Incidental Mutation 'R2930:Zmym4'
ID 264512
Institutional Source Beutler Lab
Gene Symbol Zmym4
Ensembl Gene ENSMUSG00000042446
Gene Name zinc finger, MYM-type 4
Synonyms Zfp262, 6330503C17Rik
MMRRC Submission 040512-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.586) question?
Stock # R2930 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 126755732-126861928 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 126819316 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 196 (S196G)
Ref Sequence ENSEMBL: ENSMUSP00000101714 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106108]
AlphaFold A2A791
Predicted Effect probably benign
Transcript: ENSMUST00000106108
AA Change: S196G

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000101714
Gene: ENSMUSG00000042446
AA Change: S196G

DomainStartEndE-ValueType
TRASH 341 377 6.53e-4 SMART
TRASH 389 429 7.22e-6 SMART
TRASH 441 479 1.77e0 SMART
TRASH 486 525 4.95e-4 SMART
TRASH 531 569 1.05e-2 SMART
TRASH 579 615 2.82e1 SMART
low complexity region 640 649 N/A INTRINSIC
TRASH 687 723 8.49e-3 SMART
TRASH 729 764 1.14e-3 SMART
TRASH 772 810 4.48e-2 SMART
TRASH 816 851 2.06e-1 SMART
low complexity region 974 993 N/A INTRINSIC
low complexity region 1002 1021 N/A INTRINSIC
Pfam:DUF3504 1357 1527 1.7e-68 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123597
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129028
Predicted Effect probably benign
Transcript: ENSMUST00000135003
SMART Domains Protein: ENSMUSP00000120813
Gene: ENSMUSG00000042446

DomainStartEndE-ValueType
TRASH 90 126 6.53e-4 SMART
TRASH 138 178 7.22e-6 SMART
TRASH 190 228 1.77e0 SMART
TRASH 235 274 3.05e-4 SMART
low complexity region 300 309 N/A INTRINSIC
TRASH 347 383 8.49e-3 SMART
TRASH 389 424 1.14e-3 SMART
TRASH 432 470 4.48e-2 SMART
TRASH 476 511 2.06e-1 SMART
low complexity region 634 653 N/A INTRINSIC
low complexity region 662 681 N/A INTRINSIC
Pfam:DUF3504 1017 1187 1.5e-68 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151026
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154821
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 18 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 A T 2: 69,087,702 (GRCm39) V1021D probably damaging Het
Abcc3 T C 11: 94,252,636 (GRCm39) N749S probably damaging Het
Adap1 T C 5: 139,293,621 (GRCm39) D30G probably benign Het
Camk2d C A 3: 126,601,880 (GRCm39) H356Q possibly damaging Het
Cdc23 ACC AC 18: 34,770,371 (GRCm39) probably null Het
Cfap74 G A 4: 155,522,627 (GRCm39) S671N probably damaging Het
Cul7 C G 17: 46,962,526 (GRCm39) D52E probably benign Het
Dsn1 T C 2: 156,847,381 (GRCm39) D19G probably damaging Het
Fndc3b T C 3: 27,524,435 (GRCm39) T442A probably benign Het
Hsd3b5 C T 3: 98,526,528 (GRCm39) R306H probably benign Het
Ilf3 A G 9: 21,310,886 (GRCm39) K617E possibly damaging Het
Krt75 C T 15: 101,476,466 (GRCm39) R433Q probably benign Het
Myrfl C T 10: 116,653,652 (GRCm39) V472I probably damaging Het
Plxna4 A G 6: 32,142,715 (GRCm39) L1580P probably damaging Het
Thop1 T C 10: 80,909,148 (GRCm39) S60P probably damaging Het
Tshz3 G A 7: 36,471,017 (GRCm39) R1002Q possibly damaging Het
Zbtb4 G T 11: 69,667,342 (GRCm39) G216* probably null Het
Zfp729b A G 13: 67,739,973 (GRCm39) L764S probably benign Het
Other mutations in Zmym4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00537:Zmym4 APN 4 126,783,851 (GRCm39) missense probably benign
IGL00845:Zmym4 APN 4 126,794,406 (GRCm39) missense probably benign 0.28
IGL01122:Zmym4 APN 4 126,758,045 (GRCm39) missense probably damaging 1.00
IGL01374:Zmym4 APN 4 126,762,750 (GRCm39) missense probably damaging 1.00
IGL01564:Zmym4 APN 4 126,805,073 (GRCm39) missense possibly damaging 0.84
IGL02014:Zmym4 APN 4 126,794,462 (GRCm39) missense possibly damaging 0.67
IGL02187:Zmym4 APN 4 126,764,066 (GRCm39) missense probably damaging 0.97
IGL02887:Zmym4 APN 4 126,842,268 (GRCm39) missense probably damaging 0.96
IGL03371:Zmym4 APN 4 126,808,881 (GRCm39) missense possibly damaging 0.90
IGL03400:Zmym4 APN 4 126,816,920 (GRCm39) missense probably benign 0.12
arriba UTSW 4 126,809,415 (GRCm39) missense probably damaging 0.97
foreclosed UTSW 4 126,789,099 (GRCm39) missense probably damaging 1.00
Foreshortened UTSW 4 126,804,729 (GRCm39) missense possibly damaging 0.75
levantese UTSW 4 126,757,961 (GRCm39) missense probably damaging 0.99
terminated UTSW 4 126,819,588 (GRCm39) missense probably benign 0.02
BB004:Zmym4 UTSW 4 126,799,170 (GRCm39) missense probably benign 0.42
BB014:Zmym4 UTSW 4 126,799,170 (GRCm39) missense probably benign 0.42
R0149:Zmym4 UTSW 4 126,804,938 (GRCm39) missense probably benign 0.00
R0361:Zmym4 UTSW 4 126,804,938 (GRCm39) missense probably benign 0.00
R0423:Zmym4 UTSW 4 126,776,112 (GRCm39) splice site probably benign
R0532:Zmym4 UTSW 4 126,792,194 (GRCm39) nonsense probably null
R0745:Zmym4 UTSW 4 126,796,496 (GRCm39) splice site probably benign
R1183:Zmym4 UTSW 4 126,819,632 (GRCm39) missense probably damaging 0.99
R1401:Zmym4 UTSW 4 126,804,962 (GRCm39) missense probably benign 0.00
R1446:Zmym4 UTSW 4 126,776,275 (GRCm39) missense probably damaging 1.00
R1491:Zmym4 UTSW 4 126,776,105 (GRCm39) critical splice acceptor site probably null
R1566:Zmym4 UTSW 4 126,804,940 (GRCm39) missense possibly damaging 0.94
R1962:Zmym4 UTSW 4 126,796,463 (GRCm39) missense possibly damaging 0.47
R2398:Zmym4 UTSW 4 126,816,929 (GRCm39) missense probably damaging 1.00
R3891:Zmym4 UTSW 4 126,798,269 (GRCm39) missense probably benign 0.04
R3892:Zmym4 UTSW 4 126,798,269 (GRCm39) missense probably benign 0.04
R4659:Zmym4 UTSW 4 126,842,221 (GRCm39) splice site probably null
R4702:Zmym4 UTSW 4 126,816,958 (GRCm39) missense probably benign 0.01
R5160:Zmym4 UTSW 4 126,763,977 (GRCm39) missense probably damaging 0.97
R5614:Zmym4 UTSW 4 126,804,729 (GRCm39) missense possibly damaging 0.75
R5773:Zmym4 UTSW 4 126,799,163 (GRCm39) missense possibly damaging 0.52
R6450:Zmym4 UTSW 4 126,789,099 (GRCm39) missense probably damaging 1.00
R6741:Zmym4 UTSW 4 126,808,878 (GRCm39) missense possibly damaging 0.80
R7023:Zmym4 UTSW 4 126,762,593 (GRCm39) missense probably damaging 1.00
R7315:Zmym4 UTSW 4 126,776,385 (GRCm39) missense probably benign 0.09
R7468:Zmym4 UTSW 4 126,776,029 (GRCm39) missense probably benign 0.40
R7546:Zmym4 UTSW 4 126,757,961 (GRCm39) missense probably damaging 0.99
R7609:Zmym4 UTSW 4 126,819,588 (GRCm39) missense probably benign 0.02
R7764:Zmym4 UTSW 4 126,819,409 (GRCm39) missense probably benign 0.06
R7897:Zmym4 UTSW 4 126,783,332 (GRCm39) missense possibly damaging 0.76
R7918:Zmym4 UTSW 4 126,804,797 (GRCm39) critical splice acceptor site probably null
R7927:Zmym4 UTSW 4 126,799,170 (GRCm39) missense probably benign 0.42
R8129:Zmym4 UTSW 4 126,808,956 (GRCm39) missense possibly damaging 0.87
R8240:Zmym4 UTSW 4 126,798,188 (GRCm39) critical splice donor site probably null
R8248:Zmym4 UTSW 4 126,799,162 (GRCm39) missense possibly damaging 0.56
R8261:Zmym4 UTSW 4 126,798,360 (GRCm39) missense probably damaging 1.00
R8313:Zmym4 UTSW 4 126,804,762 (GRCm39) missense probably benign 0.19
R8353:Zmym4 UTSW 4 126,800,905 (GRCm39) missense possibly damaging 0.46
R8747:Zmym4 UTSW 4 126,787,198 (GRCm39) missense probably damaging 1.00
R8787:Zmym4 UTSW 4 126,816,953 (GRCm39) missense probably benign 0.41
R8795:Zmym4 UTSW 4 126,799,819 (GRCm39) missense probably benign 0.35
R8948:Zmym4 UTSW 4 126,758,060 (GRCm39) missense probably damaging 1.00
R9218:Zmym4 UTSW 4 126,809,415 (GRCm39) missense probably damaging 0.97
R9233:Zmym4 UTSW 4 126,776,310 (GRCm39) missense probably damaging 0.99
R9286:Zmym4 UTSW 4 126,783,812 (GRCm39) missense probably damaging 1.00
R9468:Zmym4 UTSW 4 126,800,993 (GRCm39) missense probably benign 0.01
R9542:Zmym4 UTSW 4 126,799,164 (GRCm39) missense probably benign 0.00
R9756:Zmym4 UTSW 4 126,771,502 (GRCm39) missense probably damaging 1.00
R9776:Zmym4 UTSW 4 126,804,942 (GRCm39) missense possibly damaging 0.51
U24488:Zmym4 UTSW 4 126,819,453 (GRCm39) missense possibly damaging 0.69
Z1177:Zmym4 UTSW 4 126,801,005 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGGAACAGGTGATGCAAGTATC -3'
(R):5'- GACTTTCCTAAACAGTTTGATCAGG -3'

Sequencing Primer
(F):5'- GCCTTCTCATCAAAATATTGCAAGC -3'
(R):5'- CCTAAACAGTTTGATCAGGTTTCTG -3'
Posted On 2015-02-05