 21,964,681 (GRCm39) missense probably damaging 0.96
R6289:H1f5 UTSW 13 21,964,609 (GRCm39) missense probably damaging 1.00
Z1176:H1f5 UTSW 13 21,964,264 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CTTAGCGGTCTTAGGCTTGGTAAC -3'
(R):5'- CAACAGCCGCATCAAGCTTG -3'

Sequencing Primer
(F):5'- AACCTTAGGTTTGGATGCCTTAGAC -3'
(R):5'- GCTCAAGAGTCTGGTGAGC -3'
Posted On 2015-02-05