Incidental Mutation 'R2931:Pirb'
ID 264534
Institutional Source Beutler Lab
Gene Symbol Pirb
Ensembl Gene ENSMUSG00000058818
Gene Name paired Ig-like receptor B
Synonyms Lilrb3, Gp91
MMRRC Submission 040513-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2931 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 3715504-3723381 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 3720205 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 389 (H389Q)
Ref Sequence ENSEMBL: ENSMUSP00000077546 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078451]
AlphaFold P97484
Predicted Effect probably benign
Transcript: ENSMUST00000078451
AA Change: H389Q

PolyPhen 2 Score 0.078 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000077546
Gene: ENSMUSG00000058818
AA Change: H389Q

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IG 34 118 1.8e-3 SMART
IG 129 315 1.2e-4 SMART
IG_like 237 302 6.2e-4 SMART
IG_like 328 415 3.4e-2 SMART
IG_like 435 502 1e-2 SMART
IG 529 618 3.6e-5 SMART
low complexity region 624 637 N/A INTRINSIC
transmembrane domain 641 663 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129493
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136238
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137474
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155131
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for disruptions of this gene display abnormalities in both B and T lymphocytes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 14 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgb C T 10: 10,318,246 (GRCm39) V193I possibly damaging Het
Asb2 T C 12: 103,301,146 (GRCm39) D151G probably damaging Het
Cyp2c69 G A 19: 39,837,927 (GRCm39) T385I probably damaging Het
Dhx15 G A 5: 52,324,074 (GRCm39) P406L probably benign Het
Dido1 T C 2: 180,303,446 (GRCm39) E1486G probably damaging Het
Kdm5d T C Y: 942,992 (GRCm39) F1492L probably benign Het
Map2k4 A T 11: 65,647,163 (GRCm39) N59K probably damaging Het
Myo18b A G 5: 112,840,993 (GRCm39) S2267P probably benign Het
Naip2 A T 13: 100,291,529 (GRCm39) D1136E probably benign Het
Otogl A T 10: 107,655,865 (GRCm39) M1080K possibly damaging Het
Sptan1 A G 2: 29,908,500 (GRCm39) T1739A probably benign Het
Strip1 T A 3: 107,532,975 (GRCm39) probably null Het
Trappc11 A T 8: 47,956,977 (GRCm39) D816E probably damaging Het
Zscan12 A G 13: 21,548,187 (GRCm39) D123G possibly damaging Het
Other mutations in Pirb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01295:Pirb APN 7 3,720,405 (GRCm39) missense probably damaging 0.99
IGL01744:Pirb APN 7 3,720,175 (GRCm39) nonsense probably null
IGL01755:Pirb APN 7 3,720,169 (GRCm39) missense probably benign 0.16
IGL02580:Pirb APN 7 3,717,205 (GRCm39) splice site probably null
IGL02941:Pirb APN 7 3,720,377 (GRCm39) missense probably damaging 1.00
R0394:Pirb UTSW 7 3,722,247 (GRCm39) missense probably benign 0.08
R0680:Pirb UTSW 7 3,720,360 (GRCm39) missense possibly damaging 0.94
R0787:Pirb UTSW 7 3,720,637 (GRCm39) missense probably benign
R0790:Pirb UTSW 7 3,720,637 (GRCm39) missense probably benign
R0832:Pirb UTSW 7 3,720,637 (GRCm39) missense probably benign
R1124:Pirb UTSW 7 3,722,731 (GRCm39) missense probably benign 0.02
R1178:Pirb UTSW 7 3,720,637 (GRCm39) missense probably benign
R1180:Pirb UTSW 7 3,720,637 (GRCm39) missense probably benign
R1181:Pirb UTSW 7 3,720,637 (GRCm39) missense probably benign
R1281:Pirb UTSW 7 3,720,189 (GRCm39) missense probably damaging 1.00
R1343:Pirb UTSW 7 3,720,637 (GRCm39) missense probably benign
R1579:Pirb UTSW 7 3,720,637 (GRCm39) missense probably benign
R1699:Pirb UTSW 7 3,720,637 (GRCm39) missense probably benign
R1768:Pirb UTSW 7 3,720,189 (GRCm39) missense probably damaging 1.00
R1909:Pirb UTSW 7 3,717,587 (GRCm39) missense probably benign 0.33
R1965:Pirb UTSW 7 3,720,637 (GRCm39) missense probably benign
R1966:Pirb UTSW 7 3,720,637 (GRCm39) missense probably benign
R2004:Pirb UTSW 7 3,720,637 (GRCm39) missense probably benign
R2305:Pirb UTSW 7 3,715,990 (GRCm39) missense probably benign 0.00
R3858:Pirb UTSW 7 3,720,662 (GRCm39) missense possibly damaging 0.54
R3928:Pirb UTSW 7 3,720,637 (GRCm39) missense probably benign
R3938:Pirb UTSW 7 3,720,637 (GRCm39) missense probably benign
R4119:Pirb UTSW 7 3,720,574 (GRCm39) missense probably damaging 1.00
R4174:Pirb UTSW 7 3,719,031 (GRCm39) critical splice donor site probably null
R4248:Pirb UTSW 7 3,722,297 (GRCm39) missense probably damaging 1.00
R4827:Pirb UTSW 7 3,720,602 (GRCm39) missense probably benign
R4828:Pirb UTSW 7 3,720,602 (GRCm39) missense probably benign
R4829:Pirb UTSW 7 3,720,602 (GRCm39) missense probably benign
R4830:Pirb UTSW 7 3,720,602 (GRCm39) missense probably benign
R4870:Pirb UTSW 7 3,715,661 (GRCm39) missense probably benign 0.00
R4909:Pirb UTSW 7 3,722,361 (GRCm39) nonsense probably null
R5146:Pirb UTSW 7 3,715,620 (GRCm39) utr 3 prime probably benign
R5244:Pirb UTSW 7 3,719,062 (GRCm39) missense probably benign 0.32
R5323:Pirb UTSW 7 3,719,598 (GRCm39) missense possibly damaging 0.85
R5921:Pirb UTSW 7 3,719,693 (GRCm39) nonsense probably null
R6316:Pirb UTSW 7 3,720,822 (GRCm39) missense probably damaging 1.00
R6502:Pirb UTSW 7 3,720,392 (GRCm39) missense probably benign 0.00
R6811:Pirb UTSW 7 3,722,641 (GRCm39) missense possibly damaging 0.91
R7216:Pirb UTSW 7 3,719,273 (GRCm39) missense probably benign 0.00
R7275:Pirb UTSW 7 3,719,177 (GRCm39) missense probably benign 0.00
R7327:Pirb UTSW 7 3,720,187 (GRCm39) nonsense probably null
R7582:Pirb UTSW 7 3,716,817 (GRCm39) critical splice donor site probably null
R7717:Pirb UTSW 7 3,720,800 (GRCm39) missense not run
R7717:Pirb UTSW 7 3,720,782 (GRCm39) missense not run
R7807:Pirb UTSW 7 3,722,864 (GRCm39) missense possibly damaging 0.55
R7844:Pirb UTSW 7 3,722,410 (GRCm39) nonsense probably null
R7947:Pirb UTSW 7 3,722,857 (GRCm39) missense probably damaging 0.96
R8206:Pirb UTSW 7 3,715,905 (GRCm39) critical splice donor site probably null
R8397:Pirb UTSW 7 3,719,045 (GRCm39) missense probably damaging 1.00
R8774:Pirb UTSW 7 3,720,728 (GRCm39) missense probably damaging 1.00
R8774-TAIL:Pirb UTSW 7 3,720,728 (GRCm39) missense probably damaging 1.00
R9033:Pirb UTSW 7 3,720,584 (GRCm39) missense probably benign
R9275:Pirb UTSW 7 3,719,859 (GRCm39) missense probably benign
R9452:Pirb UTSW 7 3,720,617 (GRCm39) missense possibly damaging 0.68
R9595:Pirb UTSW 7 3,722,406 (GRCm39) missense possibly damaging 0.78
R9605:Pirb UTSW 7 3,720,617 (GRCm39) missense possibly damaging 0.68
R9607:Pirb UTSW 7 3,720,617 (GRCm39) missense possibly damaging 0.68
X0025:Pirb UTSW 7 3,720,267 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGTTCAAGAACACAGGCTCTC -3'
(R):5'- TATGAACCCAGGCTGTCAGTAC -3'

Sequencing Primer
(F):5'- TCCTTCTCTACCTGCAACTCAG -3'
(R):5'- TGTCAGTACTGCCCAGCC -3'
Posted On 2015-02-05