Incidental Mutation 'R2944:Kremen1'
ID 264631
Institutional Source Beutler Lab
Gene Symbol Kremen1
Ensembl Gene ENSMUSG00000020393
Gene Name kringle containing transmembrane protein 1
Synonyms Krm1
MMRRC Submission 040518-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.124) question?
Stock # R2944 (G1)
Quality Score 146
Status Not validated
Chromosome 11
Chromosomal Location 5141552-5211558 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) CGGG to CGGGGGG at 5151791 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000020662]
AlphaFold Q99N43
Predicted Effect probably benign
Transcript: ENSMUST00000020662
SMART Domains Protein: ENSMUSP00000020662
Gene: ENSMUSG00000020393

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
KR 30 116 9.81e-23 SMART
Pfam:WSC 119 200 3.7e-21 PFAM
CUB 214 321 4.27e-19 SMART
transmembrane domain 391 413 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000151978
SMART Domains Protein: ENSMUSP00000121252
Gene: ENSMUSG00000020393

DomainStartEndE-ValueType
Pfam:WSC 17 98 2.3e-22 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit no abnormal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam12 T C 7: 133,577,236 (GRCm39) M179V probably null Het
Alms1 C T 6: 85,605,373 (GRCm39) T2341I probably damaging Het
Bpnt1 A G 1: 185,084,406 (GRCm39) T168A probably damaging Het
Cdcp2 A C 4: 106,959,755 (GRCm39) S57R possibly damaging Het
Cmya5 T A 13: 93,229,350 (GRCm39) K1913* probably null Het
Coro1c C G 5: 113,988,861 (GRCm39) G161R probably damaging Het
Csnk1a1 T C 18: 61,711,760 (GRCm39) M258T probably benign Het
Dnah3 A G 7: 119,550,333 (GRCm39) C3318R probably damaging Het
Fyco1 A T 9: 123,655,713 (GRCm39) M1015K probably benign Het
Hfm1 A G 5: 107,020,196 (GRCm39) S290P probably damaging Het
Lce1i G A 3: 92,685,063 (GRCm39) P38S unknown Het
Nup210l T A 3: 90,088,852 (GRCm39) S1156T probably damaging Het
Or8g35 A T 9: 39,381,234 (GRCm39) S263T possibly damaging Het
Sec14l5 T A 16: 4,998,697 (GRCm39) I579N probably benign Het
Semp2l2a A T 8: 13,887,212 (GRCm39) L293Q probably damaging Het
Sh3tc1 C A 5: 35,871,504 (GRCm39) V107L probably damaging Het
Tmprss11a T G 5: 86,576,511 (GRCm39) R113S probably benign Het
Trmt10b A G 4: 45,300,445 (GRCm39) M1V probably null Het
Ush1c T C 7: 45,850,406 (GRCm39) E791G probably damaging Het
Uspl1 T C 5: 149,138,606 (GRCm39) L328P probably damaging Het
Utrn G T 10: 12,519,163 (GRCm39) T2263K probably damaging Het
Other mutations in Kremen1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01813:Kremen1 APN 11 5,149,667 (GRCm39) missense probably benign 0.00
R0038:Kremen1 UTSW 11 5,157,703 (GRCm39) splice site probably benign
R0511:Kremen1 UTSW 11 5,165,447 (GRCm39) missense probably damaging 1.00
R1557:Kremen1 UTSW 11 5,165,373 (GRCm39) splice site probably null
R1579:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R1729:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R1784:Kremen1 UTSW 11 5,151,792 (GRCm39) unclassified probably benign
R1800:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R2079:Kremen1 UTSW 11 5,151,794 (GRCm39) frame shift probably null
R2100:Kremen1 UTSW 11 5,151,788 (GRCm39) unclassified probably benign
R2286:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R2298:Kremen1 UTSW 11 5,151,788 (GRCm39) unclassified probably benign
R2352:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R2512:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R2761:Kremen1 UTSW 11 5,151,792 (GRCm39) unclassified probably benign
R2846:Kremen1 UTSW 11 5,151,793 (GRCm39) unclassified probably benign
R2882:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R2980:Kremen1 UTSW 11 5,151,794 (GRCm39) unclassified probably benign
R3151:Kremen1 UTSW 11 5,145,012 (GRCm39) missense probably damaging 0.99
R3610:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R3831:Kremen1 UTSW 11 5,151,794 (GRCm39) unclassified probably benign
R3957:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R4231:Kremen1 UTSW 11 5,193,881 (GRCm39) nonsense probably null
R4397:Kremen1 UTSW 11 5,149,610 (GRCm39) missense probably benign 0.36
R5627:Kremen1 UTSW 11 5,149,709 (GRCm39) missense probably benign 0.01
R6818:Kremen1 UTSW 11 5,145,051 (GRCm39) missense probably benign 0.02
R7584:Kremen1 UTSW 11 5,144,964 (GRCm39) missense possibly damaging 0.95
R8803:Kremen1 UTSW 11 5,144,981 (GRCm39) missense probably benign 0.01
T0975:Kremen1 UTSW 11 5,145,105 (GRCm39) missense probably benign 0.02
Y4339:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- GTTGAAATGATCTGTAGCTGAGTC -3'
(R):5'- TGACTTCCCTGACACCTACG -3'

Sequencing Primer
(F):5'- TCAGGAGGACCAAGTGTGCC -3'
(R):5'- TGACACCTACGCCACTGG -3'
Posted On 2015-02-05