Incidental Mutation 'R2966:Fstl3'
ID 264673
Institutional Source Beutler Lab
Gene Symbol Fstl3
Ensembl Gene ENSMUSG00000020325
Gene Name follistatin-like 3
Synonyms E030038F23Rik, Flrg
MMRRC Submission 040522-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2966 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 79613108-79618464 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 79617057 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 200 (V200A)
Ref Sequence ENSEMBL: ENSMUSP00000020575 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020573] [ENSMUST00000020575] [ENSMUST00000169684]
AlphaFold Q9EQC7
Predicted Effect probably benign
Transcript: ENSMUST00000020573
SMART Domains Protein: ENSMUSP00000020573
Gene: ENSMUSG00000020323

DomainStartEndE-ValueType
signal peptide 1 37 N/A INTRINSIC
Tryp_SPc 39 264 1.53e-70 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000020575
AA Change: V200A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000020575
Gene: ENSMUSG00000020325
AA Change: V200A

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
FOLN 96 118 4.13e-6 SMART
KAZAL 116 165 1.69e-11 SMART
FOLN 168 191 1.09e-5 SMART
KAZAL 197 241 1.02e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000167987
SMART Domains Protein: ENSMUSP00000130448
Gene: ENSMUSG00000020323

DomainStartEndE-ValueType
Pfam:Trypsin 1 75 1.4e-10 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168798
Predicted Effect probably benign
Transcript: ENSMUST00000169684
SMART Domains Protein: ENSMUSP00000132215
Gene: ENSMUSG00000020323

DomainStartEndE-ValueType
signal peptide 1 37 N/A INTRINSIC
Tryp_SPc 39 264 1.53e-70 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000170380
Predicted Effect probably benign
Transcript: ENSMUST00000171681
SMART Domains Protein: ENSMUSP00000131642
Gene: ENSMUSG00000020323

DomainStartEndE-ValueType
Tryp_SPc 1 87 3.16e-1 SMART
Meta Mutation Damage Score 0.1120 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Adult mice homozygous for a knock-out allele display increased pancreatic islet number and size, beta cell hyperplasia, hepatic steatosis, increased heart weight, mild hypertension, and alterations in glucose homeostasis and fat distribution. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610021A01Rik C T 7: 41,275,829 (GRCm39) R511* probably null Het
Adamts1 A G 16: 85,593,662 (GRCm39) V691A possibly damaging Het
Add1 C A 5: 34,788,058 (GRCm39) D702E probably benign Het
Ap1s1 T C 5: 137,066,357 (GRCm39) D148G probably damaging Het
Asprv1 T A 6: 86,605,348 (GRCm39) C65S probably damaging Het
Atp11a A T 8: 12,897,853 (GRCm39) probably null Het
Atp8a1 T C 5: 67,805,049 (GRCm39) D1022G probably benign Het
Bahd1 C T 2: 118,746,887 (GRCm39) P169S probably damaging Het
Bnc2 G A 4: 84,211,754 (GRCm39) A300V probably benign Het
Cep250 A G 2: 155,836,798 (GRCm39) K2256E probably benign Het
Cfap300 C T 9: 8,027,175 (GRCm39) R121Q probably damaging Het
Chrna2 T C 14: 66,386,817 (GRCm39) V321A possibly damaging Het
Chsy1 G A 7: 65,821,912 (GRCm39) G716R probably damaging Het
Col2a1 A G 15: 97,873,976 (GRCm39) I1402T unknown Het
Ddx43 C A 9: 78,313,661 (GRCm39) Y197* probably null Het
Dyrk2 T A 10: 118,696,242 (GRCm39) K339* probably null Het
Fbxw21 A G 9: 108,974,578 (GRCm39) I314T probably benign Het
Fgd6 T A 10: 93,880,056 (GRCm39) F303L probably benign Het
Gabra5 T C 7: 57,058,389 (GRCm39) E453G probably damaging Het
Gatd1 T A 7: 140,989,080 (GRCm39) D193V probably damaging Het
Gm6871 T G 7: 41,222,864 (GRCm39) T75P probably benign Het
Gpr45 G A 1: 43,071,668 (GRCm39) D104N possibly damaging Het
Has2 A G 15: 56,545,533 (GRCm39) L23P probably damaging Het
Lrriq1 A G 10: 103,050,761 (GRCm39) S664P probably benign Het
Ltf G T 9: 110,857,540 (GRCm39) C443F possibly damaging Het
Mgam T C 6: 40,745,154 (GRCm39) V1807A possibly damaging Het
Myh1 A G 11: 67,105,410 (GRCm39) K1067E probably damaging Het
Nav2 C T 7: 49,206,780 (GRCm39) T1535I probably damaging Het
Noa1 T C 5: 77,454,191 (GRCm39) E483G possibly damaging Het
Nsd2 G C 5: 34,003,466 (GRCm39) E205D probably benign Het
Pclo T C 5: 14,731,164 (GRCm39) L3222P unknown Het
Pnpla2 C T 7: 141,038,391 (GRCm39) L215F probably damaging Het
Prss35 A G 9: 86,637,635 (GRCm39) D135G probably damaging Het
Pth T C 7: 112,985,136 (GRCm39) H79R probably benign Het
Rab21 T C 10: 115,130,814 (GRCm39) N164S probably benign Het
Rasal1 T A 5: 120,809,685 (GRCm39) L530Q probably damaging Het
Rbm15b A G 9: 106,762,791 (GRCm39) L459P probably damaging Het
Recql A G 6: 142,309,313 (GRCm39) V586A probably benign Het
Rprd2 A T 3: 95,673,745 (GRCm39) probably null Het
Sis T A 3: 72,796,343 (GRCm39) I1813L probably benign Het
Slc4a5 C T 6: 83,273,651 (GRCm39) T997I probably damaging Het
Sympk T C 7: 18,764,469 (GRCm39) V58A probably damaging Het
Trav7d-4 C T 14: 53,007,584 (GRCm39) Q26* probably null Het
Usp48 G A 4: 137,341,073 (GRCm39) V358M probably damaging Het
Vmn1r39 A C 6: 66,781,715 (GRCm39) I201S possibly damaging Het
Zcchc8 A G 5: 123,858,930 (GRCm39) S22P probably benign Het
Other mutations in Fstl3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02680:Fstl3 APN 10 79,614,506 (GRCm39) nonsense probably null
IGL03165:Fstl3 APN 10 79,615,799 (GRCm39) missense probably benign 0.02
R0382:Fstl3 UTSW 10 79,613,141 (GRCm39) missense probably benign
R2113:Fstl3 UTSW 10 79,617,012 (GRCm39) missense probably damaging 0.96
R2964:Fstl3 UTSW 10 79,617,057 (GRCm39) missense probably benign
R2965:Fstl3 UTSW 10 79,617,057 (GRCm39) missense probably benign
R5211:Fstl3 UTSW 10 79,616,012 (GRCm39) missense probably benign 0.01
R6225:Fstl3 UTSW 10 79,615,843 (GRCm39) missense probably benign 0.08
R7389:Fstl3 UTSW 10 79,615,865 (GRCm39) missense probably damaging 1.00
R7390:Fstl3 UTSW 10 79,615,865 (GRCm39) missense probably damaging 1.00
R7484:Fstl3 UTSW 10 79,615,865 (GRCm39) missense probably damaging 1.00
R9245:Fstl3 UTSW 10 79,614,411 (GRCm39) missense probably damaging 1.00
T0722:Fstl3 UTSW 10 79,615,997 (GRCm39) missense probably damaging 1.00
X0003:Fstl3 UTSW 10 79,615,997 (GRCm39) missense probably damaging 1.00
X0022:Fstl3 UTSW 10 79,615,901 (GRCm39) missense probably benign 0.06
Z1176:Fstl3 UTSW 10 79,617,032 (GRCm39) missense probably benign
Z1177:Fstl3 UTSW 10 79,615,942 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGATCTTGACAGCAGGGTGG -3'
(R):5'- ACTTTGGGGCCACCTACAAG -3'

Sequencing Primer
(F):5'- TAGTGTCCCAGGGCAGG -3'
(R):5'- TTGGGGCCACCTACAAGTATGG -3'
Posted On 2015-02-05